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Guayaquil Vacations & Trips from $338

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Your Guayaquil Vacation

Make organizing your next big adventure quick and easy with a Guayaquil vacation package. Whether it's the history, cuisine or something else that draws you to this destination, our packages will help you experience the best of it. Putting together an itinerary for your trip to Guayaquil? Begin with top cities like Puerto Santa Ana, Posorja and Pocitos. Expedia is your one-stop shop for planning your Guayaquil vacation. From flights and hotels, to rental cars and more, we're here to help you curate a travel experience like no other.

Top destinations in Guayaquil

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Guayaquil

Guayaquil

The Latest Guayaquil Vacation Packages

Price found within the past 48 hours. Click for updated prices.
  • A modern pool area with a clear blue pool, a hot tub, and outdoor seating.
    Dec 29 - Jan 1

    Oro Verde Cuenca + Flight

    San Sebastián
    3 nights
    4.5 star property
    9.4/10 - Exceptional (656 reviews)
    Roundtrip • Quito (UIO) - Guayaquil (GYE)
    UIO - CUE • Nonstop CUE - UIO • Nonstop
    $432
    $338
    per traveler
    found 1 day ago
    Oro Verde Cuenca
  • A rooftop pool with a curved edge, lounge chairs, and potted plants.
    Dec 30 - Jan 5

    Hotel Río Guayas by Art Hotels Ecuador + Flight

    Las Peñas
    6 nights
    4.0 star property
    10/10 - Exceptional (6 reviews)
    Roundtrip • New York (EWR) - Guayaquil (GYE)
    EWR - GYE • 1 stop GYE - EWR • 1 stop
    $3,569
    $2,380
    per traveler
    found 1 day ago
    Hotel Río Guayas by Art Hotels Ecuador
  • A room with a wooden bench, large vases, a chandelier, and a view through a skylight.
    Dec 29 - Jan 1

    Hotel Cruz del Vado by Art Hotels Ecuador + Flight

    Cuenca
    3 nights
    4.5 star property
    9.4/10 - Exceptional (49 reviews)
    "La ubicación, las habitaciones y las instalaciones! Todo queda caminando un hotel muy cómodo para disfrutar Cuenca"
    Reviewed November 9, 2026
    Roundtrip • Quito (UIO) - Guayaquil (GYE)
    UIO - CUE • Nonstop CUE - UIO • Nonstop
    Save 100% on your flight
    $613
    $443
    per traveler
    found 1 day ago
    Hotel Cruz del Vado by Art Hotels Ecuador
  • A hotel room with two beds, each with a different patterned bedspread. There is a nightstand with a lamp and a small potted plant.
    Jan 13 - Jan 15

    Hospedaje Casa Aida Victoria + Flight

    Downtown Cuenca
    2 nights
    1.0 star property
    Roundtrip • Quito (UIO) - Guayaquil (GYE)
    UIO - CUE • Nonstop CUE - UIO • Nonstop
    $12,834
    $9,552
    per traveler
    found 1 day ago
    Hospedaje Casa Aida Victoria
  • A spacious atrium with a high ceiling, wooden balconies, and lush indoor plants.
    Dec 29 - Jan 1

    Hotel Boutique Santa Lucia + Flight

    Downtown Cuenca
    3 nights
    4.0 star property
    9.2/10 - Wonderful (413 reviews)
    "Great place"
    Reviewed October 28, 2026
    Roundtrip • Quito (UIO) - Guayaquil (GYE)
    UIO - CUE • Nonstop CUE - UIO • Nonstop
    $509
    $396
    per traveler
    found 1 day ago
    Hotel Boutique Santa Lucia

Discover the most popular places to visit in Guayaquil

A monitor lizard on a sandy beach with a clear blue ocean in the background.

Varadero Beach

8.8/10 (11 reviews)
Why not spend a carefree afternoon at Varadero Beach during your travels in Posorja?
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What to do in Guayaquil

City Winery - Two Hemispheres

Wine Tasting Experience with Tasting Menu

$65
per adult
100% of travelers recommend
Wine Tasting Experience with Tasting Menu
See all activities in Guayaquil

Guayaquil Hotel Deals

A person sitting by a window with a towel on their head, reading a magazine.

Holiday Inn Guayaquil Airport by IHG

Holiday Inn Guayaquil Airport by IHG
3.5 star property
3.1 mi from Guayaquil
9.6 out of 10, Exceptional, (1,010 reviews)
$101 nightly
The price is $114
Nov 27 - Nov 28
Holiday Inn Guayaquil Airport by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
See all properties in Guayaquil
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.