$237 Cheap Flights from Medellín (MDE) to Santa Cruz (VVI)

View $237 flight on Sun, Nov 16, 2025Opens in a new window

Popular airlines from Jose Maria Cordova Intl. Airport (MDE) to Santa Cruz (VVI-Viru Viru Intl.)

    notification illustration

    Be in the know

    Get alerts if flight prices drop or rise*
    deals illustration

    Book smarter

    Save up to 30% on select hotels after you book a flight*
    trophy illustration

    Earn twice

    Earn your airline miles on top of our OneKeyCash
    Learn about One Key

Cheap Flights from Medellín to Santa Cruz (MDE-VVI)

Prices were available within the past 7 days and start at $237 for one-way flights and $445 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

LATAM Airlines Group
Sat, Oct 25 - Wed, Nov 5
MDE
Medellin
VVI
Santa Cruz
$445 Roundtrip, found 6 days ago
$445
Roundtrip
found 6 days ago
Select LATAM Airlines Group flight, departing Sat, Oct 25 from Medellin to Santa Cruz, returning Wed, Nov 5, priced at $445 found 6 days ago
avianca
Sat, Oct 25 - Sun, Nov 2
MDE
Medellin
VVI
Santa Cruz
$459 Roundtrip, found 22 hours ago
$459
Roundtrip
found 22 hours ago
Select avianca flight, departing Sat, Oct 25 from Medellin to Santa Cruz, returning Sun, Nov 2, priced at $459 found 22 hours ago
avianca
Thu, Dec 11 - Sat, Dec 20
MDE
Medellin
VVI
Santa Cruz
$460 Roundtrip, found 3 days ago
$460
Roundtrip
found 3 days ago
Select avianca flight, departing Thu, Dec 11 from Medellin to Santa Cruz, returning Sat, Dec 20, priced at $460 found 3 days ago
Copa
Sat, Oct 25 - Sun, Nov 2
MDE
Medellin
VVI
Santa Cruz
$479 Roundtrip, found 22 hours ago
$479
Roundtrip
found 22 hours ago
Select Copa flight, departing Sat, Oct 25 from Medellin to Santa Cruz, returning Sun, Nov 2, priced at $479 found 22 hours ago
LATAM Airlines Group
Sat, Oct 25 - Thu, Oct 30
MDE
Medellin
VVI
Santa Cruz
$481 Roundtrip, found 6 days ago
$481
Roundtrip
found 6 days ago
Select LATAM Airlines Group flight, departing Sat, Oct 25 from Medellin to Santa Cruz, returning Thu, Oct 30, priced at $481 found 6 days ago
LATAM Airlines Group
Tue, Jan 27 - Fri, Jan 30
MDE
Medellin
VVI
Santa Cruz
$482 Roundtrip, found 4 days ago
$482
Roundtrip
found 4 days ago
Select LATAM Airlines Group flight, departing Tue, Jan 27 from Medellin to Santa Cruz, returning Fri, Jan 30, priced at $482 found 4 days ago
LATAM Airlines Group
Sat, Oct 25 - Mon, Nov 3
MDE
Medellin
VVI
Santa Cruz
$492 Roundtrip, found 6 days ago
$492
Roundtrip
found 6 days ago
Select LATAM Airlines Group flight, departing Sat, Oct 25 from Medellin to Santa Cruz, returning Mon, Nov 3, priced at $492 found 6 days ago
LATAM Airlines Group
Thu, Dec 4 - Sun, Dec 7
MDE
Medellin
VVI
Santa Cruz
$517 Roundtrip, found 6 days ago
$517
Roundtrip
found 6 days ago
Select LATAM Airlines Group flight, departing Thu, Dec 4 from Medellin to Santa Cruz, returning Sun, Dec 7, priced at $517 found 6 days ago
LATAM Airlines Group
Tue, Jan 27 - Fri, Jan 30
MDE
Medellin
VVI
Santa Cruz
$520 Roundtrip, found 4 days ago
$520
Roundtrip
found 4 days ago
Select LATAM Airlines Group flight, departing Tue, Jan 27 from Medellin to Santa Cruz, returning Fri, Jan 30, priced at $520 found 4 days ago
LATAM Airlines Group
Sat, Oct 25 - Sun, Nov 2
MDE
Medellin
VVI
Santa Cruz
$529 Roundtrip, found 22 hours ago
$529
Roundtrip
found 22 hours ago
Select LATAM Airlines Group flight, departing Sat, Oct 25 from Medellin to Santa Cruz, returning Sun, Nov 2, priced at $529 found 22 hours ago

Frequently asked questions

How much does a flight from Jose Maria Cordova Intl. Airport (MDE) to Viru Viru Intl. Airport (VVI) cost?
Secure a cheap one-way flight from $237 or cheap return flight from $445 from Jose Maria Cordova Intl. Airport (MDE) to Viru Viru Intl. Airport (VVI) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Jose Maria Cordova Intl. Airport (MDE) to Viru Viru Intl. Airport (VVI)?
October is the most affordable month to fly from MDE to VVI. Traveling during quieter months is often the key to finding a great deal.
What is the cheapest airline that flies from Jose Maria Cordova Intl. Airport (MDE) to Viru Viru Intl. Airport (VVI)?
Use the filters on Expedia to compare different airlines and find the most affordable carrier that'll take you from MDE to VVI. Then, sort your results by "Price (lowest to highest)" to snap up the best deal available.
How many flights per day from Jose Maria Cordova Intl. Airport (MDE) to Viru Viru Intl. Airport (VVI)?
There are no daily nonstop flights from Jose Maria Cordova Intl. Airport (MDE) to Viru Viru Intl. Airport (VVI). But you can opt for flights with layovers. Filter your search on Expedia to include one or two stops, and you'll be on your way before you know it.
What day of the week has the most flights from MDE to VVI?
Typically you'll find the widest variety of flight choices on a Friday. Tuesdays tend to be the quietest.* However, this can change depending on the time of year, carrier and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Jose Maria Cordova Intl. Airport (MDE) to Viru Viru Intl. Airport (VVI)?
To touch down at Viru Viru Intl. Airport (VVI) on schedule, pick a flight that leaves Jose Maria Cordova Intl. Airport (MDE) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Jose Maria Cordova Intl. Airport (MDE) to Viru Viru Intl. Airport (VVI) last-minute?
Holding off until right before your break to book a flight from MDE to VVI generally means paying more. Although you may find some last-minute offers, there's no guarantee. Be flexible with your travel plans to maximize your chances of snagging a bargain.
Is it cheaper to book a MDE to VVI flight and hotel package?
Compared with arranging hotels and flights separately, booking a MDE to VVI flight and hotel package with Expedia could lead to significant savings. What's more, having everything in one convenient place will take the stress out of travel planning. Simply secure your flights and choose from our extensive range of hotels, then personalize your trip with other add-ons like car rentals and activities.
Can I cancel or change the date of my flight from Jose Maria Cordova Intl. Airport (MDE) to Viru Viru Intl. Airport (VVI)?
You can usually reschedule or cancel your MDE to VVI flight. However, if it's been more than 24 hours since booking, additional charges may apply. Check your airline's policies in your itinerary to see what changes are possible and whether any costs are involved. You'll also find further details on our Customer Service portal.

Travel information

Origin airport
José María Córdova Intl.
Destination airport
Viru Viru Intl.
Airlines serving
Copa, LATAM Airlines Group, avianca
Roundtrip price
$445
Distance
1846 mi

Book with confidence

Medellín to Santa Cruz Flights

The cheapest times to fly from Medellín to Santa Cruz

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Medellín to Santa Cruz are during the month of October. You can find some of the cheapest flights from Medellín to Santa Cruz with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Medellín to Santa Cruz

Sunday is one of the best days to book for cheap flights from Medellín to Santa Cruz: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Medellín to Santa Cruz

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Medellín to Santa Cruz in 2025. You can also book with separate airlines for your outbound and return journeys, from $237 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Medellín to Santa Cruz flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Medellín to Santa Cruz airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Medellín to Santa Cruz Flights

Explore a world of travel with Expedia

*Available to One Key members.