$139 Cheap Flights from Medellín (MDE) to Panama City (PTY)

View $139 flight on Wed, Nov 19, 2025Opens in a new window

Popular airlines from Jose Maria Cordova Intl. Airport (MDE) to Tocumen Intl. Airport (PTY)

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Cheap Flights from Medellín to Panama City (MDE-PTY)

Prices were available within the past 7 days and start at $139 for one-way flights and $238 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Copa
Thu, Oct 23 - Tue, Oct 28
MDE
Medellin
PTY
Panama City
$238 Roundtrip, found 11 hours ago
$238
Roundtrip
found 11 hours ago
Select Copa flight, departing Thu, Oct 23 from Medellin to Panama City, returning Tue, Oct 28, priced at $238 found 11 hours ago
Copa
Tue, Nov 4 - Thu, Nov 6
MDE
Medellin
PTY
Panama City
$238 Roundtrip, found 1 hour ago
$238
Roundtrip
found 1 hour ago
Select Copa flight, departing Tue, Nov 4 from Medellin to Panama City, returning Thu, Nov 6, priced at $238 found 1 hour ago
Copa
Thu, Oct 23 - Tue, Oct 28
MDE
Medellin
PTY
Panama City
$249 Roundtrip, found 11 hours ago
$249
Roundtrip
found 11 hours ago
Select Copa flight, departing Thu, Oct 23 from Medellin to Panama City, returning Tue, Oct 28, priced at $249 found 11 hours ago
Copa
Fri, Oct 24 - Sun, Oct 26
MDE
Medellin
PTY
Panama City
$249 Roundtrip, found 1 day ago
$249
Roundtrip
found 1 day ago
Select Copa flight, departing Fri, Oct 24 from Medellin to Panama City, returning Sun, Oct 26, priced at $249 found 1 day ago
Copa
Tue, Nov 18 - Sat, Nov 22
MDE
Medellin
PTY
Panama City
$264 Roundtrip, found 1 day ago
$264
Roundtrip
found 1 day ago
Select Copa flight, departing Tue, Nov 18 from Medellin to Panama City, returning Sat, Nov 22, priced at $264 found 1 day ago
Copa
Thu, Oct 23 - Tue, Oct 28
MDE
Medellin
PTY
Panama City
$270 Roundtrip, found 11 hours ago
$270
Roundtrip
found 11 hours ago
Select Copa flight, departing Thu, Oct 23 from Medellin to Panama City, returning Tue, Oct 28, priced at $270 found 11 hours ago
Copa
Tue, Nov 11 - Thu, Jan 1
MDE
Medellin
PTY
Panama City
$273 Roundtrip, found 6 hours ago
$273
Roundtrip
found 6 hours ago
Select Copa flight, departing Tue, Nov 11 from Medellin to Panama City, returning Thu, Jan 1, priced at $273 found 6 hours ago
Copa
Thu, Oct 23 - Tue, Oct 28
MDE
Medellin
PTY
Panama City
$280 Roundtrip, found 11 hours ago
$280
Roundtrip
found 11 hours ago
Select Copa flight, departing Thu, Oct 23 from Medellin to Panama City, returning Tue, Oct 28, priced at $280 found 11 hours ago
Copa
Wed, Oct 22 - Thu, Oct 23
MDE
Medellin
PTY
Panama City
$283 Roundtrip, found 1 day ago
$283
Roundtrip
found 1 day ago
Select Copa flight, departing Wed, Oct 22 from Medellin to Panama City, returning Thu, Oct 23, priced at $283 found 1 day ago
avianca
Fri, Nov 7 - Mon, Nov 10
MDE
Medellin
PTY
Panama City
$289 Roundtrip, just found
$289
Roundtrip
just found
Select avianca flight, departing Fri, Nov 7 from Medellin to Panama City, returning Mon, Nov 10, priced at $289 just found

Find the cheapest month to fly from Medellín (MDE) to Panama City (PTY)

February is typically the cheapest month to fly

From $204 - $406 per traveler.

Alternative airports near Panama City

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Tocumen Intl. PTY. Cheapest option available. Average driving time to city center is 16 minutes. Flights from $291
PTY
Tocumen Intl.
Cheapest
Average driving time to city center16 min
Flights from $291

Frequently asked questions

How much does a flight from Jose Maria Cordova Intl. Airport (MDE) to Tocumen Intl. Airport (PTY) cost?
Secure a cheap one-way flight from $139 or cheap return flight from $238 from Jose Maria Cordova Intl. Airport (MDE) to Tocumen Intl. Airport (PTY) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Jose Maria Cordova Intl. Airport (MDE) to Tocumen Intl. Airport (PTY)?
October is the most affordable month to fly from MDE to PTY. Timing your trip outside of the busy season is often the key to better flight prices.
Which airlines fly direct from Jose Maria Cordova Intl. Airport (MDE) to Tocumen Intl. Airport (PTY)?
When setting off from Jose Maria Cordova Intl. Airport (MDE), you can hop on a direct flight to Tocumen Intl. Airport (PTY) with Copa Airlines.
What is the cheapest airline that flies from Jose Maria Cordova Intl. Airport (MDE) to Tocumen Intl. Airport (PTY)?
The cheapest airline to offer flights between Jose Maria Cordova Intl. Airport (MDE) and Tocumen Intl. Airport (PTY) will vary based on your travel plans. AVIANCA and Copa Airlines are just some good options offering competitive fares. Use Expedia's search tool to compare airlines in one place and find the right MDE to PTY flight for your budget.
How many flights per day from Jose Maria Cordova Intl. Airport (MDE) to Tocumen Intl. Airport (PTY)?
With, on average, 9 direct flights that operate from Jose Maria Cordova Intl. Airport (MDE) to Tocumen Intl. Airport (PTY) each day, you'll be soaring through the skies in no time.
What are the most popular departure times for flights from Jose Maria Cordova Intl. Airport (MDE) to Tocumen Intl. Airport (PTY)?
More passengers fly between MDE and PTY at 11 AM than at any other point in the day. Looking for a quieter experience? Consider flying outside peak hours and you're likely to save on your fare as well.
What day of the week has the most flights from MDE to PTY?
Depart on a Friday if you're looking for the largest selection of flights from Jose Maria Cordova Intl. Airport (MDE) to Tocumen Intl. Airport (PTY).
What is the earliest flight from Jose Maria Cordova Intl. Airport (MDE) to Tocumen Intl. Airport (PTY)?
Hop on the earliest flight at around 5:05AM UTC-5, departing from Jose Maria Cordova Intl. Airport (MDE). You'll be in the air for around 1h 29m, arriving at Tocumen Intl. Airport (PTY) at approximately 6:34AM UTC-5.
How long does it take to fly from Jose Maria Cordova Intl. Airport (MDE) to Tocumen Intl. Airport (PTY)?
The average flight time from MDE to PTY is 1 hour and 27 minutes, covering a distance of 340 mi.
What airline has the least delays from MDE to PTY?
With 91% of flights generally landing on schedule, Copa Airlines has the best on-time performance for direct flights from Jose Maria Cordova Intl. Airport (MDE) to Tocumen Intl. Airport (PTY). To keep track of your flight status and get notifications if anything changes, use the Expedia App.
What is the best time to fly from Jose Maria Cordova Intl. Airport (MDE) to Tocumen Intl. Airport (PTY)?
Book a flight from Jose Maria Cordova Intl. Airport (MDE) to Tocumen Intl. Airport (PTY) that leaves before 3 PM to reduce the risk of delays and cancellations. Departures after this hour are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
What airports do you fly into for Panama City from Jose Maria Cordova Intl. Airport (MDE)?
You can touch down at Tocumen Intl. Airport (PTY) or Panama Pacifico Intl. Airport (BLB) when traveling to Panama City on a direct flight from Jose Maria Cordova Intl. Airport (MDE).
Is it cheaper to buy a plane ticket from Jose Maria Cordova Intl. Airport (MDE) to Tocumen Intl. Airport (PTY) last-minute?
Holding off until right before your break to book a flight from MDE to PTY often results in higher prices. While you may find some last-minute deals, there's no guarantee. Keep your travel schedule open for the best chance of landing a bargain.
Is it cheaper to book a MDE to PTY flight and hotel package?
Opting for a MDE to PTY flight and hotel package tends to be cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your trip all in one place. Pick from our extensive range of hotels and then add activities, car rentals and flights to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Jose Maria Cordova Intl. Airport (MDE) to Tocumen Intl. Airport (PTY)?
Typically, you're able to cancel or reschedule your MDE to PTY flight. However, there may be additional charges, especially if your booking was made more than 24 hours ago. Check your itinerary for the airline's policies and fees on flight changes, or if you need more details, head to our Customer Service portal.

Travel information

Origin airport
José María Córdova Intl.
Destination airport
Tocumen Intl.
Airlines serving
Copa, avianca
Roundtrip price
$237
Distance
336 mi
Average flight time
1 hour 28 mins

Book with confidence

Medellín to Panama City Flights

The cheapest times to fly from Medellín to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Medellín to Panama City are during the month of October. You can find some of the cheapest flights from Medellín to Panama City with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Medellín to Panama City

Sunday is one of the best days to book for cheap flights from Medellín to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Medellín to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Medellín to Panama City in 2025. You can also book with separate airlines for your outbound and return journeys, from $139 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Medellín to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Medellín to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Medellín to Panama City Flights

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*Available to One Key members.