A historic building with a dome and columns, surrounded by trees and benches.

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Check availability on Mesagne 5 Star Hotels

This weekend
Oct 30 - Nov 1
Next weekend
Nov 6 - Nov 8

Our top choices for Mesagne 5-star hotels

A rooftop terrace with a table set for dining, surrounded by chairs, and a decorative urn.

1. Palazzo Sant'Anna Lecce

Palazzo Sant'Anna Lecce
5.0 star property
Lecce Historic Center
10.0 out of 10, Exceptional, (297 reviews)
"Beautiful hotel, warm & friendly staff, great location"
United States
Karen
$280 nightly
The price is $317
Nov 7 - Nov 8
Total with taxes and fees
Palazzo Sant'Anna Lecce
A poolside area with lounge chairs and a swimming pool, surrounded by a historic building with stone walls and an arched entrance.

2. Masseria Donna Menga

Masseria Donna Menga
5.0 star property
Nardò
9.4 out of 10, Exceptional, (25 reviews)
"One of our best stays in Puglia! We went to 4 different hotels and this was our absolute favorite"
United States
Sam
$288 nightly
The price is $328
Oct 30 - Oct 31
Total with taxes and fees
Masseria Donna Menga
A rooftop terrace with a swimming pool, sun loungers, and a view of the landscape.

3. VISTA Ostuni

VISTA Ostuni
5.0 star property
Ostuni
10.0 out of 10, Exceptional, (31 reviews)
"Can't recommend enough, we had a wonderful stay."
United Kingdom
Marie
$533 nightly
The price is $595
Nov 15 - Nov 16
Total with taxes and fees
VISTA Ostuni
A bedroom with a bed, a nightstand, a magazine, and a pair of glasses. There is a stone wall and a bathroom visible through a glass door.

4. La Sommità Relais & Chateaux

La Sommità Relais & Chateaux
5.0 star property
Ostuni Historic Centre
9.4 out of 10, Exceptional, (204 reviews)
"I love the staff and hotel sooooo much"
United States
Carlos
$409 nightly
The price is $459
Oct 29 - Oct 30
Total with taxes and fees
La Sommità Relais & Chateaux
A modern bathroom with a freestanding bathtub, dark textured walls, and a minimalist design.

5. Paragon 700 Boutique Hotel & SPA

Paragon 700 Boutique Hotel & SPA
5.0 star property
Ostuni
9.6 out of 10, Exceptional, (46 reviews)
"Beautiful hotel Top notch Service , extremely friendly staff Food is delicious Spa is beautiful Six stars"
Canada
ardalan
$449 nightly
The price is $503
Nov 4 - Nov 5
Total with taxes and fees
Paragon 700 Boutique Hotel & SPA
A spacious indoor area with multiple seating arrangements, a reception desk, and various potted plants.

6. La Fiermontina | Luxury Home

La Fiermontina | Luxury Home
5.0 star property
Lecce Historic Center
9.8 out of 10, Exceptional, (70 reviews)
"Very convenient location, within easy walking distance of the historic center. The people who took care of us during our stay were very kind and helpful. We had a great experience and highly recommend this hotel!"
United States
Carlos
$219 nightly
The price is $250
Nov 12 - Nov 13
Total with taxes and fees
La Fiermontina | Luxury Home
A modern staircase with a metal railing, surrounded by sculptures and greenery.

7. Fiermonte Museum by La Fiermontina

Fiermonte Museum by La Fiermontina
5.0 star property
Lecce Historic Center
10.0 out of 10, Exceptional, (12 reviews)
"Beautiful clean room , the staff were very kind and helpful , the location was great , walking distance to historical sites, restaurants and piazzas"
Canada
Dean
$292 nightly
The price is $330
Nov 26 - Nov 27
Total with taxes and fees
Fiermonte Museum by La Fiermontina
A modern bedroom with a large bathtub, a sofa, a television, and a view of the outdoors.

8. Masseria Malvindi

Masseria Malvindi
5.0 star property
Mesagne
9.2 out of 10, Wonderful, (60 reviews)
"Fantastic team and wonderful location, highly recommend it to anyone with a car"
Switzerland
Rosmarie
Masseria Malvindi
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Mesagne.
Hotel Orientale

Hotel Orientale

C.so Garibaldi, 40 Brindisi BR
$105 nightly
The price is $122 total per night from Nov 28 to Nov 29
$122 total
Nov 28 - Nov 29
Total with taxes and fees
9.2/10 Wonderful! (526 reviews)
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Mesagne

The medieval castle dominates Mesagne's historic center, where you can explore ancient walls and baroque churches. Join locals at Piazza Orsini del Balzo for evening aperitivo, then wander narrow lanes to discover family-run trattorias serving Puglian specialties.

See all hotels in Mesagne
A historic building with a dome and columns, surrounded by trees and benches.

Top Mesagne Hotel Reviews

Masseria Donna Menga

Masseria Donna Menga

10/10 Excellent
"We absolutely loved our stay at Masseria Donna Menga. It’s such a beautiful, peaceful and relaxing place. The gardens and pool area are stunning, the rooms are lovely and the service was excellent. The staff were all so friendly and welcoming! Everything was just perfect, and we would happily come back!"
Aurora 1-night trip
Posted 3 weeks ago
Masseria Donna Menga

Find out more about Mesagne

Treat yourself on your next escape. After all, you love the finer things in life, both at home and when you book a getaway. You'll join the multitudes of vacationers who have made Mesagne so popular in the last year. There's no reason to delay a getaway to Mesagne any longer. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. Book one of Expedia's luxurious 5-star hotels in Mesagne and get ready to be pampered like never before. You deserve an outstanding getaway.

5-Star Hotels in Mesagne

You'll have a wonderful time at one of these 5-star hotels. Highly-rated eateries, exceptional customer care, and deeply relaxing spa offerings are waiting for you. You're sure to find exactly the accommodation you need. You'll also enjoy a high standard of care and meticulous guest relations, so get ready for a wonderful adventure. What kind of amenities will make your stay a wonderful one? A rejuvenating facial treatment to help your cares fall away? A concierge to help you suggest the next attraction to visit? Fluffy down pillows, piping hot coffees, and even spectacular views...these hotels are one-of-a-kind. Don't want to take our word for it? Explore our listings and pick the perfect accommodation for your needs.

But you aren't going to spend your entire vacation in your room, of course. We've got you covered. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what's on your agenda, the 5-star hotels in Mesagne are waiting for you to relax after a busy day.

Make Your Escape

The results are in, and Mesagne 5-star hotels are the place to be when you book your next vacation. If you've been dreaming about a vacation set here, then go ahead and book it. Expedia can help you land a great deal on accommodation. It's time to indulge yourself. Decide on one of the 5-star hotels in Mesagne today and decompress in the lap of luxury tomorrow.

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