$252 Cheap Flights from Panama City (PTY) to Santo Domingo (SDQ)

View $252 flight on Wed, Sep 10, 2025Opens in a new window

Popular airlines from Tocumen Intl. Airport (PTY) to Las Americas Intl. Airport (SDQ)

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Cheap Flights from Panama City to Santo Domingo (PTY-SDQ)

Prices were available within the past 7 days and start at $252 for one-way flights and $450 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Copa
Wed, Oct 8 - Sat, Oct 11
PTY
Panama City
SDQ
Santo Domingo
$450 Roundtrip, just found
$450
Roundtrip
just found
Select Copa flight, departing Wed, Oct 8 from Panama City to Santo Domingo, returning Sat, Oct 11, priced at $450 just found
avianca
Mon, Sep 8 - Thu, Sep 18
PTY
Panama City
SDQ
Santo Domingo
$461 Roundtrip, just found
$461
Roundtrip
just found
Select avianca flight, departing Mon, Sep 8 from Panama City to Santo Domingo, returning Thu, Sep 18, priced at $461 just found
Copa
Thu, Nov 6 - Mon, Nov 10
PTY
Panama City
SDQ
Santo Domingo
$466 Roundtrip, found 2 hours ago
$466
Roundtrip
found 2 hours ago
Select Copa flight, departing Thu, Nov 6 from Panama City to Santo Domingo, returning Mon, Nov 10, priced at $466 found 2 hours ago
Copa
Wed, Aug 13 - Sat, Aug 16
PTY
Panama City
SDQ
Santo Domingo
$471 Roundtrip, found 1 hour ago
$471
Roundtrip
found 1 hour ago
Select Copa flight, departing Wed, Aug 13 from Panama City to Santo Domingo, returning Sat, Aug 16, priced at $471 found 1 hour ago
avianca
Mon, Sep 8 - Thu, Sep 18
PTY
Panama City
SDQ
Santo Domingo
$477 Roundtrip, just found
$477
Roundtrip
just found
Select avianca flight, departing Mon, Sep 8 from Panama City to Santo Domingo, returning Thu, Sep 18, priced at $477 just found
Copa
Sat, Nov 1 - Sat, Nov 8
PTY
Panama City
SDQ
Santo Domingo
$482 Roundtrip, found 1 day ago
$482
Roundtrip
found 1 day ago
Select Copa flight, departing Sat, Nov 1 from Panama City to Santo Domingo, returning Sat, Nov 8, priced at $482 found 1 day ago
Copa
Mon, Aug 18 - Mon, Aug 25
PTY
Panama City
SDQ
Santo Domingo
$493 Roundtrip, found 15 hours ago
$493
Roundtrip
found 15 hours ago
Select Copa flight, departing Mon, Aug 18 from Panama City to Santo Domingo, returning Mon, Aug 25, priced at $493 found 15 hours ago
Aeromexico
Mon, Sep 8 - Thu, Sep 18
PTY
Panama City
SDQ
Santo Domingo
$616 Roundtrip, just found
$616
Roundtrip
just found
Select Aeromexico flight, departing Mon, Sep 8 from Panama City to Santo Domingo, returning Thu, Sep 18, priced at $616 just found
United
Wed, Oct 8 - Sat, Oct 11
PTY
Panama City
SDQ
Santo Domingo
$785 Roundtrip, just found
$785
Roundtrip
just found
Select United flight, departing Wed, Oct 8 from Panama City to Santo Domingo, returning Sat, Oct 11, priced at $785 just found
American Airlines
Fri, Oct 24 - Wed, Oct 29
PTY
Panama City
SDQ
Santo Domingo
$801 Roundtrip, just found
$801
Roundtrip
just found
Select American Airlines flight, departing Fri, Oct 24 from Panama City to Santo Domingo, returning Wed, Oct 29, priced at $801 just found

Find the cheapest month to fly from Panama City (PTY) to Santo Domingo (SDQ)

May is typically the cheapest month to fly

From $334 - $484 per traveler.

Graph displaying average flight prices per month

Alternative airports near Santo Domingo

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Las Americas Intl. SDQ. Cheapest option available. Average driving time to city center is 22 minutes. Flights from $450
SDQ
Las Americas Intl.
Cheapest
Average driving time to city center22 min
Flights from $450
Flights from Panama City (PTY) to Santo Domingo (SDQ)
Origin airport
Tocumen Intl.
Destination airport
Las Americas Intl.
Airlines serving
Aeromexico, American Airlines, Copa, Delta, Iberia, United, avianca
Roundtrip price
$449
Distance
917 mi
Average flight time
3 hours 31 mins

Panama City to Santo Domingo Flights

The cheapest times to fly from Panama City to Santo Domingo

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Panama City to Santo Domingo are during the month of October. You can find some of the cheapest flights from Panama City to Santo Domingo with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Panama City to Santo Domingo

Sunday is one of the best days to book for cheap flights from Panama City to Santo Domingo: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Panama City to Santo Domingo

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Panama City to Santo Domingo in 2025. You can also book with separate airlines for your outbound and return journeys, from $252 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Panama City to Santo Domingo flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Panama City to Santo Domingo airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Tocumen Intl. Airport (PTY) to Las Americas Intl. Airport (SDQ) cost?
Cheap round-trip flights from Tocumen Intl. Airport (PTY) to Las Americas Intl. Airport (SDQ) start at $450. This information is based on the cheapest price found on Expedia for this return journey departing within the next three months. This airfare is for a Copa flight leaving PTY on August 13 2025 and touching down at SDQ. The price was last updated on July 23 2025 and has not changed since.
What is the cheapest month to fly from PTY to SDQ?
The cheapest flights from PTY to SDQ are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
Which airlines fly direct from Tocumen Intl. Airport (PTY) to Las Americas Intl. Airport (SDQ)?
When setting off from Tocumen Intl. Airport (PTY), you can get on a direct flight to Las Americas Intl. Airport (SDQ) with Copa Airlines.
What is the cheapest airline that flies from PTY to SDQ?
Right now, the cheapest airline offering one-way flights from PTY to SDQ is Copa. You can book a seat on this route from $484. This fare is based on the lowest price found on Expedia departing within the next three months. The flight takes off from PTY on September 19 2025. Prices were last updated on July 23 2025 and have not changed since.
How many flights per day from Tocumen Intl. Airport (PTY) to Las Americas Intl. Airport (SDQ)?
When departing from Tocumen Intl. Airport (PTY), you'll have your pick from an average of 4 daily nonstop flights to Las Americas Intl. Airport (SDQ).
What are the most popular departure times for flights from Tocumen Intl. Airport (PTY) to Las Americas Intl. Airport (SDQ)?
Flights between PTY and SDQ are their busiest at 6 PM. For a more relaxed atmosphere and potentially cheaper tickets, look for a time outside the usual busy windows.
What day of the week has the most flights from PTY to SDQ?
Wednesday has the most flights from Tocumen Intl. Airport (PTY) to Las Americas Intl. Airport (SDQ). Consider taking off on this day and you'll have the best chance of finding a schedule that works for you.
What is the earliest flight from Tocumen Intl. Airport (PTY) to Las Americas Intl. Airport (SDQ)?
Catch the earliest flight at around 7:18AM UTC-5, leaving from Tocumen Intl. Airport (PTY). You'll be in the air for about 2h 26m, touching down at Las Americas Intl. Airport (SDQ) at approximately 10:44AM UTC-4.
How long does it take to fly from Tocumen Intl. Airport (PTY) to Las Americas Intl. Airport (SDQ)?
Flights from PTY to SDQ have an average travel time of 2 hours and 28 minutes. The total distance between the two is 920 mi.
What airline has the least delays from PTY to SDQ?
With 94% of flights typically arriving on schedule, Copa Airlines has the best on-time performance for direct flights from Tocumen Intl. Airport (PTY) to Las Americas Intl. Airport (SDQ). To check your flight status and get notified about any changes, use the Expedia App.
What is the best time to fly from Tocumen Intl. Airport (PTY) to Las Americas Intl. Airport (SDQ)?
Book a flight from Tocumen Intl. Airport (PTY) to Las Americas Intl. Airport (SDQ) that takes off before 3 PM to reduce the risk of delays and cancellations. Departures later than this have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
What airports do you fly into for Santo Domingo from Tocumen Intl. Airport (PTY)?
Las Americas Intl. Airport (SDQ) is the only airport in Santo Domingo with direct flights from Tocumen Intl. Airport (PTY). Compare the options and find affordable fares on Expedia.
Is it cheaper to buy a plane ticket from Tocumen Intl. Airport (PTY) to Las Americas Intl. Airport (SDQ) last-minute?
Booking your flight from PTY to SDQ right before your journey is usually more expensive. But if there's some wiggle room with your departure times and dates, you could grab a cheap last-minute fare.
Is it cheaper to book a PTY to SDQ flight and hotel package?
You can save money by securing a PTY to SDQ flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it's simple to manage it all in one place. After selecting your preferred accommodations and flights, you can add extras such as activities, car rentals and tours.
Can I cancel or change the date of my flight from Tocumen Intl. Airport (PTY) to Las Americas Intl. Airport (SDQ)?
If you booked your PTY to SDQ flight within the last 24 hours, you may be able to cancel or modify it without fees. Depending on the airline and the fare type you purchased, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal if you want more information.

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