$181 Cheap Flights from Detroit (DTW) to Tupelo (TUP)

View $181 flight on Tue, Apr 7, 2026Opens in a new window

Popular airlines from Detroit Metropolitan Wayne County Airport (DTW) to Tupelo, MS (TUP-Tupelo Regional)

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Cheap Flights from Detroit to Tupelo (DTW-TUP)

Prices were available within the past 7 days and start at $181 for one-way flights and $357 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

United
Tue, Mar 31 - Tue, Apr 14
DTW
Detroit
TUP
Tupelo
$357 Roundtrip, found 5 days ago
$357
Roundtrip
found 5 days ago
Select United flight, departing Tue, Mar 31 from Detroit to Tupelo, returning Tue, Apr 14, priced at $357 found 5 days ago
United
Mon, Mar 23 - Wed, Mar 25
DTW
Detroit
TUP
Tupelo
$375 Roundtrip, found 3 days ago
$375
Roundtrip
found 3 days ago
Select United flight, departing Mon, Mar 23 from Detroit to Tupelo, returning Wed, Mar 25, priced at $375 found 3 days ago
United
Mon, Mar 30 - Tue, Mar 31
DTW
Detroit
TUP
Tupelo
$387 Roundtrip, found 20 hours ago
$387
Roundtrip
found 20 hours ago
Select United flight, departing Mon, Mar 30 from Detroit to Tupelo, returning Tue, Mar 31, priced at $387 found 20 hours ago
United
Tue, Mar 31 - Fri, Apr 17
DTW
Detroit
TUP
Tupelo
$388 Roundtrip, found 5 days ago
$388
Roundtrip
found 5 days ago
Select United flight, departing Tue, Mar 31 from Detroit to Tupelo, returning Fri, Apr 17, priced at $388 found 5 days ago
United
Mon, Mar 30 - Mon, Apr 6
DTW
Detroit
TUP
Tupelo
$395 Roundtrip, found 20 hours ago
$395
Roundtrip
found 20 hours ago
Select United flight, departing Mon, Mar 30 from Detroit to Tupelo, returning Mon, Apr 6, priced at $395 found 20 hours ago
American Airlines
Tue, Mar 31 - Tue, Apr 14
DTW
Detroit
TUP
Tupelo
$398 Roundtrip, found 5 days ago
$398
Roundtrip
found 5 days ago
Select American Airlines flight, departing Tue, Mar 31 from Detroit to Tupelo, returning Tue, Apr 14, priced at $398 found 5 days ago
United
Fri, Apr 3 - Fri, Apr 17
DTW
Detroit
TUP
Tupelo
$401 Roundtrip, found 5 days ago
$401
Roundtrip
found 5 days ago
Select United flight, departing Fri, Apr 3 from Detroit to Tupelo, returning Fri, Apr 17, priced at $401 found 5 days ago
United
Fri, Apr 3 - Mon, Apr 6
DTW
Detroit
TUP
Tupelo
$408 Roundtrip, found 20 hours ago
$408
Roundtrip
found 20 hours ago
Select United flight, departing Fri, Apr 3 from Detroit to Tupelo, returning Mon, Apr 6, priced at $408 found 20 hours ago
United
Tue, Mar 31 - Tue, Apr 14
DTW
Detroit
TUP
Tupelo
$409 Roundtrip, found 5 days ago
$409
Roundtrip
found 5 days ago
Select United flight, departing Tue, Mar 31 from Detroit to Tupelo, returning Tue, Apr 14, priced at $409 found 5 days ago
American Airlines
Tue, Mar 31 - Tue, Apr 14
DTW
Detroit
TUP
Tupelo
$417 Roundtrip, found 5 days ago
$417
Roundtrip
found 5 days ago
Select American Airlines flight, departing Tue, Mar 31 from Detroit to Tupelo, returning Tue, Apr 14, priced at $417 found 5 days ago

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Alternative airports near Tupelo

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Tupelo Regional TUP. Cheapest and Closest option available. Average driving time to city center is 8 minutes. Flights from $520
TUP
Tupelo Regional
CheapestClosest
Average driving time to city center8 min
Flights from $520

Frequently asked questions

How much does a flight from Detroit Metropolitan Wayne County Airport (DTW) to Tupelo Regional Airport (TUP) cost?
Get a cheap one-way flight from $181 or cheap return flight from $357 from Detroit Metropolitan Wayne County Airport (DTW) to Tupelo Regional Airport (TUP) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Detroit Metropolitan Wayne County Airport (DTW) to Tupelo Regional Airport (TUP)?
The cheapest month to fly from DTW to TUP is March, when there's less demand. Off-peak season is often when airlines offer better prices between these airports.
What is the cheapest airline that flies from Detroit Metropolitan Wayne County Airport (DTW) to Tupelo Regional Airport (TUP)?
To find the cheapest airline flying from DTW to TUP, use Expedia's filter tool. Tailor your search based on what matters most to you, such as preferred carriers and number of stops. You can then sort your results by "Price (lowest to highest)" to see the cheapest fares upfront.
How many flights per day from Detroit Metropolitan Wayne County Airport (DTW) to Tupelo Regional Airport (TUP)?
Nonstop flights from Detroit Metropolitan Wayne County Airport (DTW) to Tupelo Regional Airport (TUP) aren't available daily, so you'll have to take a flight with a layover. Explore your options with our filter tool. Enter your travel details and select either "1 Stop" or "2+ Stops."
What day of the week has the most flights from DTW to TUP?
You'll generally find Tuesday the quietest day for flights, while Fridays tend to be the busiest.* However this can change from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Detroit Metropolitan Wayne County Airport (DTW) to Tupelo Regional Airport (TUP)?
To avoid possible delays on the Detroit Metropolitan Wayne County Airport (DTW) to Tupelo Regional Airport (TUP) route, aim to fly before 3 PM. Departures after this hour have a 22% higher chance of being canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Detroit Metropolitan Wayne County Airport (DTW) to Tupelo Regional Airport (TUP) last-minute?
Waiting until just before your departure to book your flight from DTW to TUP often results in higher prices. While you might find some last-minute offers, there's no guarantee. Be flexible with your travel plans for the best chance of scoring a bargain.
Is it cheaper to book a DTW to TUP flight and hotel package?
Compared with arranging flights and hotels separately, booking a DTW to TUP flight and hotel package with Expedia could lead to significant savings. What's more, managing everything in one place will take the hassle out of travel planning. Just pick your flights and choose from our extensive range of stays, then customize your trip with extras like tours, car rentals and activities.
Can I cancel or change the date of my flight from Detroit Metropolitan Wayne County Airport (DTW) to Tupelo Regional Airport (TUP)?
In most cases, you can cancel or modify your DTW to TUP flight. However, additional fees may apply, especially if you made your booking more than 24 hours ago. Double-check your itinerary for the airline's policies and fees on flight changes, or if you need more information, visit our Customer Service portal.

Travel information

Origin airport
Detroit Metropolitan Wayne County
Destination airport
Tupelo Regional
Roundtrip price
$357
Distance
622 mi

Book with confidence

Detroit to Tupelo Flights

The cheapest times to fly from Detroit to Tupelo

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Detroit to Tupelo are during the month of March. You can find some of the cheapest flights from Detroit to Tupelo with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Detroit to Tupelo

Sunday is one of the best days to book for cheap flights from Detroit to Tupelo: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Detroit to Tupelo

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Detroit to Tupelo in 2026. You can also book with separate airlines for your outbound and return journeys, from $181 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Detroit to Tupelo flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Detroit to Tupelo airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Detroit to Tupelo Flights

*Flight schedules are subject to change.

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