$274 Cheap Flights from Knoxville (TYS) to San Luis Potosi (SLP)

View $274 flight on Wed, Dec 3, 2025Opens in a new window

Popular airlines from McGhee Tyson Airport (TYS) to San Luis Potosi Intl. Airport (SLP)

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Cheap Flights from Knoxville to San Luis Potosi (TYS-SLP)

Prices were available within the past 7 days and start at $274 for one-way flights and $506 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

United
Wed, Dec 3 - Mon, Jan 19
TYS
Knoxville
SLP
San Luis Potosi
$506 Roundtrip, found 16 hours ago
$506
Roundtrip
found 16 hours ago
Select United flight, departing Wed, Dec 3 from Knoxville to San Luis Potosi, returning Mon, Jan 19, priced at $506 found 16 hours ago
American Airlines
Tue, Dec 2 - Thu, Jan 15
TYS
Knoxville
SLP
San Luis Potosi
$511 Roundtrip, found 4 days ago
$511
Roundtrip
found 4 days ago
Select American Airlines flight, departing Tue, Dec 2 from Knoxville to San Luis Potosi, returning Thu, Jan 15, priced at $511 found 4 days ago
United
Thu, Dec 4 - Mon, Jan 26
TYS
Knoxville
SLP
San Luis Potosi
$518 Roundtrip, found 16 hours ago
$518
Roundtrip
found 16 hours ago
Select United flight, departing Thu, Dec 4 from Knoxville to San Luis Potosi, returning Mon, Jan 26, priced at $518 found 16 hours ago
American Airlines
Tue, Dec 2 - Thu, Jan 15
TYS
Knoxville
SLP
San Luis Potosi
$522 Roundtrip, found 4 days ago
$522
Roundtrip
found 4 days ago
Select American Airlines flight, departing Tue, Dec 2 from Knoxville to San Luis Potosi, returning Thu, Jan 15, priced at $522 found 4 days ago
United
Thu, Dec 4 - Mon, Jan 26
TYS
Knoxville
SLP
San Luis Potosi
$525 Roundtrip, found 16 hours ago
$525
Roundtrip
found 16 hours ago
Select United flight, departing Thu, Dec 4 from Knoxville to San Luis Potosi, returning Mon, Jan 26, priced at $525 found 16 hours ago
American Airlines
Thu, Dec 4 - Mon, Jan 26
TYS
Knoxville
SLP
San Luis Potosi
$526 Roundtrip, found 16 hours ago
$526
Roundtrip
found 16 hours ago
Select American Airlines flight, departing Thu, Dec 4 from Knoxville to San Luis Potosi, returning Mon, Jan 26, priced at $526 found 16 hours ago
United
Thu, Dec 4 - Mon, Jan 26
TYS
Knoxville
SLP
San Luis Potosi
$530 Roundtrip, found 16 hours ago
$530
Roundtrip
found 16 hours ago
Select United flight, departing Thu, Dec 4 from Knoxville to San Luis Potosi, returning Mon, Jan 26, priced at $530 found 16 hours ago
American Airlines
Wed, Dec 3 - Mon, Jan 19
TYS
Knoxville
SLP
San Luis Potosi
$531 Roundtrip, found 16 hours ago
$531
Roundtrip
found 16 hours ago
Select American Airlines flight, departing Wed, Dec 3 from Knoxville to San Luis Potosi, returning Mon, Jan 19, priced at $531 found 16 hours ago
Delta
Thu, Nov 27 - Wed, Dec 3
TYS
Knoxville
SLP
San Luis Potosi
$559 Roundtrip, found 3 days ago
$559
Roundtrip
found 3 days ago
Select Delta flight, departing Thu, Nov 27 from Knoxville to San Luis Potosi, returning Wed, Dec 3, priced at $559 found 3 days ago
Aeromexico
Thu, Jan 1 - Sat, Jan 17
TYS
Knoxville
SLP
San Luis Potosi
$579 Roundtrip, found 13 hours ago
$579
Roundtrip
found 13 hours ago
Select Aeromexico flight, departing Thu, Jan 1 from Knoxville to San Luis Potosi, returning Sat, Jan 17, priced at $579 found 13 hours ago

Frequently asked questions

How much does a flight from McGhee Tyson Airport (TYS) to Ponciano Arriaga Intl. Airport (SLP) cost?
Get a cheap one-way flight from $274 or cheap return flight from $506 from McGhee Tyson Airport (TYS) to Ponciano Arriaga Intl. Airport (SLP) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from McGhee Tyson Airport (TYS) to Ponciano Arriaga Intl. Airport (SLP)?
December is the least expensive month to fly from TYS to SLP. Timing your trip outside of the busy season is often the key to better flight prices.
What is the cheapest airline that flies from McGhee Tyson Airport (TYS) to Ponciano Arriaga Intl. Airport (SLP)?
Use the filter tool on Expedia to compare different airlines and find the most affordable carrier that'll fly you from TYS to SLP. Then, sort your results by "Price (lowest to highest)" to snap up the best deal available.
How many flights per day from McGhee Tyson Airport (TYS) to Ponciano Arriaga Intl. Airport (SLP)?
Nonstop flights from McGhee Tyson Airport (TYS) to Ponciano Arriaga Intl. Airport (SLP) aren't available daily, so you'll have to take a flight with a layover. Explore your options with Expedia's filters. Enter your dates and choose either "1 Stop" or "2+ Stops."
What day of the week has the most flights from TYS to SLP?
Friday is usually the busiest day for flights, while Tuesday tends to be the quietest.* Keep in mind that flight schedules can vary depending on a range of factors, including the carrier and season.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from McGhee Tyson Airport (TYS) to Ponciano Arriaga Intl. Airport (SLP)?
Book a flight from McGhee Tyson Airport (TYS) to Ponciano Arriaga Intl. Airport (SLP) that leaves before 3 PM to reduce the risk of delays and cancellations. Departures later than this are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from McGhee Tyson Airport (TYS) to Ponciano Arriaga Intl. Airport (SLP) last-minute?
Holding off until right before your break to book a flight from TYS to SLP generally means paying more. While you may come across some last-minute deals, they aren't always guaranteed. Be flexible with your itinerary for a better chance of scoring a bargain.
Is it cheaper to book a TYS to SLP flight and hotel package?
Compared with arranging flights and hotels separately, booking a TYS to SLP flight and hotel package with Expedia could result in significant savings. Better still, having everything in one place will take the hassle out of travel planning. Simply pick your flights and select from our extensive range of hotels, then tailor your trip with extras like tours and car rentals.
Can I cancel or change the date of my flight from McGhee Tyson Airport (TYS) to Ponciano Arriaga Intl. Airport (SLP)?
If you reserved your TYS to SLP flight within the last 24 hours, you may be able to cancel or modify it without fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal for more information.

Travel information

Origin airport
McGhee Tyson
Destination airport
Ponciano Arriaga Intl.
Airlines serving
Aeromexico, American Airlines, Delta, United
Roundtrip price
$506
Distance
1383 mi

Book with confidence

Knoxville to San Luis Potosi Flights

The cheapest times to fly from Knoxville to San Luis Potosi

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Knoxville to San Luis Potosi are during the month of December. You can find some of the cheapest flights from Knoxville to San Luis Potosi with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Knoxville to San Luis Potosi

Sunday is one of the best days to book for cheap flights from Knoxville to San Luis Potosi: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Knoxville to San Luis Potosi

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Knoxville to San Luis Potosi in 2025. You can also book with separate airlines for your outbound and return journeys, from $274 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Knoxville to San Luis Potosi flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Knoxville to San Luis Potosi airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Knoxville to San Luis Potosi Flights

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*Available to One Key members.