Esquilino Vacations from $1,576

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Your Esquilino Vacation

Avoid the hassle of travel planning with an Esquilino vacation package. With everything organized before you take off, all that's left to do is enjoy this commercial neighborhood's history, dining and culture. Not sure what to do and see during your trip to Esquilino? Nearby attractions like St. Peters Basilica, Roman Forum and Pantheon are great places to start. Don't just imagine it — turn it into reality! Book your ideal Esquilino vacation with Expedia and travel your way.

The Latest Esquilino Vacation Packages

Price found within the past 48 hours. Click for updated prices.
EXE Domus Aurea

EXE Domus Aurea

3 out of 5
Rome City Centre
Price was $2,202, price is now $1,576 per person
$1,576
per person
Jul 4 - Jul 11
found 1 day ago
Roundtrip flight included
New York (NYC) to Rome (FCO)
8/10 Very Good! (498 reviews)
Everything was great. The check in process was fast. Enjoyed breakfast specially it was located on the rooftop. The room was always clean. Friendly and helpful staffs.

Reviewed on Dec 31, 2025

Hotel Delle Civette

Hotel Delle Civette

3 out of 5
Nomentano
Price was $2,644, price is now $1,644 per person
$1,644
per person
May 20 - May 25
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Rome (FCO)
9.6/10 Exceptional! (290 reviews)
Very confortable, clean and friendly staff.

Reviewed on Apr 12, 2026

ROMEO Roma

ROMEO Roma

5 out of 5
Rome City Centre
Save 100% on your flight
Price was $4,795, price is now $3,054 per person
$3,054
per person
May 13 - May 16
found 1 day ago
Roundtrip flight included
Boston (BOS) to Rome (FCO)
No reviews
DOM Hotel

DOM Hotel

5 out of 5
Rome City Centre
Save 100% on your flight
Price was $5,919, price is now $3,867 per person
$3,867
per person
May 25 - May 31
found 19 hours ago
Roundtrip flight included
New York (JFK) to Rome (FCO)
9.2/10 Wonderful! (406 reviews)
The staff make this property special. They truly treat you like family!! This place is the best!! My new favorite spot lace in Rome!!

Reviewed on Mar 17, 2026

Hotel Splendide Royal - The Leading Hotels of the World

Hotel Splendide Royal - The Leading Hotels of the World

5 out of 5
Rome City Centre
Save 100% on your flight
Price was $6,303, price is now $4,168 per person
$4,168
per person
May 29 - Jun 4
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Rome (FCO)
9.4/10 Exceptional! (1,002 reviews)
Beautifully appointed rooms, fantastic, very knowledgeable staff and Delicious breakfast. I would stay again in this hotel in a heartbeat

Reviewed on Apr 11, 2026

Where to stay in Esquilino

Find the best Esquilino areas and neighborhoods for the activities you enjoy most. Learn more about Esquilino
Rome City Centre

Rome City Centre

8 out of top 10 points of interest in this area
4.5/5(4,037 area reviews)

Follow in the footsteps of ancient Romans when you tour the Eternal City's most well-known historical sites and see where it started almost 3,000 years ago.

Find hotels in Rome City Centre

Esquilino Hotel Deals

Napoleon Hotel

Napoleon Hotel

4 out of 5
Piazza Vittorio Emanuele II 105 Rome RM
Fully refundableReserve now, pay when you stay
$175 nightly
The price is $210 total per night from Apr 13 to Apr 14
$210 total
Apr 13 - Apr 14
Total with taxes and fees
8.6/10 Excellent! (1,008 reviews)
We loved our stay.

Reviewed on Apr 12, 2026

Napoleon Hotel
NH Collection Roma Palazzo Cinquecento

NH Collection Roma Palazzo Cinquecento

5 out of 5
Piazza Dei Cinquecento, 90 Rome RM
$368 nightly
The price is $428 total per night from Apr 19 to Apr 20
$428 total
Apr 19 - Apr 20
Total with taxes and fees
9/10 Wonderful! (1,004 reviews)
Great location , staff exceptionally professional ,

Reviewed on Apr 11, 2026

NH Collection Roma Palazzo Cinquecento
Hotel Aphrodite

Hotel Aphrodite

4 out of 5
Via Marsala 90 Rome RM
Fully refundableReserve now, pay when you stay
$184 nightly
The price is $220 total per night from Apr 19 to Apr 20
$220 total
Apr 19 - Apr 20
Total with taxes and fees
7.8/10 Good! (1,002 reviews)
The staff were very helpful and nice. The room was always nice and cleaned when we back in our room from Rome exploring. The breakfast buffet was so convenient.

Reviewed on Mar 25, 2026

Hotel Aphrodite
See all 732 properties in Esquilino
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Discover the most popular places to visit in Esquilino

Piazza Santa Maria in Trastevere in Rome, Italy

Piazza Santa Maria Maggiore

3.5/5(3 reviews)

Find out about the history of Rome when you take a trip to Piazza Santa Maria Maggiore. Experience the acclaimed theater scene and fascinating museums in this vibrant area.

Piazza Santa Maria Maggiore

Piazza Vittorio Emanuele II

5/5(1 review)

Explore the great outdoors at Piazza Vittorio Emanuele II, a lovely green space in Rome. Experience the acclaimed theater scene and fascinating museums in this vibrant area.

Piazza Vittorio Emanuele II

Basilica di Santa Croce in Gerusalemme

5/5(1 review)

Find out about the history of Rome when you take a trip to Basilica di Santa Croce in Gerusalemme. Discover the fascinating museums and churches in this vibrant area.

Basilica di Santa Croce in Gerusalemme

Things to do

Rome Hop-On Hop-Off Big Bus Tour

Rome Big Bus Hop-on, Hop-off Tour by Open-top Bus

$27
per adult
84% of travellers recommend
Rome Big Bus Hop-on, Hop-off Tour by Open-top Bus
Skip-the-line: Colosseum & Forum Tour with Special Gladiator’s Gate & Arena Floor Access

Gladiator’s Gate:Special Access Colosseum Tour & Arena Floor in Small Group

$125
per adult
94% of travellers recommend
Gladiator’s Gate:Special Access Colosseum Tour & Arena Floor in Small Group
Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica

Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica

$39
per adult
90% of travellers recommend
Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica
See all activities in Rome
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.