$432 Cheap Flights from Minneapolis (MSP) to La Serena (LSC)

View $432 flight on Tue, Feb 24, 2026Opens in a new window

Popular airlines from Minneapolis - St. Paul Intl. Airport (MSP) to La Serena (LSC-La Florida)

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Cheap Flights from Minneapolis to La Serena (MSP-LSC)

Prices were available within the past 7 days and start at $432 for one-way flights and $847 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Air Canada
Tue, Feb 24 - Tue, Mar 3
MSP
Minneapolis
LSC
La Serena
$847 Roundtrip, found 1 day ago
$847
Roundtrip
found 1 day ago
Select Air Canada flight, departing Tue, Feb 24 from Minneapolis to La Serena, returning Tue, Mar 3, priced at $847 found 1 day ago
Air Canada
Tue, Feb 24 - Tue, Mar 3
MSP
Minneapolis
LSC
La Serena
$884 Roundtrip, found 1 day ago
$884
Roundtrip
found 1 day ago
Select Air Canada flight, departing Tue, Feb 24 from Minneapolis to La Serena, returning Tue, Mar 3, priced at $884 found 1 day ago
Air Canada
Tue, Feb 24 - Tue, Mar 3
MSP
Minneapolis
LSC
La Serena
$1,126 Roundtrip, found 1 day ago
$1,126
Roundtrip
found 1 day ago
Select Air Canada flight, departing Tue, Feb 24 from Minneapolis to La Serena, returning Tue, Mar 3, priced at $1,126 found 1 day ago
Air Canada
Tue, Feb 24 - Tue, Mar 3
MSP
Minneapolis
LSC
La Serena
$1,131 Roundtrip, found 1 day ago
$1,131
Roundtrip
found 1 day ago
Select Air Canada flight, departing Tue, Feb 24 from Minneapolis to La Serena, returning Tue, Mar 3, priced at $1,131 found 1 day ago
Air Canada
Tue, Feb 24 - Tue, Mar 3
MSP
Minneapolis
LSC
La Serena
$1,138 Roundtrip, found 1 day ago
$1,138
Roundtrip
found 1 day ago
Select Air Canada flight, departing Tue, Feb 24 from Minneapolis to La Serena, returning Tue, Mar 3, priced at $1,138 found 1 day ago
Air Canada
Tue, Feb 24 - Tue, Mar 3
MSP
Minneapolis
LSC
La Serena
$1,143 Roundtrip, found 1 day ago
$1,143
Roundtrip
found 1 day ago
Select Air Canada flight, departing Tue, Feb 24 from Minneapolis to La Serena, returning Tue, Mar 3, priced at $1,143 found 1 day ago
Air Canada
Tue, Feb 24 - Tue, Mar 3
MSP
Minneapolis
LSC
La Serena
$1,147 Roundtrip, found 1 day ago
$1,147
Roundtrip
found 1 day ago
Select Air Canada flight, departing Tue, Feb 24 from Minneapolis to La Serena, returning Tue, Mar 3, priced at $1,147 found 1 day ago
Air Canada
Tue, Feb 24 - Tue, Mar 3
MSP
Minneapolis
LSC
La Serena
$1,153 Roundtrip, found 1 day ago
$1,153
Roundtrip
found 1 day ago
Select Air Canada flight, departing Tue, Feb 24 from Minneapolis to La Serena, returning Tue, Mar 3, priced at $1,153 found 1 day ago
Air Canada
Tue, Feb 24 - Tue, Mar 3
MSP
Minneapolis
LSC
La Serena
$1,156 Roundtrip, found 1 day ago
$1,156
Roundtrip
found 1 day ago
Select Air Canada flight, departing Tue, Feb 24 from Minneapolis to La Serena, returning Tue, Mar 3, priced at $1,156 found 1 day ago
LATAM Airlines Group
Tue, Feb 24 - Tue, Mar 3
MSP
Minneapolis
LSC
La Serena
$1,305 Roundtrip, found 1 day ago
$1,305
Roundtrip
found 1 day ago
Select LATAM Airlines Group flight, departing Tue, Feb 24 from Minneapolis to La Serena, returning Tue, Mar 3, priced at $1,305 found 1 day ago

Frequently asked questions

How much does a flight from Minneapolis - St. Paul Intl. Airport (MSP) to La Florida Airport (LSC) cost?
Get a cheap one-way flight from $432 or cheap return flight from $847 from Minneapolis - St. Paul Intl. Airport (MSP) to La Florida Airport (LSC) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Minneapolis - St. Paul Intl. Airport (MSP) to La Florida Airport (LSC)?
Planning your getaway for February is a great way to save, as it's the cheapest month for flights between MSP and LSC. You'll usually find the lowest fares during the off-season.
What is the cheapest airline that flies from Minneapolis - St. Paul Intl. Airport (MSP) to La Florida Airport (LSC)?
To find the cheapest airline that'll fly you from MSP to LSC, use Expedia's filter tool. Customize your search based on your travel style, such as preferred carriers and seat class. You can then sort your results by "Price (lowest to highest)" to list the most affordable options first.
How many flights per day from Minneapolis - St. Paul Intl. Airport (MSP) to La Florida Airport (LSC)?
There aren't any daily nonstop flights departing from Minneapolis - St. Paul Intl. Airport (MSP) to La Florida Airport (LSC). But you can book flights with layovers. Filter your search on Expedia to include one or two stops, and you'll be cruising above the clouds in no time.
What day of the week has the most flights from MSP to LSC?
You'll generally find Tuesday the quietest day for flights, while Fridays tend to be the busiest.* However this can change from season to season and during public holidays or peak travel times.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Minneapolis - St. Paul Intl. Airport (MSP) to La Florida Airport (LSC)?
Select a flight from Minneapolis - St. Paul Intl. Airport (MSP) to La Florida Airport (LSC) that leaves before 3 PM to reduce the likelihood of delays. Departures after this time have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Minneapolis - St. Paul Intl. Airport (MSP) to La Florida Airport (LSC) last-minute?
Holding off until right before your break to book a ticket from MSP to LSC often results in higher prices. While you may come across some last-minute offers, there's no guarantee. Allow some flexibility in your schedule for a better chance of scoring a bargain.
Is it cheaper to book a MSP to LSC flight and hotel package?
You can save money by securing a MSP to LSC flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's simple to manage it all in one place. After choosing your preferred accommodations and flights, consider adding extras including car rentals, tours and activities.
Can I cancel or change the date of my flight from Minneapolis - St. Paul Intl. Airport (MSP) to La Florida Airport (LSC)?
It's generally possible to cancel or reschedule your MSP to LSC flight. However, if the booking was made more than 24 hours ago, additional charges may apply. Check your airline's policies in your itinerary to see what changes are possible and whether any costs are involved. You'll also find more information on our Customer Service portal.

Travel information

Travel information

Origin airport
Minneapolis - St. Paul Intl.
Destination airport
La Florida
Airlines serving
LATAM Airlines Group
Roundtrip price
$846
Distance
5350 mi

Book with confidence

Book with confidence

Minneapolis to La Serena Flights

The cheapest times to fly from Minneapolis to La Serena

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Minneapolis to La Serena are during the month of February. You can find some of the cheapest flights from Minneapolis to La Serena with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Minneapolis to La Serena

Sunday is one of the best days to book for cheap flights from Minneapolis to La Serena: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Minneapolis to La Serena

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Minneapolis to La Serena in 2025. You can also book with separate airlines for your outbound and return journeys, from $432 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Minneapolis to La Serena flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Minneapolis to La Serena airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Minneapolis to La Serena Flights

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*Available to One Key members.