$451 Cheap Flights from Cusco (CUZ) to Santo Domingo (SDQ)

View $451 flight on Tue, Oct 28, 2025Opens in a new window

Popular airlines from Alejandro Velasco Astete Intl. Airport (CUZ) to Las Americas Intl. Airport (SDQ)

Cheap Flights from Cusco to Santo Domingo (CUZ-SDQ)

Prices were available within the past 7 days and start at $451 for one-way flights and $898 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

avianca
Sat, Oct 11 - Tue, Oct 14
CUZ
Cusco
SDQ
Santo Domingo
$898 Roundtrip, found 1 day ago
$898
Roundtrip
found 1 day ago
Select avianca flight, departing Sat, Oct 11 from Cusco to Santo Domingo, returning Tue, Oct 14, priced at $898 found 1 day ago
avianca
Mon, Sep 1 - Thu, Sep 4
CUZ
Cusco
SDQ
Santo Domingo
$905 Roundtrip, found 1 day ago
$905
Roundtrip
found 1 day ago
Select avianca flight, departing Mon, Sep 1 from Cusco to Santo Domingo, returning Thu, Sep 4, priced at $905 found 1 day ago
avianca
Thu, Oct 9 - Sat, Oct 11
CUZ
Cusco
SDQ
Santo Domingo
$945 Roundtrip, found 1 day ago
$945
Roundtrip
found 1 day ago
Select avianca flight, departing Thu, Oct 9 from Cusco to Santo Domingo, returning Sat, Oct 11, priced at $945 found 1 day ago
avianca
Mon, Sep 1 - Wed, Sep 3
CUZ
Cusco
SDQ
Santo Domingo
$950 Roundtrip, found 1 day ago
$950
Roundtrip
found 1 day ago
Select avianca flight, departing Mon, Sep 1 from Cusco to Santo Domingo, returning Wed, Sep 3, priced at $950 found 1 day ago
avianca
Thu, Oct 9 - Sun, Oct 19
CUZ
Cusco
SDQ
Santo Domingo
$968 Roundtrip, found 6 days ago
$968
Roundtrip
found 6 days ago
Select avianca flight, departing Thu, Oct 9 from Cusco to Santo Domingo, returning Sun, Oct 19, priced at $968 found 6 days ago
avianca
Mon, Oct 6 - Thu, Oct 9
CUZ
Cusco
SDQ
Santo Domingo
$974 Roundtrip, found 1 day ago
$974
Roundtrip
found 1 day ago
Select avianca flight, departing Mon, Oct 6 from Cusco to Santo Domingo, returning Thu, Oct 9, priced at $974 found 1 day ago
avianca
Thu, Oct 9 - Sun, Oct 19
CUZ
Cusco
SDQ
Santo Domingo
$986 Roundtrip, found 6 days ago
$986
Roundtrip
found 6 days ago
Select avianca flight, departing Thu, Oct 9 from Cusco to Santo Domingo, returning Sun, Oct 19, priced at $986 found 6 days ago
avianca
Thu, Oct 9 - Sun, Oct 19
CUZ
Cusco
SDQ
Santo Domingo
$1,020 Roundtrip, found 6 days ago
$1,020
Roundtrip
found 6 days ago
Select avianca flight, departing Thu, Oct 9 from Cusco to Santo Domingo, returning Sun, Oct 19, priced at $1,020 found 6 days ago
avianca
Thu, Oct 9 - Sun, Oct 19
CUZ
Cusco
SDQ
Santo Domingo
$1,037 Roundtrip, found 6 days ago
$1,037
Roundtrip
found 6 days ago
Select avianca flight, departing Thu, Oct 9 from Cusco to Santo Domingo, returning Sun, Oct 19, priced at $1,037 found 6 days ago
American Airlines
Thu, Oct 16 - Sat, Nov 1
CUZ
Cusco
SDQ
Santo Domingo
$1,422 Roundtrip, found 21 hours ago
$1,422
Roundtrip
found 21 hours ago
Select American Airlines flight, departing Thu, Oct 16 from Cusco to Santo Domingo, returning Sat, Nov 1, priced at $1,422 found 21 hours ago
Flights from Cusco (CUZ) to Santo Domingo (SDQ)
Origin airport
Alejandro Velasco Astete Intl.
Destination airport
Las Americas Intl.
Airlines serving
American Airlines, avianca
Roundtrip price
$898
Distance
2214 mi

Cusco to Santo Domingo Flights

The cheapest times to fly from Cusco to Santo Domingo

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Cusco to Santo Domingo are during the month of October. You can find some of the cheapest flights from Cusco to Santo Domingo with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Cusco to Santo Domingo

Sunday is one of the best days to book for cheap flights from Cusco to Santo Domingo: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Cusco to Santo Domingo

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Cusco to Santo Domingo in 2025. You can also book with separate airlines for your outbound and return journeys, from $451 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Cusco to Santo Domingo flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Cusco to Santo Domingo airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Alejandro Velasco Astete Intl. Airport (CUZ) to Las Americas Intl. Airport (SDQ) cost?
Snag a cheap one-way flight from $451 or cheap return flight from $898 from Alejandro Velasco Astete Intl. Airport (CUZ) to Las Americas Intl. Airport (SDQ) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Alejandro Velasco Astete Intl. Airport (CUZ) to Las Americas Intl. Airport (SDQ)?
Traveling in October is a great way to save, as it's the cheapest month for flights between CUZ and SDQ. You'll usually find the lowest fares during the off-season.
What is the cheapest airline that flies from Alejandro Velasco Astete Intl. Airport (CUZ) to Las Americas Intl. Airport (SDQ)?
Use the filters on Expedia to compare different airlines and find the most affordable carrier that'll take you from CUZ to SDQ. Then, sort your results by "Price (lowest to highest)" to score a good deal.
How many flights per day from Alejandro Velasco Astete Intl. Airport (CUZ) to Las Americas Intl. Airport (SDQ)?
Nonstop flights from Alejandro Velasco Astete Intl. Airport (CUZ) to Las Americas Intl. Airport (SDQ) aren't available daily, so you'll need to take a flight with a layover. Explore your options with Expedia's filter tool. Enter your travel dates and click on either "1 Stop" or "2+ Stops."
What day of the week has the most flights from CUZ to SDQ?
Generally you'll find the largest variety of flight choices on a Friday. Tuesdays tend to be the quietest.* However, this can vary depending on the time of year, airline and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Alejandro Velasco Astete Intl. Airport (CUZ) to Las Americas Intl. Airport (SDQ)?
Select a flight from Alejandro Velasco Astete Intl. Airport (CUZ) to Las Americas Intl. Airport (SDQ) that takes off before 3 PM to reduce the likelihood of delays. Departures later than this have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Alejandro Velasco Astete Intl. Airport (CUZ) to Las Americas Intl. Airport (SDQ) last-minute?
Last-minute fares from CUZ to SDQ are usually more expensive. For the best prices, start searching for flights early. That being said, if you're flexible with your travel plans, it's possible to land a cheap fare right before your trip.
Is it cheaper to book a CUZ to SDQ flight and hotel package?
Compared with arranging hotels and flights separately, booking a CUZ to SDQ flight and hotel package with Expedia could lead to significant savings. Better still, having everything in one convenient place will take the stress out of travel planning. Just pick your flights and select from our wide range of stays, then tailor your trip with extras like car rentals and activities.
Can I cancel or change the date of my flight from Alejandro Velasco Astete Intl. Airport (CUZ) to Las Americas Intl. Airport (SDQ)?
In most cases, you're able to cancel or reschedule your CUZ to SDQ flight. However, additional fees may apply, especially if you made your booking more than 24 hours ago. Check your itinerary for the airline's fees and rules on flight changes, or if you'd like further information, head to our Customer Service portal.

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*Available to One Key members.