$102 Cheap Flights from Des Moines (DSM) to Louisville (SDF)

View $102 flight on Wed, Feb 11, 2026Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to Louisville Intl. Airport (SDF)

Cheap Flights from Des Moines to Louisville (DSM-SDF)

Prices were available within the past 7 days and start at $102 for one-way flights and $233 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Sat, Jan 17 - Sun, Jan 18
DSM
Des Moines
SDF
Louisville
$233 Roundtrip, found 6 days ago
$233
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sat, Jan 17 from Des Moines to Louisville, returning Sun, Jan 18, priced at $233 found 6 days ago
United
Sat, Jan 17 - Sun, Jan 18
DSM
Des Moines
SDF
Louisville
$236 Roundtrip, found 6 days ago
$236
Roundtrip
found 6 days ago
Select United flight, departing Sat, Jan 17 from Des Moines to Louisville, returning Sun, Jan 18, priced at $236 found 6 days ago
American Airlines
Wed, Dec 31 - Mon, Jan 5
DSM
Des Moines
SDF
Louisville
$242 Roundtrip, found 4 days ago
$242
Roundtrip
found 4 days ago
Select American Airlines flight, departing Wed, Dec 31 from Des Moines to Louisville, returning Mon, Jan 5, priced at $242 found 4 days ago
Southwest Airlines
Tue, Jan 13 - Sat, Jan 17
DSM
Des Moines
SDF
Louisville
$242 Roundtrip, found 2 days ago
$242
Roundtrip
found 2 days ago
Select Southwest Airlines flight, departing Tue, Jan 13 from Des Moines to Louisville, returning Sat, Jan 17, priced at $242 found 2 days ago
Delta
Fri, Feb 20 - Tue, Feb 24
DSM
Des Moines
SDF
Louisville
$247 Roundtrip, found 22 hours ago
$247
Roundtrip
found 22 hours ago
Select Delta flight, departing Fri, Feb 20 from Des Moines to Louisville, returning Tue, Feb 24, priced at $247 found 22 hours ago
Southwest Airlines
Tue, Jan 13 - Sat, Jan 17
DSM
Des Moines
SDF
Louisville
$248 Roundtrip, found 2 days ago
$248
Roundtrip
found 2 days ago
Select Southwest Airlines flight, departing Tue, Jan 13 from Des Moines to Louisville, returning Sat, Jan 17, priced at $248 found 2 days ago
Southwest Airlines
Mon, Feb 23 - Thu, Feb 26
DSM
Des Moines
SDF
Louisville
$251 Roundtrip, found 22 hours ago
$251
Roundtrip
found 22 hours ago
Select Southwest Airlines flight, departing Mon, Feb 23 from Des Moines to Louisville, returning Thu, Feb 26, priced at $251 found 22 hours ago
American Airlines
Mon, Jan 12 - Thu, Jan 15
DSM
Des Moines
SDF
Louisville
$253 Roundtrip, found 2 days ago
$253
Roundtrip
found 2 days ago
Select American Airlines flight, departing Mon, Jan 12 from Des Moines to Louisville, returning Thu, Jan 15, priced at $253 found 2 days ago
Delta
Wed, Dec 3 - Sat, Dec 6
DSM
Des Moines
SDF
Louisville
$253 Roundtrip, found 6 days ago
$253
Roundtrip
found 6 days ago
Select Delta flight, departing Wed, Dec 3 from Des Moines to Louisville, returning Sat, Dec 6, priced at $253 found 6 days ago
Southwest Airlines
Sat, Jan 17 - Sun, Jan 18
DSM
Des Moines
SDF
Louisville
$254 Roundtrip, found 6 days ago
$254
Roundtrip
found 6 days ago
Select Southwest Airlines flight, departing Sat, Jan 17 from Des Moines to Louisville, returning Sun, Jan 18, priced at $254 found 6 days ago

Find the cheapest month to fly from Des Moines (DSM) to Louisville (SDF)

August is typically the cheapest month to fly

From $158 - $422 per traveler.

Alternative airports near Louisville

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Louisville Intl. SDF. Cheapest and Closest option available. Average driving time to city center is 9 minutes. Flights from $407
SDF
Louisville Intl.
CheapestClosest
Average driving time to city center9 min
Flights from $407

Frequently asked questions

How much does a flight from Des Moines Intl. Airport (DSM) to Louisville Intl. Airport (SDF) cost?
Secure a cheap one-way flight from $102 or cheap return flight from $233 from Des Moines Intl. Airport (DSM) to Louisville Intl. Airport (SDF) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Des Moines Intl. Airport (DSM) to Louisville Intl. Airport (SDF)?
Planning your getaway for January is a good way to save, as it's the cheapest month for flights between DSM and SDF. You'll often find the lowest fares during the off-season.
What is the cheapest airline that flies from Des Moines Intl. Airport (DSM) to Louisville Intl. Airport (SDF)?
To find the cheapest airline flying from DSM to SDF, use Expedia's filter tool. Tailor your search based on what matters most to you, such as preferred carriers and cabin class. You can then sort your results by "Price (lowest to highest)" to see the cheapest flights first.
How many flights per day from Des Moines Intl. Airport (DSM) to Louisville Intl. Airport (SDF)?
Direct flights from Des Moines Intl. Airport (DSM) to Louisville Intl. Airport (SDF) aren't available daily, so you'll need to take a flight with a layover. Explore your options with our filter tool. Enter your travel details and pick either "1 Stop" or "2+ Stops."
What day of the week has the most flights from DSM to SDF?
Friday is usually the busiest day for flights, while Tuesday tends to be the quietest.* Just remember that flight schedules can change depending on a number of factors, such as the time of year and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Des Moines Intl. Airport (DSM) to Louisville Intl. Airport (SDF)?
To avoid potential delays on the Des Moines Intl. Airport (DSM) to Louisville Intl. Airport (SDF) route, aim to travel before 3 PM. Departures after this hour are 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Des Moines Intl. Airport (DSM) to Louisville Intl. Airport (SDF) last-minute?
Last-minute fares from DSM to SDF are typically more expensive. For the lowest prices, start searching for flights ahead of time. That being said, if you can play around with your travel dates, it's possible to land a cheap fare right before your trip.
Is it cheaper to book a DSM to SDF flight and hotel package?
You'll generally save money by securing a DSM to SDF flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's easy to manage it all in one convenient place. Once you've chosen your preferred accommodations and flights, consider adding extras such as car rentals, tours and activities.
Can I cancel or change the date of my flight from Des Moines Intl. Airport (DSM) to Louisville Intl. Airport (SDF)?
If you reserved your DSM to SDF flight in the last 24 hours, you may be able to cancel or modify it at no cost. Depending on the airline and the type of ticket you have, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you want more information.

Travel information

Origin airport
Des Moines Intl.
Destination airport
Louisville Intl.
Airlines serving
American Airlines, Delta, Southwest Airlines, United
Roundtrip price
$232
Distance
478 mi

Book with confidence

Des Moines to Louisville Flights

The cheapest times to fly from Des Moines to Louisville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Des Moines to Louisville are during the month of January. You can find some of the cheapest flights from Des Moines to Louisville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Des Moines to Louisville

Sunday is one of the best days to book for cheap flights from Des Moines to Louisville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Des Moines to Louisville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Des Moines to Louisville in 2025. You can also book with separate airlines for your outbound and return journeys, from $102 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Des Moines to Louisville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Des Moines to Louisville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Des Moines to Louisville Flights

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*Available to One Key members.