Southeast Missouri, MO
Travel Guide
Visit Southeast Missouri
Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive Cape Girardeau MO
$98 nightly
The price is $111 total per night from Sep 6 to Sep 7
$111 total
Sep 6 - Sep 7
Total with taxes and fees
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,003 reviews)
"Competitively priced. Complimentary happy hour and hot breakfast were exceptional. We stay at a Drury Inn whenever they are available."
Reviewed on Aug 27, 2026
Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
$58 nightly
The price is $64 total per night from Sep 13 to Sep 14
$64 total
Sep 13 - Sep 14
Total with taxes and fees
Book a stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff and the ...
The Riverview
777 Main St Cape Girardeau MO
Fully refundableReserve now, pay when you stay
$104 nightly
The price is $117 total per night from Sep 28 to Sep 29
$117 total
Sep 28 - Sep 29
Total with taxes and fees
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Century Casino & Hotel Cape ...
9.4/10 Exceptional! (647 reviews)
"Nice view of the river. The staff was nice."
Reviewed on Aug 23, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
7555 State Hwy Y French Village MO
Stay at this cabin in French Village. Enjoy free parking, patios, and climate control.
Lake Wappapello
8005 Missouri 172 Williamsville MO
Stay at this cabin in Williamsville. Enjoy free parking. Popular attractions North Main Street Historic District and Margaret Harwell Art Museum are located ...
Silo Farm Haus- located in the heart of wine country!
Ste. Genevieve MO
Stay at this vacation home in Ste Genevieve. Enjoy laundry facilities. Popular attractions Crown Valley Winery and Hawn State Park are located nearby.
10/10 Exceptional! (154 reviews)
"Our stay at the Silo House was absolutely wonderful! The home and surrounding property are stunning, and the peaceful setting made it the perfect escape from the hustle and bustle of everyday life. If you’re looking for a place to truly relax and recharge, this is it.My favorite part of the entire ..."
Reviewed on Jul 5, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Stay near popular Southeast Missouri attractions
Things to do
Night Ghost Tour of Pythian Castle in Springfield Missouri
$20
per adult
96% of travellers recommend
Explore a world of travel with Expedia
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- Visit Fredericktown
- Visit Park Hills
- Visit Ironton
- Walnut Hollow Lake
- Visit Perryville
- Visit Oran
- Visit Piedmont
- Visit Annapolis
- Visit Middle Brook
- Visit Jackson
- Visit Valles Mines
- Adults Only Vacation Packages Southeast Missouri
- Visit Desloge
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- Visit Belleview
- Visit Lesterville
- Visit Cape Girardeau
- Visit Van Buren
- Visit Black
- Visit Farmington
- Visit Pilot Knob
- Visit St. Francois County
- Visit Cadet
- Crane Lake Recreation Area
- Visit Poplar Bluff
- Visit New Offenburg
- Visit Bonne Terre
- Visit Wappapello
- Patterson Vacations
- Visit Leadwood
- Visit Dutchtown
- Visit Ellington
- Visit Caledonia
- Visit Marble Hill
- Visit Potosi
- Johnson's Shut-ins State Park
- United Rental Cars in Southeast Missouri
- Hertz Rental Cars in Southeast Missouri
- Top Rent a Car Rental Cars in Southeast Missouri
- Localiza Colombia Rental Cars in Annapolis
- Discount Car Rentals Rental Cars in Southeast Missouri
- Car rental Annapolis
- Car rental Central Fredericktown
- First-Car Rental Cars in Southeast Missouri
- Mark Twain National Forest
- Johnson's Shut-ins State Park
- Elephant Rocks State Park
- Southeast Missouri State University
- Century Casino & Hotel Cape Girardeau
- Ozark National Scenic Riverways
- Current River
- Taum Sauk Mountain State Park
- Century Casino Caruthersville
- Lake Wappapello
- Echo Bluff State Park
- Big Spring
- Current River State Park
- Alley Spring & Mill
- Rocky Falls
- K Bridge Recreation Area
- St. Joe State Park
- Washington State Park
- St. Francois State Park
- Hawn State Park
- National Shrine of Our Lady of the Miraculous Medal
- Black River Coliseum
- Hunter Valley Winery
- Riverfront Park
- Riverfront Bridge Park
