$153 Cheap Flights from San Francisco (SFO) to Greenville (GSP)
Popular airlines from San Francisco Intl. Airport (SFO) to Greenville-Spartanburg Intl. Airport (GSP)
American AirlinesAmerican Airlines
UnitedUnited
DeltaDelta
Alaska AirlinesAlaska Airlines
Southwest AirlinesSouthwest Airlines
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Cheap Flights from San Francisco to Greenville (SFO-GSP)
Alternative airports near Greenville
Prices were available within the past 7 days. Prices and availability are subject to change.
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San Francisco (SFO) to Greenville (GSP) at a glance
Travel between San Francisco (SFO) and Greenville (GSP) with a selection of airlines offering various options on this domestic long-haul route. You can compare flights from San Francisco to Greenville, whether you prefer full-service carriers or budget-friendly choices, to find the itinerary that suits your schedule and travel plans. Discover the essential details for flights from San Francisco International Airport to Greenville-Spartanburg International Airport as you plan your visit to explore Greenville's renowned attractions and neighborhoods.
- Fastest flight duration: around 5h 45m in-flight, plus roughly 1h 15m layover with one stop
- Route distance: roughly 2,200 miles (3,540 km)
- Flights per week: around 10 departures on average
- Typical fares (one-way): economy tickets often range from $165–$485, depending on seasonality and how far ahead you book
Flights from San Francisco International Airport (SFO) to Greenville-Spartanburg International Airport (GSP)
Based on the latest traveler bookings, here are the top airlines favored for flights from San Francisco to Greenville, particularly for one-stop and multi-stop journeys. Common layover spots include Charlotte-Douglas International Airport (CLT), Hartsfield-Jackson Atlanta International Airport (ATL), and Dallas-Fort Worth International Airport (DFW), each with an average layover of about 1 hour and 15 minutes. These options provide you with the flexibility to select your ideal combination of price, total travel time, and cabin class to create the best itinerary.
- American Airlines: This full-service airline provides one-stop flights, capturing about 47% of departures on this route. One-way fares generally fall between $165 and $485, with an in-flight duration of 5 hours and 45 minutes and a total travel time of approximately 7 hours and 15 minutes, including layovers.
- Delta: Known for its comprehensive service, Delta operates one-stop flights and holds around 32% of the departures for this route. With one-way fares typically ranging from $165 to $545, expect about 5 hours and 45 minutes in the air, leading to a total journey time of roughly 7 hours and 15 minutes, including layovers.
- United: Another full-service option, United offers one-stop flights that represent about 13% of the departures on this route. Their one-way fares usually range from $195 to $635, with a flight time of 5 hours and 45 minutes, resulting in a total travel duration of around 7 hours and 15 minutes, including layover time.
- Southwest Airlines: As a budget-friendly airline, Southwest provides both one-stop and multi-stop services, making up about 8% of departures on this route. One-way fares typically range from $190 to $455, featuring an in-flight experience of 5 hours and 45 minutes, culminating in a total journey time of approximately 7 hours and 15 minutes.
Travelers have the option to enhance their journey from San Francisco to Greenville. Delta provides both first-class and premium economy service, while American Airlines offers first-class seating exclusively.
Best time to fly from San Francisco (SFO) to Greenville (GSP)
The most popular months for travelers flying from San Francisco to Greenville are February, March, and April, when peak temperatures in Greenville reach up to 59.9°F in April. If you prefer quieter travel, consider September, the least busy time to visit with temperatures around 72.3°F and typically the lowest average one-way fare (around $270). Flight availability peaks in June, July, and December, with approximately 11 flights per week, making it easier to find convenient departure times. October has the fewest flights, with approximately 9 flights per week.
- Cheapest time to fly: September usually offers good deals with average one-way fare around $270, roughly 12% cheaper than the yearly average.
- More budget-friendly months to fly: October, April, and July typically offer average one-way fares of around $286.
- Most flight options: June, July, and December have the highest number of flights from San Francisco to Greenville, with approximately 11 flights per week, giving you more flexibility in scheduling your trip.
| Month | Temperature | Demand | Weekly Flights | Average one-way Fare |
| January | 41.4°F (5.2°C) | Average | 10 | $299 |
| February | 45.3°F (7.4°C) | Slightly High | 10 | $349 |
| March | 51.8°F (11.0°C) | Slightly High | 10 | $323 |
| April | 59.9°F (15.5°C) | Slightly High | 10 | $287 |
| May | 68.4°F (20.2°C) | Average | 10 | $336 |
| June | 76.1°F (24.5°C) | Average | 11 | $305 |
| July | 79.5°F (26.4°C) | Average | 11 | $289 |
| August | 77.5°F (25.3°C) | Average | 10 | $290 |
| September | 72.3°F (22.4°C) | Slightly Low | 10 | $270 |
| October | 61.9°F (16.6°C) | Slightly Low | 9 | $284 |
| November | 51.1°F (10.6°C) | Slightly Low | 10 | $360 |
| December | 45.3°F (7.4°C) | Average | 11 | $333 |
*Average one-way fare is based on Expedia flight booking data from January 2025 to April 2026 for the specified route and travel class and may change depending on availability, dates, and demand.
Alternative route from San Francisco (SFO) to Greenville (GSP)
- Oakland to Greenville (OAK-GSP): Oakland International Airport (OAK) lies roughly 12 miles from San Francisco International Airport (SFO). On this route, one-way economy prices generally fluctuate between $175 and $520, influenced by the time of year and how far in advance you book. Travelers can choose from both multi-stop and one-stop flights, with common layover points at Nashville International Airport (BNA) and Salt Lake City International Airport (SLC). Major airlines operating on this route include low-cost Southwest Airlines and Delta.
How to find the best prices for flights from San Francisco (SFO) to Greenville (GSP)
Getting some of the best deals on flights from San Francisco to Greenville is all about timing and flexibility. Here are some key tips to help you save:
- Best times to book and fly: cheaper fares are usually available when booking 2-8 weeks in advance, which coincides with when most travelers make their reservations. Early morning flights (12 am-5 am) often offer lower prices, although morning flights (5 am-12 pm) are the most popular. Additionally, flying on Tuesday tends to be cheaper, while Thursday is the most traveled day.
- Set up price alerts: stay updated on price changes by using Expedia's Price Tracker. Receive alerts when fares drop for your selected route.
- Bundle and save: bundle your flight and hotel to save on Expedia, or unlock a hotel deal after booking your flight.* Find Greenville hotel and flight deals.
- Compare flight options: use Expedia's search tool to compare airlines, routes, direct vs. non-direct flights, and flight times. You can also sort by price to find the most affordable options.
- Stay flexible with dates: being open to different travel days can sometimes help you find better prices on flights and hotels.
- Think about luggage: nowadays, it's important to check the airline's baggage policies to find the best value. That may be paying for an additional carry-on bag or booking a ticket with checked luggage included. Either way, double-check your allowance before confirming your booking to avoid excess baggage fees at the airport.
*Members only. Savings vary and are not available on all bundles. Select hotels.
Arriving at Greenville-Spartanburg International Airport from San Francisco International Airport
Greenville welcomes travelers from San Francisco with a range of transport options based on price, convenience, and proximity. Greenville city center is approximately a 20-minute drive (covering about 16 miles) from Greenville-Spartanburg International Airport, depending on traffic. Here's how to reach Greenville efficiently:
- Hotel transfer: Transfers offer a convenient way to reach your hotel in Greenville, with options including free hotel shuttles and private rides, which can be arranged in advance with your hotel.
- Car rental: Renting a car from Greenville-Spartanburg International Airport is a great option if you plan to explore and sightsee beyond the city. Browse cheap car rentals at Greenville-Spartanburg International Airport on Expedia.
- Taxi/ride-hailing: Taxis and ride-hailing services may be available from designated pickup areas outside the terminal, check locally on arrival.
San Francisco to Greenville Flights
The cheapest times to fly from San Francisco to Greenville
On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from San Francisco to Greenville are during the month of November. You can find some of the cheapest flights from San Francisco to Greenville with Expedia's search tool and vast selection of airlines.
The best time to book a flight from San Francisco to Greenville
Sunday is one of the best days to book for cheap flights from San Francisco to Greenville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.
How to find cheap round-trip tickets from San Francisco to Greenville
Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from San Francisco to Greenville in 2026. You can also book with separate airlines for your outbound and return journeys, from $153 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.
Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap San Francisco to Greenville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.
You could also save big by booking one of Expedia's vacation packages. Bundling together your San Francisco to Greenville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.
*Terms apply.
Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.
Frequently Asked Questions
How much does a flight from San Francisco, CA (SFO-San Francisco Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) cost?
You can find cheap one-way flights from $153 and cheap return flights $305 San Francisco, CA (SFO-San Francisco Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) with Expedia. One-way flights usually range from $190 to $938, and return flights typically cost between $451 and $1679. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when San Francisco, CA (SFO-San Francisco Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) ticket fares go up or down.
*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from San Francisco, CA (SFO-San Francisco Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
The cheapest month to fly from SFO to GSP is November when demand is low. Traveling in off-peak or shoulder months is usually a good way to secure cheap tickets, just remember to avoid flying during holidays if you're able to. Use the calendar view in your search to see which months have low fares on this route.
Which airlines fly direct from San Francisco, CA (SFO-San Francisco Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
Enter SFO to GSP and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
How do I find cheap flights from San Francisco, CA (SFO-San Francisco Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
To find a cheap flight from San Francisco, CA (SFO-San Francisco Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from San Francisco, CA (SFO-San Francisco Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
What is the earliest flight from San Francisco, CA (SFO-San Francisco Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
The earliest flight from San Francisco (SFO) to Greenville (GSP) usually departs at 12:05 AM, operated by United Airlines. This seasonal service is active in March and April, giving you a head start on your travel plans. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What are the most popular departure times for flights from San Francisco, CA (SFO-San Francisco Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
The most popular departure times for flights from San Francisco, CA (SFO) to Greenville, SC (GSP) are in the early morning, from 6am to 9am. About 28% of passengers prefer this time window. Many major carriers, including American Airlines, United Airlines, and Delta Airlines, offer flights during this window. This timing works well because it allows you to arrive in Greenville with plenty of time to enjoy your day.
How long does it take to fly from San Francisco, CA (SFO-San Francisco Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
Flights from SFO to GSP with one stop typically take around 8 hours 50 minutes, covering approximately 2,229 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from San Francisco, CA (SFO-San Francisco Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
You can fly first class between SFO and GSP. First class cabins are available on:
- American Airlines
- United Airlines
- Delta Air Lines
How do I earn miles on a San Francisco, CA (SFO-San Francisco Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) flight with Expedia?
It's easy to earn miles on a San Francisco, CA (SFO-San Francisco Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.
*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Greenville from San Francisco Intl. (SFO)?
From San Francisco Intl. (SFO), you can fly into Pitt-Greenville (PGV), Mid Delta Regional (GLH) and Greenville-Spartanburg Intl. (GSP) in Greenville. Some flights may connect through major hubs like Los Angeles Intl. (LAX), Miami Intl. (MIA), Seattle - Tacoma Intl. (SEA) before reaching Greenville. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from San Francisco, CA (SFO-San Francisco Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) at the last minute?
Typically, booking a last minute flight from San Francisco, CA (SFO-San Francisco Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a San Francisco, CA (SFO-San Francisco Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) flight and hotel package?
Securing a San Francisco, CA (SFO-San Francisco Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from San Francisco, CA (SFO-San Francisco Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.)?
If you booked your San Francisco, CA (SFO-San Francisco Intl.) to Greenville, SC (GSP-Greenville-Spartanburg Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.
Travel information
Origin airport | San Francisco Intl. Airport |
|---|---|
Destination airport | Greenville-Spartanburg Intl. Airport |
Distance | 2,229 miles away |
Airlines serving | American Airlines, United, Delta, Alaska Airlines, Southwest Airlines |
Popular airline | American Airlines |
Roundtrip price | $305 |