$184 Cheap Flights from Buffalo (BUF) to Tupelo (TUP)

View $184 flight on Tue, Oct 28, 2025Opens in a new window

Popular airlines from Buffalo Niagara Intl. Airport (BUF) to Tupelo, MS (TUP-Tupelo Regional)

Cheap Flights from Buffalo to Tupelo (BUF-TUP)

Prices were available within the past 7 days and start at $184 for one-way flights and $420 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Wed, Oct 29 - Thu, Oct 30
BUF
Buffalo
TUP
Tupelo
$420 Roundtrip, found 5 days ago
$420
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Oct 29 from Buffalo to Tupelo, returning Thu, Oct 30, priced at $420 found 5 days ago
American Airlines
Wed, Oct 29 - Thu, Oct 30
BUF
Buffalo
TUP
Tupelo
$446 Roundtrip, found 5 days ago
$446
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Oct 29 from Buffalo to Tupelo, returning Thu, Oct 30, priced at $446 found 5 days ago
American Airlines
Wed, Oct 29 - Thu, Oct 30
BUF
Buffalo
TUP
Tupelo
$461 Roundtrip, found 5 days ago
$461
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Oct 29 from Buffalo to Tupelo, returning Thu, Oct 30, priced at $461 found 5 days ago
American Airlines
Thu, Sep 11 - Sun, Sep 14
BUF
Buffalo
TUP
Tupelo
$472 Roundtrip, found 3 days ago
$472
Roundtrip
found 3 days ago
Select American Airlines flight, departing Thu, Sep 11 from Buffalo to Tupelo, returning Sun, Sep 14, priced at $472 found 3 days ago
American Airlines
Wed, Oct 29 - Thu, Oct 30
BUF
Buffalo
TUP
Tupelo
$487 Roundtrip, found 5 days ago
$487
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Oct 29 from Buffalo to Tupelo, returning Thu, Oct 30, priced at $487 found 5 days ago
American Airlines
Thu, Sep 11 - Sun, Sep 14
BUF
Buffalo
TUP
Tupelo
$502 Roundtrip, found 1 day ago
$502
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Sep 11 from Buffalo to Tupelo, returning Sun, Sep 14, priced at $502 found 1 day ago
American Airlines
Wed, Oct 29 - Thu, Oct 30
BUF
Buffalo
TUP
Tupelo
$511 Roundtrip, found 5 days ago
$511
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Oct 29 from Buffalo to Tupelo, returning Thu, Oct 30, priced at $511 found 5 days ago
American Airlines
Wed, Oct 29 - Thu, Oct 30
BUF
Buffalo
TUP
Tupelo
$515 Roundtrip, found 5 days ago
$515
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Oct 29 from Buffalo to Tupelo, returning Thu, Oct 30, priced at $515 found 5 days ago
American Airlines
Thu, Sep 11 - Sun, Sep 14
BUF
Buffalo
TUP
Tupelo
$517 Roundtrip, found 3 days ago
$517
Roundtrip
found 3 days ago
Select American Airlines flight, departing Thu, Sep 11 from Buffalo to Tupelo, returning Sun, Sep 14, priced at $517 found 3 days ago
United
Thu, Sep 11 - Sun, Sep 14
BUF
Buffalo
TUP
Tupelo
$627 Roundtrip, found 2 days ago
$627
Roundtrip
found 2 days ago
Select United flight, departing Thu, Sep 11 from Buffalo to Tupelo, returning Sun, Sep 14, priced at $627 found 2 days ago
Flights from Buffalo (BUF) to Tupelo (TUP)
Origin airport
Buffalo Niagara Intl.
Destination airport
Tupelo Regional
Roundtrip price
$419
Distance
806 mi

Buffalo to Tupelo Flights

The cheapest times to fly from Buffalo to Tupelo

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Buffalo to Tupelo are during the month of October. You can find some of the cheapest flights from Buffalo to Tupelo with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Buffalo to Tupelo

Sunday is one of the best days to book for cheap flights from Buffalo to Tupelo: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Buffalo to Tupelo

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Buffalo to Tupelo in 2025. You can also book with separate airlines for your outbound and return journeys, from $184 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Buffalo to Tupelo flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Buffalo to Tupelo airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Buffalo Niagara Intl. Airport (BUF) to Tupelo Regional Airport (TUP) cost?
Get a cheap one-way flight from $184 or cheap return flight from $420 from Buffalo Niagara Intl. Airport (BUF) to Tupelo Regional Airport (TUP) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Buffalo Niagara Intl. Airport (BUF) to Tupelo Regional Airport (TUP)?
Flying in October is a good way to save, as it's the cheapest month for flights between BUF and TUP. You'll typically find the lowest fares during the off-season.
What is the cheapest airline that flies from Buffalo Niagara Intl. Airport (BUF) to Tupelo Regional Airport (TUP)?
Expedia's filter tool lets you easily compare different airlines, flight durations and fares all in one place. Customize the search to your preferences, then sort by "Price (lowest to highest)" to find out which carrier offers the cheapest BUF to TUP flight.
How many flights per day from Buffalo Niagara Intl. Airport (BUF) to Tupelo Regional Airport (TUP)?
Nonstop flights from Buffalo Niagara Intl. Airport (BUF) to Tupelo Regional Airport (TUP) aren't available daily, so you'll have to take a flight with a layover. Explore your options with Expedia's filters. Enter your travel details and pick either "1 Stop" or "2+ Stops."
What day of the week has the most flights from BUF to TUP?
Usually you'll find the widest variety of flight choices on a Friday. Tuesdays are often the quietest.* But this can vary depending on the airline, season and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Buffalo Niagara Intl. Airport (BUF) to Tupelo Regional Airport (TUP)?
Opt for a flight from Buffalo Niagara Intl. Airport (BUF) to Tupelo Regional Airport (TUP) that takes off before 3 PM to reduce the likelihood of delays. Departures after this time are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Buffalo Niagara Intl. Airport (BUF) to Tupelo Regional Airport (TUP) last-minute?
Booking your ticket from BUF to TUP right before your trip is typically more expensive. But if there's some wiggle room with your travel times and dates, you could grab a cheap last-minute fare.
Is it cheaper to book a BUF to TUP flight and hotel package?
Compared with arranging flights and hotels separately, booking a BUF to TUP flight and hotel package with Expedia could lead to significant savings. Better still, having it all in one place will take the stress out of travel planning. Just secure your flights and select from our extensive range of hotels, then personalize your trip with other add-ons like tours and car rentals.
Can I cancel or change the date of my flight from Buffalo Niagara Intl. Airport (BUF) to Tupelo Regional Airport (TUP)?
It's usually possible to reschedule or cancel your BUF to TUP flight. However, if the booking was made more than 24 hours ago, additional fees may apply. Refer to your airline's policies in your itinerary to see what changes are possible and if any costs are involved. You'll also find further details on our Customer Service portal.

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*Available to One Key members.