Find hotels in Downtown, Seneca
Go beyond your typical stay in Downtown
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Discover Downtown hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Quality Inn Seneca Clemson Area US-123
Quality Inn Seneca Clemson Area US-123
8.0 out of 10, Very Good, (645)
$85 nightly
The price is $93
Oct 12 - Oct 13
Total with taxes and fees

Lakeside Lodge Clemson
Lakeside Lodge Clemson
9.0 out of 10, Wonderful, (1014)
$123 nightly
The price is $135
Oct 2 - Oct 3
Total with taxes and fees

Fairfield Inn & Suites Seneca Clemson Univ Area
Fairfield Inn & Suites Seneca Clemson Univ Area
9.4 out of 10, Exceptional, (194)
$129 nightly
The price is $142
Oct 12 - Oct 13
Total with taxes and fees

Days Inn by Wyndham Seneca / Clemson Area
Days Inn by Wyndham Seneca / Clemson Area
6.8 out of 10, (701)
$68 nightly
The price is $75
Oct 5 - Oct 6
Total with taxes and fees

Best Western Plus Clemson Hotel & Conference Center
Best Western Plus Clemson Hotel & Conference Center
8.2 out of 10, Very Good, (1000)
$101 nightly
The price is $112
Oct 3 - Oct 4
Total with taxes and fees

Tru by Hilton Seneca Clemson
Tru by Hilton Seneca Clemson
9.2 out of 10, Wonderful, (772)
$110 nightly
The price is $121
Oct 12 - Oct 13
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Downtown
Find the best Downtown areas and neighborhoods for the activities you enjoy most.
Pine Ridge Point
While Pine Ridge Point isn't home to many top sights, Lake Keowee and Keowee Key Golf Course are some notable places to visit nearby.
Indian Oaks
While there might not be top attractions in Indian Oaks, you can explore the larger area and discover places like Keowee Reservoir and Oconee County Library Seneca Branch.
Serenity Bay
Though Serenity Bay might not have many top sights, you can venture to the surrounding area to see attractions like Keowee Key Golf Course and Lake Keowee.
Keowee Plantation
When in Keowee Plantation, you can plan a visit to Keowee Reservoir and Oconee County Library Seneca Branch, some noteworthy sights in the nearby area.
Top Downtown Hotel Reviews

Comfort Inn & Suites Clemson - University Area
10/10 Excellent
Hotels in top Seneca neighborhoods
More Accommodation Types in Downtown
- Vacation Homes in Seneca
- Cottages in Seneca
- Cabin Rentals in Seneca
- Apartments in Seneca
- Condo Rentals in Seneca
- Villas in Seneca
- Motels in Seneca
- Farmstay in Seneca
- RV Parks in Seneca
- Lodges in Seneca
- B&B in Seneca
- Chalets in Seneca
- Guest Houses in Seneca
- Condo Resorts in Seneca
- Houseboats in Seneca
Explore more hotels
- The Inn at Patrick Square
- Tru by Hilton Seneca Clemson
- Hampton Inn Clemson-University Area
- Microtel Inn & Suites by Wyndham Anderson/Clemson
- Best Western Seneca-Clemson
- Comfort Suites Anderson-Clemson
- Hampton Inn & Suites Seneca-Clemson Area
- Super 8 by Wyndham Anderson/Clemson Area
- Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG
- Quality Inn
- Postcard Cabins Lake Hartwell
- Woodspring Suites Anderson North I-85