Seneca Vacation Rentals

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Check prices for these dates

In two weeks
Feb 20 - Feb 22
In two months
Apr 3 - Apr 5
In three months
May 1 - May 3
In four months
May 29 - May 31

Our top choices for Seneca vacation rentals

View from property

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
2.0 star property
Seneca
9.8 out of 10, Exceptional, (57 reviews)
"Excellent stay."
United States
Beonca
$129 nightly
The price is $142
Feb 8 - Feb 9
Total with taxes and fees
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Smart TV, fireplace

Enjoy one of our RV units son less of a headache for you this vacation!

Enjoy one of our RV units son less of a headache for you this vacation!
Seneca
8.0 out of 10, Very Good, (4 reviews)
"My partner and I stayed 5 nights and we enjoyed it so much. It's such a convenient place to reside for a get away. If you're looking for that "outback" feeling but want to be cozy; look no further. Communication was always qick with responses and was more than willing to help with anything we needed! We would definitely stay again."
United States
Denise s.
$139 nightly
The price is $153
Mar 1 - Mar 2
Total with taxes and fees
Enjoy one of our RV units son less of a headache for you this vacation!
Exterior

Cozy Clemson TIny House Cabin

Cozy Clemson TIny House Cabin
Seneca
$200 nightly
The price is $220
Feb 8 - Feb 9
Total with taxes and fees
Cozy Clemson TIny House Cabin
1 bedroom, WiFi, bed sheets

Cozy camper in Clemson Hills. 5 minutes from Clemson University. Pet friendly!

Cozy camper in Clemson Hills. 5 minutes from Clemson University. Pet friendly!
Seneca
10.0 out of 10, Exceptional, (12 reviews)
"Very clean and comfortable - very close to Clemson and easy access. "
United States
Jim A.
$183 nightly
The price is $201
Feb 9 - Feb 10
Total with taxes and fees
Cozy camper in Clemson Hills. 5 minutes from Clemson University. Pet friendly!
Private kitchen

The Clemson Cottage - 3.6 mi. to Memorial Stadium

The Clemson Cottage - 3.6 mi. to Memorial Stadium
Seneca
10.0 out of 10, Exceptional, (12 reviews)
"Adorable and clean home convenient to Clemson’s campus. We enjoyed our stay and Tyler was an exceptional host! "
United States
Mandy H.
$360 nightly
The price is $396
Feb 8 - Feb 9
Total with taxes and fees
The Clemson Cottage - 3.6 mi. to Memorial Stadium
Property grounds

Charming 3-bedroom house with WiFi and AC in serene Seneca on Lake Hartwell

Charming 3-bedroom house with WiFi and AC in serene Seneca on Lake Hartwell
Seneca
10.0 out of 10, Exceptional, (9 reviews)
"We enjoyed our stay. Had everything we needed. "
United States
Diane S.
$480 nightly
The price is $528
Feb 6 - Feb 7
Total with taxes and fees
Charming 3-bedroom house with WiFi and AC in serene Seneca on Lake Hartwell
Smart TV

Lake Retreat- Mins to CU- Kayaks, Fire Pit, Dock

Lake Retreat- Mins to CU- Kayaks, Fire Pit, Dock
Seneca
8.6 out of 10, Excellent, (4 reviews)
"Everything was in great condition! Items provided were good quality. You can tell a lot of time and thought has been put into this property. We would love to stay again. "
United States
Alisa W.
$264 nightly
The price is $290
Feb 8 - Feb 9
Total with taxes and fees
Lake Retreat- Mins to CU- Kayaks, Fire Pit, Dock
Fridge, microwave, oven, stovetop

3-bedroom 2 bath home located minutes from Keowee Mariana, shopping and Clemson

3-bedroom 2 bath home located minutes from Keowee Mariana, shopping and Clemson
Seneca
10.0 out of 10, Exceptional, (5 reviews)
"Great place with a lot close by"
United States
Aldor D.
$289 nightly
The price is $317
Feb 8 - Feb 9
Total with taxes and fees
3-bedroom 2 bath home located minutes from Keowee Mariana, shopping and Clemson
Microwave, oven, stovetop, dishwasher

The Big Golf House- 10 miles to Clemson

The Big Golf House- 10 miles to Clemson
Seneca
10.0 out of 10, Exceptional, (2 reviews)
"Absolutely! Perfect space for our needs, so for accommodating for our family & pet. "
United States
Gennifer Q.
$498 nightly
The price is $541
Feb 8 - Feb 9
Total with taxes and fees
The Big Golf House- 10 miles to Clemson
4 bedrooms, desk, iron/ironing board, WiFi

Johnsons Cove - Lakefront Retreat With EV Charger

Johnsons Cove - Lakefront Retreat With EV Charger
Seneca
10.0 out of 10, Exceptional, (1 review)
"We truly enjoyed our stay at Johnson’s Cove. The property was super clean. The kitchen was one of the best stocked rentals I have stayed in. The mattress we slept on was better than our mattress at home. The communication with the owner was fast and she was quick to respond. We rented a pontoon for the day and the dock was easy to use for loading and unloading/restroom. We will surely rent there again."
United States
Rebecca G.
$749 nightly
The price is $795
Feb 8 - Feb 9
Total with taxes and fees
Johnsons Cove - Lakefront Retreat With EV Charger
Interior

Timber Trail Estate: Stunning Views + Waterfront

Timber Trail Estate: Stunning Views + Waterfront
Seneca
6.4 out of 10, (5 reviews)
"Main floor was clean but basement and loft, cleaners missed a lot. It was very dusty with lots of cobwebs. Cleaners have missed a lot of places over and over again. The downstairs deck was full of pollen and so dirty we couldn’t sit out there. Wish there was an umbrella on top deck- no shade or cover when rains. Wish there was somewhere to put suitcases but w no closet space and no dresser tops, suitcases were all over floors. Was just hoping for a cleaner space for what we paid. Overall it was...
United States
Kristen F.
$422 nightly
The price is $480
Feb 9 - Feb 10
Total with taxes and fees
Timber Trail Estate: Stunning Views + Waterfront
Interior

Beautiful Updated Clemson Lake House - 4 Miles from Downtown Clemson and the Stadium

Beautiful Updated Clemson Lake House - 4 Miles from Downtown Clemson and the Stadium
Seneca
9.6 out of 10, Exceptional, (8 reviews)
"Owner was on point with contact prior to arrival and during stay. Check in was super easy and property was clean and decorated nicely. Everything that we needed was already at the house. There is a marina close by with restaurant also."
United States
Benjamin J.
$657 nightly
The price is $695
Feb 8 - Feb 9
Total with taxes and fees
Beautiful Updated Clemson Lake House - 4 Miles from Downtown Clemson and the Stadium
Property grounds

Deepwater Cove on Lake Keowee. Complete with Dock and Kayaks. EV Charger

Deepwater Cove on Lake Keowee. Complete with Dock and Kayaks. EV Charger
Serenity Bay
9.8 out of 10, Exceptional, (130 reviews)
"A wonderful stay! The house offered many different spaces and the lake access/dock was perfect!!"
United States
stacy s.
$651 nightly
The price is $716
Feb 6 - Feb 7
Total with taxes and fees
Deepwater Cove on Lake Keowee. Complete with Dock and Kayaks. EV Charger
Smart TV

The Pendle-Tin

The Pendle-Tin
Pendleton
9.8 out of 10, Exceptional, (9 reviews)
"Perfect for weekend getaway!"
United States
Gregg H.
$179 nightly
The price is $199
Feb 16 - Feb 17
Total with taxes and fees
The Pendle-Tin
Cabin, 2 Bedrooms, Non Smoking (No Pets, Linens Included) | In-room dining

Carolina Landing RV Resort - Caravan Park

Carolina Landing RV Resort - Caravan Park
2.0 star property
Fair Play
7.6 out of 10, Good, (47 reviews)
"Lake "
United States
Milton
$130 nightly
The price is $143
Feb 15 - Feb 16
Total with taxes and fees
Carolina Landing RV Resort - Caravan Park
Interior

Glamping with a partial lake view, 30 minutes to Clemson University

Glamping with a partial lake view, 30 minutes to Clemson University
Westminster
9.4 out of 10, Exceptional, (14 reviews)
"The camper was very clean and the set up was very nice. Didn’t have a view of the lake, but all in all had a very nice stay. "
United States
Scott S.
$190 nightly
The price is $209
Feb 9 - Feb 10
Total with taxes and fees
Glamping with a partial lake view, 30 minutes to Clemson University
Premium bedding, in-room safe, individually furnished, laptop workspace

Carolina Camp Cedar

Carolina Camp Cedar
3.5 star property
Pickens
$175 nightly
The price is $195
Feb 15 - Feb 16
Total with taxes and fees
Carolina Camp Cedar
Signature Cottage, 2 Bedrooms | Living room | 43-inch Smart TV with cable channels, TV, Netflix

Clemson Memorabilia House

Clemson Memorabilia House
3.0 star property
Clemson
9.8 out of 10, Exceptional, (9 reviews)
"We enjoyed our stay, it was the perfect size for our family of four. "
United States
Ashley
$214 nightly
The price is $238
Feb 8 - Feb 9
Total with taxes and fees
Clemson Memorabilia House
Exterior

Broyles Landing Cottage at Lake Hartwell SC

Broyles Landing Cottage at Lake Hartwell SC
Townville
10.0 out of 10, Exceptional, (17 reviews)
"Very clean cottage, convenient to Saddlers’ Creek State Park. Appreciated the goodies provided for guests."
United States
Beverly F.
$178 nightly
The price is $198
Feb 9 - Feb 10
Total with taxes and fees
Broyles Landing Cottage at Lake Hartwell SC
Exterior

Romantic Cottage Getaway, tucked peacefully in the woods

Romantic Cottage Getaway, tucked peacefully in the woods
Pickens
10.0 out of 10, Exceptional, (16 reviews)
"Amazing secluded retreat!"
United States
Stephen N.
$183 nightly
The price is $203
Feb 8 - Feb 9
Total with taxes and fees
Romantic Cottage Getaway, tucked peacefully in the woods
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Seneca Hotel Reviews

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

10/10 Excellent
"Very clean! Cozy space. Great 24 hour getaway! "
Intisar 1-night trip
Posted 8 days ago
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Find out more about Seneca

Everything you need to know about Seneca vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Seneca vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Seneca vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Seneca vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Seneca. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Seneca in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $142 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Seneca rentals

At Expedia, we put the best Seneca vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Seneca rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Seneca vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Seneca. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Explore a world of travel with Expedia

Frequently asked questions

Are there vacation rentals in Seneca?

Yes, there are vacation rentals close to popular attractions in Seneca, or you can select a secluded option if you'd like a relaxing place to stay. Discover why Seneca is known for its marina and lakeside. While you're here, grab a bite or have a drink at the coffeehouses.

What's the top vacation rental in Seneca?

Quiet cove, deep water, minutes to Clemson, pet friendly, easy path to the dock: This highly rated vacation home rental in Seneca is located on a lake and has a patio, a private yard, and a barbecue grill to put you at ease in your new surroundings. It has 4 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. You and your friends and family can relax into your vacation with amenities like a selection of games. Some other homes for rent in Seneca include Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub and Lake House with Dock, Pool, and Pet Friendly. 8 Minutes from Clemson..

How many vacation rentals are there in Seneca?

Choose from 201 Expedia vacation rentals in Seneca for a memorable vacation.

What’s there to see and do in Seneca?

Cultural attractions include The Gauntlet and Oconee Community Theatre, whereas Keowee Reservoir and Lake Keowee are a couple of picturesque spots to enjoy the outdoors. While here, Keowee Key Golf Course and Lake Hartwell are other places worth a visit.

What’s a vacation rental in Seneca like?

A vacation rental is a private property where you can stay for a few weeks or just a few days in Seneca. Vacation rentals offer amenities such as WiFi and washers and dryers so you'll have all the conveniences of home. If you're concerned about cleanliness, vacation rentals can provide a sense of security away from shared hotel elevators and busy concierge desks while still allowing you a great travel experience. You'll also get more space in a vacation rental than in a standard hotel, which makes a vacation rental an attractive choice for family trips.