$144 Cheap Flights from St. Louis (STL) to Santiago (STI)

View $144 flight on Thu, Jan 1, 2026Opens in a new window

Popular airlines from St. Louis Lambert Intl. Airport (STL) to Cibao Intl. Airport (STI)

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Cheap Flights from St. Louis to Santiago (STL-STI)

Prices were available within the past 7 days and start at $144 for one-way flights and $310 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Spirit Airlines
Thu, Dec 4 - Thu, Dec 11
STL
St. Louis
STI
Santiago de los Caballeros
$310 Roundtrip, found 23 hours ago
$310
Roundtrip
found 23 hours ago
Select Spirit Airlines flight, departing Thu, Dec 4 from St. Louis to Santiago de los Caballeros, returning Thu, Dec 11, priced at $310 found 23 hours ago
Spirit Airlines
Sun, Dec 7 - Thu, Dec 11
STL
St. Louis
STI
Santiago de los Caballeros
$354 Roundtrip, found 23 hours ago
$354
Roundtrip
found 23 hours ago
Select Spirit Airlines flight, departing Sun, Dec 7 from St. Louis to Santiago de los Caballeros, returning Thu, Dec 11, priced at $354 found 23 hours ago
Spirit Airlines
Sun, Nov 9 - Thu, Dec 11
STL
St. Louis
STI
Santiago de los Caballeros
$439 Roundtrip, found 3 days ago
$439
Roundtrip
found 3 days ago
Select Spirit Airlines flight, departing Sun, Nov 9 from St. Louis to Santiago de los Caballeros, returning Thu, Dec 11, priced at $439 found 3 days ago
Spirit Airlines
Sun, Dec 14 - Tue, Dec 30
STL
St. Louis
STI
Santiago de los Caballeros
$444 Roundtrip, found 3 days ago
$444
Roundtrip
found 3 days ago
Select Spirit Airlines flight, departing Sun, Dec 14 from St. Louis to Santiago de los Caballeros, returning Tue, Dec 30, priced at $444 found 3 days ago
American Airlines
Sun, Dec 7 - Thu, Dec 11
STL
St. Louis
STI
Santiago de los Caballeros
$466 Roundtrip, found 23 hours ago
$466
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Sun, Dec 7 from St. Louis to Santiago de los Caballeros, returning Thu, Dec 11, priced at $466 found 23 hours ago
American Airlines
Sun, Dec 7 - Thu, Dec 11
STL
St. Louis
STI
Santiago de los Caballeros
$486 Roundtrip, found 23 hours ago
$486
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Sun, Dec 7 from St. Louis to Santiago de los Caballeros, returning Thu, Dec 11, priced at $486 found 23 hours ago
United
Mon, Nov 10 - Thu, Dec 11
STL
St. Louis
STI
Santiago de los Caballeros
$491 Roundtrip, found 3 days ago
$491
Roundtrip
found 3 days ago
Select United flight, departing Mon, Nov 10 from St. Louis to Santiago de los Caballeros, returning Thu, Dec 11, priced at $491 found 3 days ago
United
Mon, Nov 10 - Thu, Dec 11
STL
St. Louis
STI
Santiago de los Caballeros
$508 Roundtrip, found 3 days ago
$508
Roundtrip
found 3 days ago
Select United flight, departing Mon, Nov 10 from St. Louis to Santiago de los Caballeros, returning Thu, Dec 11, priced at $508 found 3 days ago
American Airlines
Sun, Dec 7 - Thu, Dec 11
STL
St. Louis
STI
Santiago de los Caballeros
$522 Roundtrip, found 23 hours ago
$522
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Sun, Dec 7 from St. Louis to Santiago de los Caballeros, returning Thu, Dec 11, priced at $522 found 23 hours ago
Delta
Wed, Mar 18 - Wed, Mar 25
STL
St. Louis
STI
Santiago de los Caballeros
$522 Roundtrip, just found
$522
Roundtrip
just found
Select Delta flight, departing Wed, Mar 18 from St. Louis to Santiago de los Caballeros, returning Wed, Mar 25, priced at $522 just found

Alternative airports near Santiago de los Caballeros

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Gregorio Luperon Intl. POP. Average driving time to city center is 59 minutes. Flights from $818
POP
Gregorio Luperon Intl.
Average driving time to city center59 min
Flights from $818

Frequently asked questions

How much does a flight from Lambert-St. Louis Intl. Airport (STL) to Cibao Intl. Airport (STI) cost?
Secure a cheap one-way flight from $144 or cheap return flight from $310 from Lambert-St. Louis Intl. Airport (STL) to Cibao Intl. Airport (STI) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Lambert-St. Louis Intl. Airport (STL) to Cibao Intl. Airport (STI)?
The cheapest month to fly from STL to STI is December, when there's less demand. Off-peak season is typically when better flight deals are available between these airports.
What is the cheapest airline that flies from Lambert-St. Louis Intl. Airport (STL) to Cibao Intl. Airport (STI)?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that'll take you from STL to STI. Then, sort your results by "Price (lowest to highest)" to pick up a great deal.
How many flights per day from Lambert-St. Louis Intl. Airport (STL) to Cibao Intl. Airport (STI)?
There are no daily direct flights available from Lambert-St. Louis Intl. Airport (STL) to Cibao Intl. Airport (STI). But you can opt for flights with layovers. Filter your search results on Expedia to include one or two stops, and you'll be on your way in no time.
What day of the week has the most flights from STL to STI?
You'll generally find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can change from season to season and during public holidays or peak travel times.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Lambert-St. Louis Intl. Airport (STL) to Cibao Intl. Airport (STI)?
Choose a flight from Lambert-St. Louis Intl. Airport (STL) to Cibao Intl. Airport (STI) that takes off before 3 PM to reduce the likelihood of delays and cancellations. Departures after this hour have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Lambert-St. Louis Intl. Airport (STL) to Cibao Intl. Airport (STI) last-minute?
Booking your ticket from STL to STI right before your getaway is usually more expensive. However, if there's some wiggle room with your travel times and dates, you could grab a cheap last-minute fare.
Is it cheaper to book a STL to STI flight and hotel package?
Opting for a STL to STI flight and hotel package is generally cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your trip all in one place. Select from our extensive range of hotels and then add flights, car rentals and activities to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Lambert-St. Louis Intl. Airport (STL) to Cibao Intl. Airport (STI)?
If you booked your STL to STI flight within the last 24 hours, you may be able to cancel or modify it without fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal for more details.

Travel information

Origin airport
Lambert-St. Louis Intl.
Destination airport
Cibao Intl.
Airlines serving
American Airlines, Delta, Spirit Airlines, United
Roundtrip price
$310
Distance
1783 mi

Book with confidence

St. Louis to Santiago Flights

The cheapest times to fly from St. Louis to Santiago

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from St. Louis to Santiago are during the month of December. You can find some of the cheapest flights from St. Louis to Santiago with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from St. Louis to Santiago

Sunday is one of the best days to book for cheap flights from St. Louis to Santiago: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from St. Louis to Santiago

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from St. Louis to Santiago in 2025. You can also book with separate airlines for your outbound and return journeys, from $144 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap St. Louis to Santiago flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your St. Louis to Santiago airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

St. Louis to Santiago Flights

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*Available to One Key members.