$136 Cheap Flights from Des Moines (DSM) to Manchester (MHT)

View $136 flight on Fri, Oct 31, 2025Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to Manchester-Boston Regional Airport (MHT)

Cheap Flights from Des Moines to Manchester (DSM-MHT)

Prices were available within the past 7 days and start at $136 for one-way flights and $299 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Thu, Dec 4 - Mon, Dec 8
DSM
Des Moines
MHT
Manchester
$299 Roundtrip, found 2 days ago
$299
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Dec 4 from Des Moines to Manchester, returning Mon, Dec 8, priced at $299 found 2 days ago
Southwest Airlines
Thu, Dec 4 - Mon, Dec 8
DSM
Des Moines
MHT
Manchester
$305 Roundtrip, found 2 days ago
$305
Roundtrip
found 2 days ago
Select Southwest Airlines flight, departing Thu, Dec 4 from Des Moines to Manchester, returning Mon, Dec 8, priced at $305 found 2 days ago
Southwest Airlines
Thu, Dec 4 - Mon, Dec 8
DSM
Des Moines
MHT
Manchester
$310 Roundtrip, found 2 days ago
$310
Roundtrip
found 2 days ago
Select Southwest Airlines flight, departing Thu, Dec 4 from Des Moines to Manchester, returning Mon, Dec 8, priced at $310 found 2 days ago
Southwest Airlines
Thu, Dec 4 - Mon, Dec 8
DSM
Des Moines
MHT
Manchester
$310 Roundtrip, found 2 days ago
$310
Roundtrip
found 2 days ago
Select Southwest Airlines flight, departing Thu, Dec 4 from Des Moines to Manchester, returning Mon, Dec 8, priced at $310 found 2 days ago
Southwest Airlines
Thu, Dec 4 - Mon, Dec 8
DSM
Des Moines
MHT
Manchester
$315 Roundtrip, found 2 days ago
$315
Roundtrip
found 2 days ago
Select Southwest Airlines flight, departing Thu, Dec 4 from Des Moines to Manchester, returning Mon, Dec 8, priced at $315 found 2 days ago
Southwest Airlines
Thu, Dec 4 - Mon, Dec 8
DSM
Des Moines
MHT
Manchester
$333 Roundtrip, found 2 days ago
$333
Roundtrip
found 2 days ago
Select Southwest Airlines flight, departing Thu, Dec 4 from Des Moines to Manchester, returning Mon, Dec 8, priced at $333 found 2 days ago
Southwest Airlines
Thu, Dec 4 - Mon, Dec 8
DSM
Des Moines
MHT
Manchester
$338 Roundtrip, found 2 days ago
$338
Roundtrip
found 2 days ago
Select Southwest Airlines flight, departing Thu, Dec 4 from Des Moines to Manchester, returning Mon, Dec 8, priced at $338 found 2 days ago
Southwest Airlines
Thu, Dec 4 - Mon, Dec 8
DSM
Des Moines
MHT
Manchester
$343 Roundtrip, found 2 days ago
$343
Roundtrip
found 2 days ago
Select Southwest Airlines flight, departing Thu, Dec 4 from Des Moines to Manchester, returning Mon, Dec 8, priced at $343 found 2 days ago
United
Thu, Dec 4 - Mon, Dec 8
DSM
Des Moines
MHT
Manchester
$345 Roundtrip, found 2 days ago
$345
Roundtrip
found 2 days ago
Select United flight, departing Thu, Dec 4 from Des Moines to Manchester, returning Mon, Dec 8, priced at $345 found 2 days ago
American Airlines
Thu, Dec 4 - Mon, Dec 8
DSM
Des Moines
MHT
Manchester
$350 Roundtrip, found 2 days ago
$350
Roundtrip
found 2 days ago
Select American Airlines flight, departing Thu, Dec 4 from Des Moines to Manchester, returning Mon, Dec 8, priced at $350 found 2 days ago

Find the cheapest month to fly from Des Moines (DSM) to Manchester (MHT)

August is typically the cheapest month to fly

From $216 - $655 per traveler.

Frequently asked questions

How much does a flight from Des Moines Intl. Airport (DSM) to Manchester-Boston Regional Airport (MHT) cost?
Get a cheap one-way flight from $136 or cheap return flight from $299 from Des Moines Intl. Airport (DSM) to Manchester-Boston Regional Airport (MHT) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Des Moines Intl. Airport (DSM) to Manchester-Boston Regional Airport (MHT)?
Planning your getaway for December can help you save, as it's the cheapest month for flights between DSM and MHT. You'll often find the lowest fares during the off-season.
What is the cheapest airline that flies from Des Moines Intl. Airport (DSM) to Manchester-Boston Regional Airport (MHT)?
Expedia's filter tool lets you easily compare different airlines, flight durations and fares all in one place. Choose your preferences, then sort by "Price (lowest to highest)" to find the carrier with the cheapest DSM to MHT flight.
How many flights per day from Des Moines Intl. Airport (DSM) to Manchester-Boston Regional Airport (MHT)?
You'll need to hop on a flight with a layover when traveling from Des Moines Intl. Airport (DSM) to Manchester-Boston Regional Airport (MHT). Direct flights don't operate daily on this route. However, simply filter your search to include one or two stops to find the best option for your trip.
What day of the week has the most flights from DSM to MHT?
You'll generally find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can vary from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Des Moines Intl. Airport (DSM) to Manchester-Boston Regional Airport (MHT)?
To reach Manchester-Boston Regional Airport (MHT) on time, pick a flight that leaves from Des Moines Intl. Airport (DSM) before 3 PM. The likelihood of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Des Moines Intl. Airport (DSM) to Manchester-Boston Regional Airport (MHT) last-minute?
Booking your flight from DSM to MHT just before your journey is usually more expensive. But if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a DSM to MHT flight and hotel package?
Securing a DSM to MHT flight and hotel package is typically cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your trip all in one place. Select from our extensive range of hotels and then add activities, car rentals and flights to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Des Moines Intl. Airport (DSM) to Manchester-Boston Regional Airport (MHT)?
In most cases, you can reschedule or cancel your DSM to MHT flight. However, there may be additional fees, especially if you booked more than 24 hours ago. Double-check your itinerary for the airline's fees and policies on flight changes, or if you want further details, visit our Customer Service portal.

Travel information

Origin airport
Des Moines Intl.
Destination airport
Manchester-Boston Regional
Airlines serving
American Airlines, Southwest Airlines, United
Roundtrip price
$298
Distance
1136 mi

Book with confidence

Des Moines to Manchester Flights

The cheapest times to fly from Des Moines to Manchester

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Des Moines to Manchester are during the month of December. You can find some of the cheapest flights from Des Moines to Manchester with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Des Moines to Manchester

Sunday is one of the best days to book for cheap flights from Des Moines to Manchester: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Des Moines to Manchester

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Des Moines to Manchester in 2025. You can also book with separate airlines for your outbound and return journeys, from $136 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Des Moines to Manchester flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Des Moines to Manchester airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Des Moines to Manchester Flights

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*Available to One Key members.