Title: Seneca Vacation Rentals from $85: Search Short-Term Rentals | Expedia.com

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![Lake Keowee South Carolina](https://images.trvl-media.com/place/6548/8356140f-bae9-4afc-8d65-c18efc5581aa.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/6548/8356140f-bae9-4afc-8d65-c18efc5581aa.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Check prices for these dates

In two weeks

[Apr 3 - Apr 5](https://www.expedia.com/Hotel-Search?regionId=6548&startDate=2026-04-03&endDate=2026-04-05&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two months

[May 15 - May 17](https://www.expedia.com/Hotel-Search?regionId=6548&startDate=2026-05-15&endDate=2026-05-17&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In three months

[Jun 12 - Jun 14](https://www.expedia.com/Hotel-Search?regionId=6548&startDate=2026-06-12&endDate=2026-06-14&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In four months

[Jul 10 - Jul 12](https://www.expedia.com/Hotel-Search?regionId=6548&startDate=2026-07-10&endDate=2026-07-12&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Seneca vacation rentals

![View from property](https://images.trvl-media.com/lodging/111000000/110490000/110487400/110487306/d7c06df6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, desk, laptop workspace, bed sheets](https://images.trvl-media.com/lodging/111000000/110490000/110487400/110487306/ec2a8fca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Shower, towels, soap, shampoo](https://images.trvl-media.com/lodging/111000000/110490000/110487400/110487306/cf119645.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Cabin, 1 Queen Bed (View) | Private kitchen | Mini-fridge, stovetop, cookware/dishes/utensils, paper towels](https://images.trvl-media.com/lodging/111000000/110490000/110487400/110487306/e935ccb8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

[](https://www.expedia.com/Postcard-Cabins-Lake-Hartwell.h110487306.Hotel-Information)

Seneca

9.8/10

Exceptional

(66 reviews)

"Excellent stay."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Beonca

$139 nightly

$153 total

Mar 23 - Mar 24

Total with taxes and fees

[](https://www.expedia.com/Postcard-Cabins-Lake-Hartwell.h110487306.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/123000000/122340000/122332400/122332322/w1536h2048x0y0-6998e207.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, WiFi, bed sheets](https://images.trvl-media.com/lodging/123000000/122340000/122332400/122332322/ad885ebc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/123000000/122340000/122332400/122332322/511c9b4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/123000000/122340000/122332400/122332322/c9812bb8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cozy Clemson TIny House Cabin

[](https://www.expedia.com/Seneca-Hotels-Cozy-Clemson-TIny-House-Cabin.h122332322.Hotel-Information)

Seneca

$197 nightly

$217 total

Mar 23 - Mar 24

Total with taxes and fees

[](https://www.expedia.com/Seneca-Hotels-Cozy-Clemson-TIny-House-Cabin.h122332322.Hotel-Information)

![Private kitchen](https://images.trvl-media.com/lodging/97000000/96160000/96153700/96153668/40d3b059.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/97000000/96160000/96153700/96153668/89ea8ad4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/97000000/96160000/96153700/96153668/45872750.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/97000000/96160000/96153700/96153668/ec808a43.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Clemson Cottage - 3.6 mi. to Memorial Stadium

[](https://www.expedia.com/Seneca-Hotels-The-Clemson-Cottage-36-Mi-To-Memorial-Stadium.h96153668.Hotel-Information)

Seneca

10/10

Exceptional

(16 reviews)

"Seriously comfortable home, the beds and pillows all fantastic, nicely appointed in every way. Can’t wait to stay here again. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Susan

$360 nightly

$396 total

Mar 23 - Mar 24

Total with taxes and fees

[](https://www.expedia.com/Seneca-Hotels-The-Clemson-Cottage-36-Mi-To-Memorial-Stadium.h96153668.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/115000000/114550000/114542100/114542071/e032590e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/115000000/114550000/114542100/114542071/9b29fdfd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Cookware/dishes/utensils, paper towels](https://images.trvl-media.com/lodging/115000000/114550000/114542100/114542071/bc9bfba2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bedrooms, free WiFi, bed sheets](https://images.trvl-media.com/lodging/115000000/114550000/114542100/114542071/8a811318.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Charming 3-bedroom house with WiFi and AC in serene Seneca on Lake Hartwell

[](https://www.expedia.com/Charming-3-Bedroom-House-With-WiFi-And-AC-In-Serene-Seneca-On-Lake-Hartwell.h114542071.Hotel-Information)

Seneca

10/10

Exceptional

(9 reviews)

"We enjoyed our stay. Had everything we needed. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Diane S.

$480 nightly

$528 total

Mar 23 - Mar 24

Total with taxes and fees

[](https://www.expedia.com/Charming-3-Bedroom-House-With-WiFi-And-AC-In-Serene-Seneca-On-Lake-Hartwell.h114542071.Hotel-Information)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/119000000/118710000/118705000/118704946/7bfcd263.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/119000000/118710000/118705000/118704946/bf812e86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/119000000/118710000/118705000/118704946/fa054611.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, table tennis](https://images.trvl-media.com/lodging/119000000/118710000/118705000/118704946/1692b12e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### 3-bedroom 2 bath home located minutes from Keowee Mariana, shopping and Clemson

[](https://www.expedia.com/Seneca-Hotels-3-Bedroom-2-Bath-Home-Located-Minutes-From-Keowee-Mariana.h118704946.Hotel-Information)

Seneca

10/10

Exceptional

(5 reviews)

"Great place with a lot close by"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Aldor D.

$289 nightly

$317 total

Mar 23 - Mar 24

Total with taxes and fees

[](https://www.expedia.com/Seneca-Hotels-3-Bedroom-2-Bath-Home-Located-Minutes-From-Keowee-Mariana.h118704946.Hotel-Information)

![Smart TV](https://images.trvl-media.com/lodging/121000000/120090000/120082600/120082534/0834ba3a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/121000000/120090000/120082600/120082534/c941d493.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/121000000/120090000/120082600/120082534/51bdec15.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/121000000/120090000/120082600/120082534/ab96edf9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Lake Retreat- Mins to CU- Kayaks, Fire Pit, Dock

[](https://www.expedia.com/Seneca-Hotels-Lakefront-Tiny-Home-Retreat-On-Hartwell-Near-CU.h120082534.Hotel-Information)

Seneca

8.8/10

Excellent

(5 reviews)

"Everything was in great condition! Items provided were good quality. You can tell a lot of time and thought has been put into this property. We would love to stay again. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Alisa W.

$268 nightly

$295 total

Mar 23 - Mar 24

Total with taxes and fees

[](https://www.expedia.com/Seneca-Hotels-Lakefront-Tiny-Home-Retreat-On-Hartwell-Near-CU.h120082534.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/108000000/107520000/107517300/107517282/fc891652.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor dining](https://images.trvl-media.com/lodging/108000000/107520000/107517300/107517282/98c8974f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/108000000/107520000/107517300/107517282/d37b415d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, video games](https://images.trvl-media.com/lodging/108000000/107520000/107517300/107517282/f0fe695d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Beautiful Updated Clemson Lake House - 4 Miles from Downtown Clemson and the Stadium

[](https://www.expedia.com/Seneca-Hotels-Beautiful-Updated-Clemson-Lake-House-5-Mins-From-Downtown-Clemson-And-The-Stadium.h107517282.Hotel-Information)

Seneca

9.6/10

Exceptional

(8 reviews)

"Very accommodating host. Property is a great location and very clean. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Craig F.

$657 nightly

$695 total

Mar 23 - Mar 24

Total with taxes and fees

[](https://www.expedia.com/Seneca-Hotels-Beautiful-Updated-Clemson-Lake-House-5-Mins-From-Downtown-Clemson-And-The-Stadium.h107517282.Hotel-Information)

![4 bedrooms, desk, iron/ironing board, WiFi](https://images.trvl-media.com/lodging/115000000/114850000/114843800/114843702/41018e46.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, printers](https://images.trvl-media.com/lodging/115000000/114850000/114843800/114843702/d0ce4a3d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/115000000/114850000/114843800/114843702/aad65738.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/115000000/114850000/114843800/114843702/50a9d9d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Johnsons Cove - Lakefront Retreat With EV Charger

[](https://www.expedia.com/Seneca-Hotels-Johnsons-Cove-Lakefront-Retreat-With-EV-Charger.h114843702.Hotel-Information)

Seneca

10/10

Exceptional

(1 review)

"We truly enjoyed our stay at Johnson’s Cove. The property was super clean. The kitchen was one of the best stocked rentals I have stayed in. The mattress we slept on was better than our mattress at home. The communication with the owner was fast and she was quick to respond. We rented a pontoon for the day and the dock was easy to use for loading and unloading/restroom. We will surely rent there again."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Rebecca G.

$719 nightly

$764 total

Mar 23 - Mar 24

Total with taxes and fees

[](https://www.expedia.com/Seneca-Hotels-Johnsons-Cove-Lakefront-Retreat-With-EV-Charger.h114843702.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/88000000/87560000/87552100/87552049/436516e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/88000000/87560000/87552100/87552049/ff2ee17b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/88000000/87560000/87552100/87552049/9428aa30.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![4 bedrooms, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/88000000/87560000/87552100/87552049/077dae4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Keowee Adventures \~ Peaceful Lakefront Home on Keowee \~ 7 Miles from Clemson!

[](https://www.expedia.com/Seneca-Hotels-New-Peaceful-Lakefront-Home-On-Keowee-Only-7-Miles-From-Clemson.h87552049.Hotel-Information)

Seneca

9.8/10

Exceptional

(59 reviews)

"We had a beautiful stay over Thanksgiving in this very cozy lake house. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Felicia L.

$565 nightly

$622 total

Mar 24 - Mar 25

Total with taxes and fees

[](https://www.expedia.com/Seneca-Hotels-New-Peaceful-Lakefront-Home-On-Keowee-Only-7-Miles-From-Clemson.h87552049.Hotel-Information)

![Smart TV, video games, table tennis](https://images.trvl-media.com/lodging/98000000/97060000/97053600/97053582/eea5ec7b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/98000000/97060000/97053600/97053582/c53fb178.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/98000000/97060000/97053600/97053582/5f42512b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bedrooms, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/98000000/97060000/97053600/97053582/5e61ee35.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Lakeside Clemson Condo With 4K/Surround Sound/Xbox/Coffee Bar/Private Bathrooms

[](https://www.expedia.com/Seneca-Hotels-Lakeside-Clemson-Condo-With-4KSurround-SoundXboxCoffee-BarPrivate-Bathrooms.h97053582.Hotel-Information)

Seneca

10/10

Exceptional

(21 reviews)

"Very nice accommodations and great location for stay in Clemson. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Marisa G.

$351 nightly

$386 total

Apr 14 - Apr 15

Total with taxes and fees

[](https://www.expedia.com/Seneca-Hotels-Lakeside-Clemson-Condo-With-4KSurround-SoundXboxCoffee-BarPrivate-Bathrooms.h97053582.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/25000000/24160000/24156000/24155990/825f9309.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, video games, stereo](https://images.trvl-media.com/lodging/25000000/24160000/24156000/24155990/735219a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/25000000/24160000/24156000/24155990/ce0e5825.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/25000000/24160000/24156000/24155990/91ac5b27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Deepwater Cove on Lake Keowee. Complete with Dock and Kayaks. EV Charger

[](https://www.expedia.com/Seneca-Hotels-Deepwater-Cove-On-Lake-Keowee-Complete-With-Dock-And-Kayaks-EV-Charger.h24155990.Hotel-Information)

Serenity Bay

9.8/10

Exceptional

(130 reviews)

"Beautiful home, well furnished, very clean, easy TV"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Alan

$651 nightly

$716 total

Mar 23 - Mar 24

Total with taxes and fees

[](https://www.expedia.com/Seneca-Hotels-Deepwater-Cove-On-Lake-Keowee-Complete-With-Dock-And-Kayaks-EV-Charger.h24155990.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/38000000/37020000/37012900/37012874/b866198b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/38000000/37020000/37012900/37012874/3e3661cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, DVD player, table tennis, books](https://images.trvl-media.com/lodging/38000000/37020000/37012900/37012874/c4de2bbb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Marina](https://images.trvl-media.com/lodging/38000000/37020000/37012900/37012874/c09b9ccb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Lake Keowee Retreat! Swim, Boat, Kayak & Relax on Dock Just Steps from the Water

[](https://www.expedia.com/Seneca-Hotels-LAKE-FRONT-RETREAT-Steps-Away-From-Swimming.h37012874.Hotel-Information)

Seneca

10/10

Exceptional

(82 reviews)

"Nice location and functionality for family. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

T P.

$826 nightly

$908 total

Mar 23 - Mar 24

Total with taxes and fees

[](https://www.expedia.com/Seneca-Hotels-LAKE-FRONT-RETREAT-Steps-Away-From-Swimming.h37012874.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/128000000/127020000/127013800/127013757/f084865a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/128000000/127020000/127013800/127013757/20842dc8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/128000000/127020000/127013800/127013757/9bb2205c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/128000000/127020000/127013800/127013757/686661ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cozy Family Home in a Quiet Setting-12 Minutes from Clemson University

[](https://www.expedia.com/Seneca-Hotels-A-Cozy-Family-Home-With-A-Relaxing-Stay-In-A-Quiet-Setting.h127013757.Hotel-Information)

Seneca

$288 nightly

$316 total

Mar 29 - Mar 30

Total with taxes and fees

[](https://www.expedia.com/Seneca-Hotels-A-Cozy-Family-Home-With-A-Relaxing-Stay-In-A-Quiet-Setting.h127013757.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/106000000/105170000/105164100/105164063/967698a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/106000000/105170000/105164100/105164063/3b0074de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/106000000/105170000/105164100/105164063/5507d727.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/106000000/105170000/105164100/105164063/6daf97b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Seneca lake house with private dock only 15 minutes from Clemson!

[](https://www.expedia.com/Seneca-Hotels-Seneca-Lake-House-With-Private-Dock-Only-15-Minutes-From-Clemson.h105164063.Hotel-Information)

Seneca

9.8/10

Exceptional

(10 reviews)

"We had a great time at Seneca Lake House. We would definitely stay here again. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Scott M.

$703 nightly

$773 total

Mar 26 - Mar 27

Total with taxes and fees

[](https://www.expedia.com/Seneca-Hotels-Seneca-Lake-House-With-Private-Dock-Only-15-Minutes-From-Clemson.h105164063.Hotel-Information)

![Smart TV, fireplace](https://images.trvl-media.com/lodging/118000000/117650000/117644500/117644416/c0b82041.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Microwave, oven, stovetop](https://images.trvl-media.com/lodging/118000000/117650000/117644500/117644416/b1844261.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/118000000/117650000/117644500/117644416/f26a8dd1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, fireplace](https://images.trvl-media.com/lodging/118000000/117650000/117644500/117644416/c2f5c321.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

###  Enjoy one of our RV units son less of a headache for you this vacation!

[](https://www.expedia.com/Seneca-Hotels-Cozy-Campground-In-Enchanting-Seneca-With-AC.h117644416.Hotel-Information)

Seneca

8.0/10

Very Good

(4 reviews)

"My partner and I stayed 5 nights and we enjoyed it so much. It's such a convenient place to reside for a get away. If you're looking for that "outback" feeling but want to be cozy; look no further. Communication was always qick with responses and was more than willing to help with anything we needed! We would definitely stay again."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Denise s.

$151 nightly

$166 total

Apr 14 - Apr 15

Total with taxes and fees

[](https://www.expedia.com/Seneca-Hotels-Cozy-Campground-In-Enchanting-Seneca-With-AC.h117644416.Hotel-Information)

![1 bedroom, WiFi, bed sheets](https://images.trvl-media.com/lodging/101000000/100790000/100784300/100784243/67979a9a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/101000000/100790000/100784300/100784243/424e1883.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/101000000/100790000/100784300/100784243/e2588273.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/101000000/100790000/100784300/100784243/4513793e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cozy camper in Clemson Hills. 5 minutes from Clemson University. Pet friendly!

[](https://www.expedia.com/Seneca-Hotels-Cozy-Camper-In-Clemson-Hills-5-Minutes-From-Clemson-University-Pet-Friendly.h100784243.Hotel-Information)

Seneca

10/10

Exceptional

(12 reviews)

"Very clean and comfortable - very close to Clemson and easy access. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jim A.

$180 nightly

$198 total

Mar 23 - Mar 24

Total with taxes and fees

[](https://www.expedia.com/Seneca-Hotels-Cozy-Camper-In-Clemson-Hills-5-Minutes-From-Clemson-University-Pet-Friendly.h100784243.Hotel-Information)

![Dining](https://images.trvl-media.com/lodging/126000000/125630000/125624500/125624500/891c0bf4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/126000000/125630000/125624500/125624500/e8c5c43f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/126000000/125630000/125624500/125624500/fbb953e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Private kitchen](https://images.trvl-media.com/lodging/126000000/125630000/125624500/125624500/2d71c6c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

###  bedroom available in my house in lovely Seneca. 5 miles from Clemson University

[](https://www.expedia.com/Seneca-Hotels-Charming-1-Bedroom-House-In-Lovely-Seneca-5-Miles-From-Clemson-University.h125624500.Hotel-Information)

Seneca

10/10

Exceptional

(1 review)

"Rooms were clean and host was accommodating. Room to park my boat and was able to bring my dog!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Matthew A.

$77 nightly

$85 total

Apr 4 - Apr 5

Total with taxes and fees

[](https://www.expedia.com/Seneca-Hotels-Charming-1-Bedroom-House-In-Lovely-Seneca-5-Miles-From-Clemson-University.h125624500.Hotel-Information)

![Smart TV, fireplace, books](https://images.trvl-media.com/lodging/106000000/105770000/105769700/105769612/9e2b77c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor dining](https://images.trvl-media.com/lodging/106000000/105770000/105769700/105769612/651434b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/106000000/105770000/105769700/105769612/d1bcfdf8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/106000000/105770000/105769700/105769612/a5e27533.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Renovated Bungalow 1 Block from Downtown Seneca! 7 miles from Clemson!

[](https://www.expedia.com/Seneca-Hotels-Renovated-Bungalow-1-Block-From-Downtown-Seneca-8-Miles-From-Clemson.h105769612.Hotel-Information)

Downtown

10/10

Exceptional

(16 reviews)

"Great home base for a Clemson game. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Karen A.

$295 nightly

$320 total

Apr 1 - Apr 2

Total with taxes and fees

[](https://www.expedia.com/Seneca-Hotels-Renovated-Bungalow-1-Block-From-Downtown-Seneca-8-Miles-From-Clemson.h105769612.Hotel-Information)

![Microwave, oven, stovetop, dishwasher](https://images.trvl-media.com/lodging/120000000/119750000/119746400/119746321/c027128d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/120000000/119750000/119746400/119746321/84d2a4cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Microwave, oven, stovetop, dishwasher](https://images.trvl-media.com/lodging/120000000/119750000/119746400/119746321/5ddade10.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/120000000/119750000/119746400/119746321/9e13146e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Big Golf House- 10 miles to Clemson

[](https://www.expedia.com/Seneca-Hotels-The-Big-Seneca-Golf-House-7-Miles-To-Death-Valley.h119746321.Hotel-Information)

Seneca

10/10

Exceptional

(2 reviews)

"Absolutely! Perfect space for our needs, so for accommodating for our family & pet. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Gennifer Q.

$512 nightly

$556 total

Apr 14 - Apr 15

Total with taxes and fees

[](https://www.expedia.com/Seneca-Hotels-The-Big-Seneca-Golf-House-7-Miles-To-Death-Valley.h119746321.Hotel-Information)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/127000000/126990000/126982700/126982607/39da46e8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/127000000/126990000/126982700/126982607/d6399ba6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/127000000/126990000/126982700/126982607/428b0ad5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Iron/ironing board, travel crib, free WiFi, bed sheets](https://images.trvl-media.com/lodging/127000000/126990000/126982700/126982607/482da2fa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Carolina Cottage Retreat-12 Minutes from Clemson University

[](https://www.expedia.com/Seneca-Hotels-Carolina-Cottage-Retreat.h126982607.Hotel-Information)

Seneca

$287 nightly

$316 total

Mar 31 - Apr 1

Total with taxes and fees

[](https://www.expedia.com/Seneca-Hotels-Carolina-Cottage-Retreat.h126982607.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.com/Hotel-Search?startDate=2026-04-05&endDate=2026-04-06&regionId=6548&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true)

## Find vacation rentals that suit your style

Cabins

[](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America&regionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-06-20&d1=2026-06-20&endDate=2026-06-23&d2=2026-06-23&lodging=CABIN)

Cottages

[](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America&regionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-06-20&d1=2026-06-20&endDate=2026-06-23&d2=2026-06-23&lodging=COTTAGE)

Private vacation homes

[](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America&regionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-06-20&d1=2026-06-20&endDate=2026-06-23&d2=2026-06-23&lodging=VACATION_HOME)

Condos

[](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America&regionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-06-20&d1=2026-06-20&endDate=2026-06-23&d2=2026-06-23&lodging=CONDO)

Apartments

[](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America&regionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-06-20&d1=2026-06-20&endDate=2026-06-23&d2=2026-06-23&lodging=APARTMENT)

Aparthotels

[](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America&regionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-06-20&d1=2026-06-20&endDate=2026-06-23&d2=2026-06-23&lodging=APART_HOTEL)

Villas

[](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America&regionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-06-20&d1=2026-06-20&endDate=2026-06-23&d2=2026-06-23&lodging=VILLA)

Houseboats

[](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America&regionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-06-20&d1=2026-06-20&endDate=2026-06-23&d2=2026-06-23&lodging=HOUSE_BOAT)

Chalets

[](https://www.expedia.com/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America&regionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-06-20&d1=2026-06-20&endDate=2026-06-23&d2=2026-06-23&lodging=CHALET)

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## Top Seneca Hotel Reviews

![Lakeside Lodge Clemson](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/db449d90_y.jpg)

### Lakeside Lodge Clemson

10/10 Excellent

"The unit was terrific. Quiet and clean. only issue is daily train whistle nearby. Nice area with grrat restaurant in hotel. "

[](https://expedia.com/Anderson-Hotels-Lakeside-Lodge-Clemson.h40217319.Hotel-Information)

![The Shepherd Hotel Downtown Clemson](https://images.trvl-media.com/lodging/88000000/87690000/87688200/87688155/bd45b45c_y.jpg)

### The Shepherd Hotel Downtown Clemson

10/10 Excellent

"Loved our time here! Staff was super sweet and helpful. Room was very nice and the bed very cozy. Room felt a little small but the bathroom was larger than expected, and again all nice and clean. No complaints! Great place to stay when in the area! Love the mission to help those differently abled, as well!!"

[](https://expedia.com/Clemson-Hotels-The-Shepherd-Hotel-Downtown-Clemson.h87688155.Hotel-Information)

![Best Western Seneca-Clemson](https://images.trvl-media.com/lodging/1000000/520000/517600/517561/eaa8fc9a_y.jpg)

### Best Western Seneca-Clemson

10/10 Excellent

"Clean room! Great staff! "

[](https://expedia.com/Anderson-Hotels-Best-Western-Seneca-Clemson.h517561.Hotel-Information)

![Best Western Plus Clemson Hotel & Conference Center](https://images.trvl-media.com/lodging/1000000/10000/1400/1370/w3837h2558x3y3-4efd29d6_y.jpg)

### Best Western Plus Clemson Hotel & Conference Center

10/10 Excellent

"I enjoyed my stay at the BW Plus. It's super convenient (I walked home from downtown one night - not a short walk but very manageable). The property was clean, the staff was VERY friendly, the room was more than adequate (I had 2 queens and it had a desk/chair and side chair with 'breakfast tray.' The bathroom was just fine. The breakfast area is HUGE and has all you need to get started in the morning, plus they have ping pong and ample seating for groups. I have already booked stays for the fall."

[](https://expedia.com/Anderson-Hotels-Best-Western-Plus-University-Inn-Conference-Center.h1370.Hotel-Information)

![Tru by Hilton Seneca Clemson](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323330/83732283_y.jpg)

### Tru by Hilton Seneca Clemson

10/10 Excellent

"Clean room, friendly staff. Great place to stay!"

[](https://expedia.com/Anderson-Hotels-Tru-By-Hilton-Seneca-Clemson.h34323330.Hotel-Information)

![Fairfield Inn & Suites Seneca Clemson Univ Area    ](https://images.trvl-media.com/lodging/72000000/71600000/71594700/71594655/w4000h2662x0y0-18bf21d5_y.jpg)

### Fairfield Inn & Suites Seneca Clemson Univ Area 

10/10 Excellent

"Clean room freindly staff and convenient location to stores"

[](https://expedia.com/Seneca-Hotels-Fairfield-Inn-Suites-By-Marriott-Seneca.h71594655.Hotel-Information)

![4/3, Waterfront Home w/ Covered Dock, Child Sand Play Pit,  Pet Friendly!](https://images.trvl-media.com/lodging/34000000/33730000/33728200/33728167/7de7c272_y.jpg)

### 4/3, Waterfront Home w/ Covered Dock, Child Sand Play Pit, Pet Friendly!

10/10 Excellent

"The home was beautiful, the amenities fantastic, and we especially enjoyed the kayaks! The kitchen was also stocked with all the basics we needed which saved us from additional grocery expense for items we would only be using for a couple of days. The owner was also a delight to work with. Wonderful experience!"

[](https://expedia.com/Anderson-Hotels-Beautiful-43.h33728167.Hotel-Information)

![Lake House with Dock, Pool, and Pet Friendly.  8 Minutes from Clemson.](https://images.trvl-media.com/lodging/34000000/33940000/33932300/33932265/0adee99d_y.jpg)

### Lake House with Dock, Pool, and Pet Friendly. 8 Minutes from Clemson.

10/10 Excellent

"Lots of Wonderful space, close to campus, great communication with property manager. Easy check-in and out. "

[](https://expedia.com/Seneca-Hotels-Lake-House-With-Dock.h33932265.Hotel-Information)

![Hampton Inn & Suites Seneca-Clemson Area](https://images.trvl-media.com/lodging/7000000/6700000/6696900/6696886/8f736b3a_y.jpg)

### Hampton Inn & Suites Seneca-Clemson Area

2/10 Terrible

"Rooms good for the night. No issues with rooms"

[](https://expedia.com/Anderson-Hotels-Hampton-Inn-Suites-Seneca-Clemson-Area.h6696886.Hotel-Information)

## Find out more about Seneca

**Everything you need to know about Seneca vacation rentals**

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Seneca vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Seneca vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

**Seneca vacation rentals: An excellent choice for every season**

Whenever you want to travel, a warm welcome awaits you in Seneca. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Seneca in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $85 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

**How to find incredible deals on Seneca rentals**

At Expedia, we put the best Seneca vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Seneca rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Seneca vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Seneca. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

## Explore a world of travel with Expedia

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- [Vacation Homes in Seneca ](https://expedia.com/Seneca-Private-Vacation-Homes.d6548-aaPrivateVacationHomes.Travel-Guide-Accommodation)
- [Cottages in Seneca ](https://expedia.com/Seneca-Cottages.d6548-aaCottages.Travel-Guide-Accommodation)
- [Cabin Rentals in Seneca ](https://expedia.com/Seneca-Cabins.d6548-aaCabins.Travel-Guide-Accommodation)
- [Apartments in Seneca ](https://expedia.com/Seneca-Apartments.d6548-aaApartments.Travel-Guide-Accommodation)
- [Condo Rentals in Seneca ](https://expedia.com/Seneca-Condos.d6548-aaCondos.Travel-Guide-Accommodation)
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- [Motels in Seneca ](https://expedia.com/Seneca-Motels.d6548-aaMotels.Travel-Guide-Accommodation)
- [Farmstay in Seneca ](https://expedia.com/Seneca-Agritourism.d6548-aaAgritourism.Travel-Guide-Accommodation)
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- [RV Parks in Seneca ](https://expedia.com/Seneca-RV-Parks.d6548-aaRVParks.Travel-Guide-Accommodation)
- [B&B in Seneca ](https://expedia.com/Seneca-Bed-And-Breakfast.d6548-aaBedAndBreakfast.Travel-Guide-Accommodation)
- [Guest Houses in Seneca ](https://expedia.com/Seneca-Guest-Houses.d6548-aaGuestHouses.Travel-Guide-Accommodation)
- [Chalets in Seneca ](https://expedia.com/Seneca-Chalets.d6548-aaChalets.Travel-Guide-Accommodation)
- [Houseboats in Seneca ](https://expedia.com/Seneca-Houseboats.d6548-aaHouseboats.Travel-Guide-Accommodation)
- [Condo Resorts in Seneca ](https://expedia.com/Seneca-Condominium-Resort.d6548-aaCondominiumResort.Travel-Guide-Accommodation)

## Frequently asked questions

### Are there vacation rentals in Seneca?

### What's the top vacation rental in Seneca?

### How many vacation rentals are there in Seneca?

### What’s there to see and do in Seneca?

### What’s a vacation rental in Seneca like?

### Expedia's Latest Trends

Hotels

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- [Best Hotels in Mount Pleasant](https://expedia.com/Mount-Pleasant-Hotels.d8675.Travel-Guide-Hotels)
- [Charleston Cheap Hotels](https://expedia.com/Charleston-Hotels-Cheap-Hotels.0-0-d179997-tCheapHotels.Travel-Guide-Filter-Hotels)
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- [Best Hotels in Myrtle Beach](https://expedia.com/Myrtle-Beach-Hotels.d601685.Travel-Guide-Hotels)
- [Myrtle Beach All-inclusive Resorts](https://expedia.com/Myrtle-Beach-Hotels-All-Inclusive-Hotel.0-0-d601685-tAllinclusiveHotel.Travel-Guide-Filter-Hotels)
- [Best Hotels in North Myrtle Beach](https://expedia.com/North-Myrtle-Beach-Hotels.d8929.Travel-Guide-Hotels)
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- [Myrtle Beach Oceanfront Hotels](https://expedia.com/Myrtle-Beach-Hotels-Oceanfront-Hotels.0-0-d601685-tOceanfrontHotels.Travel-Guide-Filter-Hotels)
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- [Myrtle Beach Cheap Hotels](https://expedia.com/Myrtle-Beach-Hotels-Cheap-Hotels.0-0-d601685-tCheapHotels.Travel-Guide-Filter-Hotels)
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- [Folly Beach Oceanfront Hotels](https://expedia.com/Folly-Beach-Hotels-Oceanfront-Hotels.0-0-d7217-tOceanfrontHotels.Travel-Guide-Filter-Hotels)

Flights

- [Flights to CAE](https://expedia.com/Cheap-Flights-To-Columbia.d764.Travel-Guide-Flights)
- [Flights to CHS](https://expedia.com/Cheap-Flights-To-Charleston.d179997.Travel-Guide-Flights)
- [Flights to SAV](https://expedia.com/Cheap-Flights-To-Hilton-Head-Island.d601684.Travel-Guide-Flights)
- [Flights to MYR](https://expedia.com/Cheap-Flights-To-Myrtle-Beach.d601685.Travel-Guide-Flights)

Cars

- [Car rentals in Columbia](https://expedia.com/Car-Rentals-In-Columbia.d764.Car-Rental-Guide)
- [Car rentals in Charleston](https://expedia.com/Car-Rentals-In-Charleston.d179997.Car-Rental-Guide)
- [Car rentals in Myrtle Beach](https://expedia.com/Car-Rentals-In-Myrtle-Beach.d601685.Car-Rental-Guide)
- [Car rentals in Greenville](https://expedia.com/Car-Rentals-In-Greenville.d1388.Car-Rental-Guide)

Cruises

- [Cruises from Charleston](https://expedia.com/Cruises-from-Charleston.d179997.Cruise-Departure-Port)

Activities

- [Things to do in Myrtle Beach](https://expedia.com/Things-To-Do-In-Myrtle-Beach.d601685.Travel-Guide-Activities)

Packages

- [Myrtle Beach Vacation Packages](https://expedia.com/Myrtle-Beach.d601685.Destination-Travel-Guides)

Vacation Rentals

- [Vacation Rentals Myrtle Beach](https://expedia.com/Myrtle-Beach-Vacation-Rentals.d601685.Travel-Guide-VacationRentals)

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