$539 Cheap Flights from Chicago (MDW) to Panama City (PTY)

View $539 flight on Fri, Aug 7, 2026Opens in a new window

Popular airlines from Chicago Midway Airport (MDW) to Tocumen Intl. Airport (PTY)

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Cheap Flights from Chicago to Panama City (MDW-PTY)

Prices were available within the past 7 days and start at $539 for one-way flights and $578 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Wed, Mar 4 - Thu, Mar 5
MDW
Chicago
PTY
Panama City
$578 Roundtrip, found 3 days ago
$578
Roundtrip
found 3 days ago
Select Delta flight, departing Wed, Mar 4 from Chicago to Panama City, returning Thu, Mar 5, priced at $578 found 3 days ago
Delta
Sat, Apr 18 - Wed, Apr 22
MDW
Chicago
PTY
Panama City
$582 Roundtrip, found 1 day ago
$582
Roundtrip
found 1 day ago
Select Delta flight, departing Sat, Apr 18 from Chicago to Panama City, returning Wed, Apr 22, priced at $582 found 1 day ago
Delta
Fri, Jan 30 - Tue, Feb 3
MDW
Chicago
PTY
Panama City
$587 Roundtrip, found 1 day ago
$587
Roundtrip
found 1 day ago
Select Delta flight, departing Fri, Jan 30 from Chicago to Panama City, returning Tue, Feb 3, priced at $587 found 1 day ago
Delta
Mon, Mar 16 - Wed, Mar 18
MDW
Chicago
PTY
Panama City
$587 Roundtrip, found 4 days ago
$587
Roundtrip
found 4 days ago
Select Delta flight, departing Mon, Mar 16 from Chicago to Panama City, returning Wed, Mar 18, priced at $587 found 4 days ago
Delta
Thu, May 28 - Tue, Jun 2
MDW
Chicago
PTY
Panama City
$589 Roundtrip, found 4 days ago
$589
Roundtrip
found 4 days ago
Select Delta flight, departing Thu, May 28 from Chicago to Panama City, returning Tue, Jun 2, priced at $589 found 4 days ago
Delta
Sat, Apr 18 - Wed, Apr 22
MDW
Chicago
PTY
Panama City
$592 Roundtrip, found 1 day ago
$592
Roundtrip
found 1 day ago
Select Delta flight, departing Sat, Apr 18 from Chicago to Panama City, returning Wed, Apr 22, priced at $592 found 1 day ago
Delta
Wed, May 27 - Wed, Jun 3
MDW
Chicago
PTY
Panama City
$596 Roundtrip, found 4 days ago
$596
Roundtrip
found 4 days ago
Select Delta flight, departing Wed, May 27 from Chicago to Panama City, returning Wed, Jun 3, priced at $596 found 4 days ago
Delta
Thu, May 28 - Tue, Jun 2
MDW
Chicago
PTY
Panama City
$598 Roundtrip, found 4 days ago
$598
Roundtrip
found 4 days ago
Select Delta flight, departing Thu, May 28 from Chicago to Panama City, returning Tue, Jun 2, priced at $598 found 4 days ago
Delta
Wed, May 27 - Wed, Jun 3
MDW
Chicago
PTY
Panama City
$598 Roundtrip, found 4 days ago
$598
Roundtrip
found 4 days ago
Select Delta flight, departing Wed, May 27 from Chicago to Panama City, returning Wed, Jun 3, priced at $598 found 4 days ago
Delta
Thu, Mar 5 - Tue, Mar 10
MDW
Chicago
PTY
Panama City
$604 Roundtrip, found 3 hours ago
$604
Roundtrip
found 3 hours ago
Select Delta flight, departing Thu, Mar 5 from Chicago to Panama City, returning Tue, Mar 10, priced at $604 found 3 hours ago

Alternative airports near Panama City

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Tocumen Intl. PTY. Cheapest option available. Average driving time to city center is 16 minutes. Flights from $1,358
PTY
Tocumen Intl.
Cheapest
Average driving time to city center16 min
Flights from $1,358
Flights from Chicago (MDW) to Panama City (PTY)
Origin airport
Midway Intl.
Destination airport
Tocumen Intl.
Airlines serving
Delta
Roundtrip price
$577
Distance
2317 mi

Chicago to Panama City Flights

The cheapest times to fly from Chicago to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Chicago to Panama City are during the month of March. You can find some of the cheapest flights from Chicago to Panama City with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Chicago to Panama City

Sunday is one of the best days to book for cheap flights from Chicago to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Chicago to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Chicago to Panama City in 2026. You can also book with separate airlines for your outbound and return journeys, from $539 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Chicago to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Chicago to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Midway Intl. Airport (MDW) to Tocumen Intl. Airport (PTY) cost?
Lock in a cheap one-way flight from $539 or cheap return flight from $578 from Midway Intl. Airport (MDW) to Tocumen Intl. Airport (PTY) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Midway Intl. Airport (MDW) to Tocumen Intl. Airport (PTY)?
The cheapest month to fly from MDW to PTY is March, when there's less demand. Off-peak months are typically when you'll find lower airfares between these airports.
Which airlines fly direct from Midway Intl. Airport (MDW) to Tocumen Intl. Airport (PTY)?
Direct flights aren't available from Chicago, IL (MDW-Midway Intl.) to Tocumen Intl. Airport (PTY). However, you can find other airports offering nonstop flights. Board your plane at O'Hare Intl. Airport (ORD) and travel straight to Panama City without a layover.
What is the cheapest airline that flies from Midway Intl. Airport (MDW) to Tocumen Intl. Airport (PTY)?
Expedia's filter tool lets you easily compare different airlines, departure times and fares all in one place. Customize the search to your preferences, then sort by "Price (lowest to highest)" to find out which carrier offers the cheapest MDW to PTY flight.
How many flights per day from Midway Intl. Airport (MDW) to Tocumen Intl. Airport (PTY)?
Nonstop flights from Midway Intl. Airport (MDW) to Tocumen Intl. Airport (PTY) aren't available daily, so you'll need to take a flight with a layover. Explore your options with our filter tool. Enter your travel dates and choose either "1 Stop" or "2+ Stops."
What day of the week has the most flights from MDW to PTY?
You'll typically find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can vary from season to season and during public holidays or peak travel times.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Midway Intl. Airport (MDW) to Tocumen Intl. Airport (PTY)?
Opt for a flight from Midway Intl. Airport (MDW) to Tocumen Intl. Airport (PTY) that leaves before 3 PM to reduce the likelihood of delays. Departures after this time have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Midway Intl. Airport (MDW) to Tocumen Intl. Airport (PTY) last-minute?
Last-minute fares from MDW to PTY are generally more expensive. To secure the best rates, start searching for flights as early as possible. That said, if you're flexible with your travel plans, it's possible to find a cheap ticket right before your trip.
Is it cheaper to book a MDW to PTY flight and hotel package?
Opting for a MDW to PTY flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Pick from our wide range of hotels and then add flights, activities and car rentals to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Midway Intl. Airport (MDW) to Tocumen Intl. Airport (PTY)?
Generally, it's possible to reschedule or cancel your MDW to PTY flight. However, if the booking was made more than 24 hours ago, additional charges may apply. Refer to your airline's policies in your itinerary to see what changes are possible and if any costs are involved. You'll also find more details on our Customer Service portal.

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*Available to One Key members.