$546 Cheap Flights from Denver (DEN) to La Serena (LSC)

View $546 flight on Sun, Feb 15, 2026Opens in a new window

Popular airlines from Denver Intl. Airport (DEN) to La Serena (LSC-La Florida)

Cheap Flights from Denver to La Serena (DEN-LSC)

Prices were available within the past 7 days and start at $546 for one-way flights and $1,050 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

JetBlue Airways
Sun, Feb 15 - Wed, Feb 18
DEN
Denver
LSC
La Serena
$1,050 Roundtrip, found 5 days ago
$1,050
Roundtrip
found 5 days ago
Select JetBlue Airways flight, departing Sun, Feb 15 from Denver to La Serena, returning Wed, Feb 18, priced at $1,050 found 5 days ago
LATAM Airlines Group
Sun, Feb 15 - Wed, Feb 18
DEN
Denver
LSC
La Serena
$1,055 Roundtrip, found 5 days ago
$1,055
Roundtrip
found 5 days ago
Select LATAM Airlines Group flight, departing Sun, Feb 15 from Denver to La Serena, returning Wed, Feb 18, priced at $1,055 found 5 days ago
Air Canada
Sun, Feb 15 - Wed, Feb 18
DEN
Denver
LSC
La Serena
$1,076 Roundtrip, found 5 days ago
$1,076
Roundtrip
found 5 days ago
Select Air Canada flight, departing Sun, Feb 15 from Denver to La Serena, returning Wed, Feb 18, priced at $1,076 found 5 days ago
Air Canada
Sun, Feb 15 - Wed, Feb 18
DEN
Denver
LSC
La Serena
$1,083 Roundtrip, found 5 days ago
$1,083
Roundtrip
found 5 days ago
Select Air Canada flight, departing Sun, Feb 15 from Denver to La Serena, returning Wed, Feb 18, priced at $1,083 found 5 days ago
Delta
Sun, Feb 15 - Wed, Feb 18
DEN
Denver
LSC
La Serena
$1,085 Roundtrip, found 5 days ago
$1,085
Roundtrip
found 5 days ago
Select Delta flight, departing Sun, Feb 15 from Denver to La Serena, returning Wed, Feb 18, priced at $1,085 found 5 days ago
JetBlue Airways
Sun, Feb 15 - Wed, Feb 18
DEN
Denver
LSC
La Serena
$1,100 Roundtrip, found 5 days ago
$1,100
Roundtrip
found 5 days ago
Select JetBlue Airways flight, departing Sun, Feb 15 from Denver to La Serena, returning Wed, Feb 18, priced at $1,100 found 5 days ago
LATAM Airlines Group
Sun, Feb 15 - Wed, Feb 18
DEN
Denver
LSC
La Serena
$1,105 Roundtrip, found 5 days ago
$1,105
Roundtrip
found 5 days ago
Select LATAM Airlines Group flight, departing Sun, Feb 15 from Denver to La Serena, returning Wed, Feb 18, priced at $1,105 found 5 days ago
Air Canada
Sun, Feb 15 - Wed, Feb 18
DEN
Denver
LSC
La Serena
$1,199 Roundtrip, found 5 days ago
$1,199
Roundtrip
found 5 days ago
Select Air Canada flight, departing Sun, Feb 15 from Denver to La Serena, returning Wed, Feb 18, priced at $1,199 found 5 days ago
Delta
Sun, Feb 15 - Wed, Feb 18
DEN
Denver
LSC
La Serena
$1,215 Roundtrip, found 5 days ago
$1,215
Roundtrip
found 5 days ago
Select Delta flight, departing Sun, Feb 15 from Denver to La Serena, returning Wed, Feb 18, priced at $1,215 found 5 days ago
Delta
Sun, Feb 15 - Wed, Feb 18
DEN
Denver
LSC
La Serena
$1,230 Roundtrip, found 5 days ago
$1,230
Roundtrip
found 5 days ago
Select Delta flight, departing Sun, Feb 15 from Denver to La Serena, returning Wed, Feb 18, priced at $1,230 found 5 days ago
Flights from Denver (DEN) to La Serena (LSC)
Origin airport
Denver Intl.
Destination airport
La Florida
Roundtrip price
$1,049
Distance
5276 mi

Denver to La Serena Flights

The cheapest times to fly from Denver to La Serena

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Denver to La Serena are during the month of February. You can find some of the cheapest flights from Denver to La Serena with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Denver to La Serena

Sunday is one of the best days to book for cheap flights from Denver to La Serena: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Denver to La Serena

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Denver to La Serena in 2025. You can also book with separate airlines for your outbound and return journeys, from $546 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Denver to La Serena flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Denver to La Serena airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Denver Intl. Airport (DEN) to La Florida Airport (LSC) cost?
Snag a cheap one-way flight from $546 or cheap return flight from $1,050 from Denver Intl. Airport (DEN) to La Florida Airport (LSC) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Denver Intl. Airport (DEN) to La Florida Airport (LSC)?
February is the cheapest month to fly from DEN to LSC. Traveling during an off-peak travel window is often the key to scoring lower fares.
What is the cheapest airline that flies from Denver Intl. Airport (DEN) to La Florida Airport (LSC)?
Expedia's filter tool lets you easily compare different airlines, departure times and fares all in one place. Choose your preferences, then sort by "Price (lowest to highest)" to find out which carrier offers the cheapest DEN to LSC flight.
How many flights per day from Denver Intl. Airport (DEN) to La Florida Airport (LSC)?
There are no daily direct flights from Denver Intl. Airport (DEN) to La Florida Airport (LSC). But you can book flights with layovers. Filter your search results on Expedia to include one or two stops, and you'll be soaring above the clouds in no time.
What day of the week has the most flights from DEN to LSC?
Friday is usually the busiest day for flights, while Tuesday tends to be the quietest.* Just remember that flight schedules can vary depending on a range of factors, including the season and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Denver Intl. Airport (DEN) to La Florida Airport (LSC)?
Select a flight from Denver Intl. Airport (DEN) to La Florida Airport (LSC) that leaves before 3 PM to reduce the risk of delays and cancellations. Departures after this hour have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Denver Intl. Airport (DEN) to La Florida Airport (LSC) last-minute?
Holding off until just before your departure to book your flight from DEN to LSC generally means paying more. While it's possible to find some last-minute discounts, they're not always guaranteed. Be flexible with your itinerary to maximize your chances of snagging a bargain.
Is it cheaper to book a DEN to LSC flight and hotel package?
Compared with arranging flights and hotels separately, booking a DEN to LSC flight and hotel package with Expedia could lead to significant savings. Better still, having everything in one convenient place will take the hassle out of travel planning. Simply secure your flights and select from our wide range of hotels, then personalize your trip with extras like activities and car rentals.
Can I cancel or change the date of my flight from Denver Intl. Airport (DEN) to La Florida Airport (LSC)?
If you reserved your DEN to LSC flight within the last 24 hours, you may be able to cancel or modify it at no cost. Depending on the airline and the ticket type you purchased, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, visit our Customer Service portal for more details.

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*Available to One Key members.