Photo by RVLuckyorWhat

Find hotels in Seneca, SC from $110

Most hotels are fully refundable. Because flexibility matters.

Save an average of 15% on thousands of hotels with Expedia Rewards.

Search over 2.9 million properties and 550 airlines worldwide.

Check Seneca hotel prices

Tomorrow night
This weekend

Filter by

Popular filters
Popular filters
Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Neighborhood
Neighborhood
Popular locations
Popular locations
Meal plans available
Meal plans available
Amenities
Amenities
Accessibility
Accessibility
Traveler experience
Traveler experience

Compare 188 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

4/3BB,3 acres, covered Dock,  2 Lrg.Covered Decks,  4.9 rating, $2400 mon/winter
4.8/5 Exceptional! (177 reviews)
Labor Day!
"Great stay!"

Reviewed on Oct 23, 2022

4/3BB,3 acres, covered Dock, 2 Lrg.Covered Decks, 4.9 rating, $2400 mon/winter
Cozy cottage quiet and secluded but close to everything.
4.4/5 Wonderful! (7 reviews)
Reccomend
"Didn't have much time to actually enjoy the house, I was staying there for work. Mostly just showered and slept there. It was nice what time I was there."

Reviewed on Oct 16, 2022

Cozy cottage quiet and secluded but close to everything.
Seneca Townhome on Lake Hartwell < 4 Mi to Clemson
5.44 mi from city center
5/5 Exceptional! (11 reviews)
Weekend Escape
"We had a great time in Clemson and spent all day Saturday on the lake. The place is right next to the Clemson Marina where you can rent a boat. The house is “lived-in” and very comfy. You can’t beat the proximity to Clemson while staying on the lake!"

Reviewed on Jul 25, 2022

Seneca Townhome on Lake Hartwell < 4 Mi to Clemson

Save an average of 15% on thousands of hotels when you're signed in

Lake House Near Clemson, Priv. Dock, WiFi, 60" TV, Grill, Kayaks, Deep Water
4.9/5 Exceptional! (105 reviews)
Great Property and a great host
"This property was exactly as listed. Spacious and comfortable with a beautiful view of the private dock and the lake. Unfortunately, we didn’t have good weather to fully take advantage of it. As advertised, the location was only 10 minutes from the Clemson campus. We would definitely stay here again ..."

Reviewed on Nov 15, 2022

Lake House Near Clemson, Priv. Dock, WiFi, 60" TV, Grill, Kayaks, Deep Water
Lake Keowee Cabin 14 miles to Clemson
3.92 mi from city center
4.7/5 Exceptional! (18 reviews)
Game weekend
"Good lake property with plenty of beds and an awesome location. We really enjoyed the outdoor space."

Reviewed on Oct 17, 2022

Lake Keowee Cabin 14 miles to Clemson
Awesome Lakefront Log Cabin with Covered Dock ~ Near Clemson
5/5 Exceptional! (138 reviews)
Relaxing Getaway
"We had a great time at the Serenity Bay property. The owner was extremely responsive and the house had a great layout. I can enough good things about this property. Super relaxing stay. It was hard to go home. Thanks Susan!"

Reviewed on Nov 8, 2022

Awesome Lakefront Log Cabin with Covered Dock ~ Near Clemson
Pirate's Retreat -Beautifully renovated lake home with Dock minutes from Clemson
5/5 Exceptional! (49 reviews)
Wonderful long weekend
"What a wonderful weekend we spent at this property. Kayaking at sunrise and breakfast, lunch and dinner on the back deck were highlights for us. The game room was a hit with the kids as well. Susan was attentive and thoughtful prior to and throughout our stay. We'll be back."

Reviewed on Oct 24, 2022

Pirate's Retreat -Beautifully renovated lake home with Dock minutes from Clemson
Lake Keowee SC Vacation Home, up to 14 guests, private dock
4.9/5 Exceptional! (17 reviews)
Perfect Getaway
"This home was in a great location. It was clean, cozy, and had lots of room. The view was incredible, and it was close to restaurants and grocery stores, and only a short drive to Clemson campus. We would definitely recommend it!"

Reviewed on Nov 14, 2022

Lake Keowee SC Vacation Home, up to 14 guests, private dock
Fall fun at the cabin! Convenient to Lake Keowee and Clemson
4.6/5 Wonderful! (63 reviews)
Would definitely book again
"We thoroughly enjoyed our stay. While the weather was not in our favor, we enjoyed every minute during our stay. We enjoyed many hours of family time playing cards, board games or just relaxing. Very quiet and tranquil surroundings. Best part…we were able to bring along our 4-legged friends. We would ..."

Reviewed on Jun 13, 2022

Fall fun at the cabin! Convenient to Lake Keowee and Clemson
Fairfield Inn & Suites Seneca Clemson Univ Area
2.5 out of 5
800 BYPASS 123, Seneca, SC, 29678
Fully refundableReserve now, pay when you stay
The price is $119 per night from Dec 4 to Dec 5
$119
per night
Dec 4 - Dec 5
1.08 mi from city center
4.6/5 Wonderful! (33 reviews)
"The property is new and clean. Folks are very accommodating"

Reviewed on Nov 26, 2022

Fairfield Inn & Suites Seneca Clemson Univ Area
NEW Seneca Creek Hideaway | Hot Tub | Bar & Game Room | Close to Lakes & Clemson
The price is $212 per night from Dec 5 to Dec 6
$212
per night
Dec 5 - Dec 6
3.79 mi from city center
5/5 Exceptional! (5 reviews)
Short but sweet stay
"We stayed here with 4 other adults for the Clemson vs Miami game and it was perfect for us. Not too far from the stadium. We all even enjoyed the game room. We would definitely stay here again!"

Reviewed on Nov 21, 2022

NEW Seneca Creek Hideaway | Hot Tub | Bar & Game Room | Close to Lakes & Clemson
Lakefront home with private beach  & unbelievable sunsets on Lake Keowee
5/5 Exceptional! (50 reviews)
Outstanding Long Weekend Getaway
"Our stay was very relaxing with incredible lake views. The house had everything we needed and plenty of room for for our party of six. We thoroughly enjoyed our stay with a short drive to a Clemson football game. Easy drive back after the game also. We are looking forward to planning a return in ..."

Reviewed on Nov 21, 2022

Lakefront home with private beach & unbelievable sunsets on Lake Keowee
Perfect Lake Hartwell Getaway - Gorgeous Lake Views!
4.31 mi from city center
5/5 Exceptional! (47 reviews)
Great place!!
"Awesome place to stay in a great location on the water."

Reviewed on Nov 15, 2022

Perfect Lake Hartwell Getaway - Gorgeous Lake Views!
Bountyland Cottage ~ Lake Keowee & Clemson
The price is $153 per night from Dec 14 to Dec 15
$153
per night
Dec 14 - Dec 15
2.64 mi from city center
5/5 Exceptional! (4 reviews)
So many cute amenities
"The hit by far was the espresso bar. Loved the game room, haven’t played Pac Man in years!! There were cornhole boards and an outdoor ping pong table. Wished it hadn’t rained so we could have played more! Thoughtful touches like shaving kits and black makeup towels so not to ruin the white towels. ..."

Reviewed on Nov 29, 2022

Bountyland Cottage ~ Lake Keowee & Clemson
Cozy Bungalow on Beautiful Horse Farm w/boat parking, close to Clemson Univ
5/5 Exceptional! (17 reviews)
Peaceful and Cozy
"I needed a place to stay while visiting to see my child play in Tiger Band at a Clemson football game. I don’t like crowds or traffic, and this was the perfect peaceful getaway, only 20 min. from campus. It was fun to have a “tiny home” experience, and wake up to horses just past the front porch. ..."

Reviewed on Nov 21, 2022

Cozy Bungalow on Beautiful Horse Farm w/boat parking, close to Clemson Univ
Newly renovated lake house directly on Hartwell, 3 miles by boat from Clemson
4.9/5 Exceptional! (74 reviews)
A wonderful house!
"We stayed here for a gameday weekend and it was a great stay! Only a 15 min Uber to Clemson. Very clean house exactly as advertised with plenty of things to do! Will absolutely be looking to stay here again!"

Reviewed on Nov 23, 2022

Newly renovated lake house directly on Hartwell, 3 miles by boat from Clemson
Fishing Cabin - Keowee 2 bedrooms, 2 bathrooms - Fishing - Kayaking - Porch
4.9/5 Exceptional! (55 reviews)
Great get away
"Cute little cabin in the woods! Nicer then pics presented. Would go back again. Great fishing area. Pleasantly surprised with washer and dryer, however dryer worked but was very loud and needs to be serviced. Also toilet with tub in it got clogged several times. The owner put a propane BBQ on the ..."

Reviewed on Nov 3, 2022

Fishing Cabin - Keowee 2 bedrooms, 2 bathrooms - Fishing - Kayaking - Porch
Hampton Inn & Suites Seneca-Clemson Area
2.5 out of 5
1011 East North 1st Street, Seneca, SC, 29678
Fully refundableReserve now, pay when you stay
The price is $117 per night from Dec 11 to Dec 12
$117
per night
Dec 11 - Dec 12
1.15 mi from city center
4.7/5 Exceptional! (426 reviews)
"Very upscale property. Quiet!"

Reviewed on Oct 20, 2022

Hampton Inn & Suites Seneca-Clemson Area
Tru by Hilton Seneca Clemson
2.5 out of 5
13050 Clemson Blvd, Seneca, SC, 29678
Fully refundableReserve now, pay when you stay
The price is $110 per night from Dec 9 to Dec 10
$110
per night
Dec 9 - Dec 10
5.12 mi from city center
4.5/5 Wonderful! (381 reviews)
Convenient to Clemson and mountains
"Friendly front desk. Clean and comfy rooms. Good breakfast. Super nice fire pit"

Reviewed on Nov 1, 2022

Tru by Hilton Seneca Clemson
Boutique hotel in historic downtown Seneca (Room #4)
The price is $130 per night from Dec 3 to Dec 4
$130
per night
Dec 3 - Dec 4
0.03 mi from city center
4.9/5 Exceptional! (7 reviews)
Lofts
"Loved our stay however, we have attempted to book two more times and haven’t heard from David. Time expires."

Reviewed on Nov 26, 2022

Boutique hotel in historic downtown Seneca (Room #4)
Don't see what you're looking for?
See all available properties in Seneca
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Seneca

Find the best Seneca areas and neighborhoods for the activities you enjoy most. Learn more about Seneca

Seneca hotels information

Number of reviews 1684
Accommodation 188 hotels
Lowest Price $110
Highest Price $212

Frequently asked questions

Where is the best place for a stay in Seneca?

Hampton Inn & Suites Seneca-Clemson Area is ranked highly by Expedia customers. This hotel offers free breakfast and free parking. Traveler reviews also recommend Lakeside Lodge Clemson and Best Western Seneca-Clemson as top choices for your visit. See all available top hotels, or vacation rentals in Seneca.

What's the top vacation rental in Seneca?

4/3BB,3 acres, covered Dock, 2 Lrg.Covered Decks, 4.9 rating, $2400 mon/winter: Visitors give good reviews to this Seneca vacation home rental, which is located on a lake and has a fireplace, a balcony, and a barbecue grill to put you at ease in your new surroundings. It has 4 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. Kick off your shoes and enjoy yourself with a garden and an arcade game room. Some other homes for rent in Seneca include The Clemson Cottage | 3.6mi to Football Stadium and Cozy Bungalow on Beautiful Horse Farm w/boat parking, close to Clemson Univ. See all vacation rentals in Seneca.

What top hotels in Seneca are known for their enhanced cleaning?

If you're having a hard time finding properties with enhanced cleaning that have everything you're looking for, consider The Inn at Patrick Square, which is located 10 miles from the city center. A wallet-friendly option for your stay is Hampton Inn & Suites Seneca-Clemson Area, a 2.5-star hotel in Seneca that offers enhanced cleaning measures. For more choices, browse all hotels in Seneca with enhanced sanitizing practices.

If I need to cancel my hotel reservation in Seneca, will I receive a refund?

Yes, the majority of hotel reservations are refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If your reservation is non-refundable, it might still be possible to cancel it and be given a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Seneca.

Where can I learn more about changing or cancelling my trip to Seneca?

To find more details about updating your trip to Seneca or cancelling it, click here.

What's the best budget-friendly accommodation in Seneca?

Based on reviews, Quality Inn Seneca US-123 is a popular 2.5-star hotel for our travelers looking for an economical choice, and features free breakfast and free WiFi. View all budget hotels in Seneca.

What's the best place to stay for a family vacation to Seneca?

Tru by Hilton Seneca Clemson is a hotel with free parking and free breakfast, and it's a top choice on Expedia for families. Other good options for your stay with the kids include Days Inn by Wyndham Seneca / Clemson Area and Best Western Seneca-Clemson. Attractions in the area like Ultimate Action Sports and Georgia Visitor Information Center - Lavonia are also fun for kids of all ages. Find more child-friendly accommodations in Seneca.

What's the best pet-friendly accommodation in Seneca?

Quality Inn Seneca US-123 is a top hotel for people traveling with their pets, and offers a seasonal outdoor pool and free WiFi for its human guests. Days Inn by Wyndham Seneca / Clemson Area is another option if you're bringing your pet along. See more pet-friendly hotel accommodations in Seneca.

What are some hotels with pools in Seneca?

Best Western Seneca-Clemson is a top hotel with a seasonal outdoor pool, free WiFi, and free parking. View all hotels with pools in Seneca.

What is the best accommodation for staying close to Greenville-Spartanburg International Airport (GSP)?

Wyndham Garden Greenville Airport is one of the top choices for your stay and is a popular 3-star hotel featuring free breakfast and a restaurant. It's located 3.8 mi (6.1 km) from Greenville-Spartanburg Intl. Airport. Other good options near the airport include Best Western Greenville Airport Inn and Extended Stay America - Greenville - Airport.

What is staying in Seneca like?

Visitors to Seneca are sure to enjoy the sporting events, lakeside setting, and university setting. Welcoming and scenic, this city also attracts tourists with its coffeehouses. In Seneca, there are 188 hotels and other accommodations to choose from. Find out more about Seneca.

What should I do while I'm visiting Seneca?

Natural beauty is on display at Lake Keowee, Lake Hartwell, and Keowee Reservoir. Exploring the waterfront is a great activity, and Keowee Key Golf Course is one place to visit. The university setting is a highlight and Clemson University is worth a campus tour. Check out what more to see and do in Expedia's Seneca guide.

Recent reviews of Seneca hotels
expedia verified reviews

Plan your trip in a snap on the app

From home or hammock, organize your entire escape and explore app offers

Text yourself a download link for easy access

Get a link to download the app in the Apple App Store or Google Play Store. 1 message per request. Message and data rates may apply. Text HELP for help or STOP to unsubscribe. Review the App Download SMS terms at www.expedia.com/app. For privacy, please go to www.expedia.com/lp/lg-privacypolicy.
QR code