$3,955 Cheap Flights from Santo Domingo (SDQ) to La Serena (LSC)

View $3,955 flight on Wed, Aug 27, 2025Opens in a new window

Popular airlines from Las Americas Intl. Airport (SDQ) to La Serena (LSC-La Florida)

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Cheap Flights from Santo Domingo to La Serena (SDQ-LSC)

Prices were available within the past 7 days and start at $3,955 for one-way flights and $8,345 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Wed, Aug 27 - Sat, Aug 30
SDQ
Santo Domingo
LSC
La Serena
$8,345 Roundtrip, found 1 day ago
$8,345
Roundtrip
found 1 day ago
Select Delta flight, departing Wed, Aug 27 from Santo Domingo to La Serena, returning Sat, Aug 30, priced at $8,345 found 1 day ago
Delta
Wed, Aug 27 - Sat, Aug 30
SDQ
Santo Domingo
LSC
La Serena
$8,391 Roundtrip, found 1 day ago
$8,391
Roundtrip
found 1 day ago
Select Delta flight, departing Wed, Aug 27 from Santo Domingo to La Serena, returning Sat, Aug 30, priced at $8,391 found 1 day ago
Delta
Wed, Aug 27 - Sat, Aug 30
SDQ
Santo Domingo
LSC
La Serena
$8,581 Roundtrip, found 1 day ago
$8,581
Roundtrip
found 1 day ago
Select Delta flight, departing Wed, Aug 27 from Santo Domingo to La Serena, returning Sat, Aug 30, priced at $8,581 found 1 day ago
Delta
Wed, Aug 27 - Sat, Aug 30
SDQ
Santo Domingo
LSC
La Serena
$9,163 Roundtrip, found 1 day ago
$9,163
Roundtrip
found 1 day ago
Select Delta flight, departing Wed, Aug 27 from Santo Domingo to La Serena, returning Sat, Aug 30, priced at $9,163 found 1 day ago
Flights from Santo Domingo (SDQ) to La Serena (LSC)
Origin airport
Las Americas Intl.
Destination airport
La Florida
Roundtrip price
$8,345
Distance
3342 mi

Santo Domingo to La Serena Flights

The cheapest times to fly from Santo Domingo to La Serena

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Santo Domingo to La Serena are during the month of August. You can find some of the cheapest flights from Santo Domingo to La Serena with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Santo Domingo to La Serena

Sunday is one of the best days to book for cheap flights from Santo Domingo to La Serena: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Santo Domingo to La Serena

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Santo Domingo to La Serena in 2025. You can also book with separate airlines for your outbound and return journeys, from $3,955 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Santo Domingo to La Serena flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Santo Domingo to La Serena airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Las Americas Intl. Airport (SDQ) to La Florida Airport (LSC) cost?
Secure a cheap one-way flight from $3,955 or cheap return flight from $8,345 from Las Americas Intl. Airport (SDQ) to La Florida Airport (LSC) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Las Americas Intl. Airport (SDQ) to La Florida Airport (LSC)?
The cheapest month to fly from SDQ to LSC is August, when there's less demand. Off-peak months are generally when airlines offer better prices between these airports.
What is the cheapest airline that flies from Las Americas Intl. Airport (SDQ) to La Florida Airport (LSC)?
Use the filters on Expedia to compare airlines and find the cheapest carrier that'll take you from SDQ to LSC. Then, sort your results by "Price (lowest to highest)" to pick up a good deal.
How many flights per day from Las Americas Intl. Airport (SDQ) to La Florida Airport (LSC)?
You'll have to catch a flight with a layover if you're traveling from Las Americas Intl. Airport (SDQ) to La Florida Airport (LSC). There are no daily direct flights on this route. However, simply filter your search to include one or two stops to discover an option that works for you.
What day of the week has the most flights from SDQ to LSC?
Friday is typically the busiest day for flights, while Tuesday tends to be the quietest.* Remember that flight schedules can change based on various factors, such as the time of year and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Las Americas Intl. Airport (SDQ) to La Florida Airport (LSC)?
To avoid potential delays on the Las Americas Intl. Airport (SDQ) to La Florida Airport (LSC) route, travel before 3 PM. Later flights have a 22% higher chance of being canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Las Americas Intl. Airport (SDQ) to La Florida Airport (LSC) last-minute?
Holding off until right before your break to book a ticket from SDQ to LSC often results in higher prices. Although you may find some last-minute deals, they're not always guaranteed. Keep your travel schedule open to boost your chances of snagging a bargain.
Is it cheaper to book a SDQ to LSC flight and hotel package?
Compared with arranging flights and hotels separately, booking a SDQ to LSC flight and hotel package with Expedia could lead to significant savings. Better still, having everything in one convenient place will take the hassle out of travel planning. Simply secure your flights and select from our extensive range of stays, then personalize your trip with extras like activities, tours and car rentals.
Can I cancel or change the date of my flight from Las Americas Intl. Airport (SDQ) to La Florida Airport (LSC)?
If you booked your SDQ to LSC flight in the last 24 hours, you may be able to cancel or modify it without any fees. Depending on the airline and the type of fare you purchased, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, visit our Customer Service portal for more information.

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*Available to One Key members.