$109 Cheap Delta flights St. Louis (STL) to Buffalo (BUF)

Landing cheap one-way Delta Air Lines flights from STL to BUF from $109 on Expedia is easy — just filter by “Price (lowest to highest).” Or check out our budget-friendly return fares from $217 for your next exciting adventure.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Delta Air Lines flights to Buffalo are typically cheaper in the quieter months of January and February. Whether you’re in search of a round-trip or one-way ticket, you could land a better deal then.

Start searching one to three months ahead of your departure date to score cheaper fares on Delta Air Lines flights from Lambert-St. Louis Intl. Airport (STL) to Buffalo Niagara Intl. Airport (BUF). You can save 25% by booking your domestic flight 34 to 86 days in advance compared to last-minute reservations made 6 to 12 days out. You could also reduce costs by buying your fare on a Sunday, as it’s 6% cheaper on average than a Monday, the most expensive day to book.* Get the timing right, and you can enjoy significant savings on domestic flights.*Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

To see if there’s a direct journey from STL to BUF with Delta Air Lines or any other airlines, check the “Nonstop” filter when browsing for tickets.

Filter your results by “Morning” and “Early Morning” to see the earliest flights from STL to BUF. Heading off early means you’re 20% less likely to experience cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

Take a Delta Air Lines flight from Lambert-St. Louis Intl. Airport (STL) to Buffalo, and you’ll likely arrive at Buffalo Niagara Intl. Airport (BUF). This is the airline’s main hub here.

Delta Air Lines makes flying from STL to BUF more comfortable with a rewarding loyalty program and an excellent in-flight experience. You could even start earning points with Delta SkyMiles. Remember to join Expedia’s free One Key™ rewards program to earn OneKeyCash™*, which can be redeemed on future bookings.*OneKeyCash™ disclaimer - OneKeyCash™ is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.

Changes are often free within 24 hours of making your booking, but your airline may charge you after that time. For more information about altering your reservation, head to your “Trips,” select your flight and click on “Manage Booking.” If you want the flexibility to adjust your plans without additional costs, tick the “Changes included” and “No cancel fee” filters when organizing your next break.