Title: Panama City Vacation Rentals from $78: Search Short-Term Rentals | Expedia.com

[Panama City Travel Guide](https://expedia.com/Panama-City.dx2897)[Hotels in Panama City](https://expedia.com/Panama-City-Hotels.d2897.Travel-Guide-Hotels)[Flights to Panama City](https://expedia.com/Cheap-Flights-To-Panama-City.d2897.Travel-Guide-Flights)[Things to do in Panama City](https://expedia.com/Things-To-Do-In-Panama-City.d2897.Travel-Guide-Activities)[Car Rentals in Panama City](https://expedia.com/Car-Rentals-In-Panama-City.d2897.Car-Rental-Guide)[Panama City Vacation Packages](https://expedia.com/Panama-City.d2897.Destination-Travel-Guides)

![Panoramic view at the Downtown of Panama City - Panama](https://images.trvl-media.com/place/2897/e48f6143-9130-47fe-8b71-977ffb07b927.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/2897/e48f6143-9130-47fe-8b71-977ffb07b927.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Check prices for these dates

In two weeks

[Mar 20 - Mar 22](https://www.expedia.com/Hotel-Search?regionId=2897&startDate=2026-03-20&endDate=2026-03-22&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two months

[May 1 - May 3](https://www.expedia.com/Hotel-Search?regionId=2897&startDate=2026-05-01&endDate=2026-05-03&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In three months

[May 29 - May 31](https://www.expedia.com/Hotel-Search?regionId=2897&startDate=2026-05-29&endDate=2026-05-31&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In four months

[Jun 26 - Jun 28](https://www.expedia.com/Hotel-Search?regionId=2897&startDate=2026-06-26&endDate=2026-06-28&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Panama City vacation rentals

![50-inch LED TV with satellite channels](https://images.trvl-media.com/lodging/105000000/104460000/104456900/104456900/81757b88.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining room](https://images.trvl-media.com/lodging/105000000/104460000/104456900/104456900/dbfbf214.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![50-inch LED TV with satellite channels](https://images.trvl-media.com/lodging/105000000/104460000/104456900/104456900/f23a333a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![50-inch LED TV with satellite channels](https://images.trvl-media.com/lodging/105000000/104460000/104456900/104456900/dc088c7c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Aparthotel in Costa del Este

[](https://www.expedia.com/Panama-City-Hotels-Arcadia-Condo-Suites.h104456900.Hotel-Information)

9.4/10

Exceptional

(233 reviews)

"Really loved this place"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Alejandra

$151 nightly

$166 total

Mar 20 - Mar 21

Total with taxes and fees

[](https://www.expedia.com/Panama-City-Hotels-Arcadia-Condo-Suites.h104456900.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/126000000/125270000/125266400/125266330/94d2f2bf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Deluxe Apartment, City View | Private kitchen](https://images.trvl-media.com/lodging/126000000/125270000/125266400/125266330/ac3f0393.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Deluxe Apartment, City View | Interior](https://images.trvl-media.com/lodging/126000000/125270000/125266400/125266330/600a3940.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Deluxe Apartment, City View | Interior](https://images.trvl-media.com/lodging/126000000/125270000/125266400/125266330/7c635746.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apartment in Bella Vista

[](https://www.expedia.com/Panama-City-Hotels-Luxury-Apartment-Piso-35-With-City-View.h125266330.Hotel-Information)

$71 nightly

$78 total

Mar 9 - Mar 10

Total with taxes and fees

[](https://www.expedia.com/Panama-City-Hotels-Luxury-Apartment-Piso-35-With-City-View.h125266330.Hotel-Information)

![TV](https://images.trvl-media.com/lodging/123000000/122660000/122657100/122657050/87d5a99d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool](https://images.trvl-media.com/lodging/123000000/122660000/122657100/122657050/c9888658.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Deluxe Apartment | Balcony](https://images.trvl-media.com/lodging/123000000/122660000/122657100/122657050/618d23dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV](https://images.trvl-media.com/lodging/123000000/122660000/122657100/122657050/be270857.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apartment in San Francisco

[](https://www.expedia.com/Panama-City-Hotels-Living-73.h122657050.Hotel-Information)

$181 nightly

$218 total

Apr 1 - Apr 2

Total with taxes and fees

[](https://www.expedia.com/Panama-City-Hotels-Living-73.h122657050.Hotel-Information)

![Apartment (14D) | Dining room](https://images.trvl-media.com/lodging/118000000/117470000/117462500/117462452/2a0412bc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Apartment (14D) | Soundproofing, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/118000000/117470000/117462500/117462452/422dd5ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Apartment (5E) | Living area](https://images.trvl-media.com/lodging/118000000/117470000/117462500/117462452/e5dc9f9a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Apartment (11F) | Living area](https://images.trvl-media.com/lodging/118000000/117470000/117462500/117462452/3115996f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apartment in Bella Vista

[](https://www.expedia.com/Panama-City-Hotels-Mini-Design-By-Wynwood-House.h117462452.Hotel-Information)

$151 nightly

$166 total

Mar 16 - Mar 17

Total with taxes and fees

[](https://www.expedia.com/Panama-City-Hotels-Mini-Design-By-Wynwood-House.h117462452.Hotel-Information)

![Interior detail](https://images.trvl-media.com/lodging/16000000/15980000/15979000/15978996/2453d7ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Executive Suite, Annex Building (Queen) | Living area | 42-inch flat-screen TV with digital channels, TV](https://images.trvl-media.com/lodging/16000000/15980000/15979000/15978996/f680e3a7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Superior Double Room | View from room](https://images.trvl-media.com/lodging/16000000/15980000/15979000/15978996/c6d0b885.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Double Queen Suite | Premium bedding, in-room safe, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/16000000/15980000/15979000/15978996/db18ada2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Aparthotel in Casco Viejo

[](https://www.expedia.com/Panama-City-Hotels-La-Isabela-Suites.h15978996.Hotel-Information)

10/10

Exceptional

(181 reviews)

"Excellent place to stay in the Casco Viejo "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Zoe M

$152 nightly

$169 total

Mar 8 - Mar 9

Total with taxes and fees

[](https://www.expedia.com/Panama-City-Hotels-La-Isabela-Suites.h15978996.Hotel-Information)

![Apartment | 1 bedroom](https://images.trvl-media.com/lodging/124000000/123170000/123162800/123162773/7825c8c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Apartment | 1 bedroom](https://images.trvl-media.com/lodging/124000000/123170000/123162800/123162773/afec0f45.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Apartment | 1 bedroom](https://images.trvl-media.com/lodging/124000000/123170000/123162800/123162773/aa365767.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Apartment | 1 bedroom](https://images.trvl-media.com/lodging/124000000/123170000/123162800/123162773/b8818dd1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apartment in San Francisco

[](https://www.expedia.com/Panama-City-Hotels-Dovle-510-In-Ciudad-De-Panam.h123162773.Hotel-Information)

8.0/10

Very Good

(1 review)

"Very clean and staff were friendly and welcoming."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Steven

$127 nightly

$140 total

Mar 8 - Mar 9

Total with taxes and fees

[](https://www.expedia.com/Panama-City-Hotels-Dovle-510-In-Ciudad-De-Panam.h123162773.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/104000000/103610000/103606300/103606257/93306cc0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Apartment (24G) | Premium bedding, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/104000000/103610000/103606300/103606257/f3c16015.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Apartment (40K) | Dining room](https://images.trvl-media.com/lodging/104000000/103610000/103606300/103606257/da16c1c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Apartment (24G) | Living room | Smart TV](https://images.trvl-media.com/lodging/104000000/103610000/103606300/103606257/74f146f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Condo in Calidonia

[](https://www.expedia.com/Panama-City-Hotels-Yoo-By-Wynwood-House.h103606257.Hotel-Information)

9.2/10

Wonderful

(5 reviews)

"I will be back!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jeffrey

$206 nightly

$227 total

Mar 18 - Mar 19

Total with taxes and fees

[](https://www.expedia.com/Panama-City-Hotels-Yoo-By-Wynwood-House.h103606257.Hotel-Information)

![Apartment | Living area](https://images.trvl-media.com/lodging/114000000/113060000/113058500/113058427/c0e07415.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Apartment | Living area](https://images.trvl-media.com/lodging/114000000/113060000/113058500/113058427/4d9b3d57.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Apartment | Living area](https://images.trvl-media.com/lodging/114000000/113060000/113058500/113058427/601ad506.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Apartment | Living area](https://images.trvl-media.com/lodging/114000000/113060000/113058500/113058427/2f0279c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apartment in Veracruz

[](https://www.expedia.com/Veracruz-Hotels-Centriqo-By-Wynwood-House.h113058427.Hotel-Information)

$131 nightly

$144 total

Apr 5 - Apr 6

Total with taxes and fees

[](https://www.expedia.com/Veracruz-Hotels-Centriqo-By-Wynwood-House.h113058427.Hotel-Information)

![Restaurant](https://images.trvl-media.com/lodging/5000000/4810000/4801200/4801186/24a7280d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![View from property](https://images.trvl-media.com/lodging/5000000/4810000/4801200/4801186/765b1a36.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Studio, 1 King Bed, Non Smoking, Connecting Rooms | Premium bedding, in-room safe, individually decorated](https://images.trvl-media.com/lodging/5000000/4810000/4801200/4801186/d9012efa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Studio, 2 Double Beds, Non Smoking, Connecting Rooms | Premium bedding, in-room safe, individually decorated](https://images.trvl-media.com/lodging/5000000/4810000/4801200/4801186/da2b9bed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Aparthotel in Casco Viejo

[](https://www.expedia.com/Panama-City-Hotels-Las-Clementinas.h4801186.Hotel-Information)

9.4/10

Exceptional

(182 reviews)

"Fabulous room and wonderful people that work there. "

![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg)

Leah

$122 nightly

$134 total

Mar 10 - Mar 11

Total with taxes and fees

[](https://www.expedia.com/Panama-City-Hotels-Las-Clementinas.h4801186.Hotel-Information)

![Apartment, 2 Bedrooms (CC2A) | Premium bedding, soundproofing, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/100000000/99230000/99229300/99229225/a1353e56.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Apartment, 2 Bedrooms (CC4A) | Balcony](https://images.trvl-media.com/lodging/100000000/99230000/99229300/99229225/90de29d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Apartment, 2 Bedrooms (CC2B) | Living area | 100-inch Smart TV with satellite channels](https://images.trvl-media.com/lodging/100000000/99230000/99229300/99229225/86dc292b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Apartment, 2 Bedrooms (CC1A) | Living area | 100-inch Smart TV with satellite channels](https://images.trvl-media.com/lodging/100000000/99230000/99229300/99229225/bb5e8873.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apartment in Casco Viejo

[](https://www.expedia.com/Panama-City-Hotels-Casa-Mallet-By-Wynwood-House.h99229225.Hotel-Information)

8.2/10

Very Good

(21 reviews)

"Great place!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jad

$136 nightly

$147 total

Mar 10 - Mar 11

Total with taxes and fees

[](https://www.expedia.com/Panama-City-Hotels-Casa-Mallet-By-Wynwood-House.h99229225.Hotel-Information)

![Outdoor pool](https://images.trvl-media.com/lodging/115000000/114590000/114580500/114580453/46eb55a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Deluxe Apartment | Premium bedding, individually decorated, individually furnished](https://images.trvl-media.com/lodging/115000000/114590000/114580500/114580453/9c70698c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/115000000/114590000/114580500/114580453/267d4c66.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Bar (on property)](https://images.trvl-media.com/lodging/115000000/114590000/114580500/114580453/3b43323d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apartment in San Francisco

[](https://www.expedia.com/Wanders-Panama-By-Boutique-Apartments.h114580453.Hotel-Information)

10/10

Exceptional

(3 reviews)

"The apartment was great. It was very comfortable and spacious. The building is impressive and a great place from which to enjoy Panama City. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Gary

$309 nightly

$340 total

Apr 1 - Apr 2

Total with taxes and fees

[](https://www.expedia.com/Wanders-Panama-By-Boutique-Apartments.h114580453.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/111000000/110790000/110785700/110785630/7fec4ade.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Superior Apartment | Living area | Smart TV](https://images.trvl-media.com/lodging/111000000/110790000/110785700/110785630/2f5f574e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Courtyard](https://images.trvl-media.com/lodging/111000000/110790000/110785700/110785630/c6184862.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Deluxe Apartment, 2 Bedrooms | Terrace/patio](https://images.trvl-media.com/lodging/111000000/110790000/110785700/110785630/83a9c463.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apartment in Bella Vista

[](https://www.expedia.com/Panama-City-Hotels-Yoo-Panama-By-Boutique-Apartments.h110785630.Hotel-Information)

8.2/10

Very Good

(69 reviews)

"Great location, wonderful views, spacious apartment, with comfortable bed and good ac. Amenities in the building are great too."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

alan

$216 nightly

$223 total

Apr 1 - Apr 2

Total with taxes and fees

[](https://www.expedia.com/Panama-City-Hotels-Yoo-Panama-By-Boutique-Apartments.h110785630.Hotel-Information)

![Apartment, 2 Bedrooms (1B) | Living area | 40-inch Smart TV with cable channels](https://images.trvl-media.com/lodging/107000000/106100000/106093500/106093420/9e77777b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Apartment (2D) | Private kitchen | Coffee/tea maker, electric kettle](https://images.trvl-media.com/lodging/107000000/106100000/106093500/106093420/04577a21.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Apartment (1A) | Living area | 40-inch Smart TV with cable channels](https://images.trvl-media.com/lodging/107000000/106100000/106093500/106093420/4443ba1a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Apartment, 2 Bedrooms (1D) | Premium bedding, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/107000000/106100000/106093500/106093420/3f9c0f41.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apartment in Casco Viejo

[](https://www.expedia.com/Panama-City-Hotels-Casa-Love-By-Wynwood-House.h106093420.Hotel-Information)

9.0/10

Wonderful

(24 reviews)

"Large, clean rooms, lots of space. Great bathroom. Great location. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Joette

$99 nightly

$108 total

Mar 10 - Mar 11

Total with taxes and fees

[](https://www.expedia.com/Panama-City-Hotels-Casa-Love-By-Wynwood-House.h106093420.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/97000000/96030000/96026500/96026407/67c30365.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/97000000/96030000/96026500/96026407/55bbf1ca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV, offices](https://images.trvl-media.com/lodging/97000000/96030000/96026500/96026407/w1188h800x0y0-52c2a21b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV, offices](https://images.trvl-media.com/lodging/97000000/96030000/96026500/96026407/ff55656d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apartment in San Francisco

[](https://www.expedia.com/Panama-City-Hotels-W-Prestigious-1BR-In-San-Francisco.h96026407.Hotel-Information)

10/10

Exceptional

(1 review)

"Everything was as described. Restaurants were conveniently located. View was an added bonus and was better than pictured. We were able to enjoy the gym. The pool was a little cool but still enjoyable. Would recommend this host."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Ruben O.

$144 nightly

$144 total

Mar 17 - Mar 18

Total with taxes and fees

[](https://www.expedia.com/Panama-City-Hotels-W-Prestigious-1BR-In-San-Francisco.h96026407.Hotel-Information)

![Outdoor pool, open 7:00 AM to 10:00 PM, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/103000000/102810000/102803600/102803573/w846h1318x0y4-5df5c378.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Luxury Apartment | Balcony](https://images.trvl-media.com/lodging/103000000/102810000/102803600/102803573/ee1ac3ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Superior Apartment | Living area | Smart TV](https://images.trvl-media.com/lodging/103000000/102810000/102803600/102803573/03e26607.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Apartment (705) | Balcony](https://images.trvl-media.com/lodging/103000000/102810000/102803600/102803573/ba5a7e97.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Condo in Santa Ana

[](https://www.expedia.com/Panama-City-Hotels-Casco-View-Apartments.h102803573.Hotel-Information)

9.2/10

Wonderful

(75 reviews)

"We live this property and stay here whenever we are in town."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

chris

$87 nightly

$96 total

Mar 9 - Mar 10

Total with taxes and fees

[](https://www.expedia.com/Panama-City-Hotels-Casco-View-Apartments.h102803573.Hotel-Information)

![Apartment | 2 bedrooms, Internet](https://images.trvl-media.com/lodging/125000000/124560000/124557900/124557851/6a3c89e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Apartment | 2 bedrooms, Internet](https://images.trvl-media.com/lodging/125000000/124560000/124557900/124557851/c37bd856.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Apartment | 2 bedrooms, Internet](https://images.trvl-media.com/lodging/125000000/124560000/124557900/124557851/cd2b03a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Apartment | 2 bedrooms, Internet](https://images.trvl-media.com/lodging/125000000/124560000/124557900/124557851/2323d642.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apartment in Casco Viejo

[](https://www.expedia.com/Panama-City-Hotels-W-Engaging-2BR-In-Casco-Viejo.h124557851.Hotel-Information)

$191 nightly

$210 total

Mar 8 - Mar 9

Total with taxes and fees

[](https://www.expedia.com/Panama-City-Hotels-W-Engaging-2BR-In-Casco-Viejo.h124557851.Hotel-Information)

![Apartment, 2 Bedrooms (1A) | Living area | 40-inch Smart TV with cable channels](https://images.trvl-media.com/lodging/105000000/104140000/104135000/104134950/42608a9d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Apartment, 2 Bedrooms (1C) | Terrace/patio](https://images.trvl-media.com/lodging/105000000/104140000/104135000/104134950/50831da2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Apartment, 2 Bedrooms (1A) | Living area | 40-inch Smart TV with cable channels](https://images.trvl-media.com/lodging/105000000/104140000/104135000/104134950/0447e43a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Apartment (2A) | Living area | 40-inch Smart TV with cable channels](https://images.trvl-media.com/lodging/105000000/104140000/104135000/104134950/fc090f72.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apartment in Casco Viejo

[](https://www.expedia.com/Las-Cumbres-Hotels-Casa-Lefevre-By-Wynwood-House.h104134950.Hotel-Information)

9.2/10

Wonderful

(7 reviews)

"Staff was courteous, and the room was very beautiful. Would stay here again!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Selam

$171 nightly

$188 total

Mar 8 - Mar 9

Total with taxes and fees

[](https://www.expedia.com/Las-Cumbres-Hotels-Casa-Lefevre-By-Wynwood-House.h104134950.Hotel-Information)

![Outdoor pool](https://images.trvl-media.com/lodging/123000000/122130000/122120100/122120019/6dbcedff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Deluxe Studio, Sea View | Balcony view](https://images.trvl-media.com/lodging/123000000/122130000/122120100/122120019/cf68e67c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Rooftop terrace](https://images.trvl-media.com/lodging/123000000/122130000/122120100/122120019/fb6b983e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Deluxe Studio, Sea View | Minibar, free WiFi](https://images.trvl-media.com/lodging/123000000/122130000/122120100/122120019/9e72b36d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apartment in Calidonia

[](https://www.expedia.com/Panama-City-Hotels-Studio-Apartment-With-Ocean-View.h122120019.Hotel-Information)

8.0/10

Very Good

(2 reviews)

"It was similar to a hotel room, but a little smaller.. the bed is big enough for just one person and check in was the most difficult thing he had to wait outside in the rain and download apps"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Gwendolyn

$65 nightly

$72 total

Mar 10 - Mar 11

Total with taxes and fees

[](https://www.expedia.com/Panama-City-Hotels-Studio-Apartment-With-Ocean-View.h122120019.Hotel-Information)

![TV](https://images.trvl-media.com/lodging/90000000/89770000/89763300/89763270/b74d4780.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Pool](https://images.trvl-media.com/lodging/90000000/89770000/89763300/89763270/w1752h1309x0y1-ed7ebade.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/90000000/89770000/89763300/89763270/487aeb0f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/90000000/89770000/89763300/89763270/f4edd9ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apartment in Casco Viejo

[](https://www.expedia.com/Panama-City-Hotels-Iconic-Double-Apartment-With-Billar-In-Front-Of-The-Arco-Chato-Ruins-And-Pool.h89763270.Hotel-Information)

9.2/10

Wonderful

(7 reviews)

"Great location with lots of restaurants nearby"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Andrea S.

$249 nightly

$266 total

Mar 16 - Mar 17

Total with taxes and fees

[](https://www.expedia.com/Panama-City-Hotels-Iconic-Double-Apartment-With-Billar-In-Front-Of-The-Arco-Chato-Ruins-And-Pool.h89763270.Hotel-Information)

![Apartment (3G) | Living area | 40-inch Smart TV with digital channels](https://images.trvl-media.com/lodging/101000000/100600000/100591500/100591449/01dcce3f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Apartment (3K) | Premium bedding, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/101000000/100600000/100591500/100591449/035f9f72.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Apartment (3G) | Private kitchen | Fridge, microwave, toaster, cookware/dishes/utensils](https://images.trvl-media.com/lodging/101000000/100600000/100591500/100591449/17bc3100.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/101000000/100600000/100591500/100591449/9f5c2914.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Condo in El Chorrillo

[](https://www.expedia.com/Panama-City-Hotels-La-Cuadra-By-Wynwood-House.h100591449.Hotel-Information)

9.0/10

Wonderful

(50 reviews)

"Superb customer service. Instant responsiveness. Almost miraculous. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Peter

$123 nightly

$132 total

Mar 10 - Mar 11

Total with taxes and fees

[](https://www.expedia.com/Panama-City-Hotels-La-Cuadra-By-Wynwood-House.h100591449.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.com/Hotel-Search?startDate=2026-03-19&endDate=2026-03-20&regionId=2897&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true)

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## Find vacation rentals that suit your style

Apartments

[](https://www.expedia.com/Hotel-Search?destination=Panama+City%2C+Panam%C3%A1+Province%2C+Panama&regionId=2897&latLong=8.98144%2C-79.525482&adults=2&startDate=2026-06-03&d1=2026-06-03&endDate=2026-06-06&d2=2026-06-06&lodging=APARTMENT)

Aparthotels

[](https://www.expedia.com/Hotel-Search?destination=Panama+City%2C+Panam%C3%A1+Province%2C+Panama&regionId=2897&latLong=8.98144%2C-79.525482&adults=2&startDate=2026-06-03&d1=2026-06-03&endDate=2026-06-06&d2=2026-06-06&lodging=APART_HOTEL)

Condos

[](https://www.expedia.com/Hotel-Search?destination=Panama+City%2C+Panam%C3%A1+Province%2C+Panama&regionId=2897&latLong=8.98144%2C-79.525482&adults=2&startDate=2026-06-03&d1=2026-06-03&endDate=2026-06-06&d2=2026-06-06&lodging=CONDO)

Private vacation homes

[](https://www.expedia.com/Hotel-Search?destination=Panama+City%2C+Panam%C3%A1+Province%2C+Panama&regionId=2897&latLong=8.98144%2C-79.525482&adults=2&startDate=2026-06-03&d1=2026-06-03&endDate=2026-06-06&d2=2026-06-06&lodging=VACATION_HOME)

Villas

[](https://www.expedia.com/Hotel-Search?destination=Panama+City%2C+Panam%C3%A1+Province%2C+Panama&regionId=2897&latLong=8.98144%2C-79.525482&adults=2&startDate=2026-06-03&d1=2026-06-03&endDate=2026-06-06&d2=2026-06-06&lodging=VILLA)

Cabins

[](https://www.expedia.com/Hotel-Search?destination=Panama+City%2C+Panam%C3%A1+Province%2C+Panama&regionId=2897&latLong=8.98144%2C-79.525482&adults=2&startDate=2026-06-03&d1=2026-06-03&endDate=2026-06-06&d2=2026-06-06&lodging=CABIN)

Houseboats

[](https://www.expedia.com/Hotel-Search?destination=Panama+City%2C+Panam%C3%A1+Province%2C+Panama&regionId=2897&latLong=8.98144%2C-79.525482&adults=2&startDate=2026-06-03&d1=2026-06-03&endDate=2026-06-06&d2=2026-06-06&lodging=HOUSE_BOAT)

Chalets

[](https://www.expedia.com/Hotel-Search?destination=Panama+City%2C+Panam%C3%A1+Province%2C+Panama&regionId=2897&latLong=8.98144%2C-79.525482&adults=2&startDate=2026-06-03&d1=2026-06-03&endDate=2026-06-06&d2=2026-06-06&lodging=CHALET)

Cottages

[](https://www.expedia.com/Hotel-Search?destination=Panama+City%2C+Panam%C3%A1+Province%2C+Panama&regionId=2897&latLong=8.98144%2C-79.525482&adults=2&startDate=2026-06-03&d1=2026-06-03&endDate=2026-06-06&d2=2026-06-06&lodging=COTTAGE)

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## Top Panama City Hotel Reviews

![Hotel Ojos del Rio](https://images.trvl-media.com/lodging/11000000/10540000/10538500/10538417/dddd2643_y.jpg)

### Hotel Ojos del Rio

8/10 Good

"It’s pretty basic. It was fine clean. Staff was ok. I contacted them in advance to check about early checking, as my flight was arriving early, and I had some work meetings. They said it would be charged, which I agreed upon. But when I showed it up at the hotel, they said no."

[](https://expedia.com/Panama-City-Hotels-Hotel-Ojos-Del-Rio.h10538417.Hotel-Information)

![W Panama](https://images.trvl-media.com/lodging/22000000/21320000/21314100/21314035/5dc0b3d1_y.jpg)

### W Panama

6/10 Okay

"Lots of walking distance shops nearby. Very nice pool and bar areas with very accommodating staff.The doors to the rooms are very loud when closing almost like it’s being slammed, can be jarring when your in your room and your neighbors don’t close the door gently. I was able to get my room changed but the walls are very thin you can hear conversations next door as well as music playing, a machine humming noise coming from the vent system as well . I cut my trip short because of being uncomfortable in the room when trying to relax . I am still trying to see if I could get reimbursed for the days unused with no success so far. "

[](https://expedia.com/Panama-City-Hotels-W-Panama.h21314035.Hotel-Information)

![Aloft Panama](https://images.trvl-media.com/lodging/7000000/6580000/6577500/6577427/75c7ddd0_y.jpg)

### Aloft Panama

8/10 Good

"The hotel is nice only downside was they serve the same breakfast everyday "

[](https://expedia.com/Panama-City-Hotels-Aloft-Panama.h6577427.Hotel-Information)

![Hotel Riu Plaza Panama](https://images.trvl-media.com/lodging/4000000/3910000/3900400/3900395/6f5f0f4f_y.jpg)

### Hotel Riu Plaza Panama

4/10 Poor

"During our 8-day stay, the room had a strong moldy smell, as if it had been unoccupied for a long time. While the odor did lessen over time, it remained unpleasant throughout the entire stay. Additionally, the pool area is quite small relative to the number of guests. It was often difficult to find available lounge chairs, and the area tended to be crowded and noisy. The elevator is also small and often crowded, which added to the inconvenience. The staff was not particularly helpful during our stay. I also had a haircut at the hotel salon, and the result was very disappointing. Given these issues, I am unsure how this property qualifies as a five-star hotel. "

[](https://expedia.com/Panama-City-Hotels-Hotel-Riu-Plaza-Panama.h3900395.Hotel-Information)

![Courtyard by Marriott Panama Multiplaza Mall](https://images.trvl-media.com/lodging/2000000/1150000/1145700/1145666/7dd302e1_y.jpg)

### Courtyard by Marriott Panama Multiplaza Mall

6/10 Okay

"Great location and service."

[](https://expedia.com/Panama-City-Hotels-Courtyard-By-Marriott-Panama-Multiplaza-Mall.h1145666.Hotel-Information)

![Principe Hotel and Suites](https://images.trvl-media.com/lodging/8000000/7460000/7451800/7451703/2baee2b4_y.jpg)

### Principe Hotel and Suites

10/10 Excellent

"Good location, large comfortable rooms"

[](https://expedia.com/Panama-City-Hotels-Principe-Hotel-And-Suites.h7451703.Hotel-Information)

![The Executive Hotel](https://images.trvl-media.com/lodging/1000000/530000/522100/522086/e3ee3bd7_y.jpg)

### The Executive Hotel

10/10 Excellent

"Good hotel with facilities in a good location. Great value for money with breakfast included"

[](https://expedia.com/Panama-City-Hotels-The-Executive-Hotel.h522086.Hotel-Information)

![Las Americas Golden Tower Panama](https://images.trvl-media.com/lodging/10000000/9680000/9675300/9675263/83f7ceed_y.jpg)

### Las Americas Golden Tower Panama

8/10 Good

"Shops like malls were nearby and food places. The hotel overall is nice, but it seemed as if they rushed to prepare my room and certain things seemed not so clean. I also did not really enjoy the food there"

[](https://expedia.com/Panama-City-Hotels-Las-Americas-Golden-Tower-Panama.h9675263.Hotel-Information)

![Hyatt Regency Panama City](https://images.trvl-media.com/lodging/112000000/111850000/111843300/111843270/616200e0_y.jpg)

### Hyatt Regency Panama City

10/10 Excellent

"Amazing hotel 🏨 "

[](https://expedia.com/Panama-City-Hotels-Hyatt-Regency-Panama-City.h111843270.Hotel-Information)

## Find out more about Panama City

**Everything you need to know about Panama City vacation rentals**

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Panama City vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Panama City vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

**Panama City vacation rentals: An excellent choice for every season**

Whenever you want to travel, a warm welcome awaits you in Panama City. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Panama City in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $78 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

**How to find incredible deals on Panama City rentals**

At Expedia, we put the best Panama City vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Panama City rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Panama City vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Panama City. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

## Explore a world of travel with Expedia

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- [Florida Vacation Rentals ](https://www.expedia.com/Destinations-In-Florida.d211.Vacation-Rental-Destinations)
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- [Michigan Vacation Rentals ](https://www.expedia.com/Destinations-In-Michigan.d224.Vacation-Rental-Destinations)

- [Apartments in Panama City ](https://expedia.com/Panama-City-Apartments.d2897-aaApartments.Travel-Guide-Accommodation)
- [Condo Rentals in Panama City ](https://expedia.com/Panama-City-Condos.d2897-aaCondos.Travel-Guide-Accommodation)
- [Vacation Homes in Panama City ](https://expedia.com/Panama-City-Private-Vacation-Homes.d2897-aaPrivateVacationHomes.Travel-Guide-Accommodation)
- [B&B in Panama City ](https://expedia.com/Panama-City-Bed-And-Breakfast.d2897-aaBedAndBreakfast.Travel-Guide-Accommodation)
- [Hostels in Panama City ](https://expedia.com/Panama-City-Hostels.d2897-aaHostels.Travel-Guide-Accommodation)
- [Aparthotels in Panama City ](https://expedia.com/Panama-City-Apart-Hotels.d2897-aaApartHotels.Travel-Guide-Accommodation)
- [Guest Houses in Panama City ](https://expedia.com/Panama-City-Guest-Houses.d2897-aaGuestHouses.Travel-Guide-Accommodation)
- [Villas in Panama City ](https://expedia.com/Panama-City-Villas.d2897-aaVillas.Travel-Guide-Accommodation)
- [Lodges in Panama City ](https://expedia.com/Panama-City-Lodges.d2897-aaLodges.Travel-Guide-Accommodation)
- [Resorts in Panama City ](https://expedia.com/Panama-City-Resorts.d2897-aaResorts.Travel-Guide-Accommodation)
- [Houseboats in Panama City ](https://expedia.com/Panama-City-Houseboats.d2897-aaHouseboats.Travel-Guide-Accommodation)
- [Pensions in Panama City ](https://expedia.com/Panama-City-Pensions.d2897-aaPensions.Travel-Guide-Accommodation)
- [Castles in Panama City ](https://expedia.com/Panama-City-Castles.d2897-aaCastles.Travel-Guide-Accommodation)

## Frequently asked questions

### Can I find vacation rentals in Panama City?

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- [Caimitillo Hotels](https://expedia.com/Caimitillo-Hotels.d829297769735790592.Travel-Guide-Hotels)
- [24 de Diciembre 5 Star Hotels](https://expedia.com/5Star-24-De-Diciembre-Hotels.s50-0-d829297636442910720.Travel-Guide-Filter-Hotels)
- [Tocumen Pet-friendly Hotels](https://expedia.com/Tocumen-Hotels-Pet-Friendly-Hotel.0-0-d6053184-tPetfriendlyHotel.Travel-Guide-Filter-Hotels)
- [Taboga 5 Star Hotels](https://expedia.com/5Star-Taboga-Hotels.s50-0-d6268388.Travel-Guide-Filter-Hotels)
- [Hard Rock Hotels Hotels in Caimitillo](https://expedia.com/Caimitillo-Hotels-Hard-Rock-Hotels.0-0-d829297769735790592--bHardRockHotels.Travel-Guide-Filter-Hotels)
- [Taboga Hotels](https://expedia.com/Taboga-Hotels.d6268388.Travel-Guide-Hotels)
- [Tortí 2 Star Hotels](https://expedia.com/2Star-Torti-Hotels.s20-0-d829297631527182336.Travel-Guide-Filter-Hotels)
- [Tocumen Hotels with Free Airport Shuttle](https://expedia.com/Tocumen-Hotels-Hotels-With-Free-Airport-Shuttle.0-0-d6053184-tHotelswithFreeAirportShuttle.Travel-Guide-Filter-Hotels)

Flights

- [Flights to San Miguel](https://expedia.com/Cheap-Flights-To-San-Miguel.d6336629.Travel-Guide-Flights)
- [Flights to San Miguelito](https://expedia.com/Cheap-Flights-To-San-Miguelito.d553248623199125040.Travel-Guide-Flights)
- [Flights to Tocumen](https://expedia.com/Cheap-Flights-To-Tocumen.d6053184.Travel-Guide-Flights)

Cars

- [Car rentals in Taboga](https://expedia.com/Car-Rentals-In-Taboga.d6268388.Car-Rental-Guide)

Activities

- [Things to do in San Miguelito](https://expedia.com/Things-To-Do-In-San-Miguelito.d553248623199125040.Travel-Guide-Activities)
- [Things to do in 24 de Diciembre](https://expedia.com/Things-To-Do-In-24-De-Diciembre.d829297636442910720.Travel-Guide-Activities)
- [Things to do in Taboga](https://expedia.com/Things-To-Do-In-Taboga.d6268388.Travel-Guide-Activities)
- [Things to do in Tocumen](https://expedia.com/Things-To-Do-In-Tocumen.d6053184.Travel-Guide-Activities)

Vacation Rentals

- [Rentals in Cañita](https://expedia.com/Canita-Vacation-Rentals.d829297618541613056.Travel-Guide-VacationRentals)

General

- [Visit Caimitillo](https://expedia.com/Caimitillo.dx829297769735790592)
- [Visit Saboga](https://expedia.com/Saboga.dx829297425886765056)
- [Visit Pacora](https://expedia.com/Pacora.dx705719212110229504)
- [Visit Las Cumbres](https://expedia.com/Las-Cumbres.dx6246011)
- [Visit San Miguel](https://expedia.com/San-Miguel.dx6336629)
- [Visit Tortí](https://expedia.com/Torti.dx829297631527182336)
- [Visit Taboga](https://expedia.com/Taboga.dx6268388)
- [Visit Chiman](https://expedia.com/Chiman.dx3000473477)
- [Visit San Miguelito](https://expedia.com/San-Miguelito.dx553248623199125040)

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