$198 Cheap Flights from Des Moines (DSM) to Panama City (PTY)

View $198 flight on Mon, Nov 17, 2025Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to Tocumen Intl. Airport (PTY)

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Cheap Flights from Des Moines to Panama City (DSM-PTY)

Prices were available within the past 7 days and start at $198 for one-way flights and $462 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Fri, Nov 14 - Fri, Nov 21
DSM
Des Moines
PTY
Panama City
$462 Roundtrip, just found
$462
Roundtrip
just found
Select Delta flight, departing Fri, Nov 14 from Des Moines to Panama City, returning Fri, Nov 21, priced at $462 just found
United
Sun, Nov 16 - Sun, Nov 23
DSM
Des Moines
PTY
Panama City
$462 Roundtrip, just found
$462
Roundtrip
just found
Select United flight, departing Sun, Nov 16 from Des Moines to Panama City, returning Sun, Nov 23, priced at $462 just found
American Airlines
Mon, Nov 17 - Mon, Nov 24
DSM
Des Moines
PTY
Panama City
$466 Roundtrip, just found
$466
Roundtrip
just found
Select American Airlines flight, departing Mon, Nov 17 from Des Moines to Panama City, returning Mon, Nov 24, priced at $466 just found
Delta
Mon, Nov 17 - Mon, Nov 24
DSM
Des Moines
PTY
Panama City
$471 Roundtrip, just found
$471
Roundtrip
just found
Select Delta flight, departing Mon, Nov 17 from Des Moines to Panama City, returning Mon, Nov 24, priced at $471 just found
American Airlines
Fri, Jan 16 - Sun, Jan 18
DSM
Des Moines
PTY
Panama City
$471 Roundtrip, found 1 day ago
$471
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Jan 16 from Des Moines to Panama City, returning Sun, Jan 18, priced at $471 found 1 day ago
United
Wed, Feb 4 - Sat, Feb 14
DSM
Des Moines
PTY
Panama City
$473 Roundtrip, found 1 day ago
$473
Roundtrip
found 1 day ago
Select United flight, departing Wed, Feb 4 from Des Moines to Panama City, returning Sat, Feb 14, priced at $473 found 1 day ago
American Airlines
Mon, Nov 17 - Mon, Nov 24
DSM
Des Moines
PTY
Panama City
$474 Roundtrip, just found
$474
Roundtrip
just found
Select American Airlines flight, departing Mon, Nov 17 from Des Moines to Panama City, returning Mon, Nov 24, priced at $474 just found
Delta
Mon, Nov 17 - Mon, Nov 24
DSM
Des Moines
PTY
Panama City
$475 Roundtrip, just found
$475
Roundtrip
just found
Select Delta flight, departing Mon, Nov 17 from Des Moines to Panama City, returning Mon, Nov 24, priced at $475 just found
American Airlines
Fri, Jan 16 - Sun, Jan 18
DSM
Des Moines
PTY
Panama City
$479 Roundtrip, found 1 day ago
$479
Roundtrip
found 1 day ago
Select American Airlines flight, departing Fri, Jan 16 from Des Moines to Panama City, returning Sun, Jan 18, priced at $479 found 1 day ago
Copa
Tue, Nov 25 - Sat, Dec 6
DSM
Des Moines
PTY
Panama City
$1,166 Roundtrip, found 15 hours ago
$1,166
Roundtrip
found 15 hours ago
Select Copa flight, departing Tue, Nov 25 from Des Moines to Panama City, returning Sat, Dec 6, priced at $1,166 found 15 hours ago

Find the cheapest month to fly from Des Moines (DSM) to Panama City (PTY)

May is typically the cheapest month to fly

From $401 - $629 per traveler.

Alternative airports near Panama City

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Tocumen Intl. PTY. Cheapest option available. Average driving time to city center is 16 minutes. Flights from $462
PTY
Tocumen Intl.
Cheapest
Average driving time to city center16 min
Flights from $462

Frequently asked questions

How much does a flight from Des Moines Intl. Airport (DSM) to Tocumen Intl. Airport (PTY) cost?
Secure a cheap one-way flight from $198 or cheap return flight from $462 from Des Moines Intl. Airport (DSM) to Tocumen Intl. Airport (PTY) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Des Moines Intl. Airport (DSM) to Tocumen Intl. Airport (PTY)?
The cheapest month to fly from DSM to PTY is November, when demand is low. Off-peak months are usually when airlines offer better prices between these airports.
What is the cheapest airline that flies from Des Moines Intl. Airport (DSM) to Tocumen Intl. Airport (PTY)?
To find the cheapest airline that'll fly you from DSM to PTY, use Expedia's filter tool. Customize your search based on your travel style, such as preferred carriers and number of stops. You can then sort your results by "Price (lowest to highest)" to discover the cheapest flight right away.
How many flights per day from Des Moines Intl. Airport (DSM) to Tocumen Intl. Airport (PTY)?
Nonstop flights from Des Moines Intl. Airport (DSM) to Tocumen Intl. Airport (PTY) aren't available daily, so you'll need to take a flight with a layover. Explore your options with our filter tool. Enter your dates and select either "1 Stop" or "2+ Stops."
What day of the week has the most flights from DSM to PTY?
Friday is usually the busiest day for flights, while Tuesday tends to be the quietest.* Keep in mind that flight schedules can change based on a range of factors, including the time of year and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Des Moines Intl. Airport (DSM) to Tocumen Intl. Airport (PTY)?
To avoid possible delays on the Des Moines Intl. Airport (DSM) to Tocumen Intl. Airport (PTY) route, aim to fly before 3 PM. Later flights have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Des Moines Intl. Airport (DSM) to Tocumen Intl. Airport (PTY) last-minute?
Booking your ticket from DSM to PTY just before your getaway is usually more expensive. But if there's some wiggle room with your travel dates and times, you could score a cheap last-minute fare.
Is it cheaper to book a DSM to PTY flight and hotel package?
Opting for a DSM to PTY flight and hotel package tends to be cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your trip all in one place. Choose from our wide range of hotels and then add car rentals, flights and activities to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Des Moines Intl. Airport (DSM) to Tocumen Intl. Airport (PTY)?
In most cases, you're able to cancel or reschedule your DSM to PTY flight. However, there may be additional charges, especially if you made your booking more than 24 hours ago. Check your itinerary for the airline's fees and guidelines on flight changes, or if you'd like more details, head to our Customer Service portal.

Travel information

Origin airport
Des Moines Intl.
Destination airport
Tocumen Intl.
Airlines serving
American Airlines, Copa, Delta, United
Roundtrip price
$461
Distance
2405 mi

Book with confidence

Des Moines to Panama City Flights

The cheapest times to fly from Des Moines to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Des Moines to Panama City are during the month of November. You can find some of the cheapest flights from Des Moines to Panama City with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Des Moines to Panama City

Sunday is one of the best days to book for cheap flights from Des Moines to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Des Moines to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Des Moines to Panama City in 2025. You can also book with separate airlines for your outbound and return journeys, from $198 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Des Moines to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Des Moines to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Des Moines to Panama City Flights

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*Available to One Key members.