$496 Cheap Flights from Mexicali (MXL) to Santo Domingo (SDQ)

View $496 flight on Sat, Aug 16, 2025Opens in a new window

Popular airlines from Mexicali, Baja California Norte (MXL-General Rodolfo Sanchez Taboada Intl.) to Las Americas Intl. Airport (SDQ)

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Cheap Flights from Mexicali to Santo Domingo (MXL-SDQ)

Prices were available within the past 7 days and start at $496 for one-way flights and $575 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Aeromexico
Thu, Oct 9 - Sun, Nov 2
MXL
Mexicali
SDQ
Santo Domingo
$575 Roundtrip, found 4 days ago
$575
Roundtrip
found 4 days ago
Select Aeromexico flight, departing Thu, Oct 9 from Mexicali to Santo Domingo, returning Sun, Nov 2, priced at $575 found 4 days ago
Aeromexico
Thu, Oct 9 - Sun, Nov 2
MXL
Mexicali
SDQ
Santo Domingo
$613 Roundtrip, found 4 days ago
$613
Roundtrip
found 4 days ago
Select Aeromexico flight, departing Thu, Oct 9 from Mexicali to Santo Domingo, returning Sun, Nov 2, priced at $613 found 4 days ago
Aeromexico
Sat, Sep 13 - Sat, Sep 20
MXL
Mexicali
SDQ
Santo Domingo
$617 Roundtrip, found 3 hours ago
$617
Roundtrip
found 3 hours ago
Select Aeromexico flight, departing Sat, Sep 13 from Mexicali to Santo Domingo, returning Sat, Sep 20, priced at $617 found 3 hours ago
Aeromexico
Thu, Oct 9 - Sun, Nov 2
MXL
Mexicali
SDQ
Santo Domingo
$626 Roundtrip, found 4 days ago
$626
Roundtrip
found 4 days ago
Select Aeromexico flight, departing Thu, Oct 9 from Mexicali to Santo Domingo, returning Sun, Nov 2, priced at $626 found 4 days ago
Aeromexico
Fri, Nov 21 - Sun, Nov 23
MXL
Mexicali
SDQ
Santo Domingo
$638 Roundtrip, found 3 days ago
$638
Roundtrip
found 3 days ago
Select Aeromexico flight, departing Fri, Nov 21 from Mexicali to Santo Domingo, returning Sun, Nov 23, priced at $638 found 3 days ago
Aeromexico
Sun, Mar 15 - Sat, Mar 21
MXL
Mexicali
SDQ
Santo Domingo
$650 Roundtrip, found 8 hours ago
$650
Roundtrip
found 8 hours ago
Select Aeromexico flight, departing Sun, Mar 15 from Mexicali to Santo Domingo, returning Sat, Mar 21, priced at $650 found 8 hours ago
Aeromexico
Sun, Mar 15 - Sat, Mar 21
MXL
Mexicali
SDQ
Santo Domingo
$651 Roundtrip, found 8 hours ago
$651
Roundtrip
found 8 hours ago
Select Aeromexico flight, departing Sun, Mar 15 from Mexicali to Santo Domingo, returning Sat, Mar 21, priced at $651 found 8 hours ago
Aeromexico
Thu, Nov 20 - Wed, Nov 26
MXL
Mexicali
SDQ
Santo Domingo
$654 Roundtrip, found 3 days ago
$654
Roundtrip
found 3 days ago
Select Aeromexico flight, departing Thu, Nov 20 from Mexicali to Santo Domingo, returning Wed, Nov 26, priced at $654 found 3 days ago
Aeromexico
Sun, Mar 15 - Sat, Mar 21
MXL
Mexicali
SDQ
Santo Domingo
$656 Roundtrip, found 8 hours ago
$656
Roundtrip
found 8 hours ago
Select Aeromexico flight, departing Sun, Mar 15 from Mexicali to Santo Domingo, returning Sat, Mar 21, priced at $656 found 8 hours ago
Iberia
Sun, Mar 15 - Sat, Mar 21
MXL
Mexicali
SDQ
Santo Domingo
$1,975 Roundtrip, found 8 hours ago
$1,975
Roundtrip
found 8 hours ago
Select Iberia flight, departing Sun, Mar 15 from Mexicali to Santo Domingo, returning Sat, Mar 21, priced at $1,975 found 8 hours ago
Flights from Mexicali (MXL) to Santo Domingo (SDQ)
Origin airport
General Rodolfo Sanchez Taboada Intl.
Destination airport
Las Americas Intl.
Airlines serving
Aeromexico
Roundtrip price
$575
Distance
2980 mi

Mexicali to Santo Domingo Flights

The cheapest times to fly from Mexicali to Santo Domingo

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Mexicali to Santo Domingo are during the month of October. You can find some of the cheapest flights from Mexicali to Santo Domingo with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Mexicali to Santo Domingo

Sunday is one of the best days to book for cheap flights from Mexicali to Santo Domingo: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Mexicali to Santo Domingo

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Mexicali to Santo Domingo in 2025. You can also book with separate airlines for your outbound and return journeys, from $496 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Mexicali to Santo Domingo flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Mexicali to Santo Domingo airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from General Rodolfo Sanchez Taboada Intl. Airport (MXL) to Las Americas Intl. Airport (SDQ) cost?
Discover the latest flight deals from MXL to SDQ by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from MXL to SDQ?
The cheapest flights from MXL to SDQ are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from MXL to SDQ?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that'll take you from MXL to SDQ. Sort your results by "Price (lowest to highest)" to snap up a great deal.
How many flights per day from General Rodolfo Sanchez Taboada Intl. Airport (MXL) to Las Americas Intl. Airport (SDQ)?
Direct flights from General Rodolfo Sanchez Taboada Intl. Airport (MXL) to Las Americas Intl. Airport (SDQ) aren't available daily, so you'll have to take a flight with a layover. Explore your options with our filter tool. Enter your travel details and pick either "1 Stop" or "2+ Stops."
What day of the week has the most flights from MXL to SDQ?
Generally you'll find the largest variety of flight choices on a Friday. Tuesdays are often the quietest.* But this can vary depending on the time of year, airline and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from General Rodolfo Sanchez Taboada Intl. Airport (MXL) to Las Americas Intl. Airport (SDQ)?
To touch down at Las Americas Intl. Airport (SDQ) on time, book a flight that takes off from General Rodolfo Sanchez Taboada Intl. Airport (MXL) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from General Rodolfo Sanchez Taboada Intl. Airport (MXL) to Las Americas Intl. Airport (SDQ) last-minute?
Last-minute fares from MXL to SDQ are usually more expensive. To secure the cheapest rates, start looking for flights early. That said, if you're flexible with your travel plans, you may find a cheap fare right before you leave.
Is it cheaper to book a MXL to SDQ flight and hotel package?
You'll generally save money by securing a MXL to SDQ flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's simple to manage everything in one convenient place. After selecting your preferred accommodations and flights, consider adding extras like activities, tours and car rentals.
Can I cancel or change the date of my flight from General Rodolfo Sanchez Taboada Intl. Airport (MXL) to Las Americas Intl. Airport (SDQ)?
Typically, you're able to reschedule or cancel your MXL to SDQ flight. However, additional charges may apply, especially if your booking was made over 24 hours ago. Double-check your itinerary for the airline's fees and policies on flight changes, or if you need further details, head to our Customer Service portal.

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*Available to One Key members.