$394 Cheap Flights from Medellín (MDE) to Sao Luis (SLZ)

View $394 flight on Wed, Oct 15, 2025Opens in a new window

Popular airlines from Jose Maria Cordova Intl. Airport (MDE) to Sao Luis (SLZ-Marechal Cunha Machado Intl.)

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Cheap Flights from Medellín to Sao Luis (MDE-SLZ)

Prices were available within the past 7 days and start at $394 for one-way flights and $744 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

GOL Linhas Aereas S.A.
Wed, Oct 15 - Wed, Oct 22
MDE
Medellin
SLZ
São Luís
$744 Roundtrip, found 5 days ago
$744
Roundtrip
found 5 days ago
Select GOL Linhas Aereas S.A. flight, departing Wed, Oct 15 from Medellin to São Luís, returning Wed, Oct 22, priced at $744 found 5 days ago
GOL Linhas Aereas S.A.
Wed, Oct 15 - Fri, Oct 17
MDE
Medellin
SLZ
São Luís
$768 Roundtrip, found 5 days ago
$768
Roundtrip
found 5 days ago
Select GOL Linhas Aereas S.A. flight, departing Wed, Oct 15 from Medellin to São Luís, returning Fri, Oct 17, priced at $768 found 5 days ago
GOL Linhas Aereas S.A.
Fri, Oct 10 - Wed, Oct 22
MDE
Medellin
SLZ
São Luís
$793 Roundtrip, found 5 days ago
$793
Roundtrip
found 5 days ago
Select GOL Linhas Aereas S.A. flight, departing Fri, Oct 10 from Medellin to São Luís, returning Wed, Oct 22, priced at $793 found 5 days ago
GOL Linhas Aereas S.A.
Wed, Oct 15 - Mon, Oct 20
MDE
Medellin
SLZ
São Luís
$815 Roundtrip, found 5 days ago
$815
Roundtrip
found 5 days ago
Select GOL Linhas Aereas S.A. flight, departing Wed, Oct 15 from Medellin to São Luís, returning Mon, Oct 20, priced at $815 found 5 days ago
GOL Linhas Aereas S.A.
Fri, Oct 10 - Fri, Oct 17
MDE
Medellin
SLZ
São Luís
$826 Roundtrip, found 5 days ago
$826
Roundtrip
found 5 days ago
Select GOL Linhas Aereas S.A. flight, departing Fri, Oct 10 from Medellin to São Luís, returning Fri, Oct 17, priced at $826 found 5 days ago
LATAM Airlines Group
Tue, Oct 14 - Tue, Oct 21
MDE
Medellin
SLZ
São Luís
$857 Roundtrip, found 5 days ago
$857
Roundtrip
found 5 days ago
Select LATAM Airlines Group flight, departing Tue, Oct 14 from Medellin to São Luís, returning Tue, Oct 21, priced at $857 found 5 days ago
GOL Linhas Aereas S.A.
Fri, Oct 10 - Mon, Oct 20
MDE
Medellin
SLZ
São Luís
$864 Roundtrip, found 5 days ago
$864
Roundtrip
found 5 days ago
Select GOL Linhas Aereas S.A. flight, departing Fri, Oct 10 from Medellin to São Luís, returning Mon, Oct 20, priced at $864 found 5 days ago
LATAM Airlines Group
Mon, Oct 13 - Tue, Oct 21
MDE
Medellin
SLZ
São Luís
$868 Roundtrip, found 5 days ago
$868
Roundtrip
found 5 days ago
Select LATAM Airlines Group flight, departing Mon, Oct 13 from Medellin to São Luís, returning Tue, Oct 21, priced at $868 found 5 days ago
LATAM Airlines Group
Tue, Oct 14 - Fri, Oct 17
MDE
Medellin
SLZ
São Luís
$873 Roundtrip, found 5 days ago
$873
Roundtrip
found 5 days ago
Select LATAM Airlines Group flight, departing Tue, Oct 14 from Medellin to São Luís, returning Fri, Oct 17, priced at $873 found 5 days ago
LATAM Airlines Group
Wed, Oct 15 - Tue, Oct 21
MDE
Medellin
SLZ
São Luís
$874 Roundtrip, found 5 days ago
$874
Roundtrip
found 5 days ago
Select LATAM Airlines Group flight, departing Wed, Oct 15 from Medellin to São Luís, returning Tue, Oct 21, priced at $874 found 5 days ago

Frequently asked questions

How much does a flight from Jose Maria Cordova Intl. Airport (MDE) to Marechal Cunha Machado Intl. Airport (SLZ) cost?
Lock in a cheap one-way flight from $394 or cheap return flight from $744 from Jose Maria Cordova Intl. Airport (MDE) to Marechal Cunha Machado Intl. Airport (SLZ) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Jose Maria Cordova Intl. Airport (MDE) to Marechal Cunha Machado Intl. Airport (SLZ)?
October is the cheapest month to fly from MDE to SLZ. Traveling during quieter months is often the key to scoring lower fares.
What is the cheapest airline that flies from Jose Maria Cordova Intl. Airport (MDE) to Marechal Cunha Machado Intl. Airport (SLZ)?
Use the filters on Expedia to compare different airlines and find the cheapest carrier that'll fly you from MDE to SLZ. Then, sort your results by "Price (lowest to highest)" to snag a great deal.
How many flights per day from Jose Maria Cordova Intl. Airport (MDE) to Marechal Cunha Machado Intl. Airport (SLZ)?
There are no daily nonstop flights available from Jose Maria Cordova Intl. Airport (MDE) to Marechal Cunha Machado Intl. Airport (SLZ). But you can opt for flights with layovers. Filter your search on Expedia to include one or more stops, and you'll be on your way in no time at all.
What day of the week has the most flights from MDE to SLZ?
You'll typically find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can vary from season to season and during public holidays or peak travel times.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Jose Maria Cordova Intl. Airport (MDE) to Marechal Cunha Machado Intl. Airport (SLZ)?
To avoid potential delays on the Jose Maria Cordova Intl. Airport (MDE) to Marechal Cunha Machado Intl. Airport (SLZ) route, aim to travel before 3 PM. Later flights have a 22% higher chance of being canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Jose Maria Cordova Intl. Airport (MDE) to Marechal Cunha Machado Intl. Airport (SLZ) last-minute?
Last-minute fares from MDE to SLZ are usually more expensive. To lock in the cheapest rates, start searching for flights as early as possible. That said, if you're flexible with your travel dates, you may score a cheap ticket right before your trip.
Is it cheaper to book a MDE to SLZ flight and hotel package?
You can save money by booking a MDE to SLZ flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's simple to manage everything in one convenient place. Once you've selected your preferred accommodations and flights, you can add extras such as activities, car rentals and tours.
Can I cancel or change the date of my flight from Jose Maria Cordova Intl. Airport (MDE) to Marechal Cunha Machado Intl. Airport (SLZ)?
It's usually possible to reschedule or cancel your MDE to SLZ flight. However, if it's been more than 24 hours since booking, additional fees may apply. Refer to your airline's policies in your itinerary to see what changes are allowed and whether any costs are involved. You'll also find further details on our Customer Service portal.

Travel information

Travel information

Origin airport
José María Córdova Intl.
Destination airport
Marechal Cunha Machado Intl.
Roundtrip price
$743
Distance
2235 mi

Book with confidence

Book with confidence

Medellín to Sao Luis Flights

The cheapest times to fly from Medellín to Sao Luis

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Medellín to Sao Luis are during the month of October. You can find some of the cheapest flights from Medellín to Sao Luis with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Medellín to Sao Luis

Sunday is one of the best days to book for cheap flights from Medellín to Sao Luis: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Medellín to Sao Luis

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Medellín to Sao Luis in 2025. You can also book with separate airlines for your outbound and return journeys, from $394 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Medellín to Sao Luis flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Medellín to Sao Luis airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Medellín to Sao Luis Flights

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*Available to One Key members.