$281 Cheap Flights from Knoxville (TYS) to Zacatecas (ZCL)

View $281 flight on Wed, Nov 5, 2025Opens in a new window

Popular airlines from McGhee Tyson Airport (TYS) to Zacatecas, Zacatecas (ZCL-General Leobardo C. Ruiz Intl.)

Cheap Flights from Knoxville to Zacatecas (TYS-ZCL)

Prices were available within the past 7 days and start at $281 for one-way flights and $589 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Wed, Nov 5 - Thu, Nov 6
TYS
Knoxville
ZCL
Zacatecas
$589 Roundtrip, found 4 days ago
$589
Roundtrip
found 4 days ago
Select American Airlines flight, departing Wed, Nov 5 from Knoxville to Zacatecas, returning Thu, Nov 6, priced at $589 found 4 days ago
American Airlines
Wed, Nov 5 - Thu, Nov 6
TYS
Knoxville
ZCL
Zacatecas
$615 Roundtrip, found 4 days ago
$615
Roundtrip
found 4 days ago
Select American Airlines flight, departing Wed, Nov 5 from Knoxville to Zacatecas, returning Thu, Nov 6, priced at $615 found 4 days ago
American Airlines
Wed, Nov 5 - Thu, Nov 6
TYS
Knoxville
ZCL
Zacatecas
$616 Roundtrip, found 4 days ago
$616
Roundtrip
found 4 days ago
Select American Airlines flight, departing Wed, Nov 5 from Knoxville to Zacatecas, returning Thu, Nov 6, priced at $616 found 4 days ago
American Airlines
Wed, Nov 5 - Thu, Nov 6
TYS
Knoxville
ZCL
Zacatecas
$625 Roundtrip, found 4 days ago
$625
Roundtrip
found 4 days ago
Select American Airlines flight, departing Wed, Nov 5 from Knoxville to Zacatecas, returning Thu, Nov 6, priced at $625 found 4 days ago
American Airlines
Wed, Nov 5 - Thu, Nov 6
TYS
Knoxville
ZCL
Zacatecas
$627 Roundtrip, found 4 days ago
$627
Roundtrip
found 4 days ago
Select American Airlines flight, departing Wed, Nov 5 from Knoxville to Zacatecas, returning Thu, Nov 6, priced at $627 found 4 days ago
American Airlines
Wed, Nov 5 - Thu, Nov 6
TYS
Knoxville
ZCL
Zacatecas
$701 Roundtrip, found 4 days ago
$701
Roundtrip
found 4 days ago
Select American Airlines flight, departing Wed, Nov 5 from Knoxville to Zacatecas, returning Thu, Nov 6, priced at $701 found 4 days ago
American Airlines
Wed, Nov 5 - Thu, Nov 6
TYS
Knoxville
ZCL
Zacatecas
$726 Roundtrip, found 4 days ago
$726
Roundtrip
found 4 days ago
Select American Airlines flight, departing Wed, Nov 5 from Knoxville to Zacatecas, returning Thu, Nov 6, priced at $726 found 4 days ago
American Airlines
Wed, Nov 5 - Thu, Nov 6
TYS
Knoxville
ZCL
Zacatecas
$727 Roundtrip, found 4 days ago
$727
Roundtrip
found 4 days ago
Select American Airlines flight, departing Wed, Nov 5 from Knoxville to Zacatecas, returning Thu, Nov 6, priced at $727 found 4 days ago
Aeromexico
Mon, Dec 15 - Mon, Dec 29
TYS
Knoxville
ZCL
Zacatecas
$2,352 Roundtrip, found 1 day ago
$2,352
Roundtrip
found 1 day ago
Select Aeromexico flight, departing Mon, Dec 15 from Knoxville to Zacatecas, returning Mon, Dec 29, priced at $2,352 found 1 day ago
Delta
Mon, Dec 15 - Mon, Dec 29
TYS
Knoxville
ZCL
Zacatecas
$2,352 Roundtrip, found 1 day ago
$2,352
Roundtrip
found 1 day ago
Select Delta flight, departing Mon, Dec 15 from Knoxville to Zacatecas, returning Mon, Dec 29, priced at $2,352 found 1 day ago
Flights from Knoxville (TYS) to Zacatecas (ZCL)
Origin airport
McGhee Tyson
Destination airport
General Leobardo C. Ruiz Intl.
Airlines serving
Aeromexico, American Airlines, Delta
Roundtrip price
$588
Distance
1431 mi

Knoxville to Zacatecas Flights

The cheapest times to fly from Knoxville to Zacatecas

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Knoxville to Zacatecas are during the month of November. You can find some of the cheapest flights from Knoxville to Zacatecas with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Knoxville to Zacatecas

Sunday is one of the best days to book for cheap flights from Knoxville to Zacatecas: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Knoxville to Zacatecas

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Knoxville to Zacatecas in 2025. You can also book with separate airlines for your outbound and return journeys, from $281 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Knoxville to Zacatecas flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Knoxville to Zacatecas airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from McGhee Tyson Airport (TYS) to General Leobardo C. Ruiz Intl. Airport (ZCL) cost?
Secure a cheap one-way flight from $281 or cheap return flight from $589 from McGhee Tyson Airport (TYS) to General Leobardo C. Ruiz Intl. Airport (ZCL) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from McGhee Tyson Airport (TYS) to General Leobardo C. Ruiz Intl. Airport (ZCL)?
Traveling in November can help you save, as it's the cheapest month for flights between TYS and ZCL. You'll often find the lowest fares during the off-season.
What is the cheapest airline that flies from McGhee Tyson Airport (TYS) to General Leobardo C. Ruiz Intl. Airport (ZCL)?
Expedia's filter tool lets you easily compare airlines, flight times and fares all in one place. Tailor the search to your trip, then sort by "Price (lowest to highest)" to find out which carrier offers the cheapest TYS to ZCL flight.
How many flights per day from McGhee Tyson Airport (TYS) to General Leobardo C. Ruiz Intl. Airport (ZCL)?
You'll need to book a flight with a layover when traveling from McGhee Tyson Airport (TYS) to General Leobardo C. Ruiz Intl. Airport (ZCL). There are no daily direct flights on this route. However, simply filter your search to include one or two stops to find an option that works for you.
What day of the week has the most flights from TYS to ZCL?
You'll typically find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can change from season to season and during public holidays or peak travel times.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from McGhee Tyson Airport (TYS) to General Leobardo C. Ruiz Intl. Airport (ZCL)?
Opt for a flight from McGhee Tyson Airport (TYS) to General Leobardo C. Ruiz Intl. Airport (ZCL) that takes off before 3 PM to reduce the likelihood of delays and cancellations. Departures after this time have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from McGhee Tyson Airport (TYS) to General Leobardo C. Ruiz Intl. Airport (ZCL) last-minute?
Last-minute bookings from TYS to ZCL are typically more expensive. To lock in the lowest prices, start searching for flights as early as possible. That being said, if you're flexible with your travel dates, it's possible to land a cheap fare right before you leave.
Is it cheaper to book a TYS to ZCL flight and hotel package?
Compared with arranging hotels and flights separately, booking a TYS to ZCL flight and hotel package with Expedia could lead to significant savings. Better still, having it all in one place will take the hassle out of travel planning. Just pick your flights and select from our extensive range of stays, then customize your trip with extras like activities, tours and car rentals.
Can I cancel or change the date of my flight from McGhee Tyson Airport (TYS) to General Leobardo C. Ruiz Intl. Airport (ZCL)?
Generally, it's possible to reschedule or cancel your TYS to ZCL flight. However, if it's been more than 24 hours since booking, additional fees may apply. Refer to your airline's policies in your itinerary to see what changes are allowed and whether any costs are involved. You'll also find more information on our Customer Service portal.

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*Available to One Key members.