
Missouri Luxury Vacations
Book a Luxury Hotel + Flight or Car together to unlock savings
Top Luxury vacation packages in Missouri

Marriott St. Louis Airport
Reviewed on Oct 19, 2025

Hyatt Vacation Club at The Lodges at Timber Ridge, Branson
Reviewed on Oct 24, 2025

The Ozarker Lodge
Reviewed on Oct 23, 2025

The Elms Hotel & Spa, a Destination by Hyatt Hotel
Reviewed on Oct 15, 2025

St. Louis Union Station Hotel, Curio Collection by Hilton
Reviewed on Oct 20, 2025
5* Luxury vacations in Missouri


Four Seasons Hotel St Louis
Reviewed on Oct 5, 2025
3 Night Luxury vacations in Missouri

Hyatt Vacation Club at The Lodges at Timber Ridge, Branson
Reviewed on Oct 24, 2025

The Ozarker Lodge
Reviewed on Oct 23, 2025

The Elms Hotel & Spa, a Destination by Hyatt Hotel
Reviewed on Oct 15, 2025
4 Night Luxury vacations in Missouri

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
Reviewed on Oct 24, 2025

The Fontaine
Reviewed on Oct 11, 2025

Marriott St. Louis Airport
Reviewed on Oct 19, 2025
All you need to know about luxury vacations in Missouri
What can I expect from a luxury Missouri vacation?
Luxury means the very finest of the things you enjoy most. Indulge your every waking moment—and restful night—with a luxury Missouri vacation. Sip handcrafted cocktails by an infinity pool, sink into bliss at a full-service spa with a massage cabana on the beach, and chat, cheers, and laugh through exquisite breakfasts, lunches, and dinners with spectacular views.
How can I find all-inclusive luxury vacation packages in Missouri?
By refining your filters, the most opulent all-inclusive vacation packages will appear before your eyes. Check the 5* filter to find truly sensational stays. You barely need to lift a finger.
Can I book a cheap Missouri luxury vacation?
Affordable luxury is only ever a few clicks away. Enter your travel dates and sort the grandiose getaways on offer by price to see the most fiscally friendly retreats first. Filter by budget, too, to find your perfect balance of luxury. Right now, luxury vacations start at $348. Prices and availability are subject to change. Additional terms may apply.
How can I book a luxury family vacation in Missouri?
Tailor your luxury family escape by checking the filters that set the whole family’s hearts a-flutter. Whether that’s wet and wild water parks, heavenly hot tubs, or the kid-quieting magic of free Wi-Fi.
Can I book a package in Missouri with a luxury vacation home?
A private paradise is true luxury! Filter by property type for houses, villas, and apartments. For an amazingly affordable all-in-one luxury experience, book your accommodation, airfare, and car rental as a package.
How can I find the best luxury vacation deals in Missouri?
Find absolute delight in the dropdown! Simply sort your tempting search results by deals to find that lean-budget luxury. For a budget conscious stay, consider booking a stay away from big cities or outside the peak months.
Can I book a luxury holiday in Missouri with free cancellation and/or flexible dates?
Freedom and flexibility are the greatest luxuries of all. Get both when you filter by payment option and book a trip with free cancellation or on a buy now, pay later plan.
Why should I book my luxury trip to Missouri with Expedia?
A luxurious trip follows a stress-free booking experience. Find, build, and book the most glorious of getaways in seconds—with ATOL protection for added peace of mind.
Top Luxury Missouri Hotels

The Royal Sonesta Chase Park Plaza St. Louis
Loud music till after midnight
Reviewed on Oct 11, 2025

Ameristar Casino Resort and Spa
Great place to stay.Will visit again.
Reviewed on Oct 19, 2025

The Ritz-Carlton, St. Louis
Service is exceptional!!!
Reviewed on Sep 2, 2025


















