Title: East Prairie Vacation Rentals from $147: Search Short-Term Rentals | Expedia.com

[East Prairie Travel Guide](https://expedia.com/East-Prairie.dx3000349349)[Hotels in East Prairie](https://expedia.com/East-Prairie-Hotels.d3000349349.Travel-Guide-Hotels)[Car Rentals in East Prairie](https://expedia.com/Car-Rentals-In-East-Prairie.d3000349349.Car-Rental-Guide)[East Prairie Vacation Packages](https://expedia.com/East-Prairie.d3000349349.Destination-Travel-Guides)

![The Mississippi River near Hannibal, Missouri, USA](https://images.trvl-media.com/place/6209928/2afb9a4b-494b-462a-af23-159cb6a96bb2.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/6209928/2afb9a4b-494b-462a-af23-159cb6a96bb2.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

- ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light_bundle_and_save.svg)  
###  
Bundle & Save  
Get more, spend less whenever you see Bundle & Save deals
- ![](https://a.travel-assets.com/travel-assets-manager/pictograms-expedia/light__onekey.svg)  
###  
OneKeyCash  
Earn OneKeyCash on all your eligible bookings
- ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light_ftc.svg)  
###  
Upfront pricing  
We are not like the others - we include taxes and fees

## Check prices for these dates

In two weeks

[Apr 10 - Apr 12](https://www.expedia.com/Hotel-Search?regionId=3000349349&startDate=2026-04-10&endDate=2026-04-12&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two months

[May 22 - May 24](https://www.expedia.com/Hotel-Search?regionId=3000349349&startDate=2026-05-22&endDate=2026-05-24&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In three months

[Jun 19 - Jun 21](https://www.expedia.com/Hotel-Search?regionId=3000349349&startDate=2026-06-19&endDate=2026-06-21&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In four months

[Jul 17 - Jul 19](https://www.expedia.com/Hotel-Search?regionId=3000349349&startDate=2026-07-17&endDate=2026-07-19&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for East Prairie vacation rentals

![Exterior](https://images.trvl-media.com/lodging/101000000/100010000/100003200/100003129/e62caca8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Game room](https://images.trvl-media.com/lodging/101000000/100010000/100003200/100003129/2ea326ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/101000000/100010000/100003200/100003129/aa35e2af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Game room](https://images.trvl-media.com/lodging/101000000/100010000/100003200/100003129/w2704h1794x0y6-e0b375b4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Guest house and spacious shop located between Discovery Park and Reelfoot Lake

[](https://www.expedia.com/Union-City-Hotels-Guest-House-And-Spacious-Shop-Located-Between-Discovery-Park-And-Reelfoot-Lake.h100003129.Hotel-Information)

Union City

10/10

Exceptional

(3 reviews)

"Wonderful place to relax. Home has everything you need. The additional party barn is an added bonus!!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

william P.

$345 nightly

$387 total

Mar 27 - Mar 28

Total with taxes and fees

[](https://www.expedia.com/Union-City-Hotels-Guest-House-And-Spacious-Shop-Located-Between-Discovery-Park-And-Reelfoot-Lake.h100003129.Hotel-Information)

![Smart TV](https://images.trvl-media.com/lodging/102000000/101880000/101879200/101879138/0d61a825.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior detail](https://images.trvl-media.com/lodging/102000000/101880000/101879200/101879138/342c28ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/102000000/101880000/101879200/101879138/98a7dc87.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/102000000/101880000/101879200/101879138/5fe9a626.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Tiny house on the lake with tv free internet walk shower 

[](https://www.expedia.com/Tiptonville-Hotels-Tiny-House-On-The-Lake-With-A-Seventy-Five-Inch-T-V-Free-Internet-Walk-Shower.h101879138.Hotel-Information)

Tiptonville

10/10

Exceptional

(1 review)

"Dave was very accommodating and the home was clean."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Katherine P.

$220 nightly

$249 total

Mar 29 - Mar 30

Total with taxes and fees

[](https://www.expedia.com/Tiptonville-Hotels-Tiny-House-On-The-Lake-With-A-Seventy-Five-Inch-T-V-Free-Internet-Walk-Shower.h101879138.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/121000000/120470000/120467300/120467279/w1060h720x0y199-6f809fb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/121000000/120470000/120467300/120467279/w1050h1619x0y1-13beb152.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/121000000/120470000/120467300/120467279/18e1eee4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/121000000/120470000/120467300/120467279/w1080h809x0y1-d7340261.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Spacious 3-bedroom 2 story house in New Madrid near boat ramp with a toy room!

[](https://www.expedia.com/New-Madrid-Hotels-Spacious-3-Bedroom-2-Story-House-In-New-Madrid-Near-Boat-Ramp-With-A-Toy-Room.h120467279.Hotel-Information)

New Madrid

10/10

Exceptional

(1 review)

"The host was very quick to respond and so great to work with for on our stay. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jessica S.

$343 nightly

$369 total

Mar 27 - Mar 28

Total with taxes and fees

[](https://www.expedia.com/New-Madrid-Hotels-Spacious-3-Bedroom-2-Story-House-In-New-Madrid-Near-Boat-Ramp-With-A-Toy-Room.h120467279.Hotel-Information)

![Smart TV](https://images.trvl-media.com/lodging/123000000/122910000/122905300/122905281/3df6bc42.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/123000000/122910000/122905300/122905281/4d3b20d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, free WiFi, bed sheets](https://images.trvl-media.com/lodging/123000000/122910000/122905300/122905281/f9ad8a19.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/123000000/122910000/122905300/122905281/w1170h1560x0y486-d4d3ef58.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Tranquil charming Tiny House in Clinton

[](https://www.expedia.com/Clinton-Hotels-Tranquil-Charming-Tiny-House-In-Clinton.h122905281.Hotel-Information)

Clinton

10/10

Exceptional

(1 review)

"Super clean and comfortable. We were in the area visiting family and were so happy to find this rental. Very clean, comfortable beds, great sheets and towels. Thank you Zack and Tiff for opening your cute little rental to us. We hope you’re not booked when we return. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Laura K.

$137 nightly

$147 total

Apr 6 - Apr 7

Total with taxes and fees

[](https://www.expedia.com/Clinton-Hotels-Tranquil-Charming-Tiny-House-In-Clinton.h122905281.Hotel-Information)

![3 bedrooms, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/103000000/102520000/102511000/102510923/90dc3081.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Sun loungers, beach towels](https://images.trvl-media.com/lodging/103000000/102520000/102511000/102510923/f35fc192.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/103000000/102520000/102511000/102510923/8a25ec43.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/103000000/102520000/102511000/102510923/1c5aa03a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Sunkist beach house. Lake side house 3 bedroom house 

[](https://www.expedia.com/Tiptonville-Hotels-Sunkist-Beach-House-Lake-Side-House-3-Bedroom-House.h102510923.Hotel-Information)

Tiptonville

10/10

Exceptional

(5 reviews)

"Great experience!! A quality stay with great communication from Host. Will be back! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Steven L.

$298 nightly

$336 total

Mar 29 - Mar 30

Total with taxes and fees

[](https://www.expedia.com/Tiptonville-Hotels-Sunkist-Beach-House-Lake-Side-House-3-Bedroom-House.h102510923.Hotel-Information)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/112000000/111290000/111280100/111280094/7665fbaf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/112000000/111290000/111280100/111280094/fc29d09c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bedrooms, free WiFi, bed sheets](https://images.trvl-media.com/lodging/112000000/111290000/111280100/111280094/c83a39ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/112000000/111290000/111280100/111280094/fe24930b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Charming 3-bedroom house with WiFi, AC in amazing Hornbeak

[](https://www.expedia.com/Hornbeak-Hotels-Charming-3-Bedroom-House-With-WiFi.h111280094.Hotel-Information)

Hornbeak

10/10

Exceptional

(8 reviews)

"It was enjoyable and loved the house."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Paula F.

$248 nightly

$277 total

Apr 1 - Apr 2

Total with taxes and fees

[](https://www.expedia.com/Hornbeak-Hotels-Charming-3-Bedroom-House-With-WiFi.h111280094.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/108000000/107420000/107417500/107417404/w1290h1708x0y0-a392dd72.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/108000000/107420000/107417500/107417404/3f3e0d3c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/108000000/107420000/107417500/107417404/w1290h965x0y5-54bb22e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, DVD player](https://images.trvl-media.com/lodging/108000000/107420000/107417500/107417404/6a397950.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Hut. Cozy 2-bedroom mobile home on peaceful Reelfoot Lake with boat shed

[](https://www.expedia.com/Hornbeak-Hotels-The-Hut-Cozy-2-Bedroom-Mobile-Home-On-Peaceful-Reelfoot-Lake-With-Boat-Shed.h107417404.Hotel-Information)

Hornbeak

9.8/10

Exceptional

(51 reviews)

"The boat shed was a nice feature "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Drew N.

$213 nightly

$239 total

Mar 30 - Mar 31

Total with taxes and fees

[](https://www.expedia.com/Hornbeak-Hotels-The-Hut-Cozy-2-Bedroom-Mobile-Home-On-Peaceful-Reelfoot-Lake-With-Boat-Shed.h107417404.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/35000000/34850000/34845100/34845085/24a898e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, books, stereo](https://images.trvl-media.com/lodging/35000000/34850000/34845100/34845085/b28544f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/35000000/34850000/34845100/34845085/6bb8aa1f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, books, stereo](https://images.trvl-media.com/lodging/35000000/34850000/34845100/34845085/a5e0a4ec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Fish cleaning station, screened porch, covered front porch, fire pit, 3 BR 

[](https://www.expedia.com/Hornbeak-Hotels-Fish-Cleaning-Station.h34845085.Hotel-Information)

Hornbeak

9.8/10

Exceptional

(57 reviews)

"Had a wonderful time. Trying to plan next trip now. Hopefully we will be back there soon."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jeffrey J.

$233 nightly

$261 total

Mar 29 - Mar 30

Total with taxes and fees

[](https://www.expedia.com/Hornbeak-Hotels-Fish-Cleaning-Station.h34845085.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/124000000/123260000/123259200/123259172/5c6ff00e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/124000000/123260000/123259200/123259172/88df0145.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/124000000/123260000/123259200/123259172/a5c514e2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior detail](https://images.trvl-media.com/lodging/124000000/123260000/123259200/123259172/9ae9fe29.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### 3 bedroom house on Reelfoot Lake, perfect for families, fisherman and hunters

[](https://www.expedia.com/Hornbeak-Hotels-3-Bedroom-House-On-Reelfoot-Lake.h123259172.Hotel-Information)

Hornbeak

10/10

Exceptional

(5 reviews)

"The house was exaclty what we needed. It had everything we needed. We will be back. Great set up for a large group. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jon R.

$312 nightly

$350 total

Apr 9 - Apr 10

Total with taxes and fees

[](https://www.expedia.com/Hornbeak-Hotels-3-Bedroom-House-On-Reelfoot-Lake.h123259172.Hotel-Information)

![Private kitchen](https://images.trvl-media.com/lodging/127000000/126440000/126436700/126436651/08507a50.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/127000000/126440000/126436700/126436651/6f622dd9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/127000000/126440000/126436700/126436651/0af4355b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/127000000/126440000/126436700/126436651/6eb39dd0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### 3-bedroom house in charming Tiptonville with cool AC and washer and dryer

[](https://www.expedia.com/Tiptonville-Hotels-3-Bedroom-House-In-Charming-Tiptonville-With-Cool-AC-And-Washer-And-Dryer.h126436651.Hotel-Information)

Tiptonville

10/10

Exceptional

(1 review)

"Easy to get along with and great communication. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Shane W.

$205 nightly

$232 total

Mar 27 - Mar 28

Total with taxes and fees

[](https://www.expedia.com/Tiptonville-Hotels-3-Bedroom-House-In-Charming-Tiptonville-With-Cool-AC-And-Washer-And-Dryer.h126436651.Hotel-Information)

![Outdoor dining](https://images.trvl-media.com/lodging/84000000/83580000/83572000/83571978/0a58d14b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/84000000/83580000/83572000/83571978/f02f9bdf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/84000000/83580000/83572000/83571978/1529d729.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/84000000/83580000/83572000/83571978/35dace91.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Come and relax at the Refuge at beautiful Reelfoot Lake!

[](https://www.expedia.com/Hornbeak-Hotels-Enjoy-Beautiful-Sunsets-At-The-HUT-2-At-Beautiful-Reelfoot-Lake.h83571978.Hotel-Information)

Hornbeak

9.4/10

Exceptional

(27 reviews)

"Great place "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

William

$216 nightly

$242 total

Mar 29 - Mar 30

Total with taxes and fees

[](https://www.expedia.com/Hornbeak-Hotels-Enjoy-Beautiful-Sunsets-At-The-HUT-2-At-Beautiful-Reelfoot-Lake.h83571978.Hotel-Information)

![Outdoor dining](https://images.trvl-media.com/lodging/123000000/122500000/122496300/122496264/f77528b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/123000000/122500000/122496300/122496264/dc850646.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, coffee/tea maker, toaster](https://images.trvl-media.com/lodging/123000000/122500000/122496300/122496264/3b2e432e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, free WiFi, bed sheets](https://images.trvl-media.com/lodging/123000000/122500000/122496300/122496264/0181be39.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation rental attached to our house out in the country.

[](https://www.expedia.com/Union-City-Hotels-Vacation-Rental-Attached-To-Our-House-Out-In-The-Country.h122496264.Hotel-Information)

Union City

10/10

Exceptional

(1 review)

"Nice place. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Andrew E.

$145 nightly

$162 total

Mar 27 - Mar 28

Total with taxes and fees

[](https://www.expedia.com/Union-City-Hotels-Vacation-Rental-Attached-To-Our-House-Out-In-The-Country.h122496264.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/117000000/116630000/116626500/116626464/a12e4687.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/117000000/116630000/116626500/116626464/ac4ffd68.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Microwave, oven, stovetop](https://images.trvl-media.com/lodging/117000000/116630000/116626500/116626464/2c7cc866.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bedrooms, free WiFi, bed sheets](https://images.trvl-media.com/lodging/117000000/116630000/116626500/116626464/7517dd01.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Hut II on Reelfoot Lake

[](https://www.expedia.com/Hornbeak-Hotels-The-Hut-II-On-Reelfoot-Lake.h116626464.Hotel-Information)

Hornbeak

9.0/10

Wonderful

(4 reviews)

"It’s one of our favorite places to stay. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Laura W.

$215 nightly

$241 total

Mar 29 - Mar 30

Total with taxes and fees

[](https://www.expedia.com/Hornbeak-Hotels-The-Hut-II-On-Reelfoot-Lake.h116626464.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.com/Hotel-Search?startDate=2026-04-09&endDate=2026-04-10&regionId=3000349349&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true)

## Find vacation rentals that suit your style

Cottages

[](https://www.expedia.com/Hotel-Search?destination=East+Prairie%2C+Missouri%2C+United+States+of+America&regionId=3000349349&latLong=36.779778%2C-89.38563&adults=2&startDate=2026-06-24&d1=2026-06-24&endDate=2026-06-27&d2=2026-06-27&lodging=COTTAGE)

Cabins

[](https://www.expedia.com/Hotel-Search?destination=East+Prairie%2C+Missouri%2C+United+States+of+America&regionId=3000349349&latLong=36.779778%2C-89.38563&adults=2&startDate=2026-06-24&d1=2026-06-24&endDate=2026-06-27&d2=2026-06-27&lodging=CABIN)

Private vacation homes

[](https://www.expedia.com/Hotel-Search?destination=East+Prairie%2C+Missouri%2C+United+States+of+America&regionId=3000349349&latLong=36.779778%2C-89.38563&adults=2&startDate=2026-06-24&d1=2026-06-24&endDate=2026-06-27&d2=2026-06-27&lodging=VACATION_HOME)

Condos

[](https://www.expedia.com/Hotel-Search?destination=East+Prairie%2C+Missouri%2C+United+States+of+America&regionId=3000349349&latLong=36.779778%2C-89.38563&adults=2&startDate=2026-06-24&d1=2026-06-24&endDate=2026-06-27&d2=2026-06-27&lodging=CONDO)

Apartments

[](https://www.expedia.com/Hotel-Search?destination=East+Prairie%2C+Missouri%2C+United+States+of+America&regionId=3000349349&latLong=36.779778%2C-89.38563&adults=2&startDate=2026-06-24&d1=2026-06-24&endDate=2026-06-27&d2=2026-06-27&lodging=APARTMENT)

![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg)

Save an average of 15% on thousands of hotels when you're signed in

[Sign in

](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FEast-Prairie-Vacation-Rentals.d3000349349.Travel-Guide-VacationRentals)[

Sign up, it's free

](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FEast-Prairie-Vacation-Rentals.d3000349349.Travel-Guide-VacationRentals)

## Top East Prairie Hotel Reviews

![Country Yard Inn and Suite](https://images.trvl-media.com/lodging/91000000/90830000/90821500/90821467/fa4ef12a_y.jpg)

### Country Yard Inn and Suite

4/10 Poor

"Yes, parking seemed just like a regular parkikg area. Well lit i believe. The room was able to be kept sufficiently cool. "

[](https://expedia.com/Sikeston-Hotels-Country-Yard-Inn-And-Suite.h90821467.Hotel-Information)

![Days Inn and Suites by Wyndham Sikeston](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/be0d2e33_y.jpg)

### Days Inn and Suites by Wyndham Sikeston

2/10 Terrible

"There were roaches crawling up the wall when we went in and the outside was horrible! Looked like a vacant building!! I want my money back"

[](https://expedia.com/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information)

![Drury Inn & Suites Sikeston, MO](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/85184a8e_y.jpg)

### Drury Inn & Suites Sikeston, MO

8/10 Good

"Bedding needs to be updated. Pillows smelled and carpet could be cleaned. Bathroom was clean. Staff was friendly and helpful. "

[](https://expedia.com/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information)

![Holiday Inn Express & Suites Sikeston Southwest by IHG](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/1fd79e2a_y.jpg)

### Holiday Inn Express & Suites Sikeston Southwest by IHG

10/10 Excellent

"Clean rooms, friendly staff and convenient location."

[](https://expedia.com/Sikeston-Hotels-Holiday-Inn-Express-Suites-Sikeston-Southwest.h8144106.Hotel-Information)

![Best Western Plus Sikeston I-55](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/29a4ab37_y.jpg)

### Best Western Plus Sikeston I-55

10/10 Excellent

"Breakfast selection was fresh but not overwhelming in quality."

[](https://expedia.com/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information)

![Fairfield Inn & Suites by Marriott Sikeston](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/f2cf9c54_y.jpg)

### Fairfield Inn & Suites by Marriott Sikeston

10/10 Excellent

"Staff was amazing so friendly and welcoming. Room was very clean! "

[](https://expedia.com/Fairfield-By-Marriott-Inn-Suites-Sikeston.h111247451.Hotel-Information)

![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/77525d07_y.jpg)

### Hampton Inn Sikeston

10/10 Excellent

"Very nice and helpful staff "

[](https://expedia.com/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information)

![Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/47690ac7_y.jpg)

### Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

10/10 Excellent

"Very nice place, very nice stay! They were out of cream cheese for the bagels at breakfast though.:-)"

[](https://expedia.com/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information)

![Reelfoot Lake Inn](https://images.trvl-media.com/lodging/17000000/16770000/16770000/16769945/543bd231_y.jpg)

### Reelfoot Lake Inn

6/10 Okay

"No stores close by . the room had a musty smell. In need of upgrade. "

[](https://expedia.com/Union-City-Hotels-Reelfoot-Lake-Inn.h16769945.Hotel-Information)

## Find out more about East Prairie

**Everything you need to know about East Prairie vacation rentals**

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the East Prairie vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect East Prairie vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

**East Prairie vacation rentals: An excellent choice for every season**

Whenever you want to travel, a warm welcome awaits you in East Prairie. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit East Prairie in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $147 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

**How to find incredible deals on East Prairie rentals**

At Expedia, we put the best East Prairie vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top East Prairie rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream East Prairie vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around East Prairie. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

## Explore a world of travel with Expedia

- Trending destinations on Expedia.com
- All accommodation types in East Prairie

### Trending destinations on Expedia.com

- [Destin Vacation Rentals ](https://www.expedia.com/Destin-Vacation-Rentals.d6906.Travel-Guide-VacationRentals)
- [Panama City Vacation Rentals ](https://www.expedia.com/Panama-City-Beach-Vacation-Rentals.d8021.Travel-Guide-VacationRentals)
- [Hilton Head Vacation Rentals ](https://www.expedia.com/Hilton-Head-Island-Vacation-Rentals.d601684.Travel-Guide-VacationRentals)
- [Gulf Shores Vacation Rentals ](https://www.expedia.com/Gulf-Shores-Vacation-Rentals.d603078.Travel-Guide-VacationRentals)
- [Key West Vacation Rentals ](https://www.expedia.com/Key-West-Vacation-Rentals.d1187.Travel-Guide-VacationRentals)
- [Gatlinburg Vacation Rentals ](https://www.expedia.com/Gatlinburg-Vacation-Rentals.d7474.Travel-Guide-VacationRentals)
- [Maui Vacation Rentals ](https://www.expedia.com/Maui-Vacation-Rentals.d180073.Travel-Guide-VacationRentals)
- [Orlando Vacation Rentals ](https://www.expedia.com/Orlando-Vacation-Rentals.d178294.Travel-Guide-VacationRentals)
- [Myrtle Beach Vacation Rentals ](https://www.expedia.com/Myrtle-Beach-Vacation-Rentals.d601685.Travel-Guide-VacationRentals)
- [Orange Beach Vacation Rentals ](https://www.expedia.com/Orange-Beach-Vacation-Rentals.d9136.Travel-Guide-VacationRentals)
- [Pigeon Forge Vacation Rentals ](https://www.expedia.com/Pigeon-Forge-Vacation-Rentals.d8264.Travel-Guide-VacationRentals)
- [Ocean City Vacation Rentals ](https://www.expedia.com/Ocean-City-Vacation-Rentals.d9151.Travel-Guide-VacationRentals)
- [Outer Banks Vacation Rentals ](https://www.expedia.com/Outer-Banks-Vacation-Rentals.d602135.Travel-Guide-VacationRentals)
- [San Diego Vacation Rentals ](https://www.expedia.com/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals)
- [Siesta Key Vacation Rentals ](https://www.expedia.com/Siesta-Key-Vacation-Rentals.d6881.Travel-Guide-VacationRentals)
- [Galveston Vacation Rentals ](https://www.expedia.com/Galveston-Vacation-Rentals.d1341.Travel-Guide-VacationRentals)
- [Clearwater Beach Vacation Rentals ](https://www.expedia.com/Clearwater-Beach-Vacation-Rentals.d10759.Travel-Guide-VacationRentals)
- [Palm Springs Vacation Rentals ](https://www.expedia.com/Palm-Springs-Vacation-Rentals.d180676.Travel-Guide-VacationRentals)
- [Florida Keys Vacation Rentals ](https://www.expedia.com/Florida-Keys-Vacation-Rentals.d6023765.Travel-Guide-VacationRentals)
- [Lake Tahoe Vacation Rentals ](https://www.expedia.com/South-Lake-Tahoe-Vacation-Rentals.d10150.Travel-Guide-VacationRentals)
- [Lake of the Ozarks Vacation Rentals ](https://www.expedia.com/Lake-Ozark-Vacation-Rentals.d177772.Travel-Guide-VacationRentals)
- [Florida Vacation Rentals ](https://www.expedia.com/Destinations-In-Florida.d211.Vacation-Rental-Destinations)
- [Hawaii Vacation Rentals ](https://www.expedia.com/Destinations-In-Hawaii.d213.Vacation-Rental-Destinations)
- [Michigan Vacation Rentals ](https://www.expedia.com/Destinations-In-Michigan.d224.Vacation-Rental-Destinations)

- [Vacation Homes in East Prairie ](https://expedia.com/East-Prairie-Private-Vacation-Homes.d3000349349-aaPrivateVacationHomes.Travel-Guide-Accommodation)
- [Lodges in East Prairie ](https://expedia.com/East-Prairie-Lodges.d3000349349-aaLodges.Travel-Guide-Accommodation)
- [Motels in East Prairie ](https://expedia.com/East-Prairie-Motels.d3000349349-aaMotels.Travel-Guide-Accommodation)
- [Cottages in East Prairie ](https://expedia.com/East-Prairie-Cottages.d3000349349-aaCottages.Travel-Guide-Accommodation)
- [Apartments in East Prairie ](https://expedia.com/East-Prairie-Apartments.d3000349349-aaApartments.Travel-Guide-Accommodation)
- [Cabin Rentals in East Prairie ](https://expedia.com/East-Prairie-Cabins.d3000349349-aaCabins.Travel-Guide-Accommodation)
- [RV Parks in East Prairie ](https://expedia.com/East-Prairie-RV-Parks.d3000349349-aaRVParks.Travel-Guide-Accommodation)
- [Condo Rentals in East Prairie ](https://expedia.com/East-Prairie-Condos.d3000349349-aaCondos.Travel-Guide-Accommodation)

## Frequently asked questions

### Can I find a vacation rental in East Prairie?

### What's the top vacation rental that East Prairie has to offer?

### What can I see and do in East Prairie?

### What are vacation rentals like in East Prairie?

### Expedia's Latest Trends

Hotels

- [Columbia Hotels](https://expedia.com/Columbia-Hotels.d901.Travel-Guide-Hotels)
- [St. Joseph Hotels](https://expedia.com/St-Joseph-Hotels.d9934.Travel-Guide-Hotels)
- [Hermann Hotels](https://expedia.com/Hermann-Hotels.d183475.Travel-Guide-Hotels)
- [Branson Hotels](https://expedia.com/Branson-Hotels.d6058734.Travel-Guide-Hotels)
- [Branson Cheap Hotels](https://expedia.com/Branson-Hotels-Cheap-Hotels.0-0-d6058734-tCheapHotels.Travel-Guide-Filter-Hotels)
- [Poplar Bluff Hotels](https://expedia.com/Poplar-Bluff-Hotels.d9449.Travel-Guide-Hotels)
- [Cape Girardeau Hotels](https://expedia.com/Cape-Girardeau-Hotels.d820.Travel-Guide-Hotels)
- [Branson Hotels with an Indoor Pool](https://expedia.com/Branson-Hotels-Hotels-With-Indoor-Pool.0-0-d6058734-tHotelswithIndoorPool.Travel-Guide-Filter-Hotels)
- [Sikeston Hotels](https://expedia.com/Sikeston-Hotels.d6058766.Travel-Guide-Hotels)
- [Ridgedale Hotels](https://expedia.com/Ridgedale-Hotels.d183490.Travel-Guide-Hotels)
- [Springfield Hotels](https://expedia.com/Springfield-Hotels.d602962.Travel-Guide-Hotels)
- [Lake Ozark Hotels](https://expedia.com/Lake-Ozark-Hotels.d177772.Travel-Guide-Hotels)
- [Branson Family Hotels](https://expedia.com/Branson-Hotels-Family-Hotel.0-0-d6058734-tFamilyHotel.Travel-Guide-Filter-Hotels)
- [Joplin Hotels](https://expedia.com/Joplin-Hotels.d1705.Travel-Guide-Hotels)
- [Sedalia Hotels](https://expedia.com/Sedalia-Hotels.d6880.Travel-Guide-Hotels)
- [Rolla Hotels](https://expedia.com/Rolla-Hotels.d6058783.Travel-Guide-Hotels)
- [Springfield Cheap Hotels](https://expedia.com/Springfield-Hotels-Cheap-Hotels.0-0-d602962-tCheapHotels.Travel-Guide-Filter-Hotels)
- [Hannibal Hotels](https://expedia.com/Hannibal-Hotels.d6068.Travel-Guide-Hotels)
- [Jefferson City Hotels](https://expedia.com/Jefferson-City-Hotels.d8072.Travel-Guide-Hotels)
- [Camdenton Hotels](https://expedia.com/Camdenton-Hotels.d6048169.Travel-Guide-Hotels)
- [Kirksville Hotels](https://expedia.com/Kirksville-Hotels.d1630.Travel-Guide-Hotels)

Flights

- [Flights to Branson](https://expedia.com/Cheap-Flights-To-Branson.d6058734.Travel-Guide-Flights)
- [Flights to Columbia](https://expedia.com/Cheap-Flights-To-Columbia.d901.Travel-Guide-Flights)
- [Flights to Springfield](https://expedia.com/Cheap-Flights-To-Springfield.d602962.Travel-Guide-Flights)

Cars

- [Car rentals in Columbia](https://expedia.com/Car-Rentals-In-Columbia.d901.Car-Rental-Guide)
- [Car rentals in Springfield](https://expedia.com/Car-Rentals-In-Springfield.d602962.Car-Rental-Guide)

Activities

- [Things to do in Branson](https://expedia.com/Things-To-Do-In-Branson.d6058734.Travel-Guide-Activities)

Packages

- [Trip to Branson](https://expedia.com/Branson.d6058734.Destination-Travel-Guides)

Vacation Rentals

- [Rentals in Branson](https://expedia.com/Branson-Vacation-Rentals.d6058734.Travel-Guide-VacationRentals)

General

- [Visit Osage Beach](https://expedia.com/Osage-Beach.dx6058781)

![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg)

## Go further with the Expedia app

Save even more - get up to 20% on select hotels when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go.

Scan the QR code with your device camera and download our app