$369 Cheap Flights from Santiago (SCL) to Lisbon (LIS)

Santiago (SCL) to Lisbon (LIS) at a glance

Travel with a range of airlines operating flights from Santiago (SCL) to Lisbon (LIS) on this international long-haul journey. Evaluate options from full-service carriers to find the itinerary that suits your budget, schedule, and travel plans as you discover Lisbon's iconic sights and neighborhoods. Here are the essential details for flights departing from Arturo Merino Benitez Airport (SCL) to Humberto Delgado Airport (LIS).

• Fastest flight duration: around 13h 45m in-flight, plus roughly 2 hours layover with one stop
• Route distance: roughly 6,300 miles (10,140 km)
• Flights per week: around 7 departures on average
• Typical fares (one-way): economy tickets often range from $495–$1010, depending on seasonality and how far ahead you book

Flights from Arturo Merino Benitez Airport (SCL) to Humberto Delgado Airport (LIS)

Based on recent traveler bookings, here are the top airlines preferred for flights from Santiago to Lisbon, particularly those offering one-stop services. Common layover points include Guarulhos - Governor André Franco Montoro International Airport (GRU) with a layover of about 2 hours, and Adolfo Suárez Madrid-Barajas Airport (MAD) with a layover of approximately 2 hours and 45 minutes. This allows you to balance price, total travel time, and cabin class for the best travel experience.

• LATAM Airlines Group: This full-service airline provides convenient one-stop service, with one-way ticket prices generally falling between $495 and $1275. They operate around 77% of flights on this route, with an in-flight duration of 13 hours and 45 minutes and an overall travel time of approximately 16 hours, including layover time.

How to find the best prices for flights from Santiago (SCL) to Lisbon (LIS)

Getting some of the best deals on flights from Santiago to Lisbon is all about timing and flexibility. Here are some key tips to help you save:

1. Best times to book and fly: cheaper fares are typically found when booking at least two months in advance, which is also when most travelers make their reservations. Departures in the afternoon, between 12 PM and 6 PM, tend to offer lower prices and are the most popular flight times. Additionally, flying on Sunday provides both cheaper rates and is the most favored travel day.
2. Set up price alerts: stay updated on price changes by using Expedia's Price Tracker. Receive alerts when fares drop for your selected route.
3. Bundle and save: bundle your flight and hotel to save on Expedia, or unlock a hotel deal after booking your flight.* Find Lisbon hotel and flight deals.
4. Compare flight options: use Expedia's search tool to compare airlines, routes, direct vs. non-direct flights, and flight times. You can also sort by price to find the most affordable options.
5. Stay flexible with dates: being open to different travel days can sometimes help you find better prices on flights and hotels.
6. Think about luggage: nowadays, it's important to check the airline's baggage policies to find the best value. That may be paying for an additional carry-on bag or booking a ticket with checked luggage included. Either way, double-check your allowance before confirming your booking to avoid excess baggage fees at the airport.

*Members only. Savings vary and are not available on all bundles. Select hotels.

Arriving at Humberto Delgado Airport from Arturo Merino Benitez Airport

Lisbon welcomes travelers from Santiago with a range of transport options based on price, convenience, and proximity. Here's how to reach Lisbon efficiently:

• Hotel transfer: Transfers offer a convenient way to reach your hotel in Lisbon, with options including free hotel shuttles and private rides, which can be arranged in advance with your hotel.
• Car rental: Renting a car from Humberto Delgado Airport is a great option if you plan to explore and sightsee beyond the city. Browse cheap car rentals at Humberto Delgado Airport on Expedia.
• Taxi/ride-hailing: Taxis and ride-hailing services may be available from designated pickup areas outside the terminal, check locally on arrival.
• Public transportation: From Humberto Delgado Airport, travelers will find Lisbon Airport Station, a metro station, just about 0.1 miles away on foot, while Oriente Bus Station, a bus station, and Roma-Areeiro Station, a train station, are both located approximately 1.8 miles from the airport and are best accessed by car.

Santiago to Lisbon Flights

The cheapest times to fly from Santiago to Lisbon

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Santiago to Lisbon are during the month of December. You can find some of the cheapest flights from Santiago to Lisbon with Expedia's search tool and vast selection of airlines.

The best time to book a flight from Santiago to Lisbon

Sunday is one of the best days to book for cheap flights from Santiago to Lisbon: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

How to find cheap round-trip tickets from Santiago to Lisbon

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Santiago to Lisbon in 2026. You can also book with separate airlines for your outbound and return journeys, from $369 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Santiago to Lisbon flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

You could also save big by booking one of Expedia's vacation packages. Bundling together your Santiago to Lisbon airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

*Terms apply.

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.