$149 Cheap Flights from St. Louis (STL) to Santo Domingo (SDQ)

View $149 flight on Thu, Jan 1, 2026Opens in a new window

Popular airlines from St. Louis Lambert Intl. Airport (STL) to Las Americas Intl. Airport (SDQ)

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Cheap Flights from St. Louis to Santo Domingo (STL-SDQ)

Prices were available within the past 7 days and start at $149 for one-way flights and $427 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Frontier Airlines
Sun, Jan 11 - Thu, Jan 15
STL
St. Louis
SDQ
Santo Domingo
$427 Roundtrip, found 5 days ago
$427
Roundtrip
found 5 days ago
Select Frontier Airlines flight, departing Sun, Jan 11 from St. Louis to Santo Domingo, returning Thu, Jan 15, priced at $427 found 5 days ago
Frontier Airlines
Sun, Jan 11 - Thu, Jan 15
STL
St. Louis
SDQ
Santo Domingo
$429 Roundtrip, found 5 days ago
$429
Roundtrip
found 5 days ago
Select Frontier Airlines flight, departing Sun, Jan 11 from St. Louis to Santo Domingo, returning Thu, Jan 15, priced at $429 found 5 days ago
Frontier Airlines
Mon, Jan 5 - Thu, Jan 8
STL
St. Louis
SDQ
Santo Domingo
$430 Roundtrip, found 4 hours ago
$430
Roundtrip
found 4 hours ago
Select Frontier Airlines flight, departing Mon, Jan 5 from St. Louis to Santo Domingo, returning Thu, Jan 8, priced at $430 found 4 hours ago
Frontier Airlines
Tue, Jan 6 - Thu, Jan 8
STL
St. Louis
SDQ
Santo Domingo
$437 Roundtrip, found 4 hours ago
$437
Roundtrip
found 4 hours ago
Select Frontier Airlines flight, departing Tue, Jan 6 from St. Louis to Santo Domingo, returning Thu, Jan 8, priced at $437 found 4 hours ago
Frontier Airlines
Mon, Jan 5 - Thu, Jan 15
STL
St. Louis
SDQ
Santo Domingo
$437 Roundtrip, found 5 days ago
$437
Roundtrip
found 5 days ago
Select Frontier Airlines flight, departing Mon, Jan 5 from St. Louis to Santo Domingo, returning Thu, Jan 15, priced at $437 found 5 days ago
Spirit Airlines
Tue, Jan 6 - Sat, Jan 10
STL
St. Louis
SDQ
Santo Domingo
$443 Roundtrip, found 2 days ago
$443
Roundtrip
found 2 days ago
Select Spirit Airlines flight, departing Tue, Jan 6 from St. Louis to Santo Domingo, returning Sat, Jan 10, priced at $443 found 2 days ago
Frontier Airlines
Mon, Dec 29 - Thu, Jan 8
STL
St. Louis
SDQ
Santo Domingo
$444 Roundtrip, found 5 hours ago
$444
Roundtrip
found 5 hours ago
Select Frontier Airlines flight, departing Mon, Dec 29 from St. Louis to Santo Domingo, returning Thu, Jan 8, priced at $444 found 5 hours ago
American Airlines
Tue, Mar 24 - Tue, Mar 31
STL
St. Louis
SDQ
Santo Domingo
$518 Roundtrip, found 5 hours ago
$518
Roundtrip
found 5 hours ago
Select American Airlines flight, departing Tue, Mar 24 from St. Louis to Santo Domingo, returning Tue, Mar 31, priced at $518 found 5 hours ago
Delta
Wed, Mar 25 - Wed, Apr 1
STL
St. Louis
SDQ
Santo Domingo
$518 Roundtrip, found 13 hours ago
$518
Roundtrip
found 13 hours ago
Select Delta flight, departing Wed, Mar 25 from St. Louis to Santo Domingo, returning Wed, Apr 1, priced at $518 found 13 hours ago
United
Tue, Mar 24 - Tue, Mar 31
STL
St. Louis
SDQ
Santo Domingo
$518 Roundtrip, found 5 hours ago
$518
Roundtrip
found 5 hours ago
Select United flight, departing Tue, Mar 24 from St. Louis to Santo Domingo, returning Tue, Mar 31, priced at $518 found 5 hours ago

Find the cheapest month to fly from St. Louis (STL) to Santo Domingo (SDQ)

February is typically the cheapest month to fly

From $331 - $638 per traveler.

Alternative airports near Santo Domingo

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Las Americas Intl. SDQ. Cheapest option available. Average driving time to city center is 22 minutes. Flights from $588
SDQ
Las Americas Intl.
Cheapest
Average driving time to city center22 min
Flights from $588

Frequently asked questions

How much does a flight from Lambert-St. Louis Intl. Airport (STL) to Las Americas Intl. Airport (SDQ) cost?
Get a cheap one-way flight from $149 or cheap return flight from $427 from Lambert-St. Louis Intl. Airport (STL) to Las Americas Intl. Airport (SDQ) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Lambert-St. Louis Intl. Airport (STL) to Las Americas Intl. Airport (SDQ)?
The cheapest month to fly from STL to SDQ is January, when there's less demand. Off-peak months are generally when you'll find lower airfares between these airports.
What is the cheapest airline that flies from Lambert-St. Louis Intl. Airport (STL) to Las Americas Intl. Airport (SDQ)?
To find the cheapest airline flying from STL to SDQ, use Expedia's filter tool. Tailor your search based on what's important to you, such as preferred carriers and flight duration. You can then sort your results by "Price (lowest to highest)" to see the most affordable options first.
How many flights per day from Lambert-St. Louis Intl. Airport (STL) to Las Americas Intl. Airport (SDQ)?
There aren't any daily direct flights available from Lambert-St. Louis Intl. Airport (STL) to Las Americas Intl. Airport (SDQ). But you can book flights with layovers. Filter your search results on Expedia to include one or two stops, and you'll be on your way before you know it.
What day of the week has the most flights from STL to SDQ?
You'll usually find Tuesday the quietest day for flights, while Fridays tend to be the busiest.* However this can vary from season to season and during public holidays or peak travel times.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Lambert-St. Louis Intl. Airport (STL) to Las Americas Intl. Airport (SDQ)?
To avoid potential delays on the Lambert-St. Louis Intl. Airport (STL) to Las Americas Intl. Airport (SDQ) route, fly before 3 PM. Flights after this time are 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Lambert-St. Louis Intl. Airport (STL) to Las Americas Intl. Airport (SDQ) last-minute?
Holding off until just before your trip to book a flight from STL to SDQ generally means paying more. While you may come across some last-minute offers, they're not always guaranteed. Be flexible with your itinerary for a better chance of getting a bargain.
Is it cheaper to book a STL to SDQ flight and hotel package?
Opting for a STL to SDQ flight and hotel package is typically cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your travels all in one place. Choose from our extensive range of hotels and then add activities, car rentals and flights to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Lambert-St. Louis Intl. Airport (STL) to Las Americas Intl. Airport (SDQ)?
In most instances, you're able to reschedule or cancel your STL to SDQ flight. However, there may be additional fees, especially if your booking was made over 24 hours ago. Double-check your itinerary for the airline's fees and rules on flight changes, or if you want further details, head to our Customer Service portal.

Travel information

Origin airport
Lambert-St. Louis Intl.
Destination airport
Las Americas Intl.
Airlines serving
American Airlines, Copa, Delta, Frontier Airlines, United
Roundtrip price
$427
Distance
1873 mi

Book with confidence

St. Louis to Santo Domingo Flights

The cheapest times to fly from St. Louis to Santo Domingo

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from St. Louis to Santo Domingo are during the month of January. You can find some of the cheapest flights from St. Louis to Santo Domingo with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from St. Louis to Santo Domingo

Sunday is one of the best days to book for cheap flights from St. Louis to Santo Domingo: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from St. Louis to Santo Domingo

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from St. Louis to Santo Domingo in 2025. You can also book with separate airlines for your outbound and return journeys, from $149 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap St. Louis to Santo Domingo flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your St. Louis to Santo Domingo airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

St. Louis to Santo Domingo Flights

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*Available to One Key members.