$404 Cheap Flights from Brussels (BRU) to Panama City (PTY)

View $404 flight on Fri, Nov 28, 2025Opens in a new window

Popular airlines from Brussels Airport (BRU) to Tocumen Intl. Airport (PTY)

Cheap Flights from Brussels to Panama City (BRU-PTY)

Prices were available within the past 7 days and start at $404 for one-way flights and $660 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Air Europa
Thu, Feb 5 - Thu, Feb 19
BRU
Brussels
PTY
Panama City
$660 Roundtrip, found 2 days ago
$660
Roundtrip
found 2 days ago
Select Air Europa flight, departing Thu, Feb 5 from Brussels to Panama City, returning Thu, Feb 19, priced at $660 found 2 days ago
Air Europa
Thu, Feb 5 - Thu, Feb 19
BRU
Brussels
PTY
Panama City
$668 Roundtrip, found 2 days ago
$668
Roundtrip
found 2 days ago
Select Air Europa flight, departing Thu, Feb 5 from Brussels to Panama City, returning Thu, Feb 19, priced at $668 found 2 days ago
Air Europa
Thu, Feb 5 - Thu, Feb 19
BRU
Brussels
PTY
Panama City
$671 Roundtrip, found 2 days ago
$671
Roundtrip
found 2 days ago
Select Air Europa flight, departing Thu, Feb 5 from Brussels to Panama City, returning Thu, Feb 19, priced at $671 found 2 days ago
Air Europa
Thu, Feb 5 - Thu, Feb 19
BRU
Brussels
PTY
Panama City
$679 Roundtrip, found 2 days ago
$679
Roundtrip
found 2 days ago
Select Air Europa flight, departing Thu, Feb 5 from Brussels to Panama City, returning Thu, Feb 19, priced at $679 found 2 days ago
Iberia
Sat, May 30 - Sat, Jun 13
BRU
Brussels
PTY
Panama City
$702 Roundtrip, found 6 days ago
$702
Roundtrip
found 6 days ago
Select Iberia flight, departing Sat, May 30 from Brussels to Panama City, returning Sat, Jun 13, priced at $702 found 6 days ago
Brussels Airlines
Sun, Dec 14 - Wed, Dec 31
BRU
Brussels
PTY
Panama City
$705 Roundtrip, found 14 hours ago
$705
Roundtrip
found 14 hours ago
Select Brussels Airlines flight, departing Sun, Dec 14 from Brussels to Panama City, returning Wed, Dec 31, priced at $705 found 14 hours ago
United
Sun, Dec 14 - Wed, Dec 31
BRU
Brussels
PTY
Panama City
$718 Roundtrip, found 14 hours ago
$718
Roundtrip
found 14 hours ago
Select United flight, departing Sun, Dec 14 from Brussels to Panama City, returning Wed, Dec 31, priced at $718 found 14 hours ago
United
Thu, Dec 11 - Tue, Dec 30
BRU
Brussels
PTY
Panama City
$721 Roundtrip, found 1 day ago
$721
Roundtrip
found 1 day ago
Select United flight, departing Thu, Dec 11 from Brussels to Panama City, returning Tue, Dec 30, priced at $721 found 1 day ago
Iberia
Sat, May 30 - Sat, Jun 13
BRU
Brussels
PTY
Panama City
$737 Roundtrip, found 6 days ago
$737
Roundtrip
found 6 days ago
Select Iberia flight, departing Sat, May 30 from Brussels to Panama City, returning Sat, Jun 13, priced at $737 found 6 days ago
Swiss International Air Lines
Sun, Dec 14 - Wed, Dec 31
BRU
Brussels
PTY
Panama City
$824 Roundtrip, found 14 hours ago
$824
Roundtrip
found 14 hours ago
Select Swiss International Air Lines flight, departing Sun, Dec 14 from Brussels to Panama City, returning Wed, Dec 31, priced at $824 found 14 hours ago

Frequently asked questions

How much does a flight from Brussels - National Airport (BRU) to Tocumen Intl. Airport (PTY) cost?
Get a cheap one-way flight from $404 or cheap return flight from $660 from Brussels - National Airport (BRU) to Tocumen Intl. Airport (PTY) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Brussels - National Airport (BRU) to Tocumen Intl. Airport (PTY)?
Planning your getaway for February is a great way to save, as it's the cheapest month for flights between BRU and PTY. You'll usually find the lowest fares during the off-season.
What is the cheapest airline that flies from Brussels - National Airport (BRU) to Tocumen Intl. Airport (PTY)?
Expedia's filter tool lets you easily compare travel time, airlines and fares all in one place. Select your preferences, then sort by "Price (lowest to highest)" to find out which carrier offers the cheapest BRU to PTY flight.
How many flights per day from Brussels - National Airport (BRU) to Tocumen Intl. Airport (PTY)?
You'll need to take a flight with a layover if you're traveling from Brussels - National Airport (BRU) to Tocumen Intl. Airport (PTY). Direct flights don't operate daily on this route. However, simply filter your search to include one or more stops to discover an option that works for you.
What day of the week has the most flights from BRU to PTY?
You'll usually find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can vary from season to season and during public holidays or peak travel times.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Brussels - National Airport (BRU) to Tocumen Intl. Airport (PTY)?
To avoid possible delays on the Brussels - National Airport (BRU) to Tocumen Intl. Airport (PTY) route, aim to travel before 3 PM. Flights after this time have a 22% higher chance of being canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Brussels - National Airport (BRU) to Tocumen Intl. Airport (PTY) last-minute?
Last-minute bookings from BRU to PTY are typically more expensive. To lock in the best prices, start looking for flights well ahead of time. That said, if you can play around with your travel dates, it's possible to land a cheap ticket right before your trip.
Is it cheaper to book a BRU to PTY flight and hotel package?
Compared with arranging flights and hotels separately, booking a BRU to PTY flight and hotel package with Expedia could result in significant savings. Better yet, having everything in one convenient place will take the stress out of planning your trip. Just secure your flights and select from our extensive range of stays, then tailor your trip with extras like tours, activities and car rentals.
Can I cancel or change the date of my flight from Brussels - National Airport (BRU) to Tocumen Intl. Airport (PTY)?
It's generally possible to cancel or reschedule your BRU to PTY flight. However, for bookings made more than 24 hours ago, additional charges may apply. Refer to your airline's policies in your itinerary to see what changes are allowed and whether any costs are involved. You'll also find more details on our Customer Service portal.

Travel information

Origin airport
Brussels - National
Destination airport
Tocumen Intl.
Airlines serving
Air Europa, American Airlines, British Airways, Delta, Iberia, KLM, Turkish Airlines, United
Roundtrip price
$660
Distance
5466 mi

Book with confidence

Brussels to Panama City Flights

The cheapest times to fly from Brussels to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Brussels to Panama City are during the month of February. You can find some of the cheapest flights from Brussels to Panama City with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Brussels to Panama City

Sunday is one of the best days to book for cheap flights from Brussels to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Brussels to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Brussels to Panama City in 2025. You can also book with separate airlines for your outbound and return journeys, from $404 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Brussels to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Brussels to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Brussels to Panama City Flights

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*Available to One Key members.