A historic building with a dome and columns, surrounded by trees and benches.

Find 5 Star Hotels in Mesagne from $143

Check availability on Mesagne 5 Star Hotels

Tonight
Sep 27 - Sep 28
Tomorrow
Sep 28 - Sep 29
Next weekend
Oct 2 - Oct 4
In two weeks
Oct 9 - Oct 11

Our top choices for Mesagne 5-star hotels

A rooftop terrace with a swimming pool, sun loungers, and a view of the landscape.
A spacious lounge area with a high arched ceiling, a bar with a wine rack, and comfortable seating.
A terrace with outdoor seating and a view of a white-washed hilltop town.
A spacious lobby with a central seating area, high ceilings with skylights, and classical architecture with arches and columns.

1. VISTA Ostuni

VISTA Ostuni
Ostuni
United States
Anthony
$575 nightly
$632 total
Oct 21 - Oct 22
Total with taxes and fees
VISTA Ostuni
A poolside area with lounge chairs and a swimming pool, surrounded by a historic building with stone walls and an arched entrance.
A spacious room with a large arched window, a wooden desk, comfortable seating, and a potted plant.
A restaurant with stone walls and wooden tables and chairs.
An aerial view of a castle-like hotel with a swimming pool, outdoor seating, and well-lit pathways.

2. Masseria Donna Menga

Masseria Donna Menga
Nardò
United States
Sam
$331 nightly
$376 total
Oct 1 - Oct 2
Total with taxes and fees
Masseria Donna Menga
A modern bathroom with a freestanding bathtub, dark textured walls, and a minimalist design.
A spacious bedroom with a large bed, a round bathtub, a fireplace, and a vintage wardrobe.
A dining area with a table set for two, a wine glass, and a bottle. The room features exposed brick walls and a large window with a geometric design.
A narrow hallway with a dark wall, a sofa, a table, and a chair.

3. Paragon 700 Boutique Hotel & SPA

Paragon 700 Boutique Hotel & SPA
Ostuni
Canada
ardalan
$629 nightly
$701 total
Oct 20 - Oct 21
Total with taxes and fees
Paragon 700 Boutique Hotel & SPA
A bedroom with a bed, a nightstand, a magazine, and a pair of glasses. There is a stone wall and a bathroom visible through a glass door.
A building with arched windows and a staircase leading to a terrace with outdoor seating.
A restaurant with a rustic stone archway, modern seating, and a view of the night sky.
A poolside area with lounge chairs and a view of the city.

4. La Sommità Relais & Chateaux

La Sommità Relais & Chateaux
Ostuni Historic Centre
United Kingdom
Wayne
$400 nightly
$449 total
Oct 14 - Oct 15
Total with taxes and fees
La Sommità Relais & Chateaux
A rooftop terrace with a table set for dining, surrounded by chairs, and a decorative urn.
A bedroom with a large bed, a bathtub, a wooden nightstand, and a chandelier.
A dining area with a long table set for a meal, stone walls, and arched ceilings.
A rustic stone-walled room with a wooden table, a lamp, a chair, and a stack of towels.

5. Palazzo Sant'Anna Lecce

Palazzo Sant'Anna Lecce
Lecce Historic Center
United States
Karen
$228 nightly
$262 total
Oct 26 - Oct 27
Total with taxes and fees
Palazzo Sant'Anna Lecce
A spacious indoor area with multiple seating arrangements, a reception desk, and various potted plants.
A breakfast table set with plates of food, including eggs, fruit, and pastries, in an outdoor dining area with chairs and a potted plant in the background.
A hotel room with a large bed, a sitting area with a chair, a desk with a lamp, a mirror, and a view of the outdoors.
A modern hotel with a pool, outdoor seating, and large windows.

6. La Fiermontina | Luxury Home

La Fiermontina | Luxury Home
Lecce Historic Center
United States
Sandra L
$400 nightly
$451 total
Oct 22 - Oct 23
Total with taxes and fees
La Fiermontina | Luxury Home
A modern bedroom with a large bathtub, a sofa, a television, and a view of the outdoors.
A swimming pool with a circular light fixture on the wall and tables and chairs arranged around the pool.
A long table set with white tablecloths, wicker placemats, and white napkins.
A person sitting on a beige sofa with a view of a landscape through an open door.

7. Masseria Malvindi

Masseria Malvindi
Mesagne
Switzerland
Rosmarie
Masseria Malvindi
A modern staircase with a metal railing, surrounded by sculptures and greenery.
A dining area with a wooden table set for a meal, hanging copper pendant lights, and framed pictures on the wall.
A room with a geometric patterned floor, a large white sculpture, and a view of an outdoor patio with a table and chairs.
A marble sculpture of a reclining figure in an outdoor setting with steps and a stone wall in the background.

8. Fiermonte Museum by La Fiermontina

Fiermonte Museum by La Fiermontina
Lecce Historic Center
Canada
Dean
$295 nightly
$336 total
Oct 27 - Oct 28
Total with taxes and fees
Fiermonte Museum by La Fiermontina
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Mesagne.
Ostuni a Mare

Ostuni a Mare

Loc. Rosa Marina Ostuni BR
$190 nightly
$216 total
Oct 14 - Oct 15
Total with taxes and fees
9/10 Wonderful! (129 reviews)
Ostuni a Mare
Ostuni Palace Hotel Ristorante & SPA

Ostuni Palace Hotel Ristorante & SPA

Corso Vittorio Emanuele 218 Ostuni BR
$161 nightly
$184 total
Oct 7 - Oct 8
Total with taxes and fees
9.2/10 Wonderful! (177 reviews)
Ostuni Palace Hotel Ristorante & SPA
Hotel Orientale

Hotel Orientale

C.so Garibaldi, 40 Brindisi BR
$123 nightly
$143 total
Oct 27 - Oct 28
Total with taxes and fees
9.2/10 Wonderful! (511 reviews)
Hotel Orientale
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Mesagne

The medieval castle dominates Mesagne's historic center, where you can explore ancient walls and baroque churches. Join locals at Piazza Orsini del Balzo for evening aperitivo, then wander narrow lanes to discover family-run trattorias serving Puglian specialties.

See all hotels in Mesagne
A historic building with a dome and columns, surrounded by trees and benches.

Top Mesagne Hotel Reviews

Masseria Donna Menga

Masseria Donna Menga

10/10 Excellent
"One of our best stays in Puglia! We went to 4 different hotels and this was our absolute favorite"
Sam 1-night trip
Posted 2 months ago
Masseria Donna Menga

Find out more about Mesagne

Treat yourself on your next escape. After all, you love the finer things in life, both at home and when you book a getaway. You'll join the multitudes of vacationers who have made Mesagne so popular in the last year. There's no reason to delay a getaway to Mesagne any longer. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. Book one of Expedia's luxurious 5-star hotels in Mesagne and get ready to be pampered like never before. You deserve an outstanding getaway.

5-Star Hotels in Mesagne

You'll have a wonderful time at one of these 5-star hotels. Highly-rated eateries, exceptional customer care, and deeply relaxing spa offerings are waiting for you. You're sure to find exactly the accommodation you need. You'll also enjoy a high standard of care and meticulous guest relations, so get ready for a wonderful adventure. What kind of amenities will make your stay a wonderful one? A rejuvenating facial treatment to help your cares fall away? A concierge to help you suggest the next attraction to visit? Fluffy down pillows, piping hot coffees, and even spectacular views...these hotels are one-of-a-kind. Don't want to take our word for it? Explore our listings and pick the perfect accommodation for your needs.

But you aren't going to spend your entire vacation in your room, of course. We've got you covered. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what's on your agenda, the 5-star hotels in Mesagne are waiting for you to relax after a busy day.

Make Your Escape

The results are in, and Mesagne 5-star hotels are the place to be when you book your next vacation. If you've been dreaming about a vacation set here, then go ahead and book it. Expedia can help you land a great deal on accommodation. It's time to indulge yourself. Decide on one of the 5-star hotels in Mesagne today and decompress in the lap of luxury tomorrow.

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