The Best Hotels Closest to Biomuseo in Panama City for 2026

A modern building with colorful geometric shapes and a clear blue sky.

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Our top choices for Biomuseo hotels

A restaurant with multiple dining tables, chairs, and a central water feature.

A bar area with multiple seating options, a bar counter, and a fireplace.

A rooftop terrace with tables and chairs, a view of two white towers, and a building with a large window.

A historic building with ornate stonework and a balcony with plants.

1. Hotel La Compañía Casco Antiguo

San Felipe, 1.5 mi from Biomuseo

Carlos A

$251 nightly

$276 total

Oct 23 - Oct 24

Total with taxes and fees

A balcony with a table, chairs, and a view of a city skyline across a body of water.

A spacious living room with a high ceiling, large windows, and a decorative ceiling fan.

A hotel with a rooftop pool, lounge chairs, and a view of the sea.

A spacious lobby with high ceilings, modern furniture, and decorative lighting fixtures.

2. Sofitel Legend Casco Viejo, Panama City

San Felipe, 1.6 mi from Biomuseo

Jose

$414 nightly

$455 total

Nov 1 - Nov 2

Total with taxes and fees

A multi-story building with ornate balconies, large windows, and decorative moldings.

A room with a white sofa, a wooden chair, a mirror, and a large window with curtains.

A spacious restaurant with high wooden ceilings, multiple tables and chairs, and a bar area with shelves of bottles and glasses.

A luxurious room with ornate chandeliers, a large mirror, and a bar area with shelves of bottles.

3. Hotel Plaza Herrera

San Felipe, 1.5 mi from Biomuseo

Christina

$245 nightly

$270 total

Oct 25 - Oct 26

Total with taxes and fees

A restaurant interior with checkered flooring, wooden tables, wicker chairs, and hanging wicker lamps.

A rooftop terrace with a hot tub, wooden deck, outdoor seating, and a view of a cityscape including a clock tower.

A room with a brick wall, a wooden staircase, and hanging pendant lights.

A multi-level interior with a checkered floor, wooden railings, and potted plants.

4. Amarla Boutique Hotel Casco Viejo Adults Only

San Felipe, 1.6 mi from Biomuseo

Shanae

$208 nightly

$229 total

Oct 25 - Oct 26

Total with taxes and fees

A spacious outdoor patio with wicker furniture, potted plants, and umbrellas providing shade.

A dimly lit restaurant with wooden decor, tables, and chairs arranged for dining.

A modern bar area with wooden bar stools, a black countertop, and a display of wine bottles.

A modern hotel lobby with beige sofas, marble flooring, and a reception desk.

5. Hotel San Felipe

San Felipe, 1.5 mi from Biomuseo

Jordan

$157 nightly

$172 total

Oct 27 - Oct 28

Total with taxes and fees

A spacious indoor area with high ceilings, large windows, and multiple dining tables.

A white building with multiple balconies, large windows, and decorative railings.

A restaurant with brick walls, arched windows, and a variety of seating arrangements including tables and chairs.

A multi-story hotel with a central courtyard, balconies, and a view of the city skyline.

6. American Trade Hotel

San Felipe, 1.5 mi from Biomuseo

Ashleigh-Ann

$227 nightly

$251 total

Nov 15 - Nov 16

Total with taxes and fees

A spacious living area with a modern sofa, a wooden coffee table, and a staircase leading to an upper level.

A spacious living area with a large TV, a stone accent wall, and a modern kitchen in the background.

A modern kitchen with white cabinets, a dining table with chairs, and a spiral staircase.

A spiral staircase with a stone wall and a view of a living area with a fireplace.

7. Casa Lefevre By Wynwood House

San Felipe, 1.6 mi from Biomuseo

Selam

$186 nightly

$205 total

Nov 1 - Nov 2

Total with taxes and fees

A multi-story building with balconies, large windows, and a clear blue sky.

A hotel room with a brick wall, a large window with curtains, a bed with pillows, a nightstand, and a chair.

An outdoor patio with a white umbrella, lounge chairs, and a tiled floor.

A hallway with a brick wall, a blue door, and a chair with a cushion.

8. Las Clementinas

San Felipe, 1.6 mi from Biomuseo

James

$146 nightly

$161 total

Oct 28 - Oct 29

Total with taxes and fees

A multi-story building with balconies, arched windows, and decorative railings.

A spacious lobby with a wooden staircase, multiple seating areas, and a reception desk.

A building with a balcony and a street view.

A rooftop swimming pool with lounge chairs, potted plants, and a view of a city skyline including a prominent building with a dome.

9. Central Hotel Panama Casco Viejo

San Felipe, 1.5 mi from Biomuseo

Yvonne

$164 nightly

$180 total

Nov 4 - Nov 5

Total with taxes and fees

A hotel room with a bed, a desk with a computer, a chair, a mirror, and a staircase.

A spacious living area with a staircase leading to a second floor, a sofa, a TV, and a dining area.

A living room with a patterned sofa, a matching ottoman, a large mirror, and a staircase leading to an outdoor area.

A balcony with a view of a city skyline, a river, and a large tree.

10. Hotel Bardot Boutique

San Felipe, 1.6 mi from Biomuseo

Luz

$87 nightly

$97 total

Nov 22 - Nov 23

Total with taxes and fees

A modern indoor pool area with clear blue water, lounge chairs, and a wall of plants.

A balcony with a view of the sea, a table with a vase and a candle, and a chair.

A modern bedroom with a large window, a bed with white linens, a nightstand, and a painting on the wall.

A modern kitchen with a central island, stainless steel appliances, and a dining area with black chairs.

11. Casco View Life Residences

Santa Ana, 1.5 mi from Biomuseo

Arshak Andrew

$111 nightly

$122 total

Oct 25 - Oct 26

Total with taxes and fees

A spacious living room with blue sofas, a marble coffee table, and framed pictures on the walls.

A hotel room with a large bed, a TV, a balcony with a view of the outside, and a window with decorative ironwork.

A bedroom with a large bed, white walls, and a view of a building through arched windows.

12. Hotel Magnolia Boutique

San Felipe, 1.5 mi from Biomuseo

Boris

$80 nightly

$88 total

Nov 22 - Nov 23

Total with taxes and fees

A rooftop bar with a city skyline view, outdoor seating, and a bar area with bottles and glasses.

A room with a kitchenette, a sofa, a bed, and a mural with the phrase "Just Breathe".

A modern living room with a purple wall, two abstract paintings, a white sofa with colorful cushions, a wooden coffee table with books and bottles, and patterned floor tiles.

A restaurant interior with tables and chairs, decorative hanging lights, and a mural on the wall.

13. Tantalo Hotel

San Felipe, 1.6 mi from Biomuseo

Cynthia

$75 nightly

$83 total

Oct 27 - Oct 28

Total with taxes and fees

An outdoor patio area with wicker furniture and glass-top tables, surrounded by lush greenery and a view of the interior.

A rectangular swimming pool with a tiled edge, surrounded by a tiled patio area.

A living room with wicker furniture, a television, and a sliding glass door leading to a balcony with plants.

A hotel room with a bed, a ceiling fan, a TV, a refrigerator, and a window with curtains.

14. The Balboa Inn

Balboa, 1.7 mi from Biomuseo

Rhonda

$67 nightly

$75 total

Oct 28 - Oct 29

Total with taxes and fees

A resort with a pool area, lounge chairs, and a view of a bridge at night.

A formal dining area with round tables, white tablecloths, and blue lace borders.

A hotel room with a bed, a TV on a wooden cabinet, a nightstand with a lamp, and a view of the outdoors through a glass door.

A bar area with a counter, stools, and a seating area with tables and chairs.

15. Radisson Hotel Panama Canal

Amador, 0.9 mi from Biomuseo

Si Ming

$79 nightly

$87 total

Nov 9 - Nov 10

Total with taxes and fees

A modern bathroom with a glass shower enclosure, a herringbone wooden floor, and a stone wall feature.

A modern bathroom with a glass shower enclosure, a wooden door, and a herringbone-patterned floor.

A multi-story building with balconies adorned with string lights, a sign reading "ZABAH", and a storefront named "CORCHO".

16. Corcho

San Felipe, 1.5 mi from Biomuseo

Ashley

$88 nightly

$99 total

Nov 9 - Nov 10

Total with taxes and fees

A modern kitchen with a dining area, large windows, and a view of the city.

A modern bedroom with a large bed, bedside tables, a nightstand, a dresser, a small table with a bowl, and a hanging light fixture.

A modern kitchen with a built-in island, stainless steel appliances, and black bar stools.

A modern restaurant with a sushi bar, bar seating, and a mix of indoor and outdoor dining areas.

17. La Cuadra by Wynwood House

El Chorrillo, 1.4 mi from Biomuseo

Lise Jane

$158 nightly

$171 total

Oct 27 - Oct 28

Total with taxes and fees

A modern living room with a dining area, a sofa, and a round mirror on the wall.

A hotel room with a large bed, white walls, and a wardrobe with sliding doors.

A spacious room with a dining table, chairs, a sofa, and a large window.

A modern kitchen with white cabinets, a black induction cooktop, and a coffee maker.

18. Casa Love by Wynwood House

San Felipe, 1.4 mi from Biomuseo

Margarita Gricelda Hurtado

$107 nightly

$119 total

Oct 26 - Oct 27

Total with taxes and fees

A balcony with a view of a marina and a hilly landscape.

A modern building with a large metallic sculpture in the foreground, surrounded by palm trees and a clear blue sky.

A modern hotel lobby with a reception desk, seating area, and a large window overlooking the city.

A couple in white robes on a bed with a champagne bottle and ice bucket.

19. The Beach House

Amador, 1.6 mi from Biomuseo

JULIE

$69 nightly

$76 total

Oct 26 - Oct 27

Total with taxes and fees

A cozy indoor seating area with wooden chairs and tables, surrounded by shelves with plants and books.

A restaurant with a long counter, multiple tables, and a decorative fish tank.

A cozy café with wooden furniture, potted plants, and exposed pipes.

A modern hotel lobby with a reception desk, a large potted plant, and a minibar.

20. Viajero Casco Viejo Hostel

San Felipe, 1.6 mi from Biomuseo

Ashleigh

$31 nightly

$34 total

Oct 26 - Oct 27

Total with taxes and fees

View all properties

Compare popular hotels close to Biomuseo

Property	Star rating	Guest rating
Hotel La Compañía Casco Antiguo	9.8 Exceptional 365 reviews	View
Sofitel Legend Casco Viejo, Panama City	9.8 Exceptional 764 reviews	View
Hotel Plaza Herrera	9.8 Exceptional 51 reviews	View
Amarla Boutique Hotel Casco Viejo Adults Only	9.6 Exceptional 146 reviews	View
Hotel San Felipe	9.4 Exceptional 466 reviews	View

Top Biomuseo Hotel Reviews

Hotel Plaza Herrera

10/10 Excellent

"Perfect location in the middle of the historic old city. Excellent property condition (just renovated), spacious rooms. The staff was extremely helpful and friendly. A good breakfast to order is included at the downstairs restaurant. The only negative point is the absence of an elevator, so you will have to run up and down the stairs."

Sofitel Legend Casco Viejo, Panama City

10/10 Excellent

"Luxury, ideal location, great meals, spacious rooms, lots of in room amenities."

Central Hotel Panama Casco Viejo

8/10 Good

"Property was clean and nice, breakfast was excellent."

Hotel La Compañía Casco Antiguo

10/10 Excellent

"We like everything about this hotel. The hotel is even better than in pictures. Great location in the heart of Casco Viejo. Customer service is amazing."

Hotel San Felipe

10/10 Excellent

"Great location and awesome staff! Hotel San Felipe was perfect for exploring Casco Viejo! Large room and shower, patio area that we used to relax in the evenings and a great restaurant right across the street! If you plan to tour Casco Viejo this is a great place to stay! Looks and feels like the photos! You will not be disappointed:)"

Hotel Caracas - Casco Viejo

8/10 Good

"Room was clean and very basic. No frills! The bed and pillows were comfortable and the AC worked well. Good location."

La Palma Experience

8/10 Good

"Recibimos buena atención, aunque se presentaron algunos inconvenientes como que el aire acondicionado no enfría a suficiente o que la presión de agua no llegaba a la habitacion, nos ofrecieron cambio de habitaciones lo cual nos permitió evaluar todas las opciones. Yo regreso, pero si me gustaría un menú más variado en sus desayunos, almuerzos y cenas."

w* | Upscale 2BR in Casco Antiguo w/ View

10/10 Excellent

"Liked the cleanliness, amenities and property condition. Property location was centrally located with easy access to restaurants, grocery store and more. Watching the Pacific tide was really amasing. It was really a nice stay."

Casa Love by Wynwood House

10/10 Excellent

"The unit we stayed in was large and fully equipped, with a balcony and a full kitchen. The building was secure and conveniently located within walking distance to everything in casco viejo. There are lots of shops and restaurants nearby and we felt mostly safe walking around. The only issue we had was that the code to our lockbox didn’t work when we arrived. However, we texted the property staff and they were able to give us another code that worked right away. The internet in the unit worked fine, but be sure to have a data plan or eSIM so that you can connect with the property and order Ubers, especially when you first get in, as the WiFi in the airport can be very spotty."

Other attractions near Biomuseo

Amador Causeway

9.0/10 (1,902 reviews)

You can learn about the history of Ancon with a stop at Amador Causeway. Stroll along the seaside or visit the shops in this vibrant area.

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Amador Convention Center

9.2/10 (23 reviews)

Learn about the events happening at Amador Convention Center during your trip to Ancon. While in this walkable area, you can savor the top-notch restaurants.

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Punta Culebra Nature Center

9.0/10 (14 reviews)

Enjoy an outing to Punta Culebra Nature Center during your stay in Ancon. Stroll along the seaside in this vibrant area, or check out its top-notch restaurants.

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Maracana Stadium

8.0/10 (32 reviews)

Catch an event at Maracana Stadium during your trip to Panama City. Check out the shops and top-notch restaurants in this vibrant area.

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Smithsonian Tropical Research Institute Punta Culebra

9.2/10 (19 reviews)

You can spend time browsing the exhibits at Smithsonian Tropical Research Institute Punta Culebra in Ancon. Amble around this vibrant area's seaside and enjoy its top-notch restaurants.

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Danilo Perez Foundation

Explore the campus of Danilo Perez Foundation as part of your travels around Panama City. Check out the shops and top-notch restaurants in this vibrant area.

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Plaza de Francia

10.0/10 (1 review)

You can learn about the history of Panama City when you stop by Plaza de Francia. Check out the shops and top-notch restaurants in this vibrant area.

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Mola Museum

You can spend time browsing the exhibits at Mola Museum during your trip to Panama City. You can enjoy the bars while in the area.

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Frequently asked questions

What's the area like around Biomuseo?

Biomuseo is located in a vibrant area of Ancon known for its array of dining options and major shopping area. You'll find 1260 hotels and other accommodations within a few miles for a convenient home base.

What's the best hotel to stay near Biomuseo?

Radisson Hotel Panama Canal is one of the top choices for your stay based on our traveler data, and this hotel offers 2 outdoor pools and 2 restaurants. It's located just a short 0.9 mi (1.5 km) from Biomuseo. Another good choice is La Palma Experience, located just 0.7 mi (1.1 km) away.

How many hotels will I be able to find near Biomuseo?

Expedia has 1260 hotels and other accommodations a few miles from Biomuseo.

If I need to cancel the hotel reservation for my stay near Biomuseo, will I receive a refund?

Yes, you'll find most hotel bookings are fully refundable provided that you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you have a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Add your dates and click on "Search", then use the "fully refundable" filter to get the best options available near Biomuseo.

Where can I learn more about changing or cancelling my trip in the area near Biomuseo?

For more information about updating your stay near Biomuseo or cancelling it, click here.

What can I see and do near Biomuseo?

Interoceanic Canal Museum, Mola Museum, and Museum of History Panama feature a variety of fascinating exhibits to see while you're in town. Sights like Panama Canal Railway, Iglesia del Carmen, and Paseo de Las Bovedas are must-sees while exploring the area. You can catch a show at National Theater, Anita Villalaz Theater, and Amador Theater.

Find hotels near Biomuseo, Panama City from $34

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Our top choices for Biomuseo hotels

1. Hotel La Compañía Casco Antiguo

2. Sofitel Legend Casco Viejo, Panama City

3. Hotel Plaza Herrera

4. Amarla Boutique Hotel Casco Viejo Adults Only

5. Hotel San Felipe

6. American Trade Hotel

7. Casa Lefevre By Wynwood House

8. Las Clementinas

9. Central Hotel Panama Casco Viejo

10. Hotel Bardot Boutique

11. Casco View Life Residences

12. Hotel Magnolia Boutique

13. Tantalo Hotel

14. The Balboa Inn

15. Radisson Hotel Panama Canal

16. Corcho

17. La Cuadra by Wynwood House

18. Casa Love by Wynwood House

19. The Beach House

20. Viajero Casco Viejo Hostel

Compare popular hotels close to Biomuseo

Top Biomuseo Hotel Reviews

Hotel Plaza Herrera

Sofitel Legend Casco Viejo, Panama City

Central Hotel Panama Casco Viejo

Hotel La Compañía Casco Antiguo

Hotel San Felipe

Hotel Caracas - Casco Viejo

La Palma Experience

w* | Upscale 2BR in Casco Antiguo w/ View

Casa Love by Wynwood House

Other attractions near Biomuseo

Amador Causeway

Amador Convention Center

Punta Culebra Nature Center

Maracana Stadium

Smithsonian Tropical Research Institute Punta Culebra

Danilo Perez Foundation

Plaza de Francia

Mola Museum

Frequently asked questions