Florence County Vacations & Trips from $495

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Your Florence County Vacation

Leave the planning up to us with a Florence County vacation package. With everything arranged before you leave home, the only thing left to do is sit back, chill out and enjoy this destination's countless delights. A trip to Florence County wouldn't be complete without getting to some of its best cities, starting with Florence. Two of the most popular attractions here include Magnolia Mall and Mcleod Regional Medical Center. Lake City is another favorite city with Florence County travelers. Visitors to this exciting destination enjoy The Country Club at Lake City and Moore Farms Botanical Garden. Expedia is a one-stop shop for planning your Florence County vacation. From flights and accommodations, to rental cars and activities, we know how to create a travel experience like no other.

Top destinations in Florence County

The Latest Florence County Vacation Packages

Price found within the past 48 hours. Click for updated prices.
The Ellie Beach Resort Myrtle Beach, Tapestry By Hilton
Sands Beach Club Resort
Marina Inn At Grande Dunes
Marina Inn Grande Dunes Condos & Suites
North Beach Resort & Villas

Find the Best Florence County Vacation Packages

Florence County Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Florence Regional Airport (FLO)
Top Sights
Palmetto Shores Lake, Columns Plantation and Florence Veterans Park

Florence County Hotel Deals

Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence

2 out of 5
2038 W Lucas Street Florence SC
Fully refundableReserve now, pay when you stay
$67 nightly
The price is $75 total per night from Apr 26 to Apr 27
$75 total
Apr 26 - Apr 27
Total with taxes and fees
8.6/10 Excellent! (2,622 reviews)
The staff upon my arrival were not vrry inviting...in regards to check in and I attempted to get a cup of coffee and the clerk said it was old and was made that morning...my arrival time was 6pm...they made no apology or offered to make some fresh coffee.

Reviewed on Apr 11, 2026

Howard Johnson by Wyndham Florence
Park Inn by Radisson Florence, SC

Park Inn by Radisson Florence, SC

2.5 out of 5
1729 Mandeville Road Florence SC
Fully refundable
$89 nightly
The price is $100 total per night from Apr 26 to Apr 27
$100 total
Apr 26 - Apr 27
Total with taxes and fees
9/10 Wonderful! (2,255 reviews)
Room was clean, breakfast was hot with a variety. Staff was courteous. Only downfall, pool is permanently closed

Reviewed on Apr 11, 2026

Park Inn by Radisson Florence, SC
Comfort Inn & Suites Florence Center Area

Comfort Inn & Suites Florence Center Area

2.5 out of 5
527 Woody Jones Blvd Florence SC
Fully refundable
$99 nightly
The price is $111 total per night from May 3 to May 4
$111 total
May 3 - May 4
Total with taxes and fees
9/10 Wonderful! (1,262 reviews)
Safe area, clean hotel. Coffee empty. No water in AM

Reviewed on Apr 11, 2026

Comfort Inn & Suites Florence Center Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.