Esquilino Vacations from $868

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Your Esquilino Vacation

Avoid the hassle of travel planning with an Esquilino vacation package. With everything organized before you take off, all that's left to do is enjoy this commercial neighborhood's history, dining and culture. Not sure what to do and see during your trip to Esquilino? Nearby attractions like St. Peters Basilica, Roman Forum and Pantheon are great places to start. Don't just imagine it — turn it into reality! Book your ideal Esquilino vacation with Expedia and travel your way.

The Latest Esquilino Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Arcom Palace

Arcom Palace

4 out of 5
Price was $2,332, price is now $868 per person
$868
per person
Apr 1 - Apr 2
found 1 day ago
Roundtrip flight included
Miami (MIA) to Rome (FCO)
8.6/10 Excellent! (141 reviews)
Authentic feeling of old Italy mixed with the new. Very friendly and helpful staff...addressing and sensitive to all our needs and requests. Spacious,comfortable and clean rooms with a balcony. Filling breakfast with adequate variety of foods/beverages. Easily would revisit this place!

Reviewed on Oct 8, 2025

Tree Charme Parliament Boutique Hotel

Tree Charme Parliament Boutique Hotel

3 out of 5
Rome City Centre
Save 100% on your flight
Price was $3,367, price is now $2,062 per person
$2,062
per person
May 10 - May 16
found 20 hours ago
Roundtrip flight included
New York (JFK) to Rome (FCO)
8.8/10 Excellent! (28 reviews)
One of the best hotels I’ve ever stayed at. It’s a newer hotel in Rome. The room was clean, the staff were very helpful, and the cleaning lady was very thorough. I’d definitely stay here again when I return to Rome. Also, the breakfast and service were great!

Reviewed on Dec 3, 2025

Hotel San Giusto

Hotel San Giusto

3 out of 5
Nomentano
Price was $2,341, price is now $875 per person
$875
per person
Apr 1 - Apr 2
found 1 day ago
Roundtrip flight included
Miami (MIA) to Rome (FCO)
7/10 Good! (296 reviews)
Wonderful location !!! Right beside Bologna subway station.

Reviewed on Jul 6, 2025

SHG Hotel Antonella

SHG Hotel Antonella

4.5 out of 5
Price was $2,328, price is now $871 per person
$871
per person
Apr 1 - Apr 2
found 1 day ago
Roundtrip flight included
Miami (MIA) to Rome (FCO)
8.2/10 Very Good! (267 reviews)
Very nice staff and good room spa e

Reviewed on Feb 20, 2026

Hotel Best Roma

Hotel Best Roma

4 out of 5
Rome Historic Centre
Price was $2,363, price is now $887 per person
$887
per person
Apr 1 - Apr 2
found 1 day ago
Roundtrip flight included
Miami (MIA) to Rome (FCO)
7.6/10 Good! (455 reviews)
Hotel was clean and breakfast ok. Very poor customer service on arrival. Ignored at check in and unwelcoming. Delay on room being ready. First impressions count!

Reviewed on Sep 22, 2025

Where to stay in Esquilino

Find the best Esquilino areas and neighborhoods for the activities you enjoy most. Learn more about Esquilino
Via del Corso which includes heritage architecture, heritage elements and street scenes

Rome City Centre

8 out of top 10 points of interest in this area
4.5/5(3,994 area reviews)

Follow in the footsteps of ancient Romans when you tour the Eternal City's most well-known historical sites and see where it started almost 3,000 years ago.

Find hotels in Rome City Centre

Esquilino Hotel Deals

Napoleon Hotel

Napoleon Hotel

4 out of 5
Piazza Vittorio Emanuele II 105 Rome RM
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $139 total per night from Mar 1 to Mar 2
$139 total
Mar 1 - Mar 2
Total with taxes and fees
8.4/10 Very Good! (1,009 reviews)
Everything great

Reviewed on Feb 23, 2026

Napoleon Hotel
Hotel Aphrodite

Hotel Aphrodite

4 out of 5
Via Marsala 90 Rome RM
Fully refundableReserve now, pay when you stay
$113 nightly
The price is $143 total per night from Feb 26 to Feb 27
$143 total
Feb 26 - Feb 27
Total with taxes and fees
7.8/10 Good! (1,002 reviews)
Room was clean and the staff was very nice!

Reviewed on Feb 15, 2026

Hotel Aphrodite
NH Collection Roma Palazzo Cinquecento

NH Collection Roma Palazzo Cinquecento

5 out of 5
Piazza Dei Cinquecento, 90 Rome RM
$251 nightly
The price is $299 total per night from Mar 1 to Mar 2
$299 total
Mar 1 - Mar 2
Total with taxes and fees
9/10 Wonderful! (1,000 reviews)
Amazing staff by far these was my best hotel experience and I have visited over 500 hotels in past 10 years but the vibe the atmosphere the amount of staff caring about you and making sure you are having a great staying it’s in a next level definitely recommend

Reviewed on Feb 10, 2026

NH Collection Roma Palazzo Cinquecento
See all 708 properties in Esquilino
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Discover the most popular places to visit in Esquilino

Piazza Santa Maria in Trastevere in Rome, Italy

Piazza Santa Maria Maggiore

3.5/5(3 reviews)

Find out about the history of Rome when you take a trip to Piazza Santa Maria Maggiore. Experience the fascinating museums and acclaimed theater scene in this vibrant area.

Piazza Santa Maria Maggiore

Piazza Vittorio Emanuele II

5/5(1 review)

Explore the great outdoors at Piazza Vittorio Emanuele II, a lovely green space in Rome. Experience the fascinating museums and acclaimed theater scene in this vibrant area.

Piazza Vittorio Emanuele II

Basilica di Santa Croce in Gerusalemme

5/5(1 review)

Find out about the history of Rome when you take a trip to Basilica di Santa Croce in Gerusalemme. Discover the acclaimed theater scene and notable monuments in this vibrant area.

Basilica di Santa Croce in Gerusalemme

Things to do

Underground Rome Catacombs Tour with Aqueducts & Appian Way

Underground Rome Catacombs Tour with Aqueducts & Appian Way

$64
per adult
94% of travellers recommend
Underground Rome Catacombs Tour with Aqueducts & Appian Way
Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

$55
per adult
84% of travellers recommend
Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour
Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica

Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica

$89
per adult
90% of travellers recommend
Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica
See all activities in Rome
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.