$271 Cheap Flights from Denver (DEN) to Panama City (PTY)

View $271 flight on Thu, Jul 10, 2025Opens in a new window

Popular airlines from Denver Intl. Airport (DEN) to Tocumen Intl. Airport (PTY)

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Cheap Flights from Denver to Panama City (DEN-PTY)

Prices were available within the past 7 days and start at $271 for one-way flights and $513 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Copa
Fri, Aug 22 - Mon, Aug 25
DEN
Denver
PTY
Panama City
$513 Roundtrip, found 1 hour ago
$513
Roundtrip
found 1 hour ago
Select Copa flight, departing Fri, Aug 22 from Denver to Panama City, returning Mon, Aug 25, priced at $513 found 1 hour ago
Copa
Sun, Nov 9 - Sat, Nov 15
DEN
Denver
PTY
Panama City
$521 Roundtrip, found 1 day ago
$521
Roundtrip
found 1 day ago
Select Copa flight, departing Sun, Nov 9 from Denver to Panama City, returning Sat, Nov 15, priced at $521 found 1 day ago
American Airlines
Tue, Sep 9 - Tue, Sep 16
DEN
Denver
PTY
Panama City
$527 Roundtrip, found 7 hours ago
$527
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Tue, Sep 9 from Denver to Panama City, returning Tue, Sep 16, priced at $527 found 7 hours ago
Delta
Tue, Oct 7 - Wed, Oct 15
DEN
Denver
PTY
Panama City
$527 Roundtrip, found 1 hour ago
$527
Roundtrip
found 1 hour ago
Select Delta flight, departing Tue, Oct 7 from Denver to Panama City, returning Wed, Oct 15, priced at $527 found 1 hour ago
United
Sat, Sep 13 - Sat, Sep 27
DEN
Denver
PTY
Panama City
$527 Roundtrip, just found
$527
Roundtrip
just found
Select United flight, departing Sat, Sep 13 from Denver to Panama City, returning Sat, Sep 27, priced at $527 just found
United
Wed, Oct 15 - Sun, Oct 19
DEN
Denver
PTY
Panama City
$531 Roundtrip, just found
$531
Roundtrip
just found
Select United flight, departing Wed, Oct 15 from Denver to Panama City, returning Sun, Oct 19, priced at $531 just found
United
Wed, Oct 15 - Sun, Oct 19
DEN
Denver
PTY
Panama City
$535 Roundtrip, just found
$535
Roundtrip
just found
Select United flight, departing Wed, Oct 15 from Denver to Panama City, returning Sun, Oct 19, priced at $535 just found
United
Thu, Aug 28 - Thu, Sep 11
DEN
Denver
PTY
Panama City
$537 Roundtrip, found 3 hours ago
$537
Roundtrip
found 3 hours ago
Select United flight, departing Thu, Aug 28 from Denver to Panama City, returning Thu, Sep 11, priced at $537 found 3 hours ago
Delta
Fri, Nov 7 - Mon, Nov 17
DEN
Denver
PTY
Panama City
$538 Roundtrip, found 5 hours ago
$538
Roundtrip
found 5 hours ago
Select Delta flight, departing Fri, Nov 7 from Denver to Panama City, returning Mon, Nov 17, priced at $538 found 5 hours ago
avianca
Thu, Sep 4 - Sun, Sep 7
DEN
Denver
PTY
Panama City
$1,266 Roundtrip, found 1 hour ago
$1,266
Roundtrip
found 1 hour ago
Select avianca flight, departing Thu, Sep 4 from Denver to Panama City, returning Sun, Sep 7, priced at $1,266 found 1 hour ago

Find the cheapest month to fly from Denver (DEN) to Panama City (PTY)

November is typically the cheapest month to fly

From $491 - $1,036 per traveler.

Graph displaying average flight prices per month

Flights from Denver (DEN) to Panama City (PTY)
Origin airport
Denver Intl.
Destination airport
Tocumen Intl.
Airlines serving
American Airlines, Copa, Delta, United, avianca
Roundtrip price
$512
Distance
2635 mi
Average flight time
4 hours 51 mins

Denver to Panama City Flights

The cheapest times to fly from Denver to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Denver to Panama City are during the month of August. You can find some of the cheapest flights from Denver to Panama City with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Denver to Panama City

Sunday is one of the best days to book for cheap flights from Denver to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Denver to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Denver to Panama City in 2025. You can also book with separate airlines for your outbound and return journeys, from $271 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Denver to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Denver to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Denver Intl. Airport (DEN) to Tocumen Intl. Airport (PTY) cost?
Book cheap return tickets starting from $513 from Denver Intl. Airport (DEN) to Tocumen Intl. Airport (PTY). This information is based on the cheapest price found on Expedia for this return journey departing within the next three months. This airfare is for a Copa flight leaving DEN on August 1 2025 and touching down at PTY. The price was last updated on July 6 2025 and has not changed since.
What is the cheapest month to fly from DEN to PTY?
The cheapest flights from DEN to PTY are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
Which airlines fly direct from Denver Intl. Airport (DEN) to Tocumen Intl. Airport (PTY)?
Take a nonstop flight with Copa Airlines and fly straight from Denver Intl. Airport (DEN) to Tocumen Intl. Airport (PTY).
What is the cheapest airline that flies from DEN to PTY?
Jet off from DEN to PTY with Copa. This carrier currently offers the cheapest one-way fare for this route, starting from $709. This fare is based on the lowest price found on Expedia departing within the next three months. The flight takes off from DEN on September 19 2025. Prices were last updated on July 6 2025 and have not changed since.
How many flights per day from Denver Intl. Airport (DEN) to Tocumen Intl. Airport (PTY)?
On average, Denver Intl. Airport (DEN) only offers 1 nonstop flight to Tocumen Intl. Airport (PTY) each day. For more choices, try Expedia's easy-to-use filters. Enter your preferred travel dates, then click on "1 Stop" or "2+ Stops" to find flights with layovers.
What are the most popular departure times for flights from Denver Intl. Airport (DEN) to Tocumen Intl. Airport (PTY)?
Flights between DEN and PTY tend to be busiest at 9 PM. If you'd like a less crowded experience and possibly cheaper tickets, look for a time outside the usual busy windows.
What day of the week has the most flights from DEN to PTY?
Jet off on a Sunday if you're searching for the largest selection of flights from Denver Intl. Airport (DEN) to Tocumen Intl. Airport (PTY).
What is the earliest flight from Denver Intl. Airport (DEN) to Tocumen Intl. Airport (PTY)?
Take the earliest flight at around 9:16PM UTC-7, departing from Denver Intl. Airport (DEN). You'll be traveling for about 5h 55m, arriving at Tocumen Intl. Airport (PTY) at approximately 5:11AM UTC-5.
How long does it take to fly from Denver Intl. Airport (DEN) to Tocumen Intl. Airport (PTY)?
The average flight duration from DEN to PTY is 5 hours and 55 minutes, covering a total distance of 2,600 mi.
What airline has the least delays from DEN to PTY?
With 88% of flights generally landing on time, Copa Airlines has the best on-time performance for nonstop flights from Denver Intl. Airport (DEN) to Tocumen Intl. Airport (PTY). To keep track of your flight status and get notified if anything changes, use the Expedia App.
What is the best time to fly from Denver Intl. Airport (DEN) to Tocumen Intl. Airport (PTY)?
To avoid potential delays on the Denver Intl. Airport (DEN) to Tocumen Intl. Airport (PTY) route, travel before 3 PM. Flights after this time are 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
What airports do you fly into for Panama City from Denver Intl. Airport (DEN)?
If you're taking a direct flight from Denver Intl. Airport (DEN) to Panama City, Tocumen Intl. Airport (PTY) is the only airport you can touch down at.
Is it cheaper to buy a plane ticket from Denver Intl. Airport (DEN) to Tocumen Intl. Airport (PTY) last-minute?
Booking your ticket from DEN to PTY just before your getaway is generally more expensive. However, if you're flexible with your departure dates and times, you could land a cheap last-minute fare.
Is it cheaper to book a DEN to PTY flight and hotel package?
Securing a DEN to PTY flight and hotel package is generally cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your trip in one place. Pick from our wide range of stays and then add activities, car rentals and flights to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Denver Intl. Airport (DEN) to Tocumen Intl. Airport (PTY)?
In most cases, you can modify or cancel your DEN to PTY flight. However, there may be additional charges, especially if you made your booking more than 24 hours ago. Check your itinerary for the airline's fees and guidelines on flight changes, or if you'd like more information, go to our Customer Service portal.

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*Available to One Key members.