4/5 - Good
Verified traveler
Due to the coronavirus, we didn't really have an opportunity to check out Cape Girardeau, visiting with friends in their home instead. Next time though!
Cape Girardeau, MO
Travel Guide
Visit Cape Girardeau
Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive, Cape Girardeau, MO
$90 nightly
The price is $102 total per night from Nov 2 to Nov 3
$102 total
Nov 2 - Nov 3
Total with taxes and fees
Stay at this 3-star business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,019 reviews)
"Everything was great especially the staff"
Reviewed on Oct 16, 2025
The Riverview
777 Main St, Cape Girardeau, MO
$111 nightly
The price is $126 total per night from Oct 28 to Oct 29
$126 total
Oct 28 - Oct 29
Total with taxes and fees
Stay at this 4-star business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Isle Casino Cape Girardeau ...
9.2/10 Wonderful! (439 reviews)
"Nice clean quiet all around awesome and beautiful"
Reviewed on Oct 19, 2025
Pear Tree Inn Cape Girardeau Near the Medical Center
3248 William St, Cape Girardeau, MO
$70 nightly
The price is $79 total per night from Oct 23 to Oct 24
$79 total
Oct 23 - Oct 24
Total with taxes and fees
Stay at this hotel in Cape Girardeau. Enjoy free WiFi, a 24-hour front desk, and daily housekeeping. Our guests praise the helpful staff and the clean rooms ...
8.8/10 Excellent! (1,009 reviews)
"Room was a bit on the small side, but comfortable."
Reviewed on Oct 13, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Serenity South -- Gardens, River-Views, and Refreshing Space
Cape Girardeau
Book a stay at this family-friendly vacation home in Cape Girardeau. Enjoy a water park, a garden, and patios. Popular attractions eDen Spa & Salon and The Glenn ...
10/10 Exceptional! (144 reviews)
"Nice property near downtown in the river. This was the perfect location for our 50th high school reunion."
Reviewed on Oct 14, 2025
The Twisted Sassafras Treehouse
Cape Girardeau
Stay at this cabin in Cape Girardeau. Enjoy a garden, patios, and an in-room coffeemaker. Popular attractions Cape Girardeau Conservation Nature Center and Cape ...
10/10 Exceptional! (24 reviews)
"Amazing space. So nice being up in the trees. Had an amazing, relaxing time!!!"
Reviewed on Sep 20, 2025
Little Blue Cottage on Spanish
Cape Girardeau
Stay at this vacation home in Cape Girardeau. Popular attractions eDen Spa & Salon and The Glenn House are located nearby.
8.4/10 Very Good! (44 reviews)
All I needed
"Perfect location, close enough to walk to food and drink, and exactly one block off the main cruising route so I could watch and not be on the route. The fridge could be colder, and there's no oven, and the A/C is loud. But that was stuff I knew. The place was clean, and easy to find. The little ..."
Reviewed on Jul 22, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Popular places to visit
Southeast Missouri State University
4.5/5(76 reviews)
Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.
Isle Casino Cape Girardeau
4.5/5(48 reviews)
Why not roll the dice with a visit to Isle Casino Cape Girardeau during your travels in Cape Girardeau? While in this family-friendly area, you can savor the top-notch restaurants.
Riverfront Bridge Park
4.5/5(43 reviews)
Riverfront Bridge Park is just one of the places to see in Cape Girardeau, so why not enjoy the other things to explore during your travels? While in this family-friendly area, you can savor the top-notch restaurants.
Show Me Center
Catch an event at Show Me Center during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.
Saint Francis Medical Center
Though Saint Francis Medical Center might be what brings you to town, perhaps you'll have a chance to explore more of Cape Girardeau while you are here.
Riverfront Park
Riverfront Park is just one of the places to see in Cape Girardeau, so why not enjoy the other things to explore during your travels? While in this family-friendly area, you can savor the top-notch restaurants.
Reviews of Cape Girardeau
4.3
Top Destination
5/5 - Excellent
Verified traveler
We appreciated the close proximity of dining options enabling us to walk rather than getting back in the car after a long travel day.
3/5 - Okay
Verified traveler
I live here. Reason for the hotel was so my daughter could swim with her friends. And have a small birthday pool party and get out of the house for a night
5/5 - Excellent
Verified traveler
Just loved it all, the people,place's it was just wonderful..
5/5 - Excellent
Verified traveler
Love this city. Go see the bridge over into IL - beautiful!!! The city is a very pleasant place to visit.
4/5 - Good
Verified traveler
I really enjoyed the Missouri Wall of Fame.
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- Southeast Missouri State University
- Isle Casino Cape Girardeau
- Riverfront Bridge Park
- Riverfront Park
- Cape Rock Park
- Cape Splash Family Aquatic Center
- Hunter Valley Winery
- eDen Spa & Salon
- Cape Girardeau Conservation Nature Center
- Lazy L Safari Park
- Fort D Historic Site
- Shawnee National Forest
- Mississippi River
- Trail of Tears State Park