$316 Cheap Flights from Des Moines (DSM) to Mayagüez (MAZ)

View $316 flight on Thu, Jan 1, 2026Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to Mayagüez (MAZ-Eugenio María de Hostos)

Cheap Flights from Des Moines to Mayagüez (DSM-MAZ)

Prices were available within the past 7 days and start at $316 for one-way flights and $953 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Thu, Jan 1 - Wed, Jan 7
DSM
Des Moines
MAZ
Mayagüez
$953 Roundtrip, found 2 days ago
$953
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Jan 1 from Des Moines to Mayagüez, returning Wed, Jan 7, priced at $953 found 2 days ago
American Airlines
Thu, Jan 1 - Wed, Jan 7
DSM
Des Moines
MAZ
Mayagüez
$973 Roundtrip, found 2 days ago
$973
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Jan 1 from Des Moines to Mayagüez, returning Wed, Jan 7, priced at $973 found 2 days ago
American Airlines
Thu, Jan 1 - Wed, Jan 7
DSM
Des Moines
MAZ
Mayagüez
$983 Roundtrip, found 2 days ago
$983
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Jan 1 from Des Moines to Mayagüez, returning Wed, Jan 7, priced at $983 found 2 days ago
American Airlines
Thu, Jan 1 - Wed, Jan 7
DSM
Des Moines
MAZ
Mayagüez
$1,108 Roundtrip, found 2 days ago
$1,108
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Jan 1 from Des Moines to Mayagüez, returning Wed, Jan 7, priced at $1,108 found 2 days ago
American Airlines
Thu, Jan 1 - Wed, Jan 7
DSM
Des Moines
MAZ
Mayagüez
$1,128 Roundtrip, found 2 days ago
$1,128
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Jan 1 from Des Moines to Mayagüez, returning Wed, Jan 7, priced at $1,128 found 2 days ago
American Airlines
Thu, Jan 1 - Wed, Jan 7
DSM
Des Moines
MAZ
Mayagüez
$1,138 Roundtrip, found 2 days ago
$1,138
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Jan 1 from Des Moines to Mayagüez, returning Wed, Jan 7, priced at $1,138 found 2 days ago
Delta
Thu, Jan 1 - Wed, Jan 7
DSM
Des Moines
MAZ
Mayagüez
$1,147 Roundtrip, found 2 days ago
$1,147
Roundtrip
found 2 days ago
Select Delta flight, departing Thu, Jan 1 from Des Moines to Mayagüez, returning Wed, Jan 7, priced at $1,147 found 2 days ago
Delta
Thu, Jan 1 - Wed, Jan 7
DSM
Des Moines
MAZ
Mayagüez
$1,167 Roundtrip, found 2 days ago
$1,167
Roundtrip
found 2 days ago
Select Delta flight, departing Thu, Jan 1 from Des Moines to Mayagüez, returning Wed, Jan 7, priced at $1,167 found 2 days ago
Delta
Thu, Jan 1 - Wed, Jan 7
DSM
Des Moines
MAZ
Mayagüez
$1,177 Roundtrip, found 2 days ago
$1,177
Roundtrip
found 2 days ago
Select Delta flight, departing Thu, Jan 1 from Des Moines to Mayagüez, returning Wed, Jan 7, priced at $1,177 found 2 days ago
American Airlines
Thu, Jan 1 - Wed, Jan 7
DSM
Des Moines
MAZ
Mayagüez
$1,188 Roundtrip, found 2 days ago
$1,188
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Jan 1 from Des Moines to Mayagüez, returning Wed, Jan 7, priced at $1,188 found 2 days ago
American Airlines
Thu, Jan 1 - Wed, Jan 7
DSM
Des Moines
MAZ
Mayagüez
$1,208 Roundtrip, found 2 days ago
$1,208
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Jan 1 from Des Moines to Mayagüez, returning Wed, Jan 7, priced at $1,208 found 2 days ago
United
Thu, Jan 1 - Wed, Jan 7
DSM
Des Moines
MAZ
Mayagüez
$1,336 Roundtrip, found 2 days ago
$1,336
Roundtrip
found 2 days ago
Select United flight, departing Thu, Jan 1 from Des Moines to Mayagüez, returning Wed, Jan 7, priced at $1,336 found 2 days ago

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Flights from Des Moines (DSM) to Mayagüez (MAZ)
Origin airport
Des Moines Intl.
Destination airport
Eugenio María de Hostos
Roundtrip price
$952
Distance
2241 mi

Des Moines to Mayagüez Flights

The cheapest times to fly from Des Moines to Mayagüez

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Des Moines to Mayagüez are during the month of January. You can find some of the cheapest flights from Des Moines to Mayagüez with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Des Moines to Mayagüez

Sunday is one of the best days to book for cheap flights from Des Moines to Mayagüez: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Des Moines to Mayagüez

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Des Moines to Mayagüez in 2025. You can also book with separate airlines for your outbound and return journeys, from $316 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Des Moines to Mayagüez flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Des Moines to Mayagüez airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Des Moines Intl. Airport (DSM) to Eugenio Maria de Hostos Airport (MAZ) cost?
Lock in a cheap one-way flight from $316 or cheap return flight from $953 from Des Moines Intl. Airport (DSM) to Eugenio Maria de Hostos Airport (MAZ) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Des Moines Intl. Airport (DSM) to Eugenio Maria de Hostos Airport (MAZ)?
January is the cheapest month to fly from DSM to MAZ. Traveling during an off-peak travel window is often the key to finding a great deal.
What is the cheapest airline that flies from Des Moines Intl. Airport (DSM) to Eugenio Maria de Hostos Airport (MAZ)?
Expedia's filter tool lets you easily compare airlines, flight times and baggage options all in one place. Select your preferences, then sort by "Price (lowest to highest)" to find the carrier with the cheapest DSM to MAZ flight.
How many flights per day from Des Moines Intl. Airport (DSM) to Eugenio Maria de Hostos Airport (MAZ)?
There aren't any daily nonstop flights available from Des Moines Intl. Airport (DSM) to Eugenio Maria de Hostos Airport (MAZ). But you can choose flights with layovers. Filter your search on Expedia to include one or more stops, and you'll be soaring above the clouds in no time.
What day of the week has the most flights from DSM to MAZ?
Typically you'll find the most flight options available on a Friday. Tuesdays are often the quietest.* But this can change based on the time of year, airline and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Des Moines Intl. Airport (DSM) to Eugenio Maria de Hostos Airport (MAZ)?
Select a flight from Des Moines Intl. Airport (DSM) to Eugenio Maria de Hostos Airport (MAZ) that leaves before 3 PM to reduce the risk of delays and cancellations. Departures later than this have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Des Moines Intl. Airport (DSM) to Eugenio Maria de Hostos Airport (MAZ) last-minute?
Last-minute fares from DSM to MAZ are typically more expensive. To secure the best rates, start looking for flights as early as possible. That said, if your travel plans are flexible, it's possible to land a cheap ticket just before your departure.
Is it cheaper to book a DSM to MAZ flight and hotel package?
Compared with arranging flights and hotels separately, booking a DSM to MAZ flight and hotel package with Expedia could lead to significant savings. What's more, having everything in one place takes the hassle out of planning your trip. Just pick your flights and choose from our wide range of stays, then personalize your trip with extras like activities, tours and car rentals.
Can I cancel or change the date of my flight from Des Moines Intl. Airport (DSM) to Eugenio Maria de Hostos Airport (MAZ)?
Typically, it's possible to reschedule or cancel your DSM to MAZ flight. However, if it's been more than 24 hours since booking, additional fees may apply. Refer to your airline's policies in your itinerary to see what changes are allowed and whether any costs are involved. You'll also find more details on our Customer Service portal.

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*Available to One Key members.