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Featured Sikeston Independent Hotels

See all 44 Hotels in Sikeston
Auburn Place Hotel And Suites

Auburn Place Hotel And Suites

3265 William St, Cape Girardeau
2.5 out of 5.0
4.4 out of 5 (78 reviews)
Nice Hotel Very nice; love the setup to the interior of the building. Great location, centrally located; food, … - 

$79

$79
Americas Best Value Inn & Suites Sikeston

Americas Best Value Inn & Suites Sikeston

220 S Interstate Dr, Sikeston
2.0 out of 5.0
3.5 out of 5 (74 reviews)
conditions Hotel was nice. But the bathroom is old and outdated. Vanity cabinet deteriorating from the water - 

$63

$63
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Sikeston
3.0 out of 5.0
4.7 out of 5 (82 reviews)
The neighborhood lost electric power the evening . - 

$95

$95
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

3303 Campster Drive, Cape Girardeau
3.0 out of 5.0
4.7 out of 5 (36 reviews)
Good experience We were satisfied with all aspects of our stay. The staff was friendly and helpful. - 

$105

$105
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy, Cape Girardeau
2.5 out of 5.0
4.1 out of 5 (50 reviews)
Family getting together Expedia ad and motel keyhole both advertised evening hors derives. None were available. - 

$80

$80
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3351 Percy Drive, Cape Girardeau
3.0 out of 5.0
4.2 out of 5 (5 reviews)
Relaxing Lanor Day getaway Nice clean new hotel. Friendly staff. Would definitely recommend and stay again when i am in the ar … - 

$120

$120
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

3248 William St, Cape Girardeau
2.5 out of 5.0
4.1 out of 5 (128 reviews)
Nice clean hotel. Close to restaurants and where we were visiting - 

$80

$80
Town House Inn Cape Giradreau

Town House Inn Cape Giradreau

505 North Kingshighway Street, Cape Girardeau
2.5 out of 5.0
1.0 out of 5 (2 reviews)

$54

$54
Pear Tree Inn - Sikeston

Pear Tree Inn - Sikeston

2602 E Malone Avenue, Sikeston
2.5 out of 5.0
4.3 out of 5 (81 reviews)
Great hotel, great staff We had a great time at this hotel. Very nice room, kids loved the pool. Adults loved the compliment … - 

$80

$80
Holiday Inn Express Hotel & Suites Cape Girardeau I-55

Holiday Inn Express Hotel & Suites Cape Girardeau I-55

3253 William Street, Cape Girardeau
2.5 out of 5.0
4.8 out of 5 (85 reviews)
Overnight Business Trip Super clean hotel. Staff very friendly. Room was perfect. - 

$110

$110
Oak Tree Inn Dexter

Oak Tree Inn Dexter

1608 Hwy Business 60 W, Dexter
2.5 out of 5.0
3.7 out of 5 (43 reviews)
Nice Hotel This is not a bad place to stay. In that part of the state just a couple to chose from. I strayed h … - 

$53

$53
Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

225 Drury Lane, Jackson
3.0 out of 5.0
4.8 out of 5 (56 reviews)
Nice hotel close to Interstate highway We chose this hotel because it was along our route from Iowa City to New Orleans. We booked it for … - 

$95

$95
Americas Best Value Inn-Murphysboro/Carbondale

Americas Best Value Inn-Murphysboro/Carbondale

128 E. Walnut Street, Murphysboro
1.5 out of 5.0
2.6 out of 5 (8 reviews)
Just Fine for a Country Motel I stayed here August 20, 2017, for the solar total eclipse the next day, worried the roads would be … - 

$75

$75
Motel 6 Sikeston MO

Motel 6 Sikeston MO

110 S Interstate Dr, Sikeston
2.0 out of 5.0
3.0 out of 5 (29 reviews)
Nice Motel 6 Everything was great except there was hair in the bathtub. - 

$60

$60
Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East

207 S Mt Auburn Rd, Cape Girardeau
2.5 out of 5.0
4.7 out of 5 (24 reviews)
Wonderful! This hotel has a cookie happy hour! My daughter left a shoe in the room and they did a great job getting it to us quickly! Great custom … - 

$101

$101
Super 8 Anna

Super 8 Anna

100 Richview Dr, Anna
2.0 out of 5.0
3.2 out of 5 (9 reviews)
Perfect for our needs. We stayed for three nights. Clean hotel. No complaints at all. Cost of room was well within our bud … - 

$68

$68
Town House Inn

Town House Inn

517 E Jackson Blvd, Jackson
2.5 out of 5.0
3.5 out of 5 (10 reviews)
Nice and clean rooms!! Staff was friendly. Our room was very nice and clean. Will definitely stay again!! - 

$70

$70
Holiday Inn Express & Suites Sikeston Southwest

Holiday Inn Express & Suites Sikeston Southwest

115 Hospitality Dr, Sikeston
2.5 out of 5.0
4.5 out of 5 (11 reviews)
Nice hotel heading back home. I have use this facility before in route to the deep south. The staff is quite pleasant and very he … - 

$110

$110
Dexter Inn

Dexter Inn

1807 W Business US Highway 60, Dexter
2.5 out of 5.0
1.9 out of 5 (9 reviews)
good people older motel well kept good for what we wanted a place to sleep - 

$60

$60
Americas Best Value Inn Ullin / Mounds

Americas Best Value Inn Ullin / Mounds

128 Cheekwood Lane, Ullin
2.0 out of 5.0
5.0 out of 5 (7 reviews)
went there for the eclipse Nice place, great staff- check out the nature preserves and canoe rental, cypress swamps, bbq place … - 

$75

$75
Map

Recently booked Sikeston hotels

Drury Inn & Suites Jackson MO
3.0 out of 5.0
Last booking: 12 minutes ago
Auburn Place Hotel And Suites
2.5 out of 5.0
Last booking: 1 hour ago
Americas Best Value Inn & Suites Sikeston
2.0 out of 5.0
Last booking: 1 hour ago
Oak Tree Inn Dexter
2.5 out of 5.0
Last booking: 2 hours ago
Pear Tree Inn - Sikeston
2.5 out of 5.0
Last booking: 2 hours ago
Drury Suites Cape Girardeau
3.0 out of 5.0
Last booking: 4 hours ago
Pear Tree Inn Cape Girardeau West
2.5 out of 5.0
Last booking: 16 hours ago
Quality Inn Charleston
2.5 out of 5.0
Last booking: 22 hours ago
Motel 6 Sikeston MO
2.0 out of 5.0
Last booking: 24 hours ago

Independent Sikeston Hotel Guide

Some globe-trotters choose hotels based on location, but others book by name. And thanks to Expedia you don’t have to pick. It is why we offer such an expansive range of Independent hotels in Sikeston, Missouri. Known for well-appointed rooms and friendly, personalized service, each of the top Independent Sikeston hotels guarantees an unparalleled level of comfort and quality.

You’ll find best-in-class amenities like clean rooms and quiet atmospheres, and some Sikeston Independent locations may even offer extra little benefits and discounts for frequent travelers.