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$204 Cheap Flights from Knoxville (TYS) to Harrisburg (MDT)

View $204 flight on Thu, Oct 22, 2026Opens in a new window

Popular airlines from McGhee Tyson Airport (TYS) to Harrisburg Intl. Airport (MDT)

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Cheap Flights from Knoxville to Harrisburg (TYS-MDT)

Prices were available within the past 7 days and start at $204 for one-way flights and $299 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Sat, Oct 24 - Mon, Oct 26
TYS
Knoxville
MDT
Harrisburg
$299 Roundtrip, just found
$299
Roundtrip
just found
Select American Airlines flight, departing Sat, Oct 24 from Knoxville to Harrisburg, returning Mon, Oct 26, priced at $299 just found
United
Sat, Oct 24 - Mon, Oct 26
TYS
Knoxville
MDT
Harrisburg
$299 Roundtrip, just found
$299
Roundtrip
just found
Select United flight, departing Sat, Oct 24 from Knoxville to Harrisburg, returning Mon, Oct 26, priced at $299 just found
United
Sat, Oct 24 - Mon, Oct 26
TYS
Knoxville
MDT
Harrisburg
$304 Roundtrip, just found
$304
Roundtrip
just found
Select United flight, departing Sat, Oct 24 from Knoxville to Harrisburg, returning Mon, Oct 26, priced at $304 just found
United
Sat, Oct 24 - Mon, Oct 26
TYS
Knoxville
MDT
Harrisburg
$309 Roundtrip, just found
$309
Roundtrip
just found
Select United flight, departing Sat, Oct 24 from Knoxville to Harrisburg, returning Mon, Oct 26, priced at $309 just found
United
Sat, Oct 24 - Sun, Oct 25
TYS
Knoxville
MDT
Harrisburg
$314 Roundtrip, found 10 hours ago
$314
Roundtrip
found 10 hours ago
Select United flight, departing Sat, Oct 24 from Knoxville to Harrisburg, returning Sun, Oct 25, priced at $314 found 10 hours ago
Delta
Sat, Oct 24 - Mon, Oct 26
TYS
Knoxville
MDT
Harrisburg
$319 Roundtrip, just found
$319
Roundtrip
just found
Select Delta flight, departing Sat, Oct 24 from Knoxville to Harrisburg, returning Mon, Oct 26, priced at $319 just found
United
Fri, Sep 18 - Mon, Sep 21
TYS
Knoxville
MDT
Harrisburg
$329 Roundtrip, found 3 hours ago
$329
Roundtrip
found 3 hours ago
Select United flight, departing Fri, Sep 18 from Knoxville to Harrisburg, returning Mon, Sep 21, priced at $329 found 3 hours ago
United
Wed, Oct 21 - Sun, Oct 25
TYS
Knoxville
MDT
Harrisburg
$330 Roundtrip, found 10 hours ago
$330
Roundtrip
found 10 hours ago
Select United flight, departing Wed, Oct 21 from Knoxville to Harrisburg, returning Sun, Oct 25, priced at $330 found 10 hours ago
Delta
Tue, Sep 15 - Tue, Sep 22
TYS
Knoxville
MDT
Harrisburg
$334 Roundtrip, found 2 days ago
$334
Roundtrip
found 2 days ago
Select Delta flight, departing Tue, Sep 15 from Knoxville to Harrisburg, returning Tue, Sep 22, priced at $334 found 2 days ago
United
Wed, Oct 21 - Sun, Oct 25
TYS
Knoxville
MDT
Harrisburg
$335 Roundtrip, found 10 hours ago
$335
Roundtrip
found 10 hours ago
Select United flight, departing Wed, Oct 21 from Knoxville to Harrisburg, returning Sun, Oct 25, priced at $335 found 10 hours ago

Alternative airports near Harrisburg

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Harrisburg Intl. MDT. Cheapest option available. Average driving time to city center is 16 minutes. Flights from $652
MDT
Harrisburg Intl.
Cheapest
Average driving time to city center16 min
Flights from $652

Frequently asked questions

How much does a flight from Knoxville, TN (TYS-McGhee Tyson) to Harrisburg, PA (MDT-Harrisburg Intl.) cost?
You can find cheap one-way flights from $204 and cheap return flights from $299 Knoxville, TN (TYS-McGhee Tyson) to Harrisburg, PA (MDT-Harrisburg Intl.) with Expedia. One-way flights typically cost between $189 and $672, and return flights often range between $327 and $1176. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Knoxville, TN (TYS-McGhee Tyson) to Harrisburg, PA (MDT-Harrisburg Intl.) ticket fares go up or down.*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from Knoxville, TN (TYS-McGhee Tyson) to Harrisburg, PA (MDT-Harrisburg Intl.)?
The cheapest month to fly from TYS to MDT is October when demand is low. Traveling in off-peak or shoulder months is usually a good way to secure cheap tickets, just remember to avoid flying during holidays if you're able to. Use the calendar view in your search to see which months have low fares on this route.
Which airlines fly direct from Knoxville, TN (TYS-McGhee Tyson) to Harrisburg, PA (MDT-Harrisburg Intl.)?
Enter TYS to MDT and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
What is the cheapest airline that flies from Knoxville, TN (TYS-McGhee Tyson) to Harrisburg, PA (MDT-Harrisburg Intl.)?
American Airlines is one of the cheapest airlines offering connecting flights from Knoxville, TN (TYS) to Harrisburg, PA (MDT), with round-trip tickets starting from around $228 with a layover in Charlotte-Douglas Intl. (CLT). Use Expedia's search tool to compare the prices and schedules of airlines that fly this route to find the best option for your plans and budget.*Prices based on flights available on Expedia in the last year.
How do I find cheap flights from Knoxville, TN (TYS-McGhee Tyson) to Harrisburg, PA (MDT-Harrisburg Intl.)?
To find a cheap flight from Knoxville, TN (TYS-McGhee Tyson) to Harrisburg, PA (MDT-Harrisburg Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Knoxville, TN (TYS-McGhee Tyson) to Harrisburg, PA (MDT-Harrisburg Intl.)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
What is the earliest flight from Knoxville, TN (TYS-McGhee Tyson) to Harrisburg, PA (MDT-Harrisburg Intl.)?
The earliest flight from McGhee Tyson Airport (TYS) in Knoxville to Harrisburg International Airport (MDT) typically departs at around 5:00 AM, operated by American Airlines. This seasonal service is available in January and December, allowing you to start your day early in Harrisburg. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What are the most popular departure times for flights from Knoxville, TN (TYS-McGhee Tyson) to Harrisburg, PA (MDT-Harrisburg Intl.)?
The most popular departure times for flights from Knoxville, TN (TYS) to Harrisburg, PA (MDT) are in the early morning, from 6am to 9am. About 21% of passengers prefer this time window. Many major carriers, including American Airlines, Delta Airlines, and United Airlines, offer flights during this period. This timing is popular because it allows you to start your day early and make the most of your time in Harrisburg.
How long does it take to fly from Knoxville, TN (TYS-McGhee Tyson) to Harrisburg, PA (MDT-Harrisburg Intl.)?
Flying from TYS to MDT with a connection usually takes about 6 hours, traveling roughly 497 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Knoxville, TN (TYS-McGhee Tyson) to Harrisburg, PA (MDT-Harrisburg Intl.)?
First class is available on flights from TYS to MDT. First class cabins are available on:

  • American Airlines
  • Delta Air Lines
  • United Airlines

How do I earn miles on a Knoxville, TN (TYS-McGhee Tyson) to Harrisburg, PA (MDT-Harrisburg Intl.) flight with Expedia?
It's easy to earn miles on a Knoxville, TN (TYS-McGhee Tyson) to Harrisburg, PA (MDT-Harrisburg Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Harrisburg from McGhee Tyson (TYS)?
If you're planning to travel to Harrisburg from McGhee Tyson (TYS), you can fly into Harrisburg Intl. (MDT) Some flights may connect through major hubs like O'Hare Intl. (ORD), Charlotte-Douglas Intl. (CLT), Ronald Reagan Washington National (DCA) before reaching Harrisburg. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Knoxville, TN (TYS-McGhee Tyson) to Harrisburg, PA (MDT-Harrisburg Intl.) at the last minute?
Typically, booking a last minute flight from Knoxville, TN (TYS-McGhee Tyson) to Harrisburg, PA (MDT-Harrisburg Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Knoxville, TN (TYS-McGhee Tyson) to Harrisburg, PA (MDT-Harrisburg Intl.) flight and hotel package?
Securing a Knoxville, TN (TYS-McGhee Tyson) to Harrisburg, PA (MDT-Harrisburg Intl.) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Knoxville, TN (TYS-McGhee Tyson) to Harrisburg, PA (MDT-Harrisburg Intl.)?
If you booked your Knoxville, TN (TYS-McGhee Tyson) to Harrisburg, PA (MDT-Harrisburg Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
McGhee Tyson
Destination airport
Harrisburg Intl.
Airlines serving
American Airlines, Delta, United
Roundtrip price
$298
Distance
496 mi

Book with confidence

Knoxville to Harrisburg Flights

The cheapest times to fly from Knoxville to Harrisburg

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Knoxville to Harrisburg are during the month of October. You can find some of the cheapest flights from Knoxville to Harrisburg with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Knoxville to Harrisburg

Sunday is one of the best days to book for cheap flights from Knoxville to Harrisburg: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Knoxville to Harrisburg

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Knoxville to Harrisburg in 2026. You can also book with separate airlines for your outbound and return journeys, from $204 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Knoxville to Harrisburg flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Knoxville to Harrisburg airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Knoxville to Harrisburg Flights

*Flight schedules are subject to change.

*Available to One Key members.

 

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