$198 Cheap Flights from Des Moines (DSM) to Panama City (PTY)

View $198 flight on Wed, Sep 17, 2025Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to Tocumen Intl. Airport (PTY)

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Cheap Flights from Des Moines to Panama City (DSM-PTY)

Prices were available within the past 7 days and start at $198 for one-way flights and $461 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Wed, Sep 17 - Wed, Sep 24
DSM
Des Moines
PTY
Panama City
$461 Roundtrip, found 1 hour ago
$461
Roundtrip
found 1 hour ago
Select Delta flight, departing Wed, Sep 17 from Des Moines to Panama City, returning Wed, Sep 24, priced at $461 found 1 hour ago
United
Wed, Sep 17 - Wed, Sep 24
DSM
Des Moines
PTY
Panama City
$461 Roundtrip, found 1 hour ago
$461
Roundtrip
found 1 hour ago
Select United flight, departing Wed, Sep 17 from Des Moines to Panama City, returning Wed, Sep 24, priced at $461 found 1 hour ago
American Airlines
Wed, Sep 17 - Wed, Sep 24
DSM
Des Moines
PTY
Panama City
$466 Roundtrip, found 1 hour ago
$466
Roundtrip
found 1 hour ago
Select American Airlines flight, departing Wed, Sep 17 from Des Moines to Panama City, returning Wed, Sep 24, priced at $466 found 1 hour ago
Delta
Wed, Sep 17 - Wed, Sep 24
DSM
Des Moines
PTY
Panama City
$470 Roundtrip, found 1 hour ago
$470
Roundtrip
found 1 hour ago
Select Delta flight, departing Wed, Sep 17 from Des Moines to Panama City, returning Wed, Sep 24, priced at $470 found 1 hour ago
American Airlines
Mon, Sep 1 - Thu, Sep 4
DSM
Des Moines
PTY
Panama City
$472 Roundtrip, found 22 hours ago
$472
Roundtrip
found 22 hours ago
Select American Airlines flight, departing Mon, Sep 1 from Des Moines to Panama City, returning Thu, Sep 4, priced at $472 found 22 hours ago
American Airlines
Mon, Aug 25 - Fri, Aug 29
DSM
Des Moines
PTY
Panama City
$474 Roundtrip, found 4 hours ago
$474
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Mon, Aug 25 from Des Moines to Panama City, returning Fri, Aug 29, priced at $474 found 4 hours ago
American Airlines
Mon, Aug 25 - Fri, Aug 29
DSM
Des Moines
PTY
Panama City
$475 Roundtrip, found 4 hours ago
$475
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Mon, Aug 25 from Des Moines to Panama City, returning Fri, Aug 29, priced at $475 found 4 hours ago
Delta
Thu, Jan 22 - Sun, Feb 8
DSM
Des Moines
PTY
Panama City
$479 Roundtrip, found 1 day ago
$479
Roundtrip
found 1 day ago
Select Delta flight, departing Thu, Jan 22 from Des Moines to Panama City, returning Sun, Feb 8, priced at $479 found 1 day ago
United
Fri, Dec 5 - Fri, Dec 19
DSM
Des Moines
PTY
Panama City
$480 Roundtrip, found 1 day ago
$480
Roundtrip
found 1 day ago
Select United flight, departing Fri, Dec 5 from Des Moines to Panama City, returning Fri, Dec 19, priced at $480 found 1 day ago
Copa
Fri, Nov 14 - Thu, Nov 20
DSM
Des Moines
PTY
Panama City
$1,165 Roundtrip, found 8 hours ago
$1,165
Roundtrip
found 8 hours ago
Select Copa flight, departing Fri, Nov 14 from Des Moines to Panama City, returning Thu, Nov 20, priced at $1,165 found 8 hours ago

Find the cheapest month to fly from Des Moines (DSM) to Panama City (PTY)

August is typically the cheapest month to fly

From $322 - $585 per traveler.

Graph displaying average flight prices per month

Alternative airports near Panama City

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Tocumen Intl. PTY. Cheapest option available. Average driving time to city center is 16 minutes. Flights from $461
PTY
Tocumen Intl.
Cheapest
Average driving time to city center16 min
Flights from $461
Flights from Des Moines (DSM) to Panama City (PTY)
Origin airport
Des Moines Intl.
Destination airport
Tocumen Intl.
Airlines serving
American Airlines, Copa, Delta, United
Roundtrip price
$461
Distance
2405 mi

Des Moines to Panama City Flights

The cheapest times to fly from Des Moines to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Des Moines to Panama City are during the month of September. You can find some of the cheapest flights from Des Moines to Panama City with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Des Moines to Panama City

Sunday is one of the best days to book for cheap flights from Des Moines to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Des Moines to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Des Moines to Panama City in 2025. You can also book with separate airlines for your outbound and return journeys, from $198 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Des Moines to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Des Moines to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Des Moines Intl. Airport (DSM) to Tocumen Intl. Airport (PTY) cost?
Discover the latest flight deals from DSM to PTY by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from DSM to PTY?
The cheapest flights from DSM to PTY are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from DSM to PTY?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that'll take you from DSM to PTY. Sort your results by "Price (lowest to highest)" to snap up a great deal.
How many flights per day from Des Moines Intl. Airport (DSM) to Tocumen Intl. Airport (PTY)?
Nonstop flights from Des Moines Intl. Airport (DSM) to Tocumen Intl. Airport (PTY) aren't available daily, so you'll need to take a flight with a layover. Explore your options with our filter tool. Enter your dates and select either "1 Stop" or "2+ Stops."
What day of the week has the most flights from DSM to PTY?
Friday is usually the busiest day for flights, while Tuesday tends to be the quietest.* Keep in mind that flight schedules can change based on a range of factors, including the time of year and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Des Moines Intl. Airport (DSM) to Tocumen Intl. Airport (PTY)?
To avoid possible delays on the Des Moines Intl. Airport (DSM) to Tocumen Intl. Airport (PTY) route, aim to fly before 3 PM. Later flights have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Des Moines Intl. Airport (DSM) to Tocumen Intl. Airport (PTY) last-minute?
Booking your ticket from DSM to PTY just before your getaway is usually more expensive. But if there's some wiggle room with your travel dates and times, you could score a cheap last-minute fare.
Is it cheaper to book a DSM to PTY flight and hotel package?
Opting for a DSM to PTY flight and hotel package tends to be cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your trip all in one place. Choose from our wide range of hotels and then add car rentals, flights and activities to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Des Moines Intl. Airport (DSM) to Tocumen Intl. Airport (PTY)?
In most cases, you're able to cancel or reschedule your DSM to PTY flight. However, there may be additional charges, especially if you made your booking more than 24 hours ago. Check your itinerary for the airline's fees and guidelines on flight changes, or if you'd like more details, head to our Customer Service portal.

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*Available to One Key members.