A calm body of water, a sandy beach, and a forested area in the distance.

Cape Girardeau Vacation Rentals

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Check prices for these dates

In two weeks
Nov 20 - Nov 22
In two months
Jan 1 - Jan 3
In three months
Jan 29 - Jan 31
In four months
Feb 26 - Feb 28

Our top choices for Cape Girardeau vacation rentals

A living room with a TV, a fireplace, a sofa, and wall art.

1. Little Blue Cottage on Spanish

Little Blue Cottage on Spanish
Cape Girardeau
8.4 out of 10, Very good, (59 reviews)
"Great cute place. "
United States
Jeremy W.
$91 nightly
The price is $98
Nov 10 - Nov 11
Total with taxes and fees
Little Blue Cottage on Spanish
A kitchen with grey cabinets, a stainless steel dishwasher, a microwave, and an oven.

2. Cozy 2-bedroom house in tranquil Cape Girardeau, close to Semo & Hospitals

Cozy 2-bedroom house in tranquil Cape Girardeau, close to Semo & Hospitals
Cape Girardeau
$163 nightly
The price is $177
Dec 1 - Dec 2
Total with taxes and fees
Cozy 2-bedroom house in tranquil Cape Girardeau, close to Semo & Hospitals
A bedroom with a bed, a bottle of J. Roget champagne, two glasses, and a plate with snacks.

3. The Cottage, Rusted Route Farms

The Cottage, Rusted Route Farms
Jackson
10.0 out of 10, Exceptional, (3 reviews)
"This Cottage was very nice and clean and well maintained. The meat tray that we ordered and the breakfast tray was beyond Fabulous!!! My husband is still talking about it. . .Rick & Renee Christman"
United States
Renee C.
$185 nightly
The price is $185
Nov 15 - Nov 16
Total with taxes and fees
The Cottage, Rusted Route Farms
A modern living room with a wooden ceiling, a stone fireplace, a TV mounted on the wall, and a bar area with stools.

4. The Twisted Sassafras Treehouse

The Twisted Sassafras Treehouse
Cape Girardeau
10.0 out of 10, Exceptional, (41 reviews)
"The hosts were excellent."
United States
Jason L.
$313 nightly
The price is $330
Nov 11 - Nov 12
Total with taxes and fees
The Twisted Sassafras Treehouse
A row of colorful houses with a clear sky and trees in the background.

5. Enchanted Mermaid A-Frame | Creek + Fire pit | Pet Friendly

Enchanted Mermaid A-Frame | Creek + Fire pit | Pet Friendly
Cape Girardeau
10.0 out of 10, Exceptional, (1 review)
"Very cute, especially because it's pet friendly! Currently building additional structures on site but appears almost complete and still a beautiful setting and property."
United States
Elizabeth K.
$214 nightly
The price is $225
Nov 13 - Nov 14
Total with taxes and fees
Enchanted Mermaid A-Frame | Creek + Fire pit | Pet Friendly
Exterior

6. Purple Tiny House with Fire pit & Nature

Purple Tiny House with Fire pit & Nature
Cape Girardeau
10.0 out of 10, Exceptional, (1 review)
"First time staying in the purple house, second time staying at the property. 10/10 recommend"
United States
Shawn A.
$180 nightly
The price is $190
Nov 10 - Nov 11
Total with taxes and fees
Purple Tiny House with Fire pit & Nature
An outdoor seating area with Adirondack chairs and a wooden pergola, surrounded by trees and string lights.

7. Romantic Creekside Retreat | Fireplace | Deck | Pet Friendly

Romantic Creekside Retreat | Fireplace | Deck | Pet Friendly
Cape Girardeau
10.0 out of 10, Exceptional, (3 reviews)
"The house was very clean and Will kept and the whole property was well maintained. It was very comfortable and nicely decorated. The host was very responsive and helpful! Would definitely stay again and recommend."
United States
Sara C.
$197 nightly
The price is $208
Nov 10 - Nov 11
Total with taxes and fees
Romantic Creekside Retreat | Fireplace | Deck | Pet Friendly
An outdoor seating area with Adirondack chairs and a wooden pergola, surrounded by trees and string lights.

8. The Little Château | Woodland Escape

The Little Château | Woodland Escape
Cape Girardeau
$197 nightly
The price is $208
Nov 10 - Nov 11
Total with taxes and fees
The Little Château | Woodland Escape
A two-story house with a front porch, a small garden, and a white picket fence.

9. 3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Cape Girardeau
8.8 out of 10, Excellent, (46 reviews)
"Will definitely book again! Great location, comfortable stay."
United States
Pynktoria !.
$277 nightly
The price is $292
Nov 10 - Nov 11
Total with taxes and fees
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Exterior

10. The Little Cape Lofted Cottage | Creek & Nature

The Little Cape Lofted Cottage | Creek & Nature
Cape Girardeau
9.0 out of 10, Wonderful, (2 reviews)
"It was very clean and had a good feel. It was well stocked. I appreciated the cute little ice tray in the freezer that was full. I also appreciated 4 waters in the fridge. The bed on the loft upstairs was atrocious. You can feel the springs through the mattress. The downstairs bed was good. The pillows were fantastic! I’m a pillow snob. We needed a quick place to land for a church function so I can’t say much about the outside amenities as we weren’t there much. But it was a beautifully tucked...
United States
Trisha S.
$203 nightly
The price is $214
Nov 10 - Nov 11
Total with taxes and fees
The Little Cape Lofted Cottage | Creek & Nature
A log cabin interior with a stone fireplace, leather sofa, and a mounted deer head.

11. Gorgeous 1856 Log Cabin, Completely Renovated

Gorgeous 1856 Log Cabin, Completely Renovated
Jackson
10.0 out of 10, Exceptional, (6 reviews)
"incredible place. I was there for work, but it was a really nice relaxing area to retreat too, and also get some work done in a serene environment. It would be an incredible place for an entire family. And, a good place for friends to get together."
United States
Chandler G.
$285 nightly
The price is $285
Nov 10 - Nov 11
Total with taxes and fees
Gorgeous 1856 Log Cabin, Completely Renovated
A modern kitchen with a large island, white cabinetry, and a brick accent wall.

12. Beautifully Renovated Farmhouse in Jackson, MO

Beautifully Renovated Farmhouse in Jackson, MO
Jackson
9.4 out of 10, Exceptional, (3 reviews)
" great stay,property landscape nicely manicured, quiet and relaxing inside and outside of the the dwelling."
United States
Sandy S.
$285 nightly
The price is $285
Nov 10 - Nov 11
Total with taxes and fees
Beautifully Renovated Farmhouse in Jackson, MO
A house with a backyard swimming pool, outdoor furniture, and a barbecue area.

13. 4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
Cape Girardeau
9.8 out of 10, Exceptional, (11 reviews)
"Nice place, great times"
United States
Jace W.
$511 nightly
The price is $539
Nov 10 - Nov 11
Total with taxes and fees
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
A cozy room with a wooden table and chairs, a large window, and a door with a sign.

14. Cozy cabins on beautiful Horseshoe Lake

Cozy cabins on beautiful Horseshoe Lake
Olive Branch
9.8 out of 10, Exceptional, (44 reviews)
"Super communication! . Accommodating. Nice people"
United States
JASEN
$117 nightly
The price is $123
Nov 10 - Nov 11
Total with taxes and fees
Cozy cabins on beautiful Horseshoe Lake
A small, single-story building with a wooden exterior and large windows.

15. The Rested Duck Mallard Room

The Rested Duck Mallard Room
Olive Branch
9.4 out of 10, Exceptional, (32 reviews)
"This is an excellent place to stay. With a nice lake right across the street. If i. In the are i will stay again for sure"
United States
mike b.
$117 nightly
The price is $123
Nov 10 - Nov 11
Total with taxes and fees
The Rested Duck Mallard Room
A wooden cabin with a green door, a number '2' sign, a small porch with a wooden railing, and a wall-mounted lantern.

16. 3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!

3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!
Makanda
9.8 out of 10, Exceptional, (80 reviews)
"Very clean and comfortable stay"
United States
Alison K.
$162 nightly
The price is $179
Nov 10 - Nov 11
Total with taxes and fees
3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!
A compact kitchen with wooden cabinets and a dining area with a table and chairs.

17. Villa B offers peace and quiet with beautiful views of the countryside.

Villa B offers peace and quiet with beautiful views of the countryside.
Jackson
9.8 out of 10, Exceptional, (16 reviews)
"We were only there for 1 night for a business trip but it was perfect for our stay. Very clean and comfortable and the host was onsite to welcome us. She even gave us a tip on the best place nearby for dinner that we will be going to any time we can in the future. I would gladly stay here again for future trips."
United States
Terry H.
$159 nightly
The price is $168
Nov 10 - Nov 11
Total with taxes and fees
Villa B offers peace and quiet with beautiful views of the countryside.
A kitchen with wooden cabinets, a black refrigerator, a microwave, a stove, and a ceiling fan. There are three stools at the island.

18. Relax in the country at Countryside Villas! - Villa A

Relax in the country at Countryside Villas! - Villa A
Jackson
10.0 out of 10, Exceptional, (39 reviews)
"Great place to stay, felt like home away from home. "
United States
Brittany
$159 nightly
The price is $168
Nov 10 - Nov 11
Total with taxes and fees
Relax in the country at Countryside Villas! - Villa A
A loft-style room with a wooden interior, a sofa, a table with a pumpkin decoration, and a staircase leading to an upper level.

19. Peaceful secluded cabin located near Horseshoe Lake

Peaceful secluded cabin located near Horseshoe Lake
Miller City
9.8 out of 10, Exceptional, (40 reviews)
"Great place in a beautiful location. "
United States
George B.
$190 nightly
The price is $201
Nov 15 - Nov 16
Total with taxes and fees
Peaceful secluded cabin located near Horseshoe Lake
A window with a view of a sunset over a landscape.

20. Crossview Cottage - Direct view of Bald Knob Cross

Crossview Cottage - Direct view of Bald Knob Cross
Alto Pass
10.0 out of 10, Exceptional, (7 reviews)
"Host was timely with communications, the place was perfect for us and our dog, all the amenities were on site, it was easy to access and come and go from Alto Pass."
United States
Shea
$124 nightly
The price is $137
Nov 10 - Nov 11
Total with taxes and fees
Crossview Cottage - Direct view of Bald Knob Cross
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Cape Girardeau Hotel Reviews

Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East

10/10 Excellent
"nice hotel and good breakfast"
Edward 1-night trip
Posted less than an hour ago
Hampton Inn Cape Girardeau I 55 East

Find out more about Cape Girardeau

Everything you need to know about Cape Girardeau vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Cape Girardeau vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Cape Girardeau vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Cape Girardeau vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Cape Girardeau. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Cape Girardeau in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $98 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Cape Girardeau rentals

At Expedia, we put the best Cape Girardeau vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Cape Girardeau rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Cape Girardeau vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Cape Girardeau. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

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Frequently asked questions

Can I find vacation rentals in Cape Girardeau?

Yes, we offer vacation rentals in Cape Girardeau near Cape Splash Family Aquatic Center, or you can select a more remote option if you're looking for extra privacy while you relax. Visitors like the top-notch restaurants and shops in Cape Girardeau. Make sure you allow time to enjoy the riverfront during your vacation.

What are some of the best vacation home rentals in Cape Girardeau?

3 Bed 3 Bath Beautiful Historic District Within Walking Downtown Cape Girardeau: This Cape Girardeau vacation home rental is equipped with a barbecue grill, air-conditioning, and laundry facilities to help you feel comfortable during your stay. Kitchen amenities include a dishwasher, a fridge, and a stovetop. Some other homes for rent in Cape Girardeau include “Brickyard”-Recently Remodeled Dutch Colonial Revival in Downtown Cape Girardeau and Little Blue Cottage on Spanish.

How many vacation rentals will I find in Cape Girardeau?

Choose from 30 Expedia vacation rentals in Cape Girardeau for a memorable vacation.

What can I see and do in Cape Girardeau?

Family-friendly attractions include Cape Splash Family Aquatic Center and Cape Girardeau Conservation Nature Center, whereas Shawnee National Forest and Mississippi River are a couple of great spots to enjoy the outdoors. While here, Century Casino & Hotel Cape Girardeau and Show Me Center are other places worth a visit.

What are vacation rentals like in Cape Girardeau?

Vacation rentals are private properties you can book for a couple days or more in Cape Girardeau. Vacation rentals offer amenities such as hot tubs, fire pits, and patios so your stay will be comfortable. If you're concerned about cleanliness, vacation rentals can offer a sense of privacy away from public hotel elevators and lobbies bustling with people while still allowing you the excitement and enjoyment of travel. You'll also find more space in a vacation rental than in a standard hotel, which is another reason why a vacation rental is an attractive option for a small group gathering.