$226 Cheap Flights from Panama City (PTY) to Charleston (CHS)

View $226 flight on Tue, Feb 3, 2026Opens in a new window

Popular airlines from Tocumen Intl. Airport (PTY) to Charleston Intl. Airport (CHS)

Cheap Flights from Panama City to Charleston (PTY-CHS)

Prices were available within the past 7 days and start at $226 for one-way flights and $378 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Tue, Dec 23 - Fri, Jan 9
PTY
Panama City
CHS
Charleston
$378 Roundtrip, found 6 days ago
$378
Roundtrip
found 6 days ago
Select Delta flight, departing Tue, Dec 23 from Panama City to Charleston, returning Fri, Jan 9, priced at $378 found 6 days ago
United
Mon, Dec 15 - Mon, Jan 12
PTY
Panama City
CHS
Charleston
$380 Roundtrip, found 1 day ago
$380
Roundtrip
found 1 day ago
Select United flight, departing Mon, Dec 15 from Panama City to Charleston, returning Mon, Jan 12, priced at $380 found 1 day ago
Delta
Mon, Dec 8 - Mon, Dec 15
PTY
Panama City
CHS
Charleston
$382 Roundtrip, found 13 hours ago
$382
Roundtrip
found 13 hours ago
Select Delta flight, departing Mon, Dec 8 from Panama City to Charleston, returning Mon, Dec 15, priced at $382 found 13 hours ago
Delta
Tue, Dec 23 - Fri, Jan 9
PTY
Panama City
CHS
Charleston
$384 Roundtrip, found 6 days ago
$384
Roundtrip
found 6 days ago
Select Delta flight, departing Tue, Dec 23 from Panama City to Charleston, returning Fri, Jan 9, priced at $384 found 6 days ago
American Airlines
Fri, Dec 26 - Fri, Jan 30
PTY
Panama City
CHS
Charleston
$386 Roundtrip, found 5 days ago
$386
Roundtrip
found 5 days ago
Select American Airlines flight, departing Fri, Dec 26 from Panama City to Charleston, returning Fri, Jan 30, priced at $386 found 5 days ago
Delta
Tue, Dec 16 - Tue, Jan 13
PTY
Panama City
CHS
Charleston
$386 Roundtrip, found 1 day ago
$386
Roundtrip
found 1 day ago
Select Delta flight, departing Tue, Dec 16 from Panama City to Charleston, returning Tue, Jan 13, priced at $386 found 1 day ago
United
Mon, Dec 8 - Mon, Dec 15
PTY
Panama City
CHS
Charleston
$386 Roundtrip, found 13 hours ago
$386
Roundtrip
found 13 hours ago
Select United flight, departing Mon, Dec 8 from Panama City to Charleston, returning Mon, Dec 15, priced at $386 found 13 hours ago
United
Mon, Dec 15 - Mon, Jan 12
PTY
Panama City
CHS
Charleston
$387 Roundtrip, found 1 day ago
$387
Roundtrip
found 1 day ago
Select United flight, departing Mon, Dec 15 from Panama City to Charleston, returning Mon, Jan 12, priced at $387 found 1 day ago
Delta
Mon, Dec 8 - Mon, Dec 15
PTY
Panama City
CHS
Charleston
$388 Roundtrip, found 13 hours ago
$388
Roundtrip
found 13 hours ago
Select Delta flight, departing Mon, Dec 8 from Panama City to Charleston, returning Mon, Dec 15, priced at $388 found 13 hours ago
Copa
Tue, Nov 18 - Tue, Jan 6
PTY
Panama City
CHS
Charleston
$1,278 Roundtrip, found 15 hours ago
$1,278
Roundtrip
found 15 hours ago
Select Copa flight, departing Tue, Nov 18 from Panama City to Charleston, returning Tue, Jan 6, priced at $1,278 found 15 hours ago

Alternative airports near Charleston

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Charleston Intl. CHS. Cheapest and Closest option available. Average driving time to city center is 16 minutes. Flights from $499
CHS
Charleston Intl.
CheapestClosest
Average driving time to city center16 min
Flights from $499

Frequently asked questions

How much does a flight from Tocumen Intl. Airport (PTY) to Charleston Intl. Airport (CHS) cost?
Lock in a cheap one-way flight from $226 or cheap return flight from $378 from Tocumen Intl. Airport (PTY) to Charleston Intl. Airport (CHS) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Tocumen Intl. Airport (PTY) to Charleston Intl. Airport (CHS)?
December is the cheapest month to fly from PTY to CHS. Traveling outside of peak seasons is often the key to landing a great deal.
What is the cheapest airline that flies from Tocumen Intl. Airport (PTY) to Charleston Intl. Airport (CHS)?
To find the cheapest airline that'll fly you from PTY to CHS, use Expedia's filter tool. Customize your search based on your travel style, such as preferred carriers and cabin class. You can then sort your results by "Price (lowest to highest)" to discover the cheapest flight right away.
How many flights per day from Tocumen Intl. Airport (PTY) to Charleston Intl. Airport (CHS)?
Nonstop flights from Tocumen Intl. Airport (PTY) to Charleston Intl. Airport (CHS) aren't available daily, so you'll need to take a flight with a layover. Explore your options with Expedia's filters. Enter your dates and click on either "1 Stop" or "2+ Stops."
What day of the week has the most flights from PTY to CHS?
You'll typically find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can change from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Tocumen Intl. Airport (PTY) to Charleston Intl. Airport (CHS)?
Book a flight from Tocumen Intl. Airport (PTY) to Charleston Intl. Airport (CHS) that leaves before 3 PM to reduce the risk of cancellations. Departures later than this have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Tocumen Intl. Airport (PTY) to Charleston Intl. Airport (CHS) last-minute?
Booking your ticket from PTY to CHS shortly before your trip is generally more expensive. However, if there's some wiggle room with your departure dates and times, you could land a cheap last-minute fare.
Is it cheaper to book a PTY to CHS flight and hotel package?
Compared with arranging flights and hotels separately, booking a PTY to CHS flight and hotel package with Expedia could result in significant savings. Better still, having everything in one place takes the hassle out of travel planning. Simply secure your flights and select from our extensive range of hotels, then personalize your trip with extras like tours, car rentals and activities.
Can I cancel or change the date of my flight from Tocumen Intl. Airport (PTY) to Charleston Intl. Airport (CHS)?
It's usually possible to cancel or reschedule your PTY to CHS flight. However, if the booking was made more than 24 hours ago, additional charges may apply. Refer to your airline's policies in your itinerary to see what changes are possible and whether any costs are involved. You'll also find more information on our Customer Service portal.

Travel information

Origin airport
Tocumen Intl.
Destination airport
Charleston Intl.
Airlines serving
American Airlines, Copa, Delta, United
Roundtrip price
$377
Distance
1646 mi

Book with confidence

Panama City to Charleston Flights

The cheapest times to fly from Panama City to Charleston

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Panama City to Charleston are during the month of December. You can find some of the cheapest flights from Panama City to Charleston with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Panama City to Charleston

Sunday is one of the best days to book for cheap flights from Panama City to Charleston: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Panama City to Charleston

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Panama City to Charleston in 2025. You can also book with separate airlines for your outbound and return journeys, from $226 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Panama City to Charleston flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Panama City to Charleston airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Panama City to Charleston Flights

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*Available to One Key members.