$151 Cheap Flights from Mexico City (MEX) to Panama City (PTY)

View $151 flight on Thu, Aug 21, 2025Opens in a new window

Popular airlines from Benito Juarez International Airport (MEX) to Tocumen Intl. Airport (PTY)

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Cheap Flights from Mexico City to Panama City (MEX-PTY)

Prices were available within the past 7 days and start at $151 for one-way flights and $324 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Copa
Thu, Jan 1 - Thu, Jan 8
MEX
Mexico City
PTY
Panama City
$324 Roundtrip, found 5 days ago
$324
Roundtrip
found 5 days ago
Select Copa flight, departing Thu, Jan 1 from Mexico City to Panama City, returning Thu, Jan 8, priced at $324 found 5 days ago
Aeromexico
Wed, Aug 27 - Wed, Dec 31
MEX
Mexico City
PTY
Panama City
$328 Roundtrip, found 1 day ago
$328
Roundtrip
found 1 day ago
Select Aeromexico flight, departing Wed, Aug 27 from Mexico City to Panama City, returning Wed, Dec 31, priced at $328 found 1 day ago
Copa
Thu, Oct 23 - Sat, Oct 25
MEX
Mexico City
PTY
Panama City
$329 Roundtrip, found 2 hours ago
$329
Roundtrip
found 2 hours ago
Select Copa flight, departing Thu, Oct 23 from Mexico City to Panama City, returning Sat, Oct 25, priced at $329 found 2 hours ago
Aeromexico
Wed, Aug 27 - Sun, Aug 31
MEX
Mexico City
PTY
Panama City
$330 Roundtrip, just found
$330
Roundtrip
just found
Select Aeromexico flight, departing Wed, Aug 27 from Mexico City to Panama City, returning Sun, Aug 31, priced at $330 just found
avianca
Wed, Aug 27 - Wed, Dec 31
MEX
Mexico City
PTY
Panama City
$339 Roundtrip, found 1 day ago
$339
Roundtrip
found 1 day ago
Select avianca flight, departing Wed, Aug 27 from Mexico City to Panama City, returning Wed, Dec 31, priced at $339 found 1 day ago
Aeromexico
Tue, Dec 23 - Tue, Dec 30
MEX
Mexico City
PTY
Panama City
$340 Roundtrip, just found
$340
Roundtrip
just found
Select Aeromexico flight, departing Tue, Dec 23 from Mexico City to Panama City, returning Tue, Dec 30, priced at $340 just found
avianca
Wed, Aug 27 - Wed, Dec 31
MEX
Mexico City
PTY
Panama City
$342 Roundtrip, found 1 day ago
$342
Roundtrip
found 1 day ago
Select avianca flight, departing Wed, Aug 27 from Mexico City to Panama City, returning Wed, Dec 31, priced at $342 found 1 day ago
Copa
Sat, Sep 20 - Sat, Sep 27
MEX
Mexico City
PTY
Panama City
$342 Roundtrip, found 3 hours ago
$342
Roundtrip
found 3 hours ago
Select Copa flight, departing Sat, Sep 20 from Mexico City to Panama City, returning Sat, Sep 27, priced at $342 found 3 hours ago
WestJet
Mon, Dec 29 - Sun, Jan 18
MEX
Mexico City
PTY
Panama City
$912 Roundtrip, found 6 days ago
$912
Roundtrip
found 6 days ago
Select WestJet flight, departing Mon, Dec 29 from Mexico City to Panama City, returning Sun, Jan 18, priced at $912 found 6 days ago
United
Fri, Oct 17 - Mon, Nov 3
MEX
Mexico City
PTY
Panama City
$1,040 Roundtrip, found 23 hours ago
$1,040
Roundtrip
found 23 hours ago
Select United flight, departing Fri, Oct 17 from Mexico City to Panama City, returning Mon, Nov 3, priced at $1,040 found 23 hours ago

Find the cheapest month to fly from Mexico City (MEX) to Panama City (PTY)

August is typically the cheapest month to fly

From $274 - $479 per traveler.

Graph displaying average flight prices per month

Alternative airports near Panama City

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Tocumen Intl. PTY. Cheapest option available. Average driving time to city center is 16 minutes. Flights from $330
PTY
Tocumen Intl.
Cheapest
Average driving time to city center16 min
Flights from $330
Flights from Mexico City (MEX) to Panama City (PTY)
Origin airport
Mexico City Intl.
Destination airport
Tocumen Intl.
Airlines serving
Aeromexico, American Airlines, British Airways, Copa, Delta, Iberia, United, avianca
Roundtrip price
$324
Distance
1498 mi
Average flight time
4 hours 45 mins

Mexico City to Panama City Flights

The cheapest times to fly from Mexico City to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Mexico City to Panama City are during the month of January. You can find some of the cheapest flights from Mexico City to Panama City with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Mexico City to Panama City

Sunday is one of the best days to book for cheap flights from Mexico City to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Mexico City to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Mexico City to Panama City in 2025. You can also book with separate airlines for your outbound and return journeys, from $151 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Mexico City to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Mexico City to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Mexico City Intl. Airport (MEX) to Tocumen Intl. Airport (PTY) cost?
Snag a cheap one-way flight from $151 or cheap return flight from $324 from Mexico City Intl. Airport (MEX) to Tocumen Intl. Airport (PTY) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Mexico City Intl. Airport (MEX) to Tocumen Intl. Airport (PTY)?
The cheapest month to fly from MEX to PTY is January, when there's less demand. Off-peak season is usually when you'll find cheap fares for travel between these airports.
Which airlines fly direct from Mexico City Intl. Airport (MEX) to Tocumen Intl. Airport (PTY)?
Catch a nonstop flight with Copa Airlines and travel straight from Mexico City Intl. Airport (MEX) to Tocumen Intl. Airport (PTY).
What is the cheapest airline that flies from Mexico City Intl. Airport (MEX) to Tocumen Intl. Airport (PTY)?
To find the cheapest airline that'll fly you from MEX to PTY, use Expedia's filter tool. Customize your search based on what matters most to you, such as preferred carriers and number of stops. You can then sort your results by "Price (lowest to highest)" to see the cheapest fares upfront.
How many flights per day from Mexico City Intl. Airport (MEX) to Tocumen Intl. Airport (PTY)?
Every day, an average of 6 direct flights take off from Mexico City Intl. Airport (MEX) to Tocumen Intl. Airport (PTY). Pick the departure time that best fits your itinerary.
What are the most popular departure times for flights from Mexico City Intl. Airport (MEX) to Tocumen Intl. Airport (PTY)?
Flights between MEX and PTY tend to be busiest at 9 AM. If you're after a quieter trip and possibly cheaper prices, look for a time when demand is lower.
What day of the week has the most flights from MEX to PTY?
Jet off on a Friday if you're looking for the biggest selection of flights from Mexico City Intl. Airport (MEX) to Tocumen Intl. Airport (PTY).
What is the earliest flight from Mexico City Intl. Airport (MEX) to Tocumen Intl. Airport (PTY)?
The earliest flight departing from Mexico City Intl. Airport (MEX) is at around 1:20AM UTC-6. Catch this flight and you'll reach Tocumen Intl. Airport (PTY) at approximately 5:58AM UTC-5. The total travel time is 3h 38m.
How long does it take to fly from Mexico City Intl. Airport (MEX) to Tocumen Intl. Airport (PTY)?
Flights from MEX to PTY have an average travel time of 3 hours and 39 minutes. The distance between the two is 1,500 mi.
What airline has the least delays from MEX to PTY?
Aeromexico has the best track record for on-time direct flights from Mexico City Intl. Airport (MEX) to Tocumen Intl. Airport (PTY), with an on-time score of 91%. Use the Expedia App to look up your journey status before you leave and get notified of any trip changes.
What is the best time to fly from Mexico City Intl. Airport (MEX) to Tocumen Intl. Airport (PTY)?
To avoid possible delays on the Mexico City Intl. Airport (MEX) to Tocumen Intl. Airport (PTY) route, fly before 3 PM. Departures after this hour have a 22% higher chance of being canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
What airports do you fly into for Panama City from Mexico City Intl. Airport (MEX)?
If you're on a direct flight from Mexico City Intl. Airport (MEX) to Panama City, Tocumen Intl. Airport (PTY) is the only airport you can land at.
Is it cheaper to buy a plane ticket from Mexico City Intl. Airport (MEX) to Tocumen Intl. Airport (PTY) last-minute?
Booking your flight from MEX to PTY shortly before your trip is usually more expensive. However, if you're flexible with your itinerary, you could score a cheap last-minute fare.
Is it cheaper to book a MEX to PTY flight and hotel package?
Compared with arranging hotels and flights separately, booking a MEX to PTY flight and hotel package with Expedia could result in significant savings. Better yet, having everything in one place will take the stress out of travel planning. Simply secure your flights and choose from our extensive range of hotels, then tailor your trip with other add-ons like car rentals and activities.
Can I cancel or change the date of my flight from Mexico City Intl. Airport (MEX) to Tocumen Intl. Airport (PTY)?
If you reserved your MEX to PTY flight in the last 24 hours, you may be able to cancel or modify it without any fees. Depending on the airline and the type of fare you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal for more information.

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*Available to One Key members.