$182 Cheap Flights from Detroit (DTW) to Tupelo (TUP)

View $182 flight on Wed, May 20, 2026Opens in a new window

Popular airlines from Detroit Metropolitan Wayne County Airport (DTW) to Tupelo, MS (TUP-Tupelo Regional)

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Cheap Flights from Detroit to Tupelo (DTW-TUP)

Prices were available within the past 7 days and start at $182 for one-way flights and $358 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Mon, May 18 - Wed, May 20
DTW
Detroit
TUP
Tupelo
$358 Roundtrip, found 1 day ago
$358
Roundtrip
found 1 day ago
Select American Airlines flight, departing Mon, May 18 from Detroit to Tupelo, returning Wed, May 20, priced at $358 found 1 day ago
American Airlines
Mon, May 18 - Wed, May 20
DTW
Detroit
TUP
Tupelo
$365 Roundtrip, found 1 day ago
$365
Roundtrip
found 1 day ago
Select American Airlines flight, departing Mon, May 18 from Detroit to Tupelo, returning Wed, May 20, priced at $365 found 1 day ago
American Airlines
Wed, May 20 - Wed, May 27
DTW
Detroit
TUP
Tupelo
$385 Roundtrip, found 8 hours ago
$385
Roundtrip
found 8 hours ago
Select American Airlines flight, departing Wed, May 20 from Detroit to Tupelo, returning Wed, May 27, priced at $385 found 8 hours ago
American Airlines
Mon, May 18 - Wed, May 20
DTW
Detroit
TUP
Tupelo
$391 Roundtrip, found 8 hours ago
$391
Roundtrip
found 8 hours ago
Select American Airlines flight, departing Mon, May 18 from Detroit to Tupelo, returning Wed, May 20, priced at $391 found 8 hours ago
American Airlines
Wed, May 27 - Sat, May 30
DTW
Detroit
TUP
Tupelo
$392 Roundtrip, found 1 day ago
$392
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, May 27 from Detroit to Tupelo, returning Sat, May 30, priced at $392 found 1 day ago
American Airlines
Mon, May 18 - Wed, May 20
DTW
Detroit
TUP
Tupelo
$398 Roundtrip, found 1 day ago
$398
Roundtrip
found 1 day ago
Select American Airlines flight, departing Mon, May 18 from Detroit to Tupelo, returning Wed, May 20, priced at $398 found 1 day ago
American Airlines
Wed, May 20 - Wed, May 27
DTW
Detroit
TUP
Tupelo
$405 Roundtrip, found 4 days ago
$405
Roundtrip
found 4 days ago
Select American Airlines flight, departing Wed, May 20 from Detroit to Tupelo, returning Wed, May 27, priced at $405 found 4 days ago
American Airlines
Mon, May 18 - Wed, May 20
DTW
Detroit
TUP
Tupelo
$412 Roundtrip, found 2 days ago
$412
Roundtrip
found 2 days ago
Select American Airlines flight, departing Mon, May 18 from Detroit to Tupelo, returning Wed, May 20, priced at $412 found 2 days ago
American Airlines
Mon, May 18 - Wed, May 20
DTW
Detroit
TUP
Tupelo
$419 Roundtrip, found 2 days ago
$419
Roundtrip
found 2 days ago
Select American Airlines flight, departing Mon, May 18 from Detroit to Tupelo, returning Wed, May 20, priced at $419 found 2 days ago
United
Wed, May 27 - Sat, May 30
DTW
Detroit
TUP
Tupelo
$430 Roundtrip, found 1 day ago
$430
Roundtrip
found 1 day ago
Select United flight, departing Wed, May 27 from Detroit to Tupelo, returning Sat, May 30, priced at $430 found 1 day ago

Frequently asked questions

How much does a flight from Detroit, MI (DTW-Detroit Metropolitan Wayne County) to Tupelo, MS (TUP-Tupelo Regional) cost?
You can find cheap one-way flights from $182 and cheap return flights from $358 DTW to TUP with Expedia. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see our cheapest fares first, and use the Price Tracking tool to receive alerts when DTW to TUP ticket fares go up or down.
What is the cheapest month to fly from Detroit, MI (DTW-Detroit Metropolitan Wayne County) to Tupelo, MS (TUP-Tupelo Regional)?
The cheapest month to fly from DTW to TUP is May when demand is low. Traveling in off-peak or shoulder months is usually a good way to secure cheap tickets, just remember to avoid flying during holidays if you're able to. Use the calendar view in your search to see which months have low fares on this route.
Which airlines fly direct from Detroit, MI (DTW-Detroit Metropolitan Wayne County) to Tupelo, MS (TUP-Tupelo Regional)?
Enter DTW to TUP and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
What is the cheapest airline that flies from Detroit, MI (DTW-Detroit Metropolitan Wayne County) to Tupelo, MS (TUP-Tupelo Regional)?
United, American Airlines and Alaska Airlines are just some of the carriers that fly from Detroit, MI (DTW-Detroit Metropolitan Wayne County) to Tupelo, MS (TUP-Tupelo Regional). Use Expedia's flight search tool to compare airlines on this route and find our cheapest option for your trip. Use Expedia's search tool to compare the prices and schedules of airlines that fly this route to find the best option for your plans and budget.*Prices based on flights available on Expedia in the last year.
How do I find cheap flights from Detroit, MI (DTW-Detroit Metropolitan Wayne County) to Tupelo, MS (TUP-Tupelo Regional)?
To find a cheap flight from Detroit, MI (DTW-Detroit Metropolitan Wayne County) to Tupelo, MS (TUP-Tupelo Regional), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Detroit, MI (DTW-Detroit Metropolitan Wayne County) to Tupelo, MS (TUP-Tupelo Regional)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
What is the earliest flight from Detroit, MI (DTW-Detroit Metropolitan Wayne County) to Tupelo, MS (TUP-Tupelo Regional)?
Sort flights by "Departure (earliest)" on Expedia to find the earliest flight from DTW to TUP. To compare more early flights, use the "Early Morning" and "Morning" filters in your search.
What day of the week has the most flights from Detroit, MI (DTW-Detroit Metropolitan Wayne County) to Tupelo, MS (TUP-Tupelo Regional)?
You'll usually find the most flights from Detroit Metropolitan Wayne County (DTW) to Tupelo Regional (TUP) on a Monday, with around 3 flights available. This gives you plenty of options for your travel plans. A major airline on this route is United.
What are the most popular departure times for flights from Detroit, MI (DTW-Detroit Metropolitan Wayne County) to Tupelo, MS (TUP-Tupelo Regional)?
The most popular departure times for flights from Detroit (DTW) to Tupelo (TUP) are in the morning, from 6am to 9am. About 75% of passengers prefer this time window. Many major carriers, including United Airlines, United Airlines and United Airlines, offer flights during this window. This timing is favored as it allows you to start your day early and arrive in Tupelo with plenty of time to spare.
How long does it take to fly from Detroit, MI (DTW-Detroit Metropolitan Wayne County) to Tupelo, MS (TUP-Tupelo Regional)?
Flying from DTW to TUP with a connection usually takes about 8 hours, traveling roughly 623 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Detroit, MI (DTW-Detroit Metropolitan Wayne County) to Tupelo, MS (TUP-Tupelo Regional)?
Select the "Business class" and "First class" filters when looking for DTW to TUP flights on Expedia. This is the easiest way to compare prices, routes and flight times for your trip.
How do I earn miles on a Detroit, MI (DTW-Detroit Metropolitan Wayne County) to Tupelo, MS (TUP-Tupelo Regional) flight with Expedia?
It's easy to earn miles on a Detroit, MI (DTW-Detroit Metropolitan Wayne County) to Tupelo, MS (TUP-Tupelo Regional) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Tupelo from Detroit Metropolitan Wayne County (DTW)?
If you're planning to travel to Tupelo from Detroit Metropolitan Wayne County (DTW), you can fly into Tupelo Regional (TUP) Some flights may connect through major hubs like O'Hare Intl. (ORD), Ronald Reagan Washington National (DCA), Washington Dulles Intl. (IAD) before reaching Tupelo. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Detroit, MI (DTW-Detroit Metropolitan Wayne County) to Tupelo, MS (TUP-Tupelo Regional) at the last minute?
Typically, booking a last minute flight from Detroit, MI (DTW-Detroit Metropolitan Wayne County) to Tupelo, MS (TUP-Tupelo Regional) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Detroit, MI (DTW-Detroit Metropolitan Wayne County) to Tupelo, MS (TUP-Tupelo Regional) flight and hotel package?
Securing a Detroit, MI (DTW-Detroit Metropolitan Wayne County) to Tupelo, MS (TUP-Tupelo Regional) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Detroit, MI (DTW-Detroit Metropolitan Wayne County) to Tupelo, MS (TUP-Tupelo Regional)?
If you booked your Detroit, MI (DTW-Detroit Metropolitan Wayne County) to Tupelo, MS (TUP-Tupelo Regional) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Detroit Metropolitan Wayne County
Destination airport
Tupelo Regional
Roundtrip price
$358
Distance
622 mi

Book with confidence

Detroit to Tupelo Flights

The cheapest times to fly from Detroit to Tupelo

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Detroit to Tupelo are during the month of May. You can find some of the cheapest flights from Detroit to Tupelo with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Detroit to Tupelo

Sunday is one of the best days to book for cheap flights from Detroit to Tupelo: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Detroit to Tupelo

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Detroit to Tupelo in 2026. You can also book with separate airlines for your outbound and return journeys, from $182 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Detroit to Tupelo flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Detroit to Tupelo airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Detroit to Tupelo Flights

*Flight schedules are subject to change.

*Available to One Key members.

 

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