$337 Cheap Flights from Lisbon (LIS) to Panama City (PTY)

View $337 flight on Tue, Nov 25, 2025Opens in a new window

Popular airlines from Humberto Delgado Airport (LIS) to Tocumen Intl. Airport (PTY)

Cheap Flights from Lisbon to Panama City (LIS-PTY)

Prices were available within the past 7 days and start at $337 for one-way flights and $599 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Air Europa
Thu, Nov 6 - Thu, Nov 20
LIS
Lisbon
PTY
Panama City
$599 Roundtrip, found 3 days ago
$599
Roundtrip
found 3 days ago
Select Air Europa flight, departing Thu, Nov 6 from Lisbon to Panama City, returning Thu, Nov 20, priced at $599 found 3 days ago
Air Europa
Thu, Nov 6 - Thu, Nov 13
LIS
Lisbon
PTY
Panama City
$599 Roundtrip, found 6 days ago
$599
Roundtrip
found 6 days ago
Select Air Europa flight, departing Thu, Nov 6 from Lisbon to Panama City, returning Thu, Nov 13, priced at $599 found 6 days ago
Air Europa
Sat, Nov 29 - Mon, Dec 8
LIS
Lisbon
PTY
Panama City
$601 Roundtrip, found 5 days ago
$601
Roundtrip
found 5 days ago
Select Air Europa flight, departing Sat, Nov 29 from Lisbon to Panama City, returning Mon, Dec 8, priced at $601 found 5 days ago
Air Europa
Tue, Nov 25 - Sun, Dec 7
LIS
Lisbon
PTY
Panama City
$602 Roundtrip, just found
$602
Roundtrip
just found
Select Air Europa flight, departing Tue, Nov 25 from Lisbon to Panama City, returning Sun, Dec 7, priced at $602 just found
Air Europa
Thu, Nov 6 - Thu, Nov 20
LIS
Lisbon
PTY
Panama City
$607 Roundtrip, found 3 days ago
$607
Roundtrip
found 3 days ago
Select Air Europa flight, departing Thu, Nov 6 from Lisbon to Panama City, returning Thu, Nov 20, priced at $607 found 3 days ago
Air Europa
Wed, Nov 19 - Fri, Nov 21
LIS
Lisbon
PTY
Panama City
$610 Roundtrip, found 6 days ago
$610
Roundtrip
found 6 days ago
Select Air Europa flight, departing Wed, Nov 19 from Lisbon to Panama City, returning Fri, Nov 21, priced at $610 found 6 days ago
Air France
Mon, Nov 17 - Fri, Nov 21
LIS
Lisbon
PTY
Panama City
$699 Roundtrip, found 6 days ago
$699
Roundtrip
found 6 days ago
Select Air France flight, departing Mon, Nov 17 from Lisbon to Panama City, returning Fri, Nov 21, priced at $699 found 6 days ago
Iberia
Wed, Jan 28 - Wed, Feb 4
LIS
Lisbon
PTY
Panama City
$750 Roundtrip, found 6 days ago
$750
Roundtrip
found 6 days ago
Select Iberia flight, departing Wed, Jan 28 from Lisbon to Panama City, returning Wed, Feb 4, priced at $750 found 6 days ago
KLM
Wed, Jan 28 - Wed, Feb 4
LIS
Lisbon
PTY
Panama City
$781 Roundtrip, found 6 days ago
$781
Roundtrip
found 6 days ago
Select KLM flight, departing Wed, Jan 28 from Lisbon to Panama City, returning Wed, Feb 4, priced at $781 found 6 days ago
United
Thu, Nov 6 - Thu, Nov 13
LIS
Lisbon
PTY
Panama City
$897 Roundtrip, found 6 days ago
$897
Roundtrip
found 6 days ago
Select United flight, departing Thu, Nov 6 from Lisbon to Panama City, returning Thu, Nov 13, priced at $897 found 6 days ago

Alternative airports near Panama City

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Tocumen Intl. PTY. Cheapest option available. Average driving time to city center is 16 minutes. Flights from $721
PTY
Tocumen Intl.
Cheapest
Average driving time to city center16 min
Flights from $721

Frequently asked questions

How much does a flight from Humberto Delgado Airport (LIS) to Tocumen Intl. Airport (PTY) cost?
Grab a cheap one-way flight from $337 or cheap return flight from $599 from Humberto Delgado Airport (LIS) to Tocumen Intl. Airport (PTY) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Humberto Delgado Airport (LIS) to Tocumen Intl. Airport (PTY)?
Planning your getaway for November is a great way to save, as it's the cheapest month for flights between LIS and PTY. You'll often find the lowest fares during off-peak months.
What is the cheapest airline that flies from Humberto Delgado Airport (LIS) to Tocumen Intl. Airport (PTY)?
To find the cheapest airline flying from LIS to PTY, use Expedia's filter tool. Customize your search based on what's important to you, such as preferred carriers and seat class. You can then sort your results by "Price (lowest to highest)" to discover the cheapest flight right away.
How many flights per day from Humberto Delgado Airport (LIS) to Tocumen Intl. Airport (PTY)?
There are no daily direct flights departing from Humberto Delgado Airport (LIS) to Tocumen Intl. Airport (PTY). But you can opt for flights with layovers. Filter your search results on Expedia to include one or two stops, and you'll be soaring above the clouds before you know it.
What day of the week has the most flights from LIS to PTY?
Typically you'll find the greatest selection of flight options on a Friday. Tuesdays tend to be the quietest.* However, this can vary based on the airline, season and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Humberto Delgado Airport (LIS) to Tocumen Intl. Airport (PTY)?
To avoid potential delays on the Humberto Delgado Airport (LIS) to Tocumen Intl. Airport (PTY) route, aim to travel before 3 PM. Departures after this time have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Humberto Delgado Airport (LIS) to Tocumen Intl. Airport (PTY) last-minute?
Last-minute fares from LIS to PTY are typically more expensive. To secure the best rates, start searching for flights well in advance. That said, if your travel plans are flexible, you may land a cheap ticket right before your trip.
Is it cheaper to book a LIS to PTY flight and hotel package?
Compared with arranging hotels and flights separately, booking a LIS to PTY flight and hotel package with Expedia could result in significant savings. Better still, having it all in one place will take the stress out of planning your trip. Simply secure your flights and select from our extensive range of hotels, then customize your trip with other add-ons like tours and car rentals.
Can I cancel or change the date of my flight from Humberto Delgado Airport (LIS) to Tocumen Intl. Airport (PTY)?
If you booked your LIS to PTY flight in the last 24 hours, you may be able to cancel or modify it without fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you want more information.

Travel information

Origin airport
Humberto Delgado
Destination airport
Tocumen Intl.
Airlines serving
Air Europa, Air France, British Airways, Delta, Iberia, KLM, Turkish Airlines, United
Roundtrip price
$598
Distance
4765 mi

Book with confidence

Lisbon to Panama City Flights

The cheapest times to fly from Lisbon to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Lisbon to Panama City are during the month of November. You can find some of the cheapest flights from Lisbon to Panama City with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Lisbon to Panama City

Sunday is one of the best days to book for cheap flights from Lisbon to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Lisbon to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Lisbon to Panama City in 2025. You can also book with separate airlines for your outbound and return journeys, from $337 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Lisbon to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Lisbon to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Lisbon to Panama City Flights

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*Available to One Key members.