Popular airlines from Cibao Intl. Airport (STI) to Alejandro Velasco Astete Intl. Airport (CUZ)
American AirlinesAmerican Airlines
Cheap Flights from Santiago to Cusco (STI-CUZ)
Prices were available within the past 7 days and start at $960 for one-way flights and $881 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.
Frequently asked questions
Travel information
Origin airport | Cibao Intl. |
|---|---|
Destination airport | Alejandro Velasco Astete Intl. |
Airlines serving | American Airlines |
Roundtrip price | $881 |
Distance | 2277 mi |
Book with confidence
Santiago to Cusco Flights
The cheapest times to fly from Santiago to Cusco
On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Santiago to Cusco are during the month of February. You can find some of the cheapest flights from Santiago to Cusco with Expedia's search tool and vast selection of airlines.
The best time to book a flight from Santiago to Cusco
Sunday is one of the best days to book for cheap flights from Santiago to Cusco: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.
How to find cheap round-trip tickets from Santiago to Cusco
Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Santiago to Cusco in 2025. You can also book with separate airlines for your outbound and return journeys, from $960 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.
Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Santiago to Cusco flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.
You could also save big by booking one of Expedia's vacation packages. Bundling together your Santiago to Cusco airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.
*Terms apply.
Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.
Explore a world of travel with Expedia
- La Campana Hotels
- Hotels near Real Plaza Cusco
- Hotels near Ttio Market
- Hotels near Regional Hospital of Cusco
- Cusco Hotels
- Hotels near The Church of Jesus Christ of Latter-day Saints
- Hotels near National University of Saint Anthony the Abbot in Cuzco
- Luxury Hotels in Cusco
- Hostels in Cusco
- Hotels with Free Airport Shuttle in Cusco
- Hotels with a View in Cusco
- Hyatt Hotels in Cusco
- Flights from 28 de Julio
- Flights from La Campana
- Flights from Las Palmeras
- Flights to Cusco
- Flights from Albuquerque to Cusco
- Flights from Máncora to Cusco
- Flights from Lima to Cusco
- Flights from Delta to Cusco
- Flights from Valparaiso to Cusco
- Flights from Kalispell to Cusco
- Flights from Indianapolis to Cusco
- Flights from San Juan to Cusco
- Flights from Baltra to Cusco
- Flights from Seattle to Cusco
- Flights from Cartagena to Cusco
- Flights from Santa Fe to Cusco
- Flights from Lihue to Cusco
- Flights from Kansas City to Cusco
- Flights from Oranjestad to Cusco
- Flights from Medellin to Cusco
- Flights from Bogotá to Cusco
- Flights from Tarija to Cusco
- Flights from Chicago to Cusco
- Flights from Natales to Cusco
- Flights from Billings to Cusco
- Flights from Madison to Cusco
- Flights from Calama to Cusco
- Flights from Minneapolis - St. Paul to Cusco
- Flights from Pucallpa to Cusco
- Flights from Bocas del Toro to Cusco
- Flights from Zorritos to Cusco
- Flights from Antofagasta to Cusco
- Flights from Des Moines to Cusco
- Flights from Colorado Springs to Cusco
- Flights from Montgomery to Cusco
- Flights from San José del Cabo to Cusco
- Flights from Frankfurt to Cusco
- Flights from Santiago to Cusco
- Flights from Quito to Cusco
- Flights from Appleton to Cusco
- Flights from St. Peter to Cusco
- Flights from Ibagué to Cusco
- Flights from Birmingham to Cusco
- Flights from Imphal to Cusco
- Flights from Athens to Cusco
- Flights from Watertown to Cusco
- Flights from Oruro to Cusco
- Flights from Sioux City to Cusco
- Flights from Lansing to Cusco
- Flights from Paphos to Cusco
- Flights from Davao to Cusco
- Flights from St. Louis to Cusco
- Flights from Alice Springs to Cusco
- Flights from Bismarck to Cusco
- Flights from Sarasota to Cusco
- Flights from Houston to Cusco
- Flights from Erie to Cusco
- Flights from Nosara to Cusco
- Flights from Reno to Cusco
- Flights from Alta Floresta to Cusco
- Flights from Chichen Itza to Cusco
- Flights from Bucharest to Cusco
- Flights from Helsinki to Cusco
- Flights from Essen to Cusco
- Flights from Eau Claire to Cusco
- Flights from North Bay to Cusco
- Flights from Fortaleza to Cusco
- Flights from Geneva to Cusco
- Flights from Memphis to Cusco
- Flights from Cascais to Cusco
- Flights from McAllen to Cusco
- Flights from Caceres to Cusco
- Flights from Dallas to Cusco
- Flights from Phoenix to Cusco
- Flights from Austin to Cusco