Esquilino Vacations from $961

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Your Esquilino Vacation

Avoid the hassle of travel planning with an Esquilino vacation package. With everything organized before you take off, all that's left to do is enjoy this commercial neighborhood's history, dining and culture. Not sure what to do and see during your trip to Esquilino? Nearby attractions like St. Peters Basilica, Roman Forum and Pantheon are great places to start. Don't just imagine it — turn it into reality! Book your ideal Esquilino vacation with Expedia and travel your way.

The Latest Esquilino Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Grand Hotel Olympic

Grand Hotel Olympic

4 out of 5
Rome City Centre
Save 100% on your flight
per person
Sep 22 - Sep 27
found 1 day ago
Roundtrip flight included
Boston (BOS) to Rome (FCO)
7.2/10 Good! (1,011 reviews)
Clean property. Air conditioning. Great breakfast. 10 min walk to the Vatican and the Metro. Friendly and helpful staff. A terrific value!

Reviewed on Jun 24, 2025

Smart Guesthouse

Smart Guesthouse

3 out of 5
Rome City Centre
Save 100% on your flight
per person
Sep 6 - Sep 13
found 1 day ago
Roundtrip flight included
New York (JFK) to Rome (FCO)
9.4/10 Exceptional! (44 reviews)
The room is in excellent condition, clean and a very comfortable bed. Super convenient since it’s 2 blocks away from the Termini. Plus, the owner answers your questions very quickly and all these details make your visit a very enjoyable experience.

Reviewed on Jun 28, 2025

EXE Domus Aurea

EXE Domus Aurea

3 out of 5
Rome City Centre
Save 100% on your flight
per person
Sep 3 - Sep 10
found 2 hours ago
Roundtrip flight included
New York (JFK) to Rome (FCO)
8/10 Very Good! (476 reviews)
Good location and friendly staff. Although this didn’t bother me, it could be a bit noisy at night due to some night walkers on the street.

Reviewed on Nov 19, 2024

Piazza di Spagna Suite de Charme

Piazza di Spagna Suite de Charme

1 out of 5
Rome City Centre
Save 100% on your flight
per person
Sep 3 - Sep 10
found 17 hours ago
Roundtrip flight included
New York (JFK) to Rome (FCO)
9.2/10 Wonderful! (212 reviews)
Already recommended this place to friends. As close to the Spanish steps for the price as one can get!

Reviewed on Jun 27, 2025

Màs Boutique Hotel

Màs Boutique Hotel

3 out of 5
Rome City Centre
Save 100% on your flight
per person
Sep 16 - Sep 22
found 9 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Rome (FCO)
9.4/10 Exceptional! (29 reviews)
Very clean and safe hotel with spacious rooms, despite the hotel itself being old and compact with a limited number of rooms. The staff is very nice, and the area is beautiful, lively, and fun.

Reviewed on Jun 15, 2025

Where to stay in Esquilino

Find the best Esquilino areas and neighborhoods for the activities you enjoy most. Learn more about Esquilino
Via del Corso which includes heritage architecture, heritage elements and street scenes

Rome City Centre

8 out of top 10 points of interest in this area
4.5/5(3,994 area reviews)

Follow in the footsteps of ancient Romans when you tour the Eternal City's most well-known historical sites and see where it started almost 3,000 years ago.

Find hotels in Rome City Centre

Esquilino Hotel Deals

Napoleon Hotel
Napoleon Hotel
4 out of 5
Piazza Vittorio Emanuele II 105, Rome, RM
Fully refundableReserve now, pay when you stay
$118 nightly
The price is $148 total per night from Jul 31 to Aug 1
$148 total
Jul 31 - Aug 1
Total includes taxes and fees
8.4/10 Very Good! (1,005 reviews)
"Muy agradable y la atención muy buena! Agradecidos con la gentileza y servicio"

Reviewed on Jun 29, 2025

Napoleon Hotel
Hotel Palladium Palace
Hotel Palladium Palace
4 out of 5
Via Gioberti 36, Rome, RM
Fully refundableReserve now, pay when you stay
$103 nightly
The price is $131 total per night from Jul 3 to Jul 4
$131 total
Jul 3 - Jul 4
Total includes taxes and fees
8/10 Very Good! (837 reviews)
"The staff was always supper friendly. Hotel was very clean, and we really enjoyed our stay."

Reviewed on Jun 17, 2025

Hotel Palladium Palace
NH Collection Roma Palazzo Cinquecento
NH Collection Roma Palazzo Cinquecento
5 out of 5
Piazza Dei Cinquecento, 90, Rome, RM
Fully refundableReserve now, pay when you stay
$299 nightly
The price is $352 total per night from Jul 30 to Jul 31
$352 total
Jul 30 - Jul 31
Total includes taxes and fees
9/10 Wonderful! (999 reviews)
"Our rooms were great - comfortable and extremely clean. Service was excellent. The breakfast buffet was delicious and had the best variety."

Reviewed on Jun 17, 2025

NH Collection Roma Palazzo Cinquecento
See all 672 properties in Esquilino
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

All Inclusive Vacations

All Inclusive Vacations

Beach Vacations

Beach Vacations

Kid Friendly Vacations

Kid Friendly Vacations

Discover the most popular places to visit in Esquilino

Palm Trees in the Evening Light

Piazza Vittorio Emanuele II

5/5(1 review)

Explore the great outdoors at Piazza Vittorio Emanuele II, a lovely green space in Rome. Experience the fascinating museums and acclaimed art scene in this vibrant area.

Piazza Vittorio Emanuele II
Piazza Santa Maria Maggiore

Piazza Santa Maria Maggiore

3.5/5(3 reviews)

Find out about the history of Rome when you take a trip to Piazza Santa Maria Maggiore. Experience the acclaimed art scene and fascinating museums in this vibrant area.

Piazza Santa Maria Maggiore

Basilica di Santa Croce in Gerusalemme

5/5(1 review)

Find out about the history of Rome when you take a trip to Basilica di Santa Croce in Gerusalemme. Discover the fascinating museums and churches in this vibrant area.

Basilica di Santa Croce in Gerusalemme

Things to do

Pompeii, Amalfi Coast and Sorrento Day Trip from Rome

From Rome: Sorrento & Amalfi Coast with Pompeii or Positano Option

$103
per adult
92% of travellers recommend
From Rome: Sorrento & Amalfi Coast with Pompeii or Positano Option
Rome Hop-On Hop-Off Big Bus Tour

Rome Hop-On Hop-Off Big Bus Tour

$20
per adult
82% of travellers recommend
Rome Hop-On Hop-Off Big Bus Tour
Having fun while tasting Chianti

Tuscany Wine Tour : 2 Wineries & San Gimignano from Florence

$93
per adult
100% of travellers recommend
Tuscany Wine Tour : 2 Wineries & San Gimignano from Florence
See all activities in Rome
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.