$318 Cheap Flights from Tupelo (TUP) to Louisville (SDF)

View $318 flight on Tue, Sep 9, 2025Opens in a new window

Popular airlines from Tupelo, MS (TUP-Tupelo Regional) to Louisville Intl. Airport (SDF)

Cheap Flights from Tupelo to Louisville (TUP-SDF)

Prices were available within the past 7 days and start at $318 for one-way flights and $417 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Contour Airlines
Tue, Oct 7 - Tue, Oct 21
TUP
Tupelo
SDF
Louisville
$417 Roundtrip, found 3 days ago
$417
Roundtrip
found 3 days ago
Select Contour Airlines flight, departing Tue, Oct 7 from Tupelo to Louisville, returning Tue, Oct 21, priced at $417 found 3 days ago
Contour Airlines
Sat, Nov 8 - Thu, Nov 27
TUP
Tupelo
SDF
Louisville
$424 Roundtrip, found 3 days ago
$424
Roundtrip
found 3 days ago
Select Contour Airlines flight, departing Sat, Nov 8 from Tupelo to Louisville, returning Thu, Nov 27, priced at $424 found 3 days ago
Contour Airlines
Mon, Sep 22 - Sat, Sep 27
TUP
Tupelo
SDF
Louisville
$426 Roundtrip, found 6 days ago
$426
Roundtrip
found 6 days ago
Select Contour Airlines flight, departing Mon, Sep 22 from Tupelo to Louisville, returning Sat, Sep 27, priced at $426 found 6 days ago
Contour Airlines
Sat, Sep 20 - Tue, Sep 23
TUP
Tupelo
SDF
Louisville
$433 Roundtrip, found 6 days ago
$433
Roundtrip
found 6 days ago
Select Contour Airlines flight, departing Sat, Sep 20 from Tupelo to Louisville, returning Tue, Sep 23, priced at $433 found 6 days ago
Contour Airlines
Mon, Sep 22 - Wed, Sep 24
TUP
Tupelo
SDF
Louisville
$435 Roundtrip, found 6 days ago
$435
Roundtrip
found 6 days ago
Select Contour Airlines flight, departing Mon, Sep 22 from Tupelo to Louisville, returning Wed, Sep 24, priced at $435 found 6 days ago
Contour Airlines
Tue, Oct 7 - Wed, Oct 22
TUP
Tupelo
SDF
Louisville
$437 Roundtrip, found 3 days ago
$437
Roundtrip
found 3 days ago
Select Contour Airlines flight, departing Tue, Oct 7 from Tupelo to Louisville, returning Wed, Oct 22, priced at $437 found 3 days ago
Contour Airlines
Mon, Sep 22 - Tue, Sep 23
TUP
Tupelo
SDF
Louisville
$442 Roundtrip, found 6 days ago
$442
Roundtrip
found 6 days ago
Select Contour Airlines flight, departing Mon, Sep 22 from Tupelo to Louisville, returning Tue, Sep 23, priced at $442 found 6 days ago
Contour Airlines
Wed, Nov 12 - Sat, Nov 15
TUP
Tupelo
SDF
Louisville
$444 Roundtrip, found 4 days ago
$444
Roundtrip
found 4 days ago
Select Contour Airlines flight, departing Wed, Nov 12 from Tupelo to Louisville, returning Sat, Nov 15, priced at $444 found 4 days ago
Contour Airlines
Sat, Oct 18 - Sat, Nov 1
TUP
Tupelo
SDF
Louisville
$456 Roundtrip, found 3 days ago
$456
Roundtrip
found 3 days ago
Select Contour Airlines flight, departing Sat, Oct 18 from Tupelo to Louisville, returning Sat, Nov 1, priced at $456 found 3 days ago
Contour Airlines
Fri, Oct 31 - Sat, Nov 15
TUP
Tupelo
SDF
Louisville
$457 Roundtrip, found 3 days ago
$457
Roundtrip
found 3 days ago
Select Contour Airlines flight, departing Fri, Oct 31 from Tupelo to Louisville, returning Sat, Nov 15, priced at $457 found 3 days ago
Contour Airlines
Sat, Nov 15 - Thu, Nov 27
TUP
Tupelo
SDF
Louisville
$464 Roundtrip, found 3 days ago
$464
Roundtrip
found 3 days ago
Select Contour Airlines flight, departing Sat, Nov 15 from Tupelo to Louisville, returning Thu, Nov 27, priced at $464 found 3 days ago

Alternative airports near Louisville

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Louisville Intl. SDF. Cheapest and Closest option available. Average driving time to city center is 9 minutes. Flights from $424
SDF
Louisville Intl.
CheapestClosest
Average driving time to city center9 min
Flights from $424
Flights from Tupelo (TUP) to Louisville (SDF)
Origin airport
Tupelo Regional
Destination airport
Louisville Intl.
Roundtrip price
$417
Distance
318 mi

Tupelo to Louisville Flights

The cheapest times to fly from Tupelo to Louisville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Tupelo to Louisville are during the month of October. You can find some of the cheapest flights from Tupelo to Louisville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Tupelo to Louisville

Sunday is one of the best days to book for cheap flights from Tupelo to Louisville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Tupelo to Louisville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Tupelo to Louisville in 2025. You can also book with separate airlines for your outbound and return journeys, from $318 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Tupelo to Louisville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Tupelo to Louisville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Tupelo Regional Airport (TUP) to Louisville Intl. Airport (SDF) cost?
Lock in a cheap one-way flight from $318 or cheap return flight from $417 from Tupelo Regional Airport (TUP) to Louisville Intl. Airport (SDF) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Tupelo Regional Airport (TUP) to Louisville Intl. Airport (SDF)?
October is the most affordable month to fly from TUP to SDF. Avoiding peak travel times is often the key to better flight prices.
What is the cheapest airline that flies from Tupelo Regional Airport (TUP) to Louisville Intl. Airport (SDF)?
Expedia's filter tool lets you easily compare airlines, flight times and baggage options all in one place. Tailor the search to your trip, then sort by "Price (lowest to highest)" to find out which carrier offers the cheapest TUP to SDF flight.
How many flights per day from Tupelo Regional Airport (TUP) to Louisville Intl. Airport (SDF)?
Direct flights from Tupelo Regional Airport (TUP) to Louisville Intl. Airport (SDF) aren't available daily, so you'll need to take a flight with a layover. Explore your options with our filter tool. Enter your dates and choose either "1 Stop" or "2+ Stops."
What day of the week has the most flights from TUP to SDF?
Friday is typically the busiest day for flights, while Tuesday is often the quietest.* Keep in mind that flight schedules can change depending on a number of factors, such as the time of year and carrier.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Tupelo Regional Airport (TUP) to Louisville Intl. Airport (SDF)?
Choose a flight from Tupelo Regional Airport (TUP) to Louisville Intl. Airport (SDF) that leaves before 3 PM to reduce the risk of delays and cancellations. Departures after this hour have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Tupelo Regional Airport (TUP) to Louisville Intl. Airport (SDF) last-minute?
Last-minute bookings from TUP to SDF are typically more expensive. For the lowest prices, start looking for flights well ahead of time. That being said, if your travel plans are flexible, you may find a cheap fare just before your departure.
Is it cheaper to book a TUP to SDF flight and hotel package?
Securing a TUP to SDF flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your travels all in one place. Select from our extensive range of accommodations and then add car rentals, activities and flights to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Tupelo Regional Airport (TUP) to Louisville Intl. Airport (SDF)?
In most cases, you can modify or cancel your TUP to SDF flight. However, additional charges may apply, especially if your booking was made more than 24 hours ago. Check your itinerary for the airline's policies and fees on flight changes, or if you'd like more information, head to our Customer Service portal.

Explore a world of travel with Expedia

*Available to One Key members.