Esquilino Vacations from $952

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Your Esquilino Vacation

Avoid the hassle of travel planning with an Esquilino vacation package. With everything organized before you take off, all that's left to do is enjoy this commercial neighborhood's history, dining and culture. Not sure what to do and see during your trip to Esquilino? Nearby attractions like St. Peters Basilica, Roman Forum and Pantheon are great places to start. Don't just imagine it — turn it into reality! Book your ideal Esquilino vacation with Expedia and travel your way.

The Latest Esquilino Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Smart Guesthouse

Smart Guesthouse

3 out of 5
Rome City Centre
Save 100% on your flight
per person
Oct 26 - Nov 1
found 1 day ago
Roundtrip flight included
New York (JFK) to Rome (FCO)
9.4/10 Exceptional! (56 reviews)
Clean and comfortable. Check in 3PM, check out 10AM. Free wifi, bottle water, espresso machine. Good linens and nice bed.

Reviewed on Aug 16, 2025

Vibe Nazionale

Vibe Nazionale

3 out of 5
Rome City Centre
Save 100% on your flight
per person
Oct 19 - Oct 25
found 1 day ago
Roundtrip flight included
New York (JFK) to Rome (FCO)
8/10 Very Good! (61 reviews)
Great location, rooms in good condition, good breakfast with outstanding staff working the breakfast room. But the front desk was rude and generally unhelpful. (Exception was Margarita, who was outstanding). Would not stay there again. V

Reviewed on Oct 3, 2023

CC Palace Hotel Roma

CC Palace Hotel Roma

4 out of 5
Rome City Centre
Save 100% on your flight
per person
Oct 26 - Nov 1
found 1 day ago
Roundtrip flight included
New York (JFK) to Rome (FCO)
9.8/10 Exceptional! (345 reviews)
Clean property with excellent breakfast and service. Value for money was likely not there.

Reviewed on Aug 3, 2025

Piazza di Spagna Suite de Charme

Piazza di Spagna Suite de Charme

1 out of 5
Rome City Centre
Save 100% on your flight
per person
Oct 19 - Oct 24
found 1 day ago
Roundtrip flight included
New York (JFK) to Rome (FCO)
9.2/10 Wonderful! (217 reviews)
Good location and customer service. Small room but for 2 nights it was very good!

Reviewed on Jul 6, 2025

Hotel Varese Roma

Hotel Varese Roma

3 out of 5
Rome City Centre
Save 100% on your flight
per person
Oct 12 - Oct 17
found 1 day ago
Roundtrip flight included
New York (JFK) to Rome (FCO)
8.6/10 Excellent! (327 reviews)
The service was excellent.

Reviewed on Aug 16, 2025

Where to stay in Esquilino

Find the best Esquilino areas and neighborhoods for the activities you enjoy most. Learn more about Esquilino
Via del Corso which includes heritage architecture, heritage elements and street scenes

Rome City Centre

8 out of top 10 points of interest in this area
4.5/5(3,994 area reviews)

Follow in the footsteps of ancient Romans when you tour the Eternal City's most well-known historical sites and see where it started almost 3,000 years ago.

Find hotels in Rome City Centre

Esquilino Hotel Deals

Napoleon Hotel

Napoleon Hotel

4 out of 5
Piazza Vittorio Emanuele II 105, Rome, RM
Fully refundableReserve now, pay when you stay
$95 nightly
The price is $122 total per night from Aug 26 to Aug 27
$122 total
Aug 26 - Aug 27
Total includes taxes and fees
8.2/10 Very Good! (1,003 reviews)
"Great hotel - close to the colosseum"

Reviewed on Aug 10, 2025

Napoleon Hotel
Hotel Palladium Palace

Hotel Palladium Palace

4 out of 5
Via Gioberti 36, Rome, RM
Fully refundableReserve now, pay when you stay
$112 nightly
The price is $141 total per night from Aug 29 to Aug 30
$141 total
Aug 29 - Aug 30
Total includes taxes and fees
8/10 Very Good! (864 reviews)
"Amazing staff. Their breakfast is wonderful, lots of options."

Reviewed on Aug 13, 2025

Hotel Palladium Palace
NH Collection Roma Palazzo Cinquecento

NH Collection Roma Palazzo Cinquecento

5 out of 5
Piazza Dei Cinquecento, 90, Rome, RM
Fully refundableReserve now, pay when you stay
$332 nightly
The price is $389 total per night from Aug 26 to Aug 27
$389 total
Aug 26 - Aug 27
Total includes taxes and fees
9/10 Wonderful! (1,001 reviews)
Rome stay
"We stayed 4 nights and loved it. We only had breakfast there once, but it was great. The AC is a major plus."

Reviewed on Aug 13, 2025

NH Collection Roma Palazzo Cinquecento
See all 679 properties in Esquilino
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Esquilino

Piazza Santa Maria Maggiore

Piazza Santa Maria Maggiore

Find out about the history of Rome when you take a trip to Piazza Santa Maria Maggiore. Experience the acclaimed art scene and fascinating museums in this vibrant area.

Piazza Santa Maria Maggiore
Palm Trees in the Evening Light

Piazza Vittorio Emanuele II

Explore the great outdoors at Piazza Vittorio Emanuele II, a lovely green space in Rome. Experience the acclaimed theater scene and fascinating museums in this vibrant area.

Piazza Vittorio Emanuele II

Basilica di Santa Croce in Gerusalemme

Find out about the history of Rome when you take a trip to Basilica di Santa Croce in Gerusalemme. Discover the acclaimed theater scene and notable monuments in this vibrant area.

Basilica di Santa Croce in Gerusalemme

Things to do

Rome Hop-On Hop-Off Big Bus Tour

Rome Hop-On Hop-Off Big Bus Tour

$27
per adult
82% of travellers recommend
Rome Hop-On Hop-Off Big Bus Tour
Having fun while tasting Chianti

Tuscany Wine Tour : 2 Wineries & San Gimignano from Florence

$221
per adult
100% of travellers recommend
Tuscany Wine Tour : 2 Wineries & San Gimignano from Florence
Pompeii and Naples Day Trip from Rome by High Speed Train

Pompeii & Naples Tour from Rome by Train, Includes Lunch

$249
per adult
74% of travellers recommend
Pompeii & Naples Tour from Rome by Train, Includes Lunch
See all activities in Rome
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.