$219 Cheap Flights from Des Moines (DSM) to Santa Fe (SAF)

View $219 flight on Wed, Apr 22, 2026Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to Santa Fe Municipal Airport (SAF)

Cheap Flights from Des Moines to Santa Fe (DSM-SAF)

Prices were available within the past 7 days and start at $219 for one-way flights and $244 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Fri, Jan 30 - Sun, Feb 1
DSM
Des Moines
SAF
Santa Fe
$244 Roundtrip, found 7 hours ago
$244
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Fri, Jan 30 from Des Moines to Santa Fe, returning Sun, Feb 1, priced at $244 found 7 hours ago
United
Fri, Jan 30 - Sun, Feb 1
DSM
Des Moines
SAF
Santa Fe
$244 Roundtrip, found 7 hours ago
$244
Roundtrip
found 7 hours ago
Select United flight, departing Fri, Jan 30 from Des Moines to Santa Fe, returning Sun, Feb 1, priced at $244 found 7 hours ago
United
Wed, Oct 15 - Sat, Oct 18
DSM
Des Moines
SAF
Santa Fe
$254 Roundtrip, found 4 days ago
$254
Roundtrip
found 4 days ago
Select United flight, departing Wed, Oct 15 from Des Moines to Santa Fe, returning Sat, Oct 18, priced at $254 found 4 days ago
United
Sat, Oct 11 - Tue, Oct 14
DSM
Des Moines
SAF
Santa Fe
$279 Roundtrip, found 5 days ago
$279
Roundtrip
found 5 days ago
Select United flight, departing Sat, Oct 11 from Des Moines to Santa Fe, returning Tue, Oct 14, priced at $279 found 5 days ago
United
Mon, Mar 23 - Sat, Mar 28
DSM
Des Moines
SAF
Santa Fe
$283 Roundtrip, found 4 days ago
$283
Roundtrip
found 4 days ago
Select United flight, departing Mon, Mar 23 from Des Moines to Santa Fe, returning Sat, Mar 28, priced at $283 found 4 days ago
United
Thu, Apr 16 - Mon, Apr 20
DSM
Des Moines
SAF
Santa Fe
$285 Roundtrip, found 2 days ago
$285
Roundtrip
found 2 days ago
Select United flight, departing Thu, Apr 16 from Des Moines to Santa Fe, returning Mon, Apr 20, priced at $285 found 2 days ago
United
Thu, Oct 23 - Mon, Oct 27
DSM
Des Moines
SAF
Santa Fe
$292 Roundtrip, found 1 hour ago
$292
Roundtrip
found 1 hour ago
Select United flight, departing Thu, Oct 23 from Des Moines to Santa Fe, returning Mon, Oct 27, priced at $292 found 1 hour ago
United
Mon, Mar 23 - Sat, Mar 28
DSM
Des Moines
SAF
Santa Fe
$299 Roundtrip, found 4 days ago
$299
Roundtrip
found 4 days ago
Select United flight, departing Mon, Mar 23 from Des Moines to Santa Fe, returning Sat, Mar 28, priced at $299 found 4 days ago
American Airlines
Wed, Feb 4 - Sun, Feb 8
DSM
Des Moines
SAF
Santa Fe
$304 Roundtrip, found 1 day ago
$304
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Feb 4 from Des Moines to Santa Fe, returning Sun, Feb 8, priced at $304 found 1 day ago
United
Sat, Oct 11 - Tue, Oct 14
DSM
Des Moines
SAF
Santa Fe
$309 Roundtrip, found 5 days ago
$309
Roundtrip
found 5 days ago
Select United flight, departing Sat, Oct 11 from Des Moines to Santa Fe, returning Tue, Oct 14, priced at $309 found 5 days ago

Alternative airports near Santa Fe

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Santa Fe Municipal SAF. Cheapest and Closest option available. Average driving time to city center is 17 minutes. Flights from $324
SAF
Santa Fe Municipal
CheapestClosest
Average driving time to city center17 min
Flights from $324

Frequently asked questions

How much does a flight from Des Moines Intl. Airport (DSM) to Santa Fe Municipal Airport (SAF) cost?
Lock in a cheap one-way flight from $219 or cheap return flight from $244 from Des Moines Intl. Airport (DSM) to Santa Fe Municipal Airport (SAF) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Des Moines Intl. Airport (DSM) to Santa Fe Municipal Airport (SAF)?
The cheapest month to fly from DSM to SAF is January, when there's less demand. Off-peak months are often when you'll find cheap fares for travel between these airports.
What is the cheapest airline that flies from Des Moines Intl. Airport (DSM) to Santa Fe Municipal Airport (SAF)?
Expedia's filter tool lets you easily compare airlines, flight times and baggage options all in one place. Select your preferences, then sort by "Price (lowest to highest)" to find the carrier with the cheapest DSM to SAF flight.
How many flights per day from Des Moines Intl. Airport (DSM) to Santa Fe Municipal Airport (SAF)?
You'll need to hop on a flight with a layover if you're traveling from Des Moines Intl. Airport (DSM) to Santa Fe Municipal Airport (SAF). Direct flights don't operate daily on this route. However, simply filter your search to include one or more stops to discover the best option for your trip.
What day of the week has the most flights from DSM to SAF?
Friday is usually the busiest day for flights, while Tuesday tends to be the quietest.* Just remember that flight schedules can vary based on various factors, including the time of year and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Des Moines Intl. Airport (DSM) to Santa Fe Municipal Airport (SAF)?
To avoid possible delays on the Des Moines Intl. Airport (DSM) to Santa Fe Municipal Airport (SAF) route, fly before 3 PM. Later flights have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Des Moines Intl. Airport (DSM) to Santa Fe Municipal Airport (SAF) last-minute?
Holding off until just before your departure to book a flight from DSM to SAF often results in higher prices. While you may come across some last-minute discounts, there's no guarantee. Allow some flexibility in your schedule to boost your chances of getting a bargain.
Is it cheaper to book a DSM to SAF flight and hotel package?
Compared with arranging hotels and flights separately, booking a DSM to SAF flight and hotel package with Expedia could lead to significant savings. What's more, having everything in one convenient place will take the stress out of travel planning. Just pick your flights and choose from our wide range of hotels, then tailor your trip with other add-ons like tours and car rentals.
Can I cancel or change the date of my flight from Des Moines Intl. Airport (DSM) to Santa Fe Municipal Airport (SAF)?
In most cases, you can cancel or modify your DSM to SAF flight. However, additional charges may apply, especially if you made your booking more than 24 hours ago. Check your itinerary for the airline's guidelines and fees on flight changes, or if you'd like more information, visit our Customer Service portal.

Travel information

Travel information

Origin airport
Des Moines Intl.
Destination airport
Santa Fe Municipal
Airlines serving
American Airlines, United
Roundtrip price
$244
Distance
785 mi

Book with confidence

Book with confidence

Des Moines to Santa Fe Flights

The cheapest times to fly from Des Moines to Santa Fe

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Des Moines to Santa Fe are during the month of January. You can find some of the cheapest flights from Des Moines to Santa Fe with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Des Moines to Santa Fe

Sunday is one of the best days to book for cheap flights from Des Moines to Santa Fe: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Des Moines to Santa Fe

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Des Moines to Santa Fe in 2025. You can also book with separate airlines for your outbound and return journeys, from $219 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Des Moines to Santa Fe flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Des Moines to Santa Fe airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Des Moines to Santa Fe Flights

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*Available to One Key members.