$596 Cheap Flights from Panama City (PTY) to Sao Luis (SLZ)

View $596 flight on Sat, Sep 13, 2025Opens in a new window

Popular airlines from Tocumen Intl. Airport (PTY) to Sao Luis (SLZ-Marechal Cunha Machado Intl.)

Cheap Flights from Panama City to Sao Luis (PTY-SLZ)

Prices were available within the past 7 days and start at $596 for one-way flights and $680 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

avianca
Sat, May 16 - Sat, May 23
PTY
Panama City
SLZ
São Luís
$680 Roundtrip, found 3 days ago
$680
Roundtrip
found 3 days ago
Select avianca flight, departing Sat, May 16 from Panama City to São Luís, returning Sat, May 23, priced at $680 found 3 days ago
avianca
Sat, May 16 - Sat, May 23
PTY
Panama City
SLZ
São Luís
$797 Roundtrip, found 3 days ago
$797
Roundtrip
found 3 days ago
Select avianca flight, departing Sat, May 16 from Panama City to São Luís, returning Sat, May 23, priced at $797 found 3 days ago
Copa
Sat, Dec 20 - Tue, Jan 6
PTY
Panama City
SLZ
São Luís
$1,714 Roundtrip, found 5 days ago
$1,714
Roundtrip
found 5 days ago
Select Copa flight, departing Sat, Dec 20 from Panama City to São Luís, returning Tue, Jan 6, priced at $1,714 found 5 days ago
Flights from Panama City (PTY) to Sao Luis (SLZ)
Origin airport
Tocumen Intl.
Destination airport
Marechal Cunha Machado Intl.
Roundtrip price
$679
Distance
2550 mi

Panama City to Sao Luis Flights

The cheapest times to fly from Panama City to Sao Luis

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Panama City to Sao Luis are during the month of May. You can find some of the cheapest flights from Panama City to Sao Luis with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Panama City to Sao Luis

Sunday is one of the best days to book for cheap flights from Panama City to Sao Luis: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Panama City to Sao Luis

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Panama City to Sao Luis in 2025. You can also book with separate airlines for your outbound and return journeys, from $596 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Panama City to Sao Luis flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Panama City to Sao Luis airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Tocumen Intl. Airport (PTY) to Marechal Cunha Machado Intl. Airport (SLZ) cost?
Grab a cheap one-way flight from $596 or cheap return flight from $680 from Tocumen Intl. Airport (PTY) to Marechal Cunha Machado Intl. Airport (SLZ) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Tocumen Intl. Airport (PTY) to Marechal Cunha Machado Intl. Airport (SLZ)?
Planning your trip for May may help you find better deals, as it's the cheapest month for flights between PTY and SLZ. You'll usually find the lowest prices during the off-season.
What is the cheapest airline that flies from Tocumen Intl. Airport (PTY) to Marechal Cunha Machado Intl. Airport (SLZ)?
Use the filter tool on Expedia to compare airlines and find the most affordable carrier that'll take you from PTY to SLZ. Then, sort your results by "Price (lowest to highest)" to pick up a good deal.
How many flights per day from Tocumen Intl. Airport (PTY) to Marechal Cunha Machado Intl. Airport (SLZ)?
You'll have to hop on a flight with a layover when traveling from Tocumen Intl. Airport (PTY) to Marechal Cunha Machado Intl. Airport (SLZ). There are no daily direct flights on this route. However, just filter your search to include one or more stops to discover the best option for your trip.
What day of the week has the most flights from PTY to SLZ?
Friday is usually the busiest day for flights, while Tuesday is often the quietest.* Remember that flight schedules can vary based on a number of factors, such as the time of year and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Tocumen Intl. Airport (PTY) to Marechal Cunha Machado Intl. Airport (SLZ)?
Choose a flight from Tocumen Intl. Airport (PTY) to Marechal Cunha Machado Intl. Airport (SLZ) that takes off before 3 PM to reduce the likelihood of delays and cancellations. Departures after this hour have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Tocumen Intl. Airport (PTY) to Marechal Cunha Machado Intl. Airport (SLZ) last-minute?
Booking your ticket from PTY to SLZ shortly before your trip is typically more expensive. However, if there's some wiggle room with your departure times and dates, you could grab a cheap last-minute fare.
Is it cheaper to book a PTY to SLZ flight and hotel package?
You'll generally save money by securing a PTY to SLZ flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's simple to manage everything in one convenient place. Once you've selected your ideal accommodations and flights, consider adding extras including activities, car rentals and tours.
Can I cancel or change the date of my flight from Tocumen Intl. Airport (PTY) to Marechal Cunha Machado Intl. Airport (SLZ)?
If you reserved your PTY to SLZ flight within the last 24 hours, you may be able to cancel or modify it without any fees. Depending on the airline and the type of fare you purchased, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, visit our Customer Service portal if you want more information.

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*Available to One Key members.