A calm lake with mountains in the background.

Seneca Vacation Rentals

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Check prices for these dates

In two weeks
Oct 2 - Oct 4
In two months
Nov 13 - Nov 15
In three months
Dec 11 - Dec 13
In four months
Jan 8 - Jan 10

Our top choices for Seneca vacation rentals

View from property

1. Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
2.0 star property
Seneca
9.6 out of 10, Exceptional, (105 reviews)
"Me and my family had a great time"
United States
Nirumol
$133 nightly
The price is $146
Oct 19 - Oct 20
Total with taxes and fees
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Exterior

2. Cozy Clemson TIny House Cabin

Cozy Clemson TIny House Cabin
Seneca
10.0 out of 10, Exceptional, (3 reviews)
"The property was very clean and well maintained. The living space is large and the bathroom quite large as well. It was perfect for our needs. It is close to everything in the area. Jim was extremely helpful and super quick with his responses to our questions."
United States
Peter M.
$198 nightly
The price is $218
Sep 23 - Sep 24
Total with taxes and fees
Cozy Clemson TIny House Cabin
Terrace/patio

3. Cozy Family Home in a Quiet Setting-12 Minutes from Clemson University

Cozy Family Home in a Quiet Setting-12 Minutes from Clemson University
Seneca
10.0 out of 10, Exceptional, (1 review)
"Beautiful home, no complaints."
United States
Brenda
$324 nightly
The price is $356
Sep 20 - Sep 21
Total with taxes and fees
Cozy Family Home in a Quiet Setting-12 Minutes from Clemson University
Smart TV, fireplace, books

4. Renovated Bungalow 1 Block from Downtown Seneca! 7 miles from Clemson!

Renovated Bungalow 1 Block from Downtown Seneca! 7 miles from Clemson!
Downtown
10.0 out of 10, Exceptional, (22 reviews)
"Great host! We had a great experience during our stay. "
United States
David E.
$347 nightly
The price is $381
Sep 20 - Sep 21
Total with taxes and fees
Renovated Bungalow 1 Block from Downtown Seneca! 7 miles from Clemson!
1 bedroom, WiFi, bed sheets

5. Cozy camper in Clemson Hills. 5 minutes from Clemson University. Pet friendly!

Cozy camper in Clemson Hills. 5 minutes from Clemson University. Pet friendly!
Seneca
10.0 out of 10, Exceptional, (15 reviews)
"Perfect pet friendly spot to enjoy a weekend getaway! Quiet campground, homey vibe, and awesome location!"
United States
Josie G.
$183 nightly
The price is $201
Sep 21 - Sep 22
Total with taxes and fees
Cozy camper in Clemson Hills. 5 minutes from Clemson University. Pet friendly!
Coffee/tea maker, fridge, microwave, oven

6. Carolina Cottage Retreat-12 Minutes from Clemson University

Carolina Cottage Retreat-12 Minutes from Clemson University
Seneca
10.0 out of 10, Exceptional, (2 reviews)
"We were very pleased with our stay. Four bedrooms was perfect for us. The little coffee bar was an enjoyable perk!"
United States
Karen S.
$334 nightly
The price is $367
Sep 20 - Sep 21
Total with taxes and fees
Carolina Cottage Retreat-12 Minutes from Clemson University
Living area

7. Peaceful 3-bedroom home 4 miles from Clemson.

Peaceful 3-bedroom home 4 miles from Clemson.
Seneca
$263 nightly
The price is $289
Sep 20 - Sep 21
Total with taxes and fees
Peaceful 3-bedroom home 4 miles from Clemson.
3 bedrooms, iron/ironing board, travel crib, WiFi (free)

8. Walk to Boat Ramp Lake Keowee w/ Parking + Firepit

Walk to Boat Ramp Lake Keowee w/ Parking + Firepit
Seneca
$429 nightly
The price is $447
Sep 22 - Sep 23
Total with taxes and fees
Walk to Boat Ramp Lake Keowee w/ Parking + Firepit
3 bedrooms, WiFi (free)

9. Renovated 3BR near Lake Keowee & Clemson

Renovated 3BR near Lake Keowee & Clemson
Seneca
10.0 out of 10, Exceptional, (2 reviews)
"Fantastic location and really nicely done home. It was a perfect touch having a desk in one of the rooms to be able to get work done."
United States
Brenda B.
$348 nightly
The price is $382
Sep 23 - Sep 24
Total with taxes and fees
Renovated 3BR near Lake Keowee & Clemson
Dining

10. Iroquois Crossroads - 10 min from Clemson & lakes

Iroquois Crossroads - 10 min from Clemson & lakes
Seneca
10.0 out of 10, Exceptional, (1 review)
"Swati was a wonderful host! I always have questions and they answered right away on everything i asked! The house was clean and comfortable, with everything you need! We were there to visit our son at Clemson and it was so convenient. Towels and linens were plentiful, kitchen was well-stocked. There is a really sweet screened in back porch. I was hoping to sit out there but we had tons of rain. I will definitely stay here again!"
United States
Joyce W.
$367 nightly
The price is $404
Sep 20 - Sep 21
Total with taxes and fees
Iroquois Crossroads - 10 min from Clemson & lakes
Coffee/tea maker, fridge, microwave, oven

11. 3 bedroom 2 bath home located minutes from Keowee Mariana, shopping and Clemson

3 bedroom 2 bath home located minutes from Keowee Mariana, shopping and Clemson
Seneca
9.8 out of 10, Exceptional, (12 reviews)
"Easy check in, pet-friendly, great location!!"
United States
Jason M.
$320 nightly
The price is $352
Oct 5 - Oct 6
Total with taxes and fees
3 bedroom 2 bath home located minutes from Keowee Mariana, shopping and Clemson
Living area

12. Camping on Fancy-Perfect for small family getaway or couples retreat!

Camping on Fancy-Perfect for small family getaway or couples retreat!
Seneca
$160 nightly
The price is $176
Sep 21 - Sep 22
Total with taxes and fees
Camping on Fancy-Perfect for small family getaway or couples retreat!
Coffee/tea maker, fridge, microwave, oven

13. The Big Golf House- 10 miles to Clemson

The Big Golf House- 10 miles to Clemson
Seneca
10.0 out of 10, Exceptional, (4 reviews)
"Great house and host!"
United States
David E.
$572 nightly
The price is $628
Sep 20 - Sep 21
Total with taxes and fees
The Big Golf House- 10 miles to Clemson
Property grounds

14. Waterfront 3br home on Lake Hartwell near Clemson

Waterfront 3br home on Lake Hartwell near Clemson
Seneca
9.8 out of 10, Exceptional, (15 reviews)
"We enjoyed our stay. Had everything we needed. "
United States
Diane S.
$480 nightly
The price is $528
Sep 21 - Sep 22
Total with taxes and fees
Waterfront 3br home on Lake Hartwell near Clemson
Smart TV

15. Lake Retreat- Mins to CU- Kayaks, Fire Pit, Dock

Lake Retreat- Mins to CU- Kayaks, Fire Pit, Dock
Seneca
8.0 out of 10, Very good, (7 reviews)
"Adorable and clean house! The yard is beautiful "
United States
Diana H.
$265 nightly
The price is $292
Sep 23 - Sep 24
Total with taxes and fees
Lake Retreat- Mins to CU- Kayaks, Fire Pit, Dock
Exterior

16. 3-bedroom Clemson house in Seneca minutes from school

3-bedroom Clemson house in Seneca minutes from school
Seneca
$697 nightly
The price is $767
Sep 22 - Sep 23
Total with taxes and fees
3-bedroom Clemson house in Seneca minutes from school
Terrace/patio

17. Beautiful Lake Keowee Home w/ Boat Dock & Fire Pit

Beautiful Lake Keowee Home w/ Boat Dock & Fire Pit
Seneca
9.4 out of 10, Exceptional, (36 reviews)
"Love this place! Everything was clean, felt like out of a Magazine."
United States
Y. Cesin R.
$729 nightly
The price is $802
Sep 27 - Sep 28
Total with taxes and fees
Beautiful Lake Keowee Home w/ Boat Dock & Fire Pit
Exterior

18. Adorable 2-bedroom 1- full bath mobile home with AC close to Lake Keowee, SC

Adorable 2-bedroom 1- full bath mobile home with AC close to Lake Keowee, SC
Seneca
8.8 out of 10, Excellent, (3 reviews)
"A little further out than I thought. Other than that, everything else was great. Would stay there again. The host was super nice and answered any question that I had. I had a very pleasant stay."
United States
Randy M.
$178 nightly
The price is $196
Oct 2 - Oct 3
Total with taxes and fees
Adorable 2-bedroom 1- full bath mobile home with AC close to Lake Keowee, SC
House (3 Bedrooms) | Interior

19. Beautiful Lake Keowee Home w/ Boat Dock & Fire Pit

Beautiful Lake Keowee Home w/ Boat Dock & Fire Pit
3.0 star property
Seneca
$713 nightly
The price is $785
Sep 27 - Sep 28
Total with taxes and fees
Beautiful Lake Keowee Home w/ Boat Dock & Fire Pit
Interior

20. Beautiful Updated Clemson Lake House - 4 Miles from Downtown Clemson and the Stadium

Beautiful Updated Clemson Lake House - 4 Miles from Downtown Clemson and the Stadium
Seneca
9.6 out of 10, Exceptional, (11 reviews)
"Everything was lovely."
United States
Allison C.
$657 nightly
The price is $695
Sep 20 - Sep 21
Total with taxes and fees
Beautiful Updated Clemson Lake House - 4 Miles from Downtown Clemson and the Stadium
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Seneca Hotel Reviews

Lakeside Lodge Clemson

Lakeside Lodge Clemson

10/10 Excellent
"Great size rooms, very clean and well decorated!"
Kerry 1-night trip
Posted 17 hours ago
Lakeside Lodge Clemson

Find out more about Seneca

Everything you need to know about Seneca vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Seneca vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Seneca vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Seneca vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Seneca. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Seneca in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $146 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Seneca rentals

At Expedia, we put the best Seneca vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Seneca rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Seneca vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Seneca. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Explore a world of travel with Expedia

Frequently asked questions

Are there vacation rentals in Seneca?

Yes, there are vacation rentals in Seneca close to Blue Ridge Arts Center, or you can go with a more secluded option if you'd like a relaxing place to stay. Discover why Seneca is known for its marina and lakeside. While you're here, grab a bite or have a drink at the coffeehouses.

What's the top vacation rental in Seneca?

4/3, Waterfront Home w/ Covered Dock, Child Sand Play Pit, Pet Friendly!: This highly rated vacation home rental in Seneca is located on a lake and has a fireplace, a balcony, and a barbecue grill to put you at ease in your new surroundings. It has 4 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. Kick off your shoes and enjoy yourself with a garden and an arcade game room. Some other homes for rent in Seneca include Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub and New to VRBO! Big water views, private dock, pool table, 15 min Clemson!.

How many vacation rentals are there in Seneca?

Choose from 219 Expedia vacation rentals in Seneca for a memorable vacation.

What’s there to see and do in Seneca?

Cultural attractions include The Gauntlet and Oconee Community Theatre, whereas Keowee Reservoir and Lake Keowee are a couple of picturesque spots to enjoy the outdoors. While here, Keowee Key Golf Course and Lake Hartwell are other places worth a visit.

What’s a vacation rental in Seneca like?

A vacation rental is a private property where you can stay for a few weeks or just a few days in Seneca. Vacation rentals offer amenities such as WiFi and washers and dryers so you'll have all the conveniences of home. If you're concerned about cleanliness, vacation rentals can provide a sense of security away from shared hotel elevators and busy concierge desks while still allowing you a great travel experience. You'll also get more space in a vacation rental than in a standard hotel, which makes a vacation rental an attractive choice for family trips.