Name: Drury Inn & Suites Sikeston, MO
Price range: $122 total
Rating: 9.4

Drury Plaza Hotel Cape Girardeau Conference Center

3351 Percy Drive Cape Girardeau MO

$100 nightly

$113 total

Apr 19 - Apr 20

Total with taxes and fees

Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...

9.6/10 Exceptional! (1,004 reviews)

The hotel, staff and food were all top of the line. Awesome stay!

Reviewed on Apr 9, 2026

The Riverview

777 Main St Cape Girardeau MO

$122 nightly

$138 total

Apr 20 - Apr 21

Total with taxes and fees

Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Century Casino & Hotel Cape ...

9.4/10 Exceptional! (545 reviews)

Nice stay in Cape. Unfortunately I didn't have a great view from my room, but I didn't pay for the river view so that was expected. In general it was a lovely clean hotel, with everything I needed.

Reviewed on Apr 10, 2026

Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Miner Sikeston MO

$106 nightly

$122 total

Apr 20 - Apr 21

Total with taxes and fees

Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...

9.4/10 Exceptional! (1,004 reviews)

Helpful and friendly staff. Room and hotel was clean. A great stay!

Reviewed on Apr 10, 2026

See all 644 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

7555 State Hwy Y French Village MO

Stay at this cabin in French Village. Enjoy free parking, patios, and climate control.

9.8/10 Exceptional! (58 reviews)

Cozy and most of all very accomodating staff. The best stay.. there is no one like it. (No exaggeration)

Reviewed on Apr 10, 2026

St Francis River: The Blue Yurt and Hot Tub

Fredericktown MO

Stay at this cabin in Fredericktown. Enjoy air conditioning.

8.8/10 Excellent! (21 reviews)

Absolutely loved the location. Once we found it. One bummer was the hot tub doesn’t get hot and that was the biggest thing we were looking forward to. Other than that, everything was pretty functional. Dishes weren’t clean, but we hand washed them ourselves. Nice little get away.

Reviewed on Mar 14, 2026

Johnson's Shut-ins State Park

148 Taum Sauk Trail Middle Brook MO

Stay at this cabin in Middle Brook. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Johnson's Shut-ins State Park and Taum Sauk ...

10/10 Exceptional! (1 review)

These newer cabins are clean and have everything you need. Highly recommend!

Reviewed on Nov 5, 2025

See all properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Popular places to visit

Southeast Missouri State University

Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.

Elephant Rocks State Park

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

Lake Wappapello

Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.

Current River State Park

Commune with nature and explore the great outdoors at Current River State Park during your travels in Salem. While you're in the area, stroll along the riverfront.