Dupo Vacations from $540

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Your Dupo Vacation

Book a Dupo vacation package and get set to experience the highlights of this city. Think about staying in the neighborhood of Soulard, which is great for distilleries and craft breweries, bars and pubs and markets. There's plenty to explore during your trip to Dupo, including Eckert’s Millstadt Farm and Triple Lakes Golf Course. Whoever you're taking time off with and whatever you plan to spend, your ultimate Dupo vacation is just clicks away with Expedia.

The Latest Dupo vacation packages

Price found within the past 48 hours. Click for updated prices.
Riverside Inn Hannibal

Riverside Inn Hannibal

2.5 out of 5
Price was $699, price is now $540 per person
$540
per person
Mar 19 - Mar 23
found 16 hours ago
Roundtrip flight included
Phoenix (PHX) to St. Louis (STL)
9.4/10 Exceptional! (162 reviews)
Clean, spacious room with a big desk; fully functional kitchen (full size fridge, stove, dishwasher, dishes, pots and pans); large walk-in shower; and comfortable bed. Quiet (unlike larger chain hotels). Great view of the river. Delicious Mexican food downstairs. 11/10, will stay here again.

Reviewed on Nov 23, 2025

The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
Price was $1,157, price is now $793 per person
$793
per person
Feb 13 - Feb 16
found 1 day ago
Roundtrip flight included
Boston (BOS) to St. Louis (STL)
9.2/10 Wonderful! (1,600 reviews)
It’s a nice place, clean but dated. The reason I give it three stars is that I felt it was very overpriced. It is more or less your average hotel but it is priced like a five star resort.

Reviewed on Jan 10, 2026

White House at Grand Central

White House at Grand Central

4 out of 5
Grand Center
Price was $915, price is now $651 per person
$651
per person
Mar 15 - Mar 21
found 1 day ago
Roundtrip flight included
Boston (BOS) to St. Louis (STL)
8.6/10 Excellent! (123 reviews)
Very clean and very friendly people

Reviewed on Nov 11, 2025

The Knight Center at Washington University

The Knight Center at Washington University

2.5 out of 5
Price was $1,203, price is now $903 per person
$903
per person
Mar 15 - Mar 21
found 1 day ago
Roundtrip flight included
Boston (BOS) to St. Louis (STL)
9.4/10 Exceptional! (425 reviews)
I like academic environments. This works well for me when visiting STL. I have stayed here during two different trips, and I would do it again if/when the occasion arises.

Reviewed on Dec 27, 2025

Hermann Grain Bins BNB

Hermann Grain Bins BNB

2 out of 5
Price was $906, price is now $702 per person
$702
per person
Feb 14 - Feb 16
found 11 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to St. Louis (STL)
2/10 (1 review)
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Dupo Hotel Deals

Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

4 out of 5
315 Chestnut St St. Louis MO
Fully refundableReserve now, pay when you stay
$125 nightly
The price is $147 total per night from Jan 16 to Jan 17
$147 total
Jan 16 - Jan 17
Total with taxes and fees
8.4/10 Very Good! (4,031 reviews)
There were issues at the hotel but also some nice things to enjoy. The parking was not fun - they were refinishing a walking area with sticky stuff and the shower was not fully clean but the Brewhouse was nice and the bed was comfortable. The Arch being nearby was great. The staff was hospitable ...

Reviewed on Jan 7, 2026

Hyatt Regency St. Louis at The Arch
Hampton Inn St. Louis-Downtown (At the Gateway Arch)

Hampton Inn St. Louis-Downtown (At the Gateway Arch)

2.5 out of 5
333 Washington Ave St. Louis MO
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $114 total per night from Jan 20 to Jan 21
$114 total
Jan 20 - Jan 21
Total with taxes and fees
8.6/10 Excellent! (1,215 reviews)
No, the room wasn't spotless. One of the ottomans underneath the desk has some type of white crumbs or something on it. Other than that, the hospitality was nice.

Reviewed on Jan 11, 2026

Hampton Inn St. Louis-Downtown (At the Gateway Arch)
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

4 out of 5
421 N 8th St St. Louis MO
Fully refundableReserve now, pay when you stay
$97 nightly
The price is $115 total per night from Jan 25 to Jan 26
$115 total
Jan 25 - Jan 26
Total with taxes and fees
8.6/10 Excellent! (1,190 reviews)
Wonderful stay

Reviewed on Jan 8, 2026

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
See all 1,645 properties in Dupo
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Dupo Vacation Packages

Dupo Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Lambert-St. Louis Intl. Airport (STL)
Population
3,900
Max Temp Winter
40ºF
Max Temp Summer
85ºF
Top Sights
Eckert’s Millstadt Farm and Triple Lakes Golf Course

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Frequently asked questions

How much does a Dupo vacation package cost?
You'll find cheap prices from $540 on Expedia for your Dupo escape. However, factors like the season, length of stay and your choice of hotel will determine how much your vacation to Dupo costs.
What are the cheapest months to go to Dupo?
You can usually find reduced prices and greater availability in November, December and January. Take a look at our cheap Dupo vacation packages and you could land some great off-season deals.
How many days is enough for Dupo?
With a well-organized travel plan, you can easily tick off the most popular Dupo attractions in a few days. But if you'd like to discover hidden spots or go on day tours, consider booking your Dupo vacation for longer.
How to find the best Dupo package deals?
Use Expedia's handy filters to find some great Dupo package deals. When you start your search, just set your maximum budget and then sort the results by "Price: low to high." If you want to save, plan your trip for midweek, or look for Dupo package deals in the off-season. Play around with your travel dates and you may land even better discounts. As a rule of thumb, it's typically best to lock in your vacation package as early as possible.
Is it cheaper to book a Dupo vacation as a package?
An Expedia vacation package could land you significant savings when compared to booking hotels and flights individually. Better still, you can customize your Dupo escape to fit your exact style. Pick your preferred flight time, select the hotel type and add a car rental. Browse our bundle deals and find out how much you can save.
When to book a vacation package to Dupo?
If you're considering a spontaneous Dupo getaway, browse our last-minute deals that can be booked up to one week before you go. Don't want to leave things to the last minute? You can score terrific deals on your flights and hotels by booking well in advance.
Does Expedia offer Book Now, Pay Later Dupo vacation packages?
If you're anything like us, you love exploring new places but are not a fan of the big price tag that can come with it. That's why we offer Book Now, Pay Later vacations. With the help of online lender Affirm, you can spread the overall cost of your Dupo break across 3, 6 or 12 months. There are also no late payment fees or hidden costs, so you can secure cheap vacation packages with payment plans as soon as you spot them.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.