A historic building with a dome and columns, surrounded by trees and benches.

Find 5 Star Hotels in Mesagne from $96

Check availability on Mesagne 5 Star Hotels

Tonight
Oct 24 - Oct 25
Tomorrow
Oct 25 - Oct 26
Next weekend
Oct 30 - Nov 1
In two weeks
Nov 6 - Nov 8

Our top choices for Mesagne 5-star hotels

A rooftop terrace with a table set for dining, surrounded by chairs, and a decorative urn.
A bedroom with a large bed, a bathtub, a wooden nightstand, and a chandelier.
A stone-walled indoor swimming pool with a small window and a door.
A dining area with a long table set for a meal, stone walls, and arched ceilings.

1. Palazzo Sant'Anna Lecce

Palazzo Sant'Anna Lecce
Lecce Historic Center
United States
Karen
$243 nightly
$279 total
Oct 27 - Oct 28
Total with taxes and fees
Palazzo Sant'Anna Lecce
A poolside area with lounge chairs and a swimming pool, surrounded by a historic building with stone walls and an arched entrance.
A spacious room with a large arched window, a wooden desk, comfortable seating, and a potted plant.
A restaurant with stone walls and wooden tables and chairs.
An aerial view of a castle-like hotel with a swimming pool, outdoor seating, and well-lit pathways.

2. Masseria Donna Menga

Masseria Donna Menga
Nardò
United States
Sam
$319 nightly
$363 total
Oct 25 - Oct 26
Total with taxes and fees
Masseria Donna Menga
A rooftop terrace with a swimming pool, sun loungers, and a view of the landscape.
A hotel with a pool, lounge chairs, and a view of a historic town with white buildings and a church.
A spacious lounge area with a high arched ceiling, a bar with a wine rack, and comfortable seating.
A terrace with outdoor seating and a view of a white-washed hilltop town.

3. VISTA Ostuni

VISTA Ostuni
Ostuni
United Kingdom
Marie
$540 nightly
$603 total
Nov 16 - Nov 17
Total with taxes and fees
VISTA Ostuni
A bedroom with a bed, a nightstand, a magazine, and a pair of glasses. There is a stone wall and a bathroom visible through a glass door.
A building with arched windows and a staircase leading to a terrace with outdoor seating.
A poolside area with lounge chairs and a view of the city.
A restaurant with a rustic stone archway, modern seating, and a view of the night sky.

4. La Sommità Relais & Chateaux

La Sommità Relais & Chateaux
Ostuni Historic Centre
United States
Carlos
$386 nightly
$434 total
Oct 25 - Oct 26
Total with taxes and fees
La Sommità Relais & Chateaux
A dining area with a table set for two, a wine glass, and a bottle. The room features exposed brick walls and a large window with a geometric design.
A narrow hallway with a dark wall, a sofa, a table, and a chair.
A bar area with a marble counter, black leather chairs, and a patterned floor.
A rustic dining area with a large round table, multiple wine glasses, and a central wooden column with a gear-like structure.

5. Paragon 700 Boutique Hotel & SPA

Paragon 700 Boutique Hotel & SPA
Ostuni
Canada
ardalan
$448 nightly
$502 total
Nov 15 - Nov 16
Total with taxes and fees
Paragon 700 Boutique Hotel & SPA
A spacious indoor area with multiple seating arrangements, a reception desk, and various potted plants.
A hotel room with a high arched ceiling, a bed, a sofa, a small table, and a mirror.
A hotel room with a large bed, a sitting area with a chair, a desk with a lamp, a mirror, and a view of the outdoors.
A breakfast table set with plates of food, including eggs, fruit, and pastries, in an outdoor dining area with chairs and a potted plant in the background.

6. La Fiermontina | Luxury Home

La Fiermontina | Luxury Home
Lecce Historic Center
United States
Carlos
$220 nightly
$251 total
Nov 10 - Nov 11
Total with taxes and fees
La Fiermontina | Luxury Home
A modern staircase with a metal railing, surrounded by sculptures and greenery.
A room with a geometric patterned floor, a large white sculpture, and a view of an outdoor patio with a table and chairs.
A marble sculpture of a reclining figure in an outdoor setting with steps and a stone wall in the background.
A wooden deck with outdoor furniture, a glass door leading to a room, and a view of a historic building in the background.

7. Fiermonte Museum by La Fiermontina

Fiermonte Museum by La Fiermontina
Lecce Historic Center
Canada
Dean
$285 nightly
$323 total
Nov 3 - Nov 4
Total with taxes and fees
Fiermonte Museum by La Fiermontina
A modern bedroom with a large bathtub, a sofa, a television, and a view of the outdoors.
A long table set for a formal event with clear glassware and white tablecloths.
A spacious kitchen with a long counter, multiple chairs, and large vases.
Pool

8. Masseria Malvindi

Masseria Malvindi
Mesagne
Switzerland
Rosmarie
Masseria Malvindi
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Mesagne.
Hotel Orientale

Hotel Orientale

C.so Garibaldi, 40 Brindisi BR
$112 nightly
$130 total
Nov 1 - Nov 2
Total with taxes and fees
Hotel Orientale
Ostuni a Mare

Ostuni a Mare

Loc. Rosa Marina Ostuni BR
Get rates
9/10 Wonderful! (139 reviews)
Ostuni a Mare
Hotel Monte Sarago

Hotel Monte Sarago

Corso Mazzini 233 Ostuni BR
$81 nightly
$96 total
Nov 7 - Nov 8
Total with taxes and fees
9.2/10 Wonderful! (337 reviews)
Hotel Monte Sarago
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Mesagne

The medieval castle dominates Mesagne's historic center, where you can explore ancient walls and baroque churches. Join locals at Piazza Orsini del Balzo for evening aperitivo, then wander narrow lanes to discover family-run trattorias serving Puglian specialties.

See all hotels in Mesagne
A historic building with a dome and columns, surrounded by trees and benches.

Top Mesagne Hotel Reviews

Masseria Donna Menga

Masseria Donna Menga

10/10 Excellent
"We absolutely loved our stay at Masseria Donna Menga. It’s such a beautiful, peaceful and relaxing place. The gardens and pool area are stunning, the rooms are lovely and the service was excellent. The staff were all so friendly and welcoming! Everything was just perfect, and we would happily come back!"
Aurora 1-night trip
Posted 2 weeks ago
Masseria Donna Menga

Find out more about Mesagne

Treat yourself on your next escape. After all, you love the finer things in life, both at home and when you book a getaway. You'll join the multitudes of vacationers who have made Mesagne so popular in the last year. There's no reason to delay a getaway to Mesagne any longer. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. Book one of Expedia's luxurious 5-star hotels in Mesagne and get ready to be pampered like never before. You deserve an outstanding getaway.

5-Star Hotels in Mesagne

You'll have a wonderful time at one of these 5-star hotels. Highly-rated eateries, exceptional customer care, and deeply relaxing spa offerings are waiting for you. You're sure to find exactly the accommodation you need. You'll also enjoy a high standard of care and meticulous guest relations, so get ready for a wonderful adventure. What kind of amenities will make your stay a wonderful one? A rejuvenating facial treatment to help your cares fall away? A concierge to help you suggest the next attraction to visit? Fluffy down pillows, piping hot coffees, and even spectacular views...these hotels are one-of-a-kind. Don't want to take our word for it? Explore our listings and pick the perfect accommodation for your needs.

But you aren't going to spend your entire vacation in your room, of course. We've got you covered. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what's on your agenda, the 5-star hotels in Mesagne are waiting for you to relax after a busy day.

Make Your Escape

The results are in, and Mesagne 5-star hotels are the place to be when you book your next vacation. If you've been dreaming about a vacation set here, then go ahead and book it. Expedia can help you land a great deal on accommodation. It's time to indulge yourself. Decide on one of the 5-star hotels in Mesagne today and decompress in the lap of luxury tomorrow.

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